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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis

edited by

Regina M. Day

and Jeffrey R. Koenitzer

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5060 | Submission Open

Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins

(This special issue belongs to the Section Molecular Biology)

Reproductive Toxicity of Chemicals

edited by

Maria Laura Zenclussen

submission deadline 30 Dec 2025 | 5 articles | Viewed by 4966 | Submission Open

Keywords: reproductive health; fertility; anthropogenic chemicals; impaired fertility; reproductive toxicity; embryo; toxicants; hormone disruption; chemical exposure

(This special issue belongs to the Section Molecular Toxicology)

Immune Regulation and T Cell Dynamics

edited by Tatiana Akimova

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4800 | Submission Open

Keywords: autoimmunity; T cells; FOXP3; Treg; regulatory T cells; transplantation; tolerance; T cell activation; exhaustion; T cell-mediated immunity; T cell immunotherapy

(This special issue belongs to the Section Molecular Immunology)

The Role of Extracellular Matrix in Cancer

edited by

José M. Muñoz-Félix

submission deadline 30 Dec 2025 | 1 articles | Viewed by 4671 | Submission Open

Keywords: extracellular matrix; cancer; collagen; integrins; metastasis

(This special issue belongs to the Section Molecular Oncology)

Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments

edited by

Joan Torras-Ambròs

and Juliana Bordignon-Draibe

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3782 | Submission Open

Keywords: primary glomerular diseases; membranous nephropathy; IgA nephropathy; glomerular inflammatory mechanisms; aberrantly glycosylated IgA1; galactose-deficient IgA1 (Gd-IgA1); alternative complement pathway; C5; factor B; factor D; APRIL; BAFF; phospholipase A2 receptor (PLA2R); thrombospondin type I domain-containing 7A (THSD7A); exostosins 1 and 2 (EXT1/2); neural epidermal growth factor-like 1 protein (NELL-1); semaphorin 3B (Sema3B); neural cell adhesion molecule 1 (NCAM1)

(This special issue belongs to the Section Molecular Immunology)

Heart Failure: From Molecular Mechanisms to Clinically Translational Innovations

edited by

Carmela Rita Balistreri

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3612 | Submission Open

Keywords: heart failure; pathophysiology; cellular and molecular mechanisms; traditional biomarkers: limits and benefits; emerging molecular biomarkers; innovative therapies; i.e.; personalized therapies; targeted therapies; etc.; the application of artificial intelligence; multi-omics technologies; imaging innovative biomarkers; clinical translation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in the Genetic Research on Psychiatric Disorders

edited by Lawrence Shih-Hsin Wu

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3268 | Submission Open

Keywords: genetics; bipolar disorder; schizophrenia; major depressive disorder; autism; substance abuse; genomics

(This special issue belongs to the Section Molecular Neurobiology)

Neurogenetic Disorders: Neurogenetics, Pathogenesis, and Gene Therapy

edited by

Paschalis Theotokis

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3204 | Submission Open

Keywords: precision medicine; gene therapy; neurogenetics; rare monogenic diseases; inherited nervous system disorders; mitochondrial diseases (e.g.; LHON; MELAS); lysosomal storage disorders (e.g.; Tay– Sachs; Gaucher); hereditary neuropathies (e.g.; CMT; hATTR); motor neuron diseases (e.g.; SMA; ALS); spinocerebellar ataxias (e.g.; SCA); biomarkers in neurology

(This special issue belongs to the Section Molecular Neurobiology)

Neuroimmune Axis in Cancer and Inflammatory Diseases

edited by

Patrick Ming-Kuen Tang

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3078 | Submission Open

Keywords: neuro-immune axis; cancer progression; drug resistance; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

The Emerging Role of Quantum Sciences and Radiation Biology in Biomedical Applications, 2nd Edition

edited by

Livio Giuliani

Pierre Madl

and

Nikolaj Sorgenfrei Blom

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3067 | Submission Open

Keywords: quantum sciences; radiation biology; biomedical applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Insights into Mitochondrial Iron Metabolism: Connections to Cancer and Other Pathologies

edited by Michael Petronek

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3015 | Submission Open

Keywords: iron metabolism; mitochondrial iron; cellular homeostasis; iron– sulfur cluster biogenesis; heme synthesis; mitochondrial ferritin; cancer biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innate Immunity: New Insights into Genetic and Signaling Networks

edited by

Styliani Sarrou

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2986 | Submission Open

Keywords: innate immunity; innate immune response; signaling pathways; genetic variations

(This special issue belongs to the Section Molecular Immunology)

Advances in the Pathogenesis and Treatment of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2569 | Submission Open

Keywords: heart failure; biomarkers; pathways of heart failure; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Strategies in Cancer Therapy

edited by

Paolo Coghi

and

Carmine Coluccini

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2527 | Submission Open

Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression

(This special issue belongs to the Section Molecular Oncology)

Advances in Drug Delivery Systems: From Nanoparticles to Precision Medicine

edited by

Satya Prakash

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2506 | Submission Open

Keywords: polymer-based nanoparticles; lipid nanoparticles; PLGA and chitosan nano/microparticles for gene therapy; targeted drug delivery; nucleic acid-loaded nanoparticles; siRNA nanoparticles; nanoparticle-mediated mirna delivery; nanoparticles in cancer therapy; nanoparticles in vaccine design; nanoparticle-mediated gene therapy

(This special issue belongs to the Section Molecular Pharmacology)

Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology

edited by

Giuseppe Murdaca

and

Sebastiano Gangemi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2488 | Submission Open

Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Hypertension and Cardiovascular Disease: 2nd Edition

edited by

Edyta Zbroch

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2466 | Submission Open

Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms of Diabetic Cardiomyopathy

edited by Martin Michel

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2410 | Submission Open

Keywords: diabetes; cardiomyopathy; animal models; novel treatments; pathophyiology; SGLT2 inhibitors; neprilysin inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Cancer Stem Cell Research: 2nd Edition

edited by

Tomoyasu Sugiyama

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2256 | Submission Open

Keywords: cancer stem cell; biomarker; signaling; cancer-associated fibroblast; artificial intelligence; cell therapy; antibody therapy; cell therapy; gene expression

(This special issue belongs to the Section Molecular Oncology)

Plant Stress Biology

edited by Rui Li

submission deadline 30 Dec 2025 | 3 articles | Viewed by 2245 | Submission Open

Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Anti-Cancer Drugs, 2nd Edition

edited by

Christiana Neophytou

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2050 | Submission Open

Keywords: combination therapy in cancer; small-molecule inhibitors in cancer; anti-cancer agents derived from natural sources; immunotherapy advances in cancer therapy; targeting metastatic dormancy; modulation of the tumor microenvironment; 3D model approaches in cancer research; predictive biomarkers for cancer chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Advances in the Pathophysiology and Treatment of Eye Diseases

edited by

Georgios Panos

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1984 | Submission Open

Keywords: ocular pathophysiology; eye diseases; molecular mechanisms; biomolecular pathways; therapeutic targets; translational ophthalmology; retinal degeneration; oxidative stress in ocular disorders; angiogenesis in eye diseases; neuroprotection in ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dietary Antioxidants in Human Health

edited by

Marika Cordaro

Roberta Fusco

and

Rosanna Di Paola

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1797 | Submission Open

Keywords: diet; functional food; oxidative stress; mitochondrial disfunction; human health; animal models; nutrition; molecular pathways; human pathology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences

edited by

Andrei Smertenko

submission deadline 30 Dec 2025 | 4 articles | Viewed by 1782 | Submission Open

Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Lectins

edited by Yuichiro Sato

submission deadline 30 Dec 2025 | 2 articles | Viewed by 1780 | Submission Open

Keywords: lectin; carbohydrate-binding specificity; virus; antiviral activity; cancer; anticancer activity; glycan-targeted therapy

(This special issue belongs to the Section Molecular Biology)

Cutting-Edge Advances in Natural Bioactive Compounds

edited by

Luisa M. P. F. Amaral

and

Romeu A. Videira

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1740 | Submission Open

Keywords: natural bioactive compounds; discovery and isolation; chemical characterization; biological activities; mechanisms of action; pharmaceuticals; nutraceuticals; agricultural applications; cosmetic innovations

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Stroke: Novel Molecular Mechanisms and Therapeutic Approaches

edited by Kang-Ho Choi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1671 | Submission Open

Keywords: stroke; cerebrovascular disease; mechanisms; treatment; diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential

edited by

Rachel Shukrun

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1485 | Submission Open

Keywords: neutrophil extracellular traps (NETs) ; NETosis ; inflammation ; cancer microenvironment ; autoimmune disease ; thrombosis ; molecular signaling ; innate immunity ; biomarkers ; targeted therapy

(This special issue belongs to the Section Molecular Immunology)

Hematologic Malignancies: From Molecular Pathology to Novel Therapeutics

edited by

Myrna Gloria Candelaria

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1367 | Submission Open

Keywords: pathogenesis; B-cell lymphoma regulation; epigenetics and hematology; bispecific antibodies in hematology; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Forensic Science: Integrating Innovation and Investigation

edited by

Aniello Maiese

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1326 | Submission Open

Keywords: DNA profiling; artificial intelligence; trace evidence analysis; immunohistochemical markers; molecular biology techniques; super-resolution microscopy; integrated forensic approach; new bioinformatics techniques; digital pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Leptin Biology

edited by

Víctor Sánchez-Margalet

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1222 | Submission Open

Keywords: leptin; leptin expression; leptin receptor; leptin action

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Myocardial Injury and Ventricular Dysfunction: Pathways and Therapeutic Targets

edited by

Antonio Lax

submission deadline 30 Dec 2025 | 1 articles | Viewed by 923 | Submission Open

Keywords: myocardial injury; ventricular dysfunction; drug development; gene therapy; molecular modulators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circulating Cell-Free Nucleic Acids and Cancers: 3rd Edition

edited by

Bruna Scaggiante

submission deadline 30 Dec 2025 | 1 articles | Viewed by 910 | Submission Open

Keywords: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next-generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing

(This special issue belongs to the Section Molecular Oncology)

Gene-Level Pharmacological Research on Natural Products

edited by

Wansu Park

submission deadline 30 Dec 2025 | Viewed by 909 | Submission Open

Keywords: natural products; gene-level pathways; pharmacological efficacy

(This special issue belongs to the Section Molecular Pharmacology)

New Challenges of Parkinson’s Disease, 2nd Edition

edited by

Franca Rosa Guerini

and

Cristina Agliardi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 878 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; synuclein; diagnosis; genetics; epigenetics; extracellular vesicles; biomarkers; treatments; rehabilitation

(This special issue belongs to the Section Molecular Neurobiology)

Novel Multifunctional Materials with Electrical, Catalytic, and Biological Properties

edited by

Jana Pisk

and

Luka Pavic

submission deadline 30 Dec 2025 | Viewed by 836 | Submission Open

Keywords: novel multifunctional materials; innovative design and synthesis; electrical properties; catalytic properties; biological properties

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Cell Adhesion

edited by

Surajit Bhattacharjya

submission deadline 30 Dec 2025 | Viewed by 777 | Submission Open

Keywords: cell adhesion; cell– cell communication; structures; drug discovery; integrins; cadherins; selectins

(This special issue belongs to the Section Molecular Biophysics)

Molecular and Cellular Mechanisms in Learning and Memory

edited by

Giovanna Traina

submission deadline 30 Dec 2025 | Viewed by 645 | Submission Open

Keywords: learning; memory; animal models; conditioning; molecular mechanisms; genetic mechanisms; epigenetic mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms of Genotoxicity

edited by

Bernd Kaina

submission deadline 30 Dec 2025 | Viewed by 626 | Submission Open

Keywords: DNA damage; gene instab; genetic instab; DNA methyl; genotoxic; gene mutation; DNA repair; genotoxicity; toxicogenetic; toxicogenomic

(This special issue belongs to the Section Molecular Toxicology)

Stem Cell Innovations and Reproductive Biotechnologies

edited by

Marcin Samiec

submission deadline 30 Dec 2025 | Viewed by 598 | Submission Open

Keywords: mammals; birds; stem cell research; pluri-/multipotency; differentiation/dedifferentiation; assisted reproductive technologies (ARTs); transgenic research; biomedicine

(This special issue belongs to the Section Molecular Biology)

Diabetic Retinopathy—Innovation in Diagnosis and Treatment

edited by

Peter Koulen

submission deadline 30 Dec 2025 | Viewed by 596 | Submission Open

Keywords: diabetes mellitus; diabetic macular edema; diagnostics; drug development; neovascularization; neurodegeneration; neuroprotection; retina; therapeutics; vascular disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Genomic Technologies for Molecular Safety Assessment

edited by

Eric Blomme

submission deadline 30 Dec 2025 | Viewed by 572 | Submission Open

Keywords: gene expression; safety assessment; genomic technologies; genomic tools; molecular toxicology; toxicity; predictive safety assessments; proteomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Pathophysiology of Multiple Sclerosis and Neuroinflammation

edited by

Fabrizio Michetti

submission deadline 30 Dec 2025 | Viewed by 497 | Submission Open

Keywords: multiple sclerosis (MS); autoimmune diseases; encephalomyelitis; neuroinflammation; central nervous system (CNS); autoimmunity and neurodegeneration; molecular basis of immune mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Metal-Based Compounds: Molecular Mechanisms of Pharmacological Action and Toxicity

edited by

Danijela Z. Krstić

submission deadline 30 Dec 2025 | Viewed by 489 | Submission Open

Keywords: metal elements and ions; metal complexes; metal nanoclusters; pharmacology andpharmacokinetics; in vitro toxicity; in vivo toxicity; toxicity biomarkers; enzymes as pharmacological and toxicity targets; toxicity mechanisms; metallodrugs

(This special issue belongs to the Section Molecular Toxicology)

Brain Ischemia: From Molecular Mechanisms to Innovative Therapies

edited by

Ryszard Pluta

submission deadline 30 Dec 2025 | Viewed by 367 | Submission Open

Keywords: ischemic neurodegeneration; focal brain ischemia; global brain ischemia; perinatal asphyxia; ischemic stroke; traumatic brain injury; apnea; neuroinflammation; proteins; genes; genes involved in neurodegeneration; glia-to-neurons genetic conversion; dementia; Alzheimer’s disease; genetic conversion of ischemia to Alzheimer's disease; new therapeutic approaches; biomarkers

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Antimicrobial Resistance

edited by

Dan-Alexandru Țoc

and

Carmen Costache

submission deadline 30 Dec 2025 | Viewed by 361 | Submission Open

Keywords: antimicrobial resistance; MRSA; ESBL-producing bacteria; carbapenem-resistant enterobacterales (CRE); vancomycin-resistant enterococci (VRE); linezolid resistance; novel antibiotic combinations; resistance mechanisms; horizontal gene transfer; molecular epidemiology

(This special issue belongs to the Section Molecular Pharmacology)

Electromagnetic Field Interactions with Biomolecules

edited by Samina Masood

submission deadline 30 Dec 2025 | Viewed by 360 | Submission Open

Keywords: magnetic field; biomolecules; medicine; drug delivery; protective methods; disease control

(This special issue belongs to the Section Biochemistry)

Advances in Regenerative Medicine, Organ Bioengineering and Transplantation

edited by

Dorota Latek

submission deadline 30 Dec 2025 | Viewed by 360 | Submission Open

Keywords: regenerative medicine; organ bioengineering; transplantation; allografting; stem cells; drug discovery; immunosuppression; xenotransplantation; organogenesis; biomaterials

(This special issue belongs to the Section Molecular Immunology)

Neuroimmune Regulation of Acute and Chronic Pain

edited by Karen M. Wagner

submission deadline 30 Dec 2025 | Viewed by 316 | Submission Open

Keywords: acute pain; chronic pain; central sensitization; neuroinflammation; neuroimmunity; neurovascular coupling; cytokines; chemokines; catacholamines; stress

(This special issue belongs to the Section Molecular Neurobiology)

Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies

edited by

Piotr Sobolewski

submission deadline 30 Dec 2025 | Viewed by 259 | Submission Open

Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 801-850 on page 17 of 70.

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