Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments

Dear Colleagues,

IgA and membranous nephropathies are the most prevalent primary glomerular diseases and constitute a frequent etiology of end-stage renal failure. Recent advances in our knowledge of the pathogenesis of both nephropathies have highlighted new variables that will allow us to better understand the complex mechanisms involved in their development and pathogenesis.

A myriad of new protein markers in membranous nephropathy have been described that warrant further research to understand the pathways and mechanisms of this disease. Moreover, the “four hit” hypothesis in IgA nephropathy, with a central role in galactose-deficient IgA1, needs a better description, and new essential research items must be established, to develop a clear understanding of this disease.

The pharmaceutic industry is making considerable efforts to better understand both of these diseases, investigating alternative complement pathways, as well as B-cell blocking with anti-CD20 or anti-APRIL antibodies. This topic constitutes a hot spot in clinical nephrology.

This Special Issue entitled “Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments” will include papers investigating the pathological mechanisms involved in primary nephropathies, as well as diagnostics using new biomarkers. Furthermore, it will present experimental in vitro and in vivo studies and clinical studies examining potential new approaches to attenuating kidney dysfunction.

This Special Issue welcomes original research and review papers, with potential topics including, but not limited to, the keywords below.

Prof. Dr. Joan Torras-Ambròs
Dr. Juliana Bordignon-Draibe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.