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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Protein S in Coagulation, Inflammation, and Cancer

edited by

Rinku Majumder

submission deadline 31 Oct 2026 | Viewed by 176 | Submission Open

Keywords: Protein S; hemostasis; anticoagulation; inflammation; cancer biology; thrombotic disorders; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Natural Products and Functional Biomaterials in Wound Healing and Cancer Treatment

edited by Shaik Nyamathulla

submission deadline 31 Oct 2026 | Viewed by 176 | Submission Open

Keywords: cancer; wound healing; biomaterials; diabetes; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ion Channel in Physiology

edited by Isaac E. García

submission deadline 31 Oct 2026 | Viewed by 172 | Submission Open

Keywords: ion channels; channel gating mechanisms; structure–function relationships; electrophysiology; cryo-electron microscopy (cryo-EM); connexin hemichannels and gap junctions; pannexin channels; ion transporters; cell signaling and homeostasis; channelopathies

(This special issue belongs to the Section Molecular Biophysics)

Beyond the Single Gene: The Polygenic Architecture of Drug Response

edited by

Leonardo Beltrán-Angarita

submission deadline 31 Oct 2026 | Viewed by 171 | Submission Open

Keywords: pharmacogenomics; pharmacogenetics; polygenic architecture; polygenic risk scores; precision medicine; adverse drug reactions; epistasis/gene–gene interactions; genomic biomarkers

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research and Insight in Plant Genetic Breeding

edited by

Bing He

submission deadline 31 Oct 2026 | Viewed by 171 | Submission Open

Keywords: plant genetic breeding; crop genomics; gene editing; molecular markers; functional genomics; germplasm enhancement; omics breeding; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Nanobodies and Monoclonal Antibodies: Epitope, Structure and Neutralization

edited by David Vance

submission deadline 31 Oct 2026 | Viewed by 165 | Submission Open

Keywords: monoclonal antibody; nanobody; antibody-antigen interactions; epitope mapping; neutralizing mechanisms; structural biology; vaccine design

(This special issue belongs to the Section Molecular Nanoscience)

Bioactive Lipid Signaling in Cardiovascular and Metabolism-Associated Diseases

edited by

Nathalie Mercier

submission deadline 31 Oct 2026 | Viewed by 159 | Submission Open

Keywords: bioactive lipids; inflammation; lipid metabolism; lipid signaling pathways; cardiovascular and metabolism-associated diseases; cellular phenotype; lipid receptors; cardiovascular treatments; lipidomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Respiratory Tract Infections: Molecular Pathogenesis, Advanced Diagnostics, and Translational Strategies

edited by Roy Rillera Marzo

submission deadline 31 Oct 2026 | Viewed by 158 | Submission Open

Keywords: respiratory tract infections; host–pathogen interactions; molecular diagnostics; genomics and proteomics; antimicrobial resistance; biomarkers; immune response; precision medicine; translational research; infectious disease epidemiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Functional Materials for Environmental Remediation and Ecosystem Sustainability

edited by Chenyu Wang

submission deadline 31 Oct 2026 | Viewed by 147 | Submission Open

Keywords: functional nanomaterials; environmental remediation; water pollution control; self-assembled systems; ecosystem sustainability; advanced adsorbents; catalysis and oxidation; polyphosphate-based materials; green chemistry; environmental sensors

(This special issue belongs to the Section Molecular Nanoscience)

New Predictive Biomarkers for Ovarian Cancers

edited by

Olga Lilia Garibay-Cerdenares

submission deadline 31 Oct 2026 | Viewed by 141 | Submission Open

Keywords: ovarian cancer; biomarkers; chemorresistance; nanotechnology; ovarian cancer signaling; metabolic plasticity in ovarian cancer; omics in ovarian cancer

(This special issue belongs to the Section Molecular Oncology)

Aging, Regeneration and Stem Cell Biology of Fascial Tissue

edited by

Carla Stecco

and

Zhao Xiaoxiao

submission deadline 31 Oct 2026 | Viewed by 102 | Submission Open

Keywords: fascia; aging; regeneration; stem cells; extracellular matrix; fibrosis; mechanobiology; mesenchymal stem cells; tissue repair; myofascial pain

(This special issue belongs to the Section Molecular Biology)

Spike Protein Receptor

edited by

Salvatore Giovanni De Simone

submission deadline 15 Nov 2026 | Viewed by 301 | Submission Open

Keywords: spike protein; receptor binding; ACE2 interaction; viral entry; structural virology; immune recognition; antibody and IgA epitopes; variant transmissibility; receptor-blocking therapeutics

(This special issue belongs to the Section Molecular Biophysics)

Medicinal Plants and Natural Compounds in Health and Disease: Progresses, Challenges, Opportunities, 2nd Edition

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Nov 2026 | 4 articles | Viewed by 30732 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; oxidative stress; gene expression; protein expression; cellular signaling; ethnopharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Unraveling the Molecular Mechanisms of Neurodegeneration

edited by

Michela Ferrucci

submission deadline 20 Nov 2026 | 5 articles | Viewed by 21077 | Submission Open

Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Emerging Therapies in Neurovascular Disease

edited by Leonidas D. Panos

submission deadline 20 Nov 2026 | 3 articles | Viewed by 19084 | Submission Open

Keywords: neurovascular diseases; blood–brain barrier; endothelial dysfunction; cellular signaling; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

edited by

Montserrat Fernández-Guarino

submission deadline 20 Nov 2026 | 9 articles | Viewed by 17548 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnostics and Genomics of Tumors, 2nd Edition

edited by

Petra Korać

submission deadline 20 Nov 2026 | 11 articles | Viewed by 13549 | Submission Open

Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Advancing Regenerative Medicine: Basic Research and Translation in Clinics

edited by

Dragan Primorac

submission deadline 20 Nov 2026 | 4 articles | Viewed by 11309 | Submission Open

Keywords: regenerative medicine; stem cells; tissue engineering; exosomes; orthobiologics

(This special issue belongs to the Section Molecular Biology)

Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition

edited by

Alessandro Fanzani

and

Silvia Codenotti

submission deadline 20 Nov 2026 | 4 articles | Viewed by 9868 | Submission Open

Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies

(This special issue belongs to the Section Molecular Oncology)

Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition

edited by

Zhidong Zhou

submission deadline 20 Nov 2026 | 3 articles | Viewed by 9858 | Submission Open

Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies

(This special issue belongs to the Section Molecular Neurobiology)

Glioblastoma: Molecular Pathogenesis and Treatment

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 Nov 2026 | 4 articles | Viewed by 8842 | Submission Open

Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Compounds in Neuroscience

edited by

Sarmistha Mitra

submission deadline 20 Nov 2026 | 3 articles | Viewed by 7516 | Submission Open

Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

edited by

Matteo Bordoni

submission deadline 20 Nov 2026 | 3 articles | Viewed by 7489 | Submission Open

Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Cancer Stem Cells

edited by

Ilze Štrumfa

and Inta Liepniece-Karele

submission deadline 20 Nov 2026 | 4 articles | Viewed by 6195 | Submission Open

Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma

(This special issue belongs to the Section Molecular Oncology)

Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches

edited by Magaly Martinez-Ferrer

submission deadline 20 Nov 2026 | 1 articles | Viewed by 5896 | Submission Open

Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker

(This special issue belongs to the Section Molecular Oncology)

Bioactives from Natural Products

edited by

Antía González Pereira

submission deadline 20 Nov 2026 | 4 articles | Viewed by 5861 | Submission Open

Keywords: natural products; bioactive compounds; therapeutic potential; secondary metabolites; omics technologies; biotechnology; phytochemistry; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genomics, Genetics, and the Future of Fruit Improvement

edited by Zoe Hilioti

submission deadline 20 Nov 2026 | 3 articles | Viewed by 4543 | Submission Open

Keywords: fruit traits; genetics; genetic diversity; omics; new breeding techniques; fruit quality; shelf life

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Cancer Stem Cells

edited by

Sabrina Battista

submission deadline 20 Nov 2026 | 1 articles | Viewed by 3658 | Submission Open

Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy

(This special issue belongs to the Section Biochemistry)

Molecular Research on Dyslipidemia

edited by

Aleksandra Zeljkovic

and

Jelena Vekić

submission deadline 20 Nov 2026 | 2 articles | Viewed by 3575 | Submission Open

Keywords: dyslipidemia; chronic non-communicable diseases; dysregulation of lipid homeostasis; genetic and epigenetic regulation; lipidomics in personalized medicine; lipid biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Next-Generation Therapeutic Polymers: From Molecular Design to Dual Antibacterial/Antithrombotic Action

edited by

Piotr Dobrzynski

submission deadline 20 Nov 2026 | 2 articles | Viewed by 3040 | Submission Open

Keywords: antibacterial polymers; antifouling polymers; anticoagulant polymers; heparin-mimicking polymers; heparin-conjugated polymers; phosphorylcholine-based polymers; polymeric nitric oxide donors; polymers, loaded with silver ions, or antibiotics; antibacterial nano- and micro particles; anticoagulant layers

(This special issue belongs to the Section Materials Science)

Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies

edited by Noah R. Johnson and

Chih Hung Lo

submission deadline 20 Nov 2026 | 3 articles | Viewed by 2677 | Submission Open

Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery

(This special issue belongs to the Section Molecular Neurobiology)

Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery

edited by

Rosamaria Pennisi

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2608 | Submission Open

Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems

(This special issue belongs to the Section Molecular Biology)

Current Research on Colloidal Emulsions: Preparation and Applications

edited by Alexander Djerdjev

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2522 | Submission Open

Keywords: emulsion formulation and stability; nano-, micro-, and high-internal-phase emulsions; drug delivery; aerogels; pickering emulsions; food emulsions; oil–water interface; surfactants; zeta potential at hydrophobic interfaces; advances in emulsion technology

(This special issue belongs to the Section Materials Science)

Allergic Reactions and Immune Factors

edited by

Liborija Lugovic-Mihic

submission deadline 20 Nov 2026 | 3 articles | Viewed by 2344 | Submission Open

Keywords: allergic reactions; immunity; immunological factors; hypersensitivity; antibody; cytokine; immune response; etiology; pathogenesis; clinical manifestations; diagnostic; therapy

(This special issue belongs to the Section Molecular Immunology)

Biomolecular Condensates and Their Role in Cellular Organization and Disease

edited by Anna Bratek-Skicki

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2309 | Submission Open

Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases

(This special issue belongs to the Section Molecular Biology)

Flow Cytometry as a Tool for Diagnostics and Biomarker Research

edited by

Leslie Chavez-Galan

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2244 | Submission Open

Keywords: biomarkers; flow cytometry; spectral cytometry; mass cytometry; translational research; human health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Autophagy in Aging and Age Related Diseases

edited by

Tímea Sigmond

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2154 | Submission Open

Keywords: autophagy; aging; molecular mechanisms; age related diseases; mitochondria

(This special issue belongs to the Section Biochemistry)

Recent Progress in Synthesis, Properties, and Applications of Polyoxometalates and Their Nanocrystals

edited by

Xiang Ma

and

Pengtao Ma

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1926 | Submission Open

Keywords: polyoxometalates; POMs; metal cluster compound; inorganic chemistry; nanocrystals

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

New Advances in Animal Reproduction

edited by Valdevane Rocha Araújo

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1864 | Submission Open

Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds

(This special issue belongs to the Section Molecular Biology)

Plant Responses to Abiotic and Biotic Stresses: 2nd Editon

edited by

Longxing Tao

and

Tingting Chen

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1797 | Submission Open

Keywords: climate change and crop production; abiotic stress; biotic stress; plant resistance to abiotic and biotic stresses; molecular mechanism; physiological responses; plant hormones; carbohydrate metabolism and transport; molecular signaling; reactive oxygen species (ROS); calcium ions; photosynthesis; respiration; energy metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms

edited by

Ning Liu

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1747 | Submission Open

Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Marine Natural Products as a Source of Therapeutics—Recent Trends

edited by

Komal Anjum

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1563 | Submission Open

Keywords: marine natural products; marine-associated microbes; antimicrobial drug; antibiotics; marine-derived peptides; anti-inflammatory; molecular pharmacology; targeted therapies; extraction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Sepsis: Molecular and Biochemical Perspectives

edited by

Akrivi Chrysanthopoulou

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1492 | Submission Open

Keywords: sepsis; outcome; molecular diagnosis; machine learning; biochemical biomarkers; targeted immunotherapy; personalized medicine; sepsis inflammatory endotypes

(This special issue belongs to the Section Biochemistry)

Radiobiology: New Challenges and Advances

edited by

Lorenzo Manti

and

Pavel Bláha

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1405 | Submission Open

Keywords: strategies for overcoming cancer radioresistance and normal-tissue damage mitigation; combined approaches: BNCT, proton–boron capture therapy, radioimmunotherapy; emerging technologies and novel temporal regimes: FLASH RT mechanisms and radiobiology of laser-accelerated particles; radiobiology of new ions and of novel dose-delivery modalities in particle radiotherapy; limphopoenia in radiotherapy and biomarkers of radiation response; three-dimensional models; microdosimetry: standardising measurements; DNA damage/repair; tumour microenvironment: autophagy, ferroptosis, fibroblast activation protein; non-cancer effects and non-targeted effects

(This special issue belongs to the Section Molecular Biology)

Dietary Polyphenols and Human Health

edited by

Chunmei Li

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1283 | Submission Open

Keywords: natural polyphenols; health and disease; neurodegenerative diseases; gut microbiota; lowest effective dose; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathogenesis and Treatment Approaches of Hematological Malignancies

edited by

Yosuke Minami

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1212 | Submission Open

Keywords: leukemia; lymphoma; minimal residual disease (MRD); cancer genomic profiling (CGP); molecular targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Biophysical Studies of Protein Structure-Function Relationships

edited by

Almerinda Di Venere

Giampiero Mei

and Velia Minicozzi

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1090 | Submission Open

Keywords: protein structure; molecular dynamics; computational modeling; drug discovery

(This special issue belongs to the Section Molecular Biophysics)

Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges

edited by

David Rodríguez-Lucena

and

Belén Begines

submission deadline 20 Nov 2026 | 1 articles | Viewed by 993 | Submission Open

Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy

(This special issue belongs to the Section Materials Science)

Molecular Understanding Involved in Age-Related Diseases

edited by

David Della-Morte

and

Francesca Pacifici

submission deadline 20 Nov 2026 | 1 articles | Viewed by 978 | Submission Open

Keywords: sirtuins; frailty; aging; age-related diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research

edited by

Paola Muggeo

submission deadline 20 Nov 2026 | 1 articles | Viewed by 890 | Submission Open

Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 1101-1150 on page 23 of 63.

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