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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Regulatory Mechanisms in Kidney Development and Function

edited by Gary F. Gerlach

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1205 | Submission Open

Keywords: drosophila nephrocyte; zebrafish pronephros; mesonephros; murine nephrogenesis; slit diaphragm; podocytes; junctions; tubule; mesenchymal-to-epithelia transition (MET); epithelial-to-mesenchymal transition (EMT); tubule segmentation; transcription factors; signaling pathways; foot processes; cytoskeleton; brush boarder; intercalated cells; renin angiotensin; diabetic kidney disease; podocytopathies; FSGS; minimal change disease; IgAN

(This special issue belongs to the Section Molecular Biology)

Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets

edited by

Marcello Candelli

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1205 | Submission Open

Keywords: sepsis; immunometabolism; metabolic reprogramming; cellular bioenergetics; innate and adaptive immunity; mitochondrial dysfunction; inflammatory signaling; metabolic biomarkers; therapeutic modulation; host–pathogen interactions

(This special issue belongs to the Section Molecular Immunology)

mRNA Vaccines Against Viral Infectious Diseases: Progress and Prospects

edited by

Barbara Ridolfi

and Maria Teresa Maggiorella

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1154 | Submission Open

Keywords: viruses; mRNA vaccines; mRNA structure; mRNA platform technologies; lipid nanoparticle (LNP) delivery; immunization strategies; adjuvants; preclinical trials; clinical trials; germline-targeting; broadly neutralizing antibodies; humoral immune response; cellular immune response; host–vaccine interactions

(This special issue belongs to the Section Molecular Microbiology)

New Insight into Biomaterials for Tissue Engineering and Regenerative Medicine

edited by

Diana Torge

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1141 | Submission Open

Keywords: biomaterials; tissue regeneration; regenerative medicine; bone regeneration; periodontal disease; morphology; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Current Molecular Advances in Apoptosis

edited by

Mariarosaria Boccellino

and

Davide Viggiano

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1093 | Submission Open

Keywords: apoptosis; glomerulonephritis; aging; caspase; endonuclease; DNA; cytokeratin

(This special issue belongs to the Section Biochemistry)

Novel Therapeutic Strategies and Targets in Rheumatoid Arthritis

edited by David Fox and

James J. Moon

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1092 | Submission Open

Keywords: RA; synovium; FLS; synovial fluid; microbiome; autoimmunity; DMARD; joint inflammation; joint damage; nanoparticle

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Topics in Polymeric Nanoparticles

edited by

Andrei Honciuc

and

Mirela Honciuc

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1092 | Submission Open

Keywords: polymeric nanoparticles; nanostructured materials; functional polymers; Janus particles; self-assembly; drug delivery; environmental remediation; microplastics; biodegradability; nanomedicine; green synthesis; adsorbents; life cycle assessment; surface functionalization; smart materials; biocompatibility; environmental impact; bioaccumulation; responsive polymers; hybrid nanomaterials

(This special issue belongs to the Section Macromolecules)

Advances in Anticancer Drug Discovery: Design, Synthesis and Molecular Insights

edited by

Michele De Franco

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1073 | Submission Open

Keywords: anticancer agents; drug design; drug synthesis; structure-activity relationship (SAR); target interactions; medicinal chemistry; lead optimization; targeted therapy; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Immune Responses, Viral Infection and Neurodegenerative Diseases

edited by

Xin Dang

and Barbara Hanson

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1049 | Submission Open

Keywords: immune response; innate immunity; viral neuropathogenesis; viral biomarker; AD; PD; neurodegenerative diseases

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Early-Life Environmental Effects on Brain Development

edited by

Sarah E. Latchney

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1049 | Submission Open

Keywords: early-life environment; brain development; neurodevelopmental programming; environmental exposures; developmental neurotoxicology; gene–environment interactions; maternal health; epigenetic regulation; neuroimmune interactions; endocrine disruption

(This special issue belongs to the Section Molecular Neurobiology)

New Molecular Research on High-Fat Diet on Human Health and Disease

edited by

Berta Alejandra Espinosa Escalona

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1043 | Submission Open

Keywords: obesity; diet-induced obesity; antioxidants

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genome Editing and Biotechnology in Fruit Improvement

edited by Hongxia Miao

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1012 | Submission Open

Keywords: fruit improvement; horticultural crops; genome editing; biotechnology; molecular biology; plant genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Horizons in Pain Therapeutics

edited by Alaa Abd-Elsayed

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1006 | Submission Open

Keywords: spinal cord stimulation; peripheral nerve stimulation; stem cell therapy; platelet-rich plasma (PRP) injections; chronic pain management; interventional pain procedure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Approaches in Biomedicine: Innovations and Insights

edited by

Carlos Leon

submission deadline 31 Jan 2027 | Viewed by 995 | Submission Open

Keywords: computational biomedicine; artificial intelligence; machine learning; omic technologies; system biology; medical imaging; structural biology; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Alternative Splicing, Isoform Diversity, and Cell Function

edited by

Tetiana Zaǐchuk

submission deadline 31 Jan 2027 | 1 articles | Viewed by 987 | Submission Open

Keywords: alternative splicing; isoform diversity; RNA-binding proteins; splicing regulation; cellular stress response; proteomic complexity; splicing in disease; computational splicing analysis

(This special issue belongs to the Section Molecular Biology)

Vitamin D Metabolism and Molecular Signaling in Human Diseases

edited by

Anna Cieslinska

submission deadline 31 Jan 2027 | 1 articles | Viewed by 983 | Submission Open

Keywords: vitamin D; vitamin D metabolism; molecular signaling; genomic and non-genomic pathways; epigenetics; immune regulation; inflammation; metabolic disorders; autoimmune diseases; cancer biology; gut microbiota; genetic polymorphisms; precision medicine

(This special issue belongs to the Section Molecular Biology)

Green Gold: Microalgae as a Sustainable Source of Nutrients and Bioactive Compounds

edited by

Blanca Hernández-Ledesma

and Pilar Gómez-Cortés

submission deadline 31 Jan 2027 | 1 articles | Viewed by 963 | Submission Open

Keywords: microalgae; sustainable nutrition; bioactive compounds; functional foods; nutraceuticals; alternative proteins; phycochemistry; circular bioeconomy; biorefinery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Advances in Targeted Molecular Therapies for Genetic Disease

edited by Viorica-Elena Rădoi

submission deadline 31 Jan 2027 | 2 articles | Viewed by 939 | Submission Open

Keywords: genetic diseases; precision medicine; gene editing; RNA-based therapeutics; genomic profiling; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Small Molecules in Tissue Repair and Regeneration

edited by

Ildiko Bock-Marquette

submission deadline 31 Jan 2027 | 1 articles | Viewed by 938 | Submission Open

Keywords: small molecules; organ and tissue regeneration; development; aging

(This special issue belongs to the Section Molecular Biology)

Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition

edited by

Jan Wijnholds

submission deadline 31 Jan 2027 | 1 articles | Viewed by 937 | Submission Open

Keywords: hereditary retinal disease; retinal inflammation; retinal gene augmentation, editing, optogenetics and splice modulation therapy; natural history studies of the retina; human iPSC-derived retinal organoids and retinal pigment epithelium; retinal iPSC-derived cell therapy; retinal pathology; pre- and clinical gene therapy; animal models for retinal dystrophy; retinal imaging; retina-on-a-chip

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Surfactants: Design, Synthesis and Properties

edited by

Joanna Krawczyk

submission deadline 31 Jan 2027 | 1 articles | Viewed by 930 | Submission Open

Keywords: design and synthesis of surfactants; adsorption and aggregation properties of surfactants; behavior of surfactants at different interfaces; application of biosurfactants and specialist surfactants (industry, agriculture, medicine, pharmacy)

(This special issue belongs to the Section Materials Science)

Functional Materials for Biomedical Applications and Uses

edited by

Magdalena Laskowska

submission deadline 31 Jan 2027 | 1 articles | Viewed by 902 | Submission Open

Keywords: functional materials; nanomaterials; biomedical applications; molecular engineering

(This special issue belongs to the Section Materials Science)

Molecular Research and Insights in Rapeseed Abiotic Stress

edited by

Ahsan Ayyaz

submission deadline 31 Jan 2027 | 1 articles | Viewed by 886 | Submission Open

Keywords: rapeseed (Brassica napus); abiotic stress; drought tolerance; salinity stress; heavy metal toxicity; molecular mechanisms; stress signaling; omics (transcriptomics, proteomics, metabolomics); molecular breeding; CRISPR-Cas9; stress-responsive genes; hormone cross-talk; epigenetic regulation; stress resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Research Progress on Photosensitizers and Photodynamic Therapy

edited by

Michal Heger

submission deadline 31 Jan 2027 | 1 articles | Viewed by 875 | Submission Open

Keywords: photodynamic therapy; photosensitizers; tumor microenvironment; nanotechnology; immunotherapy; targeted drug delivery; reactive oxygen species; hypoxia; combination therapy; molecular mechanisms

(This special issue belongs to the Section Biochemistry)

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutic Tools in Chronic Diseases

edited by

Elena Grossini

submission deadline 31 Jan 2027 | 1 articles | Viewed by 869 | Submission Open

Keywords: cell-free therapy; exosomes; immunomodulation; molecular mechanisms; regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diverse Molecular Mechanisms of Berberine Action—Identifying Potential Targets and Therapeutic Potential

edited by

Dariusz Szukiewicz

submission deadline 31 Jan 2027 | 1 articles | Viewed by 865 | Submission Open

Keywords: berberine; isoquinoline alkaloid; AMPK activator; natural compound; metabolic syndrome; wieight loss; antioxidant effects; anti-inflammatory effects; antitumor activity; neuroprotection

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Vector–Pathogen–Host Interaction, Vaccines and Immunobiologicals

edited by Carlo José Freire Oliveira and

Marcos Vinícius Da Silva

submission deadline 31 Jan 2027 | 1 articles | Viewed by 835 | Submission Open

Keywords: host–pathogen–vector interactions; active biomolecules; immunomodulation; vaccines; binding molecules; immunobiologicals

(This special issue belongs to the Section Molecular Immunology)

Supramolecular Liquid Crystal Compounds—from Molecular Design to Functional Materials

edited by

Katarzyna Merkel

submission deadline 31 Jan 2027 | Viewed by 834 | Submission Open

Keywords: supramolecular; self-assembled; liquid crystal; hydrogen bonding

(This special issue belongs to the Section Materials Science)

Exploring the Crossroads of Autoimmunity, Inflammatory Diseases, and Cancer

edited by

Xuming Mao

submission deadline 31 Jan 2027 | 1 articles | Viewed by 826 | Submission Open

Keywords: autoimmune disorders; tumor microenvironment; chronic inflammation; immune checkpoint inhibitors; machine learning; epidemiology

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Stroke: Biomarkers and Mechanisms

edited by Jae Sang Oh

submission deadline 31 Jan 2027 | 1 articles | Viewed by 826 | Submission Open

Keywords: stroke; glymphatic system; biomarkers; human-derived specimens; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Systems Mechanisms of Neural Circuit Function and Plasticity

edited by

Hyunjung Oh

submission deadline 31 Jan 2027 | 1 articles | Viewed by 825 | Submission Open

Keywords: neural circuits; neuroplasticity; synaptic organization; brain aging; mood disorders; neurodegenerative disorders; cognitive function

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Therapeutic Innovations in Urological Cancers

edited by Michele Marchioni,

Luigi Schips

and Angelo Cafarelli

submission deadline 31 Jan 2027 | 1 articles | Viewed by 801 | Submission Open

Keywords: urological cancers; molecular pathways; precision oncology; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Identification of Molecular Biomarkers Through Digital Pathology

edited by

Rafael Parra-Medina

submission deadline 31 Jan 2027 | 1 articles | Viewed by 799 | Submission Open

Keywords: digital pathology; molecular biomarkers; computational pathology; artificial intelligence; deep learning; spatial biology; multi-omics integration; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular and Cellular Pathology of Cancer Research

edited by

Onur Bender

and

Ahmet Acar

submission deadline 31 Jan 2027 | 2 articles | Viewed by 797 | Submission Open

Keywords: cancer molecular pathology; cancer genomics; experimental therapeutics; inhibitors; immuno-oncology; tumor heterogeneity; liquid biopsy; organoids; spatial biology; digital PCR; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

The Molecular Basis of Vascular Pathology: 2nd Edition

edited by

Jolanta Neubauer-Geryk

submission deadline 31 Jan 2027 | 1 articles | Viewed by 756 | Submission Open

Keywords: vascular pathologies; blood vessels; dysfunction; vascular damage; blood flow; biomarkers; biomolecules; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunoregulatory Mechanisms of Gut Microbiota

edited by

José Fachi

submission deadline 31 Jan 2027 | 1 articles | Viewed by 716 | Submission Open

Keywords: gut microbiota; mucosal immunity; host–microbe interactions; immune homeostasis; dysbiosis; microbial metabolites; short-chain fatty acids; barrier function; colitis

(This special issue belongs to the Section Molecular Microbiology)

New Mechanisms and Therapeutics in Neurological Diseases—5th Edition

edited by

Barbara Mroczko

submission deadline 31 Jan 2027 | 1 articles | Viewed by 702 | Submission Open

Keywords: neurodegeneration; neuroinflammation; neurodegenerative diseases; neurodevelopmental disorders; tumor markers; specific proteins

(This special issue belongs to the Section Molecular Neurobiology)

Translational Pharmacology of GLP-1 Receptor Agonists Beyond Metabolic Diseases

edited by

Carlos-Alberto Calderon-Ospina

submission deadline 31 Jan 2027 | 1 articles | Viewed by 688 | Submission Open

Keywords: GLP-1 receptor agonists; translational pharmacology; neuroprotection; pleiotropic effects; inflammation; neuropsychiatric disorders; addiction; obstructive sleep apnea; energy balance; pharmacokinetics; cardiovascular protection

(This special issue belongs to the Section Molecular Pharmacology)

Genetic and Molecular Mechanisms in Neurological Diseases

edited by Serena Barral

submission deadline 31 Jan 2027 | 1 articles | Viewed by 683 | Submission Open

Keywords: neurological diseases; genetic mechanisms; molecular pathways; human neuronal models; brain organoids; iPSC-derived neural cells; neurodevelopment and neurodegeneration; disease modeling; human in vitro systems; genotype-phenotype relationships

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Agricultural Hydrology: Plant-Soil-Water Interactions

edited by

Muhammad Bilal Khan

submission deadline 31 Jan 2027 | Viewed by 668 | Submission Open

Keywords: soil–plant–water system; agricultural hydrology; water-use efficiency; root water uptake; rhizosphere interactions; biogeochemical cycling; ecosystem functioning; climate change impacts; wastewater treatment

(This special issue belongs to the Section Molecular Plant Sciences)

Progress of Novel Biomarkers and Molecular Targets in Cancer

edited by

Pietro Tralongo

submission deadline 31 Jan 2027 | 1 articles | Viewed by 652 | Submission Open

Keywords: cancer biomarkers; molecular targets; precision oncology; molecular pathology; translational oncology; next-generation sequencing; liquid biopsy; tumor microenvironment; predictive biomarkers; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Current Research on the Molecular and Cellular Mechanisms of Cancer

edited by Seungbaek Lee

submission deadline 31 Jan 2027 | 1 articles | Viewed by 649 | Submission Open

Keywords: cancer biology; molecular oncology; tumor microenvironment; therapeutic resistance; precision oncology

(This special issue belongs to the Section Molecular Biology)

Advances in Computational Drug Design and Molecular Modeling

edited by Ana C Stucki-Mafud

submission deadline 31 Jan 2027 | Viewed by 640 | Submission Open

Keywords: preclinical phase of drug development; computer-aided drug design; artificial intelligence; machine learning; deep learning; structure-based drug design; ligand-based drug design; virtual screening; pharmacophore modeling; molecular modeling

(This special issue belongs to the Section Molecular Informatics)

Aptamers in Cancer Therapy: Mechanisms, Applications, and Translational Perspectives

edited by

Gabor István Csonka

submission deadline 31 Jan 2027 | Viewed by 625 | Submission Open

Keywords: aptamers; targeted drug delivery; cancer immunotherapy; molecular imaging; biomarkers; precision oncology; SELEX; theranostics; translational oncology; mechanistic insights

(This special issue belongs to the Section Molecular Oncology)

Advanced Antimicrobial Materials: Molecular Design, Mechanism of Action and Applications

edited by

Katsuaki Dan

submission deadline 31 Jan 2027 | 1 articles | Viewed by 621 | Submission Open

Keywords: bacteria; viruses; antimicrobial materials; molecular design; action mechanism; social implementation; antimicrobial resistance; synergistic effects; infectious diseases; anti-inflammatory diseases

(This special issue belongs to the Section Materials Science)

Cancer Drugs That Target Epigenetic Processes

edited by Eileen Brantley

submission deadline 31 Jan 2027 | 1 articles | Viewed by 619 | Submission Open

Keywords: histone modifications; non-coding RNA; DNA methylation; cancer agents

(This special issue belongs to the Section Molecular Oncology)

Emerging Roles of Extracellular Vesicles in Neurological Diseases

edited by Anudeep Yekula

submission deadline 31 Jan 2027 | Viewed by 614 | Submission Open

Keywords: extracellular vesicles; exosomes; neurological diseases; liquid biopsy; neurodegeneration; neuro-oncology; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Valorization of Lignocellulosic Biomass: 2nd Edition

edited by

Haishun Du

submission deadline 31 Jan 2027 | Viewed by 609 | Submission Open

Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials

(This special issue belongs to the Section Materials Science)

Strategies and Visions for Nano- and Molecular-Design Materials in Future Photovoltaic Applications

edited by

Ivana Validžić

submission deadline 31 Jan 2027 | 1 articles | Viewed by 604 | Submission Open

Keywords: novel photovoltaic materials; semiconductors; perovskites; organic materials; dye-sensitized materials; bio-based materials; advanced materials; innovative energy materials

(This special issue belongs to the Section Materials Science)

Kidney Diseases: Molecular Mechanisms and Therapies

edited by

George J. Dugbartey

submission deadline 31 Jan 2027 | 1 articles | Viewed by 589 | Submission Open

Keywords: kidney diseases; pathophysiology; molecular mechanisms; therapeutic targets; acute kidney injury; chronic kidney disease; polycystic kidney disease; end-stage renal disease; IgA nephropathy; diabetic nephropathy; hypertensive nephropathy; renal cancer; kidney infarction; kidney infection; kidney failure; kidney stones; renal tubular acidosis; renal artery stenosis; acute tubular necrosis; glomerulopathy; interstitial nephritis; nephrotic syndrome; simple kidney cyst

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2201-2250 on page 45 of 62.

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