Next-Gen Cell Immunotherapies: From CAR-T to Synthetic Platforms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 93
Editor
2. Center for Chronic Immunodeficiency (CCI), Medical Center—University of Freiburg, 79106 Freiburg, Germany
3. Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
Interests: gene therapy; genome editing; epigenome editing; designer nucleases; CRISPR-Cas
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cell-based immunotherapies have revolutionized the treatment of cancer and other severe diseases. While CAR-T cell therapies have achieved remarkable clinical success, significant challenges remain, including limited efficacy in solid tumors, cellular exhaustion, restricted persistence, manufacturing hurdles, and safety concerns. Recent advances in genome engineering, epigenetic modulation, synthetic biology, and gene regulation provide powerful tools to overcome these limitations and expand the therapeutic potential of engineered immune cells.
We are pleased to invite submissions for this Special Issue, titled “Next-Gen Cell Immunotherapies: From CAR-T to Synthetic Platforms”.
The aim of this Special Issue is to highlight innovative molecular approaches for the development and optimization of therapeutic cell platforms, including CAR-T, CAR-NK, TCR-engineered, macrophage-based, and other emerging cell therapies. By integrating advances in molecular biology, immunology, biotechnology, and translational medicine, this collection seeks to showcase technologies that enhance the efficacy, safety, persistence, and clinical applicability of engineered cellular therapies.
Original research articles, reviews, and systematic reviews are welcome. Topics of interest include, but are not limited to, the following:
- Genetic and epigenetic engineering of therapeutic cells;
- Synthetic biology and advanced cell-design strategies;
- Novel immune cell therapy platforms and translational applications;
- Manufacturing, safety, and clinical implementation of engineered cell therapies.
We look forward to receiving your contributions.
Dr. Claudio Mussolino
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cell-based immunotherapy
- CAR-T cells
- genome engineering
- epigenetic engineering
- synthetic biology
- CRISPR
- immune cell engineering
- CAR-NK cells
- T cell exhaustion
- multiplex editing
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
