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Neuroimmune Axis in Cancer and Inflammatory Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 1204

Special Issue Editor


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Guest Editor
State Key Laboratory of Translational Oncology, Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong
Interests: tumor microenvironment; drug resistance; immunotherapy; cell engineering; gene therapy
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Special Issue Information

Dear Colleagues,

Effective cancer treatments remain an unmet clinical need worldwide. Cancer cells are genetically unstable and highly heterogeneous, characteristics that largely contribute to the development of drug resistance in cancer patients due to primary and secondary mechanisms at the molecular level.

Increasing evidence demonstrates the importance of the neuro-immune axis in the tumor microenvironment for regulating cancer progression and drug resistance. Compared with cancer cells, the tumor microenvironment is developed from non-cancer cells and has no genetic instability, thereby making its neuro-immune axis an ideal target for the development of cancer therapy. A better understanding of the dynamics and interactions of the neuro-immune axis in the tumor microenvironment at the molecular level may lead to the discovery of safe and effective clinical strategies for cancer.

The aim of this Special Issue is to collect original research and review articles describing the following:

  1. Novel neuro-immune interactions in the tumor microenvironment;
  2. Molecular mechanisms of neuro-immune axis for regulating cancer progression and drug resistance;
  3. Therapeutic strategies to target the neuro-immune axis for cancer treatment.

Dr. Patrick Ming-Kuen Tang
Guest Editor

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Keywords

  • neuro-immune axis
  • cancer progression
  • drug resistance
  • cancer therapy

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Published Papers (1 paper)

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Review

30 pages, 1114 KB  
Review
Tumor Innervation: From Bystander to Emerging Therapeutic Target for Cancer
by Zoey Zeyuan Ji, Max Kam-Kwan Chan, Philip Chiu-Tsun Tang, Calvin Sze-Hang Ng, Chunjie Li, Dongmei Zhang, David J. Nikolic-Paterson, Ka-Fai To, Xiaohua Jiang and Patrick Ming-Kuen Tang
Int. J. Mol. Sci. 2025, 26(18), 9257; https://doi.org/10.3390/ijms26189257 - 22 Sep 2025
Viewed by 361
Abstract
Innervation is ubiquitous in diseased tissues, including cancer. Increasing evidence suggests that innervation not only plays a direct role in cancer pain, but is also closely related to disease progression, including cancer growth, metastasis, and drug resistance. At the molecular level, tumor-associated nerves [...] Read more.
Innervation is ubiquitous in diseased tissues, including cancer. Increasing evidence suggests that innervation not only plays a direct role in cancer pain, but is also closely related to disease progression, including cancer growth, metastasis, and drug resistance. At the molecular level, tumor-associated nerves can interact with cancer cells and the tumor microenvironment through neurotrophic factors, thereby promoting tumor occurrence and development, and represent a potential intervention for solid tumors with nerve enrichment. By dissecting the transcriptome dynamics of cancer-associated neurons with single cell resolution, numbers of novel therapeutic targets for tumor denervation have been uncovered, including a novel phenomenon—Macrophage to Neuron-like cell Transition (MNT). This review systematically summarizes the latest research findings of tumor denervation, from molecular mechanisms to the innovative denervation strategies, paving the way for novel, safe, and effective cancer treatments in the clinic. Full article
(This article belongs to the Special Issue Neuroimmune Axis in Cancer and Inflammatory Diseases)
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