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Adipose Tissue and Adipose Tissue-Derived Stem Cells in Multidisciplinary Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 December 2025) | Viewed by 461

Special Issue Editor


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Guest Editor
Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany
Interests: adipose tissue; adipose-derived stem cells

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of the Special Issue "Adipose Tissue and Adipose Tissue-Derived Stem Cells in Regenerative Medicine".

The utilization of adipose tissue for the regeneration of soft tissue defects has a long history. Additionally, adipose tissue has been used as a plentiful and easily accessible source of adult mesenchymal stem cells for more than two decades. In recent years, it has been shown that adipose tissue could serve as an optimal biomaterial for various biomedical applications beyond its homologous use in autologous fat grafting. The stem cells derived from adipose tissue can be differentiated into various lineages, possess immunomodulatory properties, and secrete a range of growth factors and cytokines. In addition to soft tissue, bone, and cartilage regeneration and wound healing, adipose tissue-derived stem cells have demonstrated promising results in the treatment of autoimmune and neurodegenerative diseases. Their pluripotent differentiation potential, immunosuppressive properties, low immunogenicity, and paracrine activity create numerous possibilities for clinical applications across multiple disciplines in the future.

This Special Issue focuses on recent studies that involve adipose tissue or adipose tissue-derived stem cells within an interdisciplinary framework. It invites research that explores the unique biomaterial properties of adipose tissue for diverse applications, as well as investigations into the properties of adipose tissue-derived stem cells and their implications across fields such as tissue engineering, regenerative medicine, immunology, and beyond. Studies that bridge these disciplines to advance our understanding and utilization of adipose tissue in various biomedical contexts are particularly encouraged.

Dr. Oliver Felthaus
Guest Editor

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Keywords

  • adipose tissue
  • adipose-derived stem cells
  • regenerative medicine
  • tissue engineering

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Published Papers (1 paper)

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Research

24 pages, 7205 KB  
Article
Influence of Donor Age, Donor Body Mass Index, and Harvesting Site on Cell Preparations from Human Adipose Tissue
by Olga Hahn, Philipp-Kjell Ficht, Wendy Bergmann-Ewert, Juliane Meyer, Anne Wolff and Kirsten Peters
Int. J. Mol. Sci. 2026, 27(3), 1351; https://doi.org/10.3390/ijms27031351 - 29 Jan 2026
Abstract
Adipose tissue includes various cell types beyond the typical adipocytes. The stromal vascular fraction (SVF) contains mesenchymal stem cells (MSCs), pericytes, and endothelial cells, which can be isolated from adipose tissue by mechanical and enzymatic methods. The composition of the SVF is heterogeneous, [...] Read more.
Adipose tissue includes various cell types beyond the typical adipocytes. The stromal vascular fraction (SVF) contains mesenchymal stem cells (MSCs), pericytes, and endothelial cells, which can be isolated from adipose tissue by mechanical and enzymatic methods. The composition of the SVF is heterogeneous, and donor factors such as sex, age, body mass index (BMI), and harvesting site are associated with variations in cellular composition and viability. The expression of specific surface markers, which determine the immunophenotype of the cells, can also vary. In this study, we investigated the effects of donor age, BMI, and harvesting site on cell yield, viability, and size. Our results showed that BMI significantly influenced cell yield and size, with overweight and obese donors yielding more cells than normal-weight donors. Additionally, cells isolated from the adipose tissue of the thighs/legs were larger than those from other areas. Flow cytometry showed considerable variability in SVF composition among donors. These results emphasize that SVF donor characteristics have a significant impact on cell yield, viability, and cell size, with the immunophenotype being highly donor-dependent. Understanding these factors is crucial for optimizing cell yield and defining populations for therapeutic applications of SVF cells. Full article
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