Heart Failure: From Molecular Mechanisms to Clinically Translational Innovations
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 December 2025 | Viewed by 10
Special Issue Editor
Interests: genetic and pathology of aortopathy and cerebrovascular diseases; inflammatpry diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heart failure (HF) is a cardiac syndrome characterized by the presence of nonspecific signs and symptoms, such as weakness and dyspnea. These signs, such as left ventricular edema, overlap with other pathological conditions, such as chronic kidney disease and liver failure. However, in HF, symptoms reflect the deterioration of left ventricular function, which is notoriously associated with high rates of morbidity and mortality, with a significant economic impact on healthcare services. HF is, in fact, now considered a major public health problem. Its management is complex, and using traditional blood biomarkers is inappropriate. Panels of molecules and metabolic pathways, reflecting its complex pathophysiology, could represent optimal biochemical biomarkers, as well as targets. These, when integrated with imaging biomarkers, could facilitate the diagnosis of HF, as well as prognosis, outcomes, and therapies. The available literature provides increasing evidence on emerging biomarkers, as well as innovative treatments, such as targeted therapies, developed through applying artificial intelligence and multi-omics technologies. These efforts aimed to facilitate diagnosis, predict prognosis and outcomes, and suggest more innovative and personalized therapies. This Special Issue is dedicated to furthering this line of research, and contributions should include original articles, reviews, short communications, and letters.
Dr. Carmela Rita Balistreri
Guest Editor
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Keywords
- heart failure
- pathophysiology
- cellular and molecular mechanisms
- traditional biomarkers: limits and benefits
- emerging molecular biomarkers
- innovative therapies, i.e., personalized therapies, targeted therapies, etc.
- the application of artificial intelligence
- multi-omics technologies
- imaging innovative biomarkers
- clinical translation
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