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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Cell Metabolism in Endocrine Diseases, 2nd Edition

edited by

Antonella Muscella

submission deadline 30 Dec 2026 | Viewed by 120 | Submission Open

Keywords: cellular metabolism; homeostasis; endocrine disorders; hormonal signals; dynamic system

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Next-Gen Cell Immunotherapies: From CAR-T to Synthetic Platforms

edited by Claudio Mussolino

submission deadline 30 Dec 2026 | Viewed by 111 | Submission Open

Keywords: cell-based immunotherapy; CAR-T cells; genome engineering; epigenetic engineering; synthetic biology; CRISPR; immune cell engineering; CAR-NK cells; T cell exhaustion; multiplex editing

(This special issue belongs to the Section Molecular Immunology)

Food and Plants Nanotechnology: Challenges and Future Prospects

edited by Luís R. Silva

submission deadline 30 Dec 2026 | Viewed by 83 | Submission Open

Keywords: nanotechnology; food safety; smart nanocarriers; nanosensors; antimicrobial nanomaterials; nano-enabled delivery systems

(This special issue belongs to the Section Molecular Nanoscience)

Galectins (Gals), 2nd Edition

edited by

Luciano Pirone

submission deadline 31 Dec 2026 | 12 articles | Viewed by 26926 | Submission Open

Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience

edited by Qi Zhang,

Marilena Carbone

and

André F. Moreira

submission deadline 31 Dec 2026 | 15 articles | Viewed by 20473 | Submission Open

Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes

(This special issue belongs to the Section Molecular Nanoscience)

Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics

edited by

Pulak R. Manna

submission deadline 31 Dec 2026 | 4 articles | Viewed by 19608 | Submission Open

Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’s disease; therapeutics; healthy aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures

edited by

Daniela Caccamo

submission deadline 31 Dec 2026 | 3 articles | Viewed by 16301 | Submission Open

Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microglia in Neurological Disorders: Potential Therapeutic Targets and Underlying Mechanisms

edited by

Masashi Tanaka

submission deadline 31 Dec 2026 | 4 articles | Viewed by 14989 | Submission Open

Keywords: cerebral amyloid angiopathy; Alzheimer's disease; amyloid-β fibril formation

(This special issue belongs to the Section Molecular Neurobiology)

Natural Products for Neuroprotection and Neurodegeneration

edited by

Patrycja Kupnicka

submission deadline 31 Dec 2026 | 7 articles | Viewed by 12163 | Submission Open

Keywords: natural products; bioactive compounds; neuroprotection; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research and Advances in Ocular Disease

edited by Da-Wen Lu

submission deadline 31 Dec 2026 | 5 articles | Viewed by 10359 | Submission Open

Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Trends in Redox Physiology Research

edited by Fotios Tekos

submission deadline 31 Dec 2026 | 5 articles | Viewed by 9380 | Submission Open

Keywords: redox biology; oxidative stress; antioxidant mechanisms; redox signaling; cellular homeostasis; inflammation and redox; nutritional redox modulation; environmental toxicology and redox; mitochondrial dysfunction; oxidative stress biomarkers

(This special issue belongs to the Section Biochemistry)

Highlights in Pathophysiology and Treatment of Osteoarthritis

edited by

Antonella Fioravanti

and

Serena Guiducci

submission deadline 31 Dec 2026 | 3 articles | Viewed by 8965 | Submission Open

Keywords: osteoarthritis; pathophysiology (cytokines, adipokines, chemokines, epigenetics, microbiome); cartilage; synovial membrane; subchondral bone; treatment; disease-modifying osteoarthritis drugs; non-pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Basis and Treatment of Skin Diseases and Their Associated Complications (2nd Edition)

edited by

Maria Maisto

and

Vincenzo Piccolo

submission deadline 31 Dec 2026 | 5 articles | Viewed by 8589 | Submission Open

Keywords: diagnosis; biomarkers; imaging; histopathology; cutaneous comorbidities complication; therapy; management; clinical Trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Biology: Infection and Pathology, Diagnosis and Treatment

edited by

Gergana Zahmanova

submission deadline 31 Dec 2026 | 7 articles | Viewed by 8279 | Submission Open

Keywords: viral infection; viral pathogenesis; diagnostics; antiviral therapy; host–virus interactions; emerging viruses; zoonotic viruses; one health; vaccine development; CRISPR antivirals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Tryptophan Metabolism

edited by

Katsunori Nonogaki

submission deadline 31 Dec 2026 | 2 articles | Viewed by 6716 | Submission Open

Keywords: tryptophan; serotonin; kynurenine; indole; metabolism; IPA; Tph; IDO1; health; disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Liquid Biopsies in Oncology—3rd Edition

edited by

Sandra V. Fernandez

and

Carmela Paolillo

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6445 | Submission Open

Keywords: precision oncology; personalized therapy; cancer biomarkers; liquid biopsy; biological fluids; circulating molecules; circulating tumor cells; CTCs; ctDNA; ctRNA; cell-free DNA; cfDNA; NGS; circulating miRNAs; exosomes; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6239 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 31 Dec 2026 | 3 articles | Viewed by 5953 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

Plant Adaptation to Abiotic Stresses: Evolutionary, Multi-Omics, and Molecular Perspectives

edited by

Guang Chen

and

Qiufang Shen

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5950 | Submission Open

Keywords: plant; evolutionary adaptation; molecular evolution; abiotic stresses; stress tolerance; functional genomics; molecular regulatory network; genomics; transcriptomics; metabolomics; proteomics; epigenomics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Translational Insights in Neurological Disorders

edited by Tiago Santos

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5787 | Submission Open

Keywords: neurological disorders; molecular mechanisms; translational neuroscience; drug targets; biomarkers; neurodegenerative disorders; neuroinflammatory conditions; demyelinating conditions; cerebrovascular conditions; neurodevelopmental disorders; mood disorders; anxiety disorders; spinal cord injury; traumatic brain injury; precision neurology; therapeutic development

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Sex Determination and Differentiation

edited by

Martin A. Estermann

submission deadline 31 Dec 2026 | 3 articles | Viewed by 5667 | Submission Open

Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution

(This special issue belongs to the Section Molecular Biology)

Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets

edited by Leonid Livshits

submission deadline 31 Dec 2026 | 2 articles | Viewed by 5281 | Submission Open

Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties

(This special issue belongs to the Section Molecular Biology)

Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition

edited by

Orit Uziel

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5114 | Submission Open

Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication

(This special issue belongs to the Section Molecular Biology)

The Interactions Between Nutrients and Adipose Tissue

edited by

Junseok Son

submission deadline 31 Dec 2026 | 5 articles | Viewed by 4913 | Submission Open

Keywords: adipose tissue; nutrients; metabolic health; insulin resistance; inflammation; energy homeostasis; adipokines; obesity; lipolysis; thermogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cardiovascular and Metabolic Pharmacology

edited by

Alma Martelli

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4747 | Submission Open

Keywords: cardiovascular pharmacology; metabolic pharmacology; hypertension; diabetes; obesity; atherosclerosis; hyperlipidemias; heart failure

(This special issue belongs to the Section Molecular Pharmacology)

Machine Learning Applications in Bioinformatics and Biomedicine: 4th Edition

edited by Hao Lv

submission deadline 31 Dec 2026 | 8 articles | Viewed by 4663 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

The Role of Natural Products in Drug Discovery: 2nd Edition

edited by

Luciana Scotti

and

Marcus Tullius Scotti

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4607 | Submission Open

Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Animal Molecular Genetics

edited by

Jarosław Króliczewski

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4513 | Submission Open

Keywords: epigenetics; functional genomics; gene expression; gene polymorphism; genetic diseases; genetic techniques and assays; genome-wide association; genetic markers; quantitative genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches

edited by

Eric Santoni-Rugiu

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4426 | Submission Open

Keywords: genomic-defined NSCLC; molecular diagnostics; actionable targets; intrinsic resistance; acquired resistance

(This special issue belongs to the Section Molecular Oncology)

Membrane Channels in Intercellular Communication

edited by

Camillo Peracchia

and

Jean Jiang

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4380 | Submission Open

Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell–cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH

(This special issue belongs to the Section Biochemistry)

From DNA Damage to Cell Death: Emerging Drug Targets and Therapeutic Opportunities

edited by

Mateusz Kciuk

and Beata Marciniak

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4334 | Submission Open

Keywords: apoptosis; cancer therapy; cell death pathways; chemoresistance; DNA damage response (DDR); DNA repair inhibitors; drug discovery; ferroptosis; genomic instability; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights

edited by

Luigi Rosa

and

Pietro Giorgio Spezia

submission deadline 31 Dec 2026 | 4 articles | Viewed by 4175 | Submission Open

Keywords: human virome; molecular virology; functional virology; metagenomics; virus–host interactions; immune modulation; pseudovirus assays; antiviral screening; omics integration; molecular immunology

(This special issue belongs to the Section Molecular Microbiology)

Biological Effects of Radiation on Human Cells and Tissues

edited by

Maria Paola Bertuccio

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3972 | Submission Open

Keywords: radiation exposure; molecular pathways; inflammation; immune response; biochemical markers; electromagnetic hypersensitivity

(This special issue belongs to the Section Molecular Biology)

Advances in HIV Research: Molecular Basis and Potential Therapies

edited by

Sharilyn Almodovar

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3885 | Submission Open

Keywords: human immunodeficiency virus; HIV prevention; HIV therapeutics; HIV vaccines; antiretroviral therapies; long-acting ART; HIV genetic therapy; HIV animal models; HIV in vitro models; viral reservoirs; HIV latency; HIV persistence; HIV evolution; HIV quasispecies; HIV proteins; HIV cure; HIV immunopathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pulmonary Fibrosis: Molecular Mechanisms and Therapeutic Strategies

edited by

Barbara Ruaro

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3761 | Submission Open

Keywords: machine learning; pulmonary fibrosis; interstitial lung diseases; molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stress-Activated Molecular Remodeling: Lipids, Chaperones, and the Cytoskeleton

edited by

Nikolas Nikolaidis

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3661 | Submission Open

Keywords: cellular stress response; molecular remodeling; lipid signaling; membrane dynamics; cytoskeletal reorganization; chaperones; heat shock proteins; proteostasis; membrane–protein interactions; stress-induced trafficking; mechano-transduction; cell survival signaling

(This special issue belongs to the Section Molecular Biology)

Sex and Gender Medicine—Physiology: A New Horizon in Human Physiology

edited by

Rosanna Mallamaci

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3602 | Submission Open

Keywords: sex and gender; personalized medicine; sex-specific evidence; sex-specific differences

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Flowers: Molecular and Genetic Regulation of Growth and Development

edited by Yaqin Wang

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3566 | Submission Open

Keywords: flower; growth and development; molecular regulation; genetic breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Proteomics: Insights from Biomedical Applications and Beyond

edited by

Elva Morretta

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3537 | Submission Open

Keywords: functional proteomics; drug discovery; biomedicine; biomarker identification; protein molecular functions; pathway investigation

(This special issue belongs to the Section Molecular Immunology)

Biotransformation and Engineering of Fungals and Microalgae

edited by

Alejandro Chamizo-Ampudia

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3503 | Submission Open

Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae–fungi synergy

(This special issue belongs to the Section Molecular Microbiology)

PPAR Update: Molecular Mechanisms and Therapeutic Perspectives

edited by

Naoki Tanaka

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3290 | Submission Open

Keywords: PPAR; PPARα; SPPARMα; pemafibrate; lipid metabolism; inflammation; fibrosis; nuclear receptor; translational research; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Roles of Non-Coding RNAs in Cancer

edited by Amit K. Mitra

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3289 | Submission Open

Keywords: lncRNA; miRNA; cancer; genomics; targeted therapy; biomarkers; drug resistance

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances on Viral Immunology and Pathogenesis of Viral Infections

edited by Yeong-Bin Baek

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3049 | Submission Open

Keywords: viral immunology; viral pathogenesis; innate sensing and interferon; cytokine networks and inflammasomes; adaptive immunity (T- and B-cell quality); immunometabolism and lipid signaling; host-directed antiviral strategies; transcriptomics and spatial omics; mechanism of action and target engagement; complex bioactive modulators

(This special issue belongs to the Section Molecular Microbiology)

Oral Cancer: From Molecular Mechanisms to Therapeutics

edited by Diana Russo

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2979 | Submission Open

Keywords: oral cancer; molecular mechanisms; carcinogenesis; therapeutic strategies; biomarkers; immunotherapy; tumor microenvironment; drug resistance; precision medicine; head and neck oncology

(This special issue belongs to the Section Molecular Oncology)

The Unresolved Molecular Bases of Major Histocompatibility Complex (MHC) Function with Transplantation and Diseases Linkage

edited by Antonio Arnaiz-Villena

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2972 | Submission Open

Keywords: HLA; disease; autoimmunity; immune deficiency; MHC phylogeny; HLA pharmacogenomics; immune modulatory MHC and HLA genes (G, E, F); transplantation; hemochromatosis; MHC/HLA epithelial interaction; MHC evolution; MHC phylogenetics; Vertebrate MHC; Amimal MHC; Veterinary

(This special issue belongs to the Section Molecular Immunology)

Updates on Synthetic and Natural Antioxidants (2nd Edition)

edited by

Izabela Sadowska-Bartosz

and

Grzegorz Bartosz

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2764 | Submission Open

Keywords: antioxidants; synthetic; natural compounds

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms in Heart Rate Regulation and Cardiac Arrhythmias

edited by Yingjie Liu

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2729 | Submission Open

Keywords: cardiac arrhythmias; heart rate regulation; molecular mechanisms; intrinsic regulation; neurohumoral regulation; arrhythmia development; treatment strategies

(This special issue belongs to the Section Molecular Biology)

Plant Breeding: Improvements and Applications of High-Yield, High-Quality and Stress-Resistant Genetic Traits

edited by Juwu Gong

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2671 | Submission Open

Keywords: plant breeding; crop genetic improvement; gene editing; stress resistance; crop quality; crop yield; gene resource utilization

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Compounds in the Prevention of Chronic Diseases: 2nd Edition

edited by

Diego A. Moreno

Antonio J. Ruiz-Alcaraz

and

Paola Maycotte

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2620 | Submission Open

Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Upper and Lower Airway Diseases in Allergy and Immunology: From Bench to Bedside

edited by

Giovanni Paoletti

Giulia Costanzo

and

Enrico Marco Heffler

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2607 | Submission Open

Keywords: unified airway disease; allergic rhinitis; asthma; chronic rhinosinusitis; eosinophilic; airway inflammation; airway epithelial barrier; immune dysregulation; respiratory microbiome; biomarkers; allergy and immunology

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 1801-1850 on page 37 of 63.

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