Gastrointestinal Diseases and Pharmacology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 September 2026 | Viewed by 972
Editors
Interests: leaky gut; enteric glia; colitis; engineered probiotics
Special Issues, Collections and Topics in MDPI journals
Interests: gut–brain axis; neurodegenerative diseases; neuroinflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gastrointestinal (GI) diseases represent a major global health challenge and include a broad spectrum of conditions ranging from chronic inflammatory disorders and gastrointestinal cancers to functional diseases characterized by visceral pain, altered motility, and hypersensitivity, such as irritable bowel syndrome (IBS). Despite advances in clinical management, many GI disorders remain insufficiently treated, highlighting the need for innovative pharmacological approaches and a deeper understanding of gastrointestinal pathophysiology. This Special Issue aims to bring together contributions addressing the pharmacological mechanisms and therapeutic strategies targeting gastrointestinal diseases. We particularly welcome submissions from pharmacologists studying drug effects on intestinal motility, inflammation, epithelial barrier function, tissue remodeling, and neuroimmune interactions involving the enteric nervous system and the gut–brain axis. Original research articles and review papers covering molecular, preclinical, translational, or clinical aspects of gastrointestinal pharmacology, including novel therapeutic targets and emerging drug candidates for GI disorders, are encouraged. This Special Issue seeks to provide a platform for researchers to share advances that may contribute to the development of new pharmacological strategies for the treatment of gastrointestinal diseases.
This Special Issue invites contributions focused on pharmacological mechanisms and therapeutic strategies for gastrointestinal diseases. Topics include pharmacological mechanisms underlying gastrointestinal inflammatory diseases and cancers; drug effects on intestinal motility and gastrointestinal dysmotility; pharmacological modulation of visceral pain and hypersensitivity, including irritable bowel syndrome (IBS) and other functional gastrointestinal disorders; regulation of intestinal inflammation, immune responses, tissue remodeling, and epithelial barrier function; and pharmacological modulation of the enteric nervous system and gut–brain axis. We also welcome studies addressing novel therapeutic targets, emerging drug candidates, microbiota–drug interactions, and pharmacological modulation of gut microbiota. Contributions describing preclinical models as well as translational and clinical pharmacology studies in gastrointestinal diseases are encouraged.
Dr. Giuseppe Esposito
Guest Editor
Dr. Irene Palenca
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gastrointestinal diseases
- gastrointestinal pharmacology
- inflammatory bowel diseases
- gastrointestinal cancer
- irritable bowel syndrome
- visceral hypersensitivity
- enteric nervous system
- gut–brain axis
- intestinal motility
- neurogastroenterology
- drug discovery
- gastrointestinal inflammation
- translational pharmacology
- therapeutic targets
- microbiota–drug interactions
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