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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant-Derived Bioactive Compounds for Pharmacological Applications, 2nd Edition

edited by

Ilian Badjakov

and

Ivayla Dincheva

submission deadline 30 Oct 2026 | 2 articles | Viewed by 716 | Submission Open

Keywords: plant-derived bioactive compounds; pharmacological applications; antioxidant activity; anti-inflammatory agents; antimicrobial properties; neuroprotective effects; drug discovery; high-throughput screening; extraction and isolation techniques; structural characterization; CRISPR technology; genome editing; bioprocess engineering; bioreactor production; therapeutic potential; metabolite profiling

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathology, Diagnosis and Therapeutic Strategies of Thrombotic Diseases

edited by Emanuele Valeriani

submission deadline 30 Oct 2026 | 1 articles | Viewed by 716 | Submission Open

Keywords: anticoagulants; cardiovascular diseases; diagnosis; platelet aggregation inhibitors; venous thromboembolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuro-Immune-Endocrine Systems: Mechanisms, Biomarkers, and Disease Implications

edited by

Grażyna Gromadzka

submission deadline 30 Oct 2026 | Viewed by 704 | Submission Open

Keywords: neuro-immune-endocrine interactions; aging; autoimmune diseases; metabolic disorders; cancer; neuropsychiatric disorders; neuroinflammation; molecular signaling; biomarkers; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Pleiotropic Effects of Statins: Molecular Interactions and Therapeutic Potential in Human Diseases

edited by

Giulio Preta

submission deadline 30 Oct 2026 | 1 articles | Viewed by 692 | Submission Open

Keywords: statins; pleiotropic effects; lipid metabolism; adjuvant therapy

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Cellular Research on Cardiac Repair and Regeneration

edited by

Francesca Pagano

and

Vittorio Picchio

submission deadline 30 Oct 2026 | 1 articles | Viewed by 688 | Submission Open

Keywords: cardiac repair; cardiomyocyte differentiation; cardiac fibroblast activation; cardiac fibrosis; cardiac tissue microenvironment; cardiac remodeling

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence in Nano- and Bio-Technology Systems: Focus on Molecular Research

edited by

Abbas Amini

submission deadline 30 Oct 2026 | Viewed by 617 | Submission Open

Keywords: artificial intelligence; nanotechnology, biotechnology; medicine; energy systems; blockchain

(This special issue belongs to the Section Molecular Nanoscience)

Nanomaterials and Regulated Cell Death Pathways: Novel Therapeutic Opportunities

edited by

Anton S. Tkachenko

submission deadline 30 Oct 2026 | Viewed by 598 | Submission Open

Keywords: apoptosis; ferroptosis; nanotherapy; nanotoxicity; necroptosis; oxidative stress; PANoptosis; pyroptosis; regulated cell death

(This special issue belongs to the Section Molecular Nanoscience)

Bioactive Molecules and Their Health Impacts: From Antioxidants to Therapeutic Potentials

edited by

Alessandro Attanzio

and

Marilena Briglia

submission deadline 30 Oct 2026 | Viewed by 530 | Submission Open

Keywords: bioactive molecules; cell signaling; redox homeostasis; mitochondrial bioenergetics; epigenetic modulation; host–microbiome crosstalk; therapeutic strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The GPR81 Receptor: Lactate as Signaling Molecule in Health and Disease

edited by

Tania Fiaschi

submission deadline 30 Oct 2026 | Viewed by 475 | Submission Open

Keywords: lactate; GPR81 receptor; signaling cascade

(This special issue belongs to the Section Molecular Biology)

Plant Stress Responses and Their Gene Regulatory Networks

edited by

Anamika Pandey

and

Mohd. Kamran Khan

submission deadline 30 Oct 2026 | Viewed by 407 | Submission Open

Keywords: plant stress responses; gene regulatory networks (GRNs); functional genomics; multi-omics integration; transcriptional regulation; epigenetic regulation; CRISPR/cas gene editing; abiotic and biotic stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into the Smallest Fullerene Nanocomposites from the Lab to Space

edited by

Quentin A. Parker

and

SeyedAbdolreza Sadjadi

submission deadline 30 Oct 2026 | Viewed by 406 | Submission Open

Keywords: fullerenes; C20; nanocomposites; molecular structure; outer space

(This special issue belongs to the Section Molecular Nanoscience)

Venoms and Beyond: Molecular Targets, Cellular and In Vivo Effects

edited by

Yuri N. Utkin

and

R. Manjunatha Kini

submission deadline 30 Oct 2026 | Viewed by 405 | Submission Open

Keywords: animal venoms; toxins; structure; biological activity; molecular mechanisms; molecular targets

(This special issue belongs to the Section Molecular Toxicology)

The Molecular and Genetic Mechanisms of Hypercholesterolemia

edited by

Seyed Saeed Tamehri Zadeh

submission deadline 30 Oct 2026 | Viewed by 395 | Submission Open

Keywords: ASCVD; MI; CVD; CAD; PVD; ischemic stroke; Lp(a); LPA gene; Lp(a)-lowering treatments; homozygous familial hypercholesterolemia; heterozygous familial hypercholesterolemia; low-density lipoprotein; epidemiology; genetic determinants; lipid metabolism; PCSK9 inhibitors; emerging therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nanomedicine: Application of Nanostructured Biomaterials in the Biomedical Field

edited by

Yaser Dahman

submission deadline 30 Oct 2026 | Viewed by 395 | Submission Open

Keywords: nanomedicine; nanostructured biomaterials; targeted drug delivery; tissue regeneration; biosensing

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Mechanisms Underlying Plant Abiotic Stress Tolerance

edited by

Muhammad Tanveer Altaf

and

Muhammad Junaid Rao

submission deadline 30 Oct 2026 | Viewed by 379 | Submission Open

Keywords: abiotic stress (extreme temperatures, drought, salinity, submergence, heavy metals, and others); combine stresses; stress physiology; molecular biology; gene regulation; signal transduction; multi-omics approaches; plant–environment interaction; climate adaptation; crop improvement; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

The Mechanisms of Cucurbit Breeding, Cultivation and Quality Regulation

edited by Xiaotao Ding and Yongxue Zhang

submission deadline 30 Oct 2026 | Viewed by 301 | Submission Open

Keywords: omics; cultivation; breeding; quality; abiotic stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Advances in Genetic Variants Involved in Breast and Ovarian Cancer

edited by

Maria Aparecida Nagai

submission deadline 30 Oct 2026 | Viewed by 277 | Submission Open

Keywords: breast cancer; ovarian cancer; genetic variants; HBOC; genetic testing; hereditary

(This special issue belongs to the Section Molecular Genetics and Genomics)

Zebrafish Models of Human Disease: Uncovering Immunometabolic Mechanisms and Therapeutic Targets

edited by Juliana Moreira Mendonça Gomes

submission deadline 30 Oct 2026 | Viewed by 276 | Submission Open

Keywords: zebrafish; immunometabolism; metabolism; inflammation; cancer; obesity; diabetes; cardiovascular disease; MASH; disease modeling

(This special issue belongs to the Section Molecular Biology)

New Insight into the Discovery of Antiviral and Antibacterial Agents

edited by

Brankica Filipic

submission deadline 30 Oct 2026 | Viewed by 239 | Submission Open

Keywords: antiviral agents; antibacterial compounds; antimicrobial resistance; anti-virulence strategies; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

State-of-the-Art Molecular Endocrinology and Metabolism in Turkey

edited by

Gulali Aktas

submission deadline 30 Oct 2026 | Viewed by 198 | Submission Open

Keywords: molecular endocrinology; metabolic disorders; hormone signaling; multi-omics; precision medicine; diabetes and obesity; MASLD; endocrine disruptors; biomarkers; artificial intelligence in endocrinology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Anti-Parasitic Drugs: Mechanisms, Novel Molecules and Big Data Applications

edited by

Chun-Xue Zhou

submission deadline 30 Oct 2026 | Viewed by 194 | Submission Open

Keywords: anti-parasitic drugs; novel drug discovery; mechanism of action; drug resistance; big data analysis; machine learning; parasitic infections; drug delivery; preclinical evaluation; natural products

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Biomarkers, Nutritional Status, and Immune Regulation in Gut and Lung Diseases

edited by

Andreina Bruno

submission deadline 30 Oct 2026 | Viewed by 194 | Submission Open

Keywords: immunity; immunometabolism; metabolism; adipocytokines; nutrition; microbiome; biomarkers; gut; lung; circular health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Plant Virus Life Cycle, Molecular Diagnosis, Virus–Host Interactions and Molecular Farming

edited by

Srividhya Venkataraman

submission deadline 30 Oct 2026 | Viewed by 191 | Submission Open

Keywords: plant viruses; molecular biology; replication; assembly; transmission; trafficking; virus–host interactions; plant defense responses; molecular diagnostics; RNA silencing structure

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Signatures of Environmental Toxicants in One Health: Implications for Biodiversity, Animal and Human Health

edited by Leonardo Bittencourt and

Rafael R. Lima

submission deadline 30 Oct 2026 | Viewed by 183 | Submission Open

Keywords: one health; omics; environmental toxicology; ecotoxicology; anthropocene; biodiversity; molecular biomarkers; bioindicators and sentinel species; environmental biomonitoring

(This special issue belongs to the Section Molecular Toxicology)

Co-Infections in Parasitic Diseases: Molecular Mechanisms, Diagnostic Challenges, and Therapeutic Strategies

edited by

Cecilia Parodi

and Paula Gabriela Ragone

submission deadline 30 Oct 2026 | Viewed by 180 | Submission Open

Keywords: parasites; protozoan; co-infections; disease outcome; immune modulation; metagenomic analysis; diagnostic methods; treatment strategies; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Improving Antimicrobial Activity of Biopolymer-Based Films: Mechanisms, Functionalization Strategies, and Applications

edited by

Gabriela Dudek

submission deadline 30 Oct 2026 | Viewed by 166 | Submission Open

Keywords: biopolymer-based films; antimicrobial activity; functionalization strategies; bioactive compounds; nanoparticles; deep eutectic solvents; plasticizers; structure–property relationships; biodegradable materials; coatings and membranes

(This special issue belongs to the Section Materials Science)

Global Impact of Malignant Pleural Mesothelioma: Current Knowledge, Emerging Therapies and Future Perspectives

edited by Saé Muñiz-Hernández

submission deadline 30 Oct 2026 | Viewed by 143 | Submission Open

Keywords: pattern identification through AI; gene-driven mesothelioma; biomarkers; organoid models; genetic and epigenetic analysis

(This special issue belongs to the Section Molecular Oncology)

In Silico Methods of Assessing the Therapeutic Potential of Natural Substances

edited by

Radosław Zajdel

and

Anna Merecz-Sadowska

submission deadline 31 Oct 2026 | 6 articles | Viewed by 20468 | Submission Open

Keywords: in silico screening; natural products; molecular docking; computational drug discovery; QSAR modeling; molecular dynamics simulations; natural compounds; drug-target interactions; virtual screening; structure-activity relationships; computational chemistry; cheminformatics; ADMET prediction; bioinformatics; phytochemicals; machine learning in drug discovery; computer-aided drug design; pharmacophore modeling; natural therapeutics; computational pharmacology

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Rifaat Safadi and Johnny Amer

submission deadline 31 Oct 2026 | 8 articles | Viewed by 15633 | Submission Open

Keywords: MASLD (metabolic dysfunction-associated steatotic liver disease); lipotoxicity; inflammation; mitochondrial dysfunction; gut–liver axis; liver–spleen axis; fibrosis biomarkers; translational hepatology; precision liver medicine; insulin resistance; molecular therapeutics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Endocrinology of Pregnancy

edited by

Georgios Valsamakis

submission deadline 31 Oct 2026 | 3 articles | Viewed by 14916 | Submission Open

Keywords: pregnancy; endocrine system; fetal development; maternal health; metabolism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Genomics of Human Disease

edited by

Sungkyoung Choi

submission deadline 31 Oct 2026 | 9 articles | Viewed by 12970 | Submission Open

Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Protein Structure-Function and Drug Discovery

edited by Francesc Xavier Avilés and F. Xavier Gomis-Rüth

submission deadline 31 Oct 2026 | 6 articles | Viewed by 12184 | Submission Open

Keywords: protein structure; protein function; protein drug target; inhibition; protein structure-function; protein drug discovery; protein inhibition; protein activation; protein regulation; protein structure-function and evolution; protein structure-function engineering and design; protein structure-function and drug discovery

(This special issue belongs to the Section Macromolecules)

Natural Medicines and Functional Foods for Human Health

edited by Qiong Wang

submission deadline 31 Oct 2026 | 3 articles | Viewed by 11637 | Submission Open

Keywords: functional food; natural medicine; traditional Chinese medicine; memory; depression; dementia; Alzheimer’s disease; Parkinson’s disease; space medicine; sleeplessness; anti-inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

edited by Yang Mao-Draayer

submission deadline 31 Oct 2026 | 1 articles | Viewed by 11405 | Submission Open

Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging

(This special issue belongs to the Section Molecular Neurobiology)

Anti-Inflammatory and Anti-Oxidant Effects of Extracts from Plants

edited by

Sheila Leone

and

Lucia Recinella

submission deadline 31 Oct 2026 | 5 articles | Viewed by 10988 | Submission Open

Keywords: oxidative stress; inflammation; herbal extracts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research Advances in Antibiotic Resistance

edited by

José Pascual Abad

and

Irma Marín

submission deadline 31 Oct 2026 | 5 articles | Viewed by 9944 | Submission Open

Keywords: antibiotic resistance; resistant pathogenic microorganisms; One Health; prevalence of antibiotic-resistant microorganisms; multidrug resistance; antibiotic resistance levels; alternative anti-infectious strategies and compounds; antibiotic-resistant genes; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights and Novel Therapeutics in Chronic Kidney Disease

edited by

Marijn Speeckaert

submission deadline 31 Oct 2026 | 6 articles | Viewed by 9626 | Submission Open

Keywords: chronic kidney disease (CKD); molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 31 Oct 2026 | 2 articles | Viewed by 9521 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Endothelial Cell Injury and Repair

edited by

Eleni Gavriilaki

and

Panagiota Anyfanti

submission deadline 31 Oct 2026 | 5 articles | Viewed by 9038 | Submission Open

Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapeutic Potential of Natural Compounds

edited by

Magdalena Bartnik

and Adrianna Sławińska-Brych

submission deadline 31 Oct 2026 | 7 articles | Viewed by 8155 | Submission Open

Keywords: natural products; biological activity; bioactive compounds; mechanistic study; mechanism of action; drug discovery; pharmacological activity; synergism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Molecular Mechanisms of Chronic Kidney Disease

edited by

Lǎcrǎmioara Ionela Butnariu

submission deadline 31 Oct 2026 | 2 articles | Viewed by 7896 | Submission Open

Keywords: chronic kidney disease; molecular mechanism; signaling pathways; endothelial dysfunction; inflammation; genetic variants; epigenetics; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ferroptosis, ROS and Cell Death Cytomodulator Compounds

edited by Alireza Valanezhad

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7435 | Submission Open

Keywords: cell death; ferroptosis; ROS; GPX4; lipid peroxidation; inhibitors; inducers; cytomodulator compounds; cancer; disease; bone formation

(This special issue belongs to the Section Biochemistry)

The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer

edited by

Katharina M. Robertson

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7407 | Submission Open

Keywords: inflammation; metabolism; tumor-associated macrophages; tumor microenvironment; early-onset colorectal cancer; colorectal neoplasms; obesity; immunotherapy; epigenetics; cytokines; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 31 Oct 2026 | 3 articles | Viewed by 7304 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pathways to Infertility

edited by

Apostolos Kaponis

submission deadline 31 Oct 2026 | 5 articles | Viewed by 6542 | Submission Open

Keywords: infertility; molecules; meiotic arrest; premature ovarian insufficiency; sperm function; progesterone resistance; mitochondrial dysfunction; epigenetic dysregulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Genomic Aspects of Viral Pathogens

edited by

Joanna Dąbrowska

submission deadline 31 Oct 2026 | 4 articles | Viewed by 6471 | Submission Open

Keywords: viral pathogens; genetic and molecular mechanisms; viral infection; viral replication; host interaction

(This special issue belongs to the Section Molecular Microbiology)

Design of Bioactive Agents and Interaction with Biological Systems

edited by

Josef Jampilek

submission deadline 31 Oct 2026 | 3 articles | Viewed by 6131 | Submission Open

Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry

(This special issue belongs to the Section Molecular Biology)

Bone and Cartilage Injury and Repair: Molecular Aspects

edited by Silvia María Díaz-Prado

submission deadline 31 Oct 2026 | 3 articles | Viewed by 6010 | Submission Open

Keywords: bone and cartilage repair; regenerative medicine; inflammation and immune response; stem cell therapy; extracellular matrix remodeling; biomaterials; drug delivery systems; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Reproduction and Fertility of Aquatic Animals: 3rd Edition

edited by

Hui Qiao

and Hongtuo Fu

submission deadline 31 Oct 2026 | 5 articles | Viewed by 5555 | Submission Open

Keywords: reproduction; aquatic animals; sex determination; gonadal development; steroid hormones; sex-related genes; monosex culture

(This special issue belongs to the Section Molecular Biology)

Biosensors: Emerging Technologies and Real-Time Monitoring

edited by Velmurugan Thavasi

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5469 | Submission Open

Keywords: biosensors; real-time monitoring; wearable sensors; electrochemical detection; optical biosensors; point-of-care (POC) diagnostics; biomarker identification and analysis; wireless technologies

(This special issue belongs to the Section Biochemistry)

Displaying special issue 701-750 on page 15 of 62.

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