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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Trends in Experimental Models for Cancer Research submission deadline 20 Jan 2026 | 4 articles | Viewed by 9546 | Submission Open
Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models
(This special issue belongs to the Section Molecular Oncology)
Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 9475 | Submission Open
Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic
(This special issue belongs to the Section Biochemistry)
Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease submission deadline 20 Jan 2026 | 1 articles | Viewed by 9232 | Submission Open
Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning
(This special issue belongs to the Section Molecular Informatics)
Natural Compounds in Human Health and Disease
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 9167 | Submission Open
Keywords: nutrition; human health; obesity; polyphenol; tea; pathology; animal model
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Developmental Biology: Computational and Experimental Approaches, 2nd Edition submission deadline 20 Jan 2026 | 5 articles | Viewed by 8974 | Submission Open
Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations
(This special issue belongs to the Section Molecular Biology)
New Advances in the Treatment and Diagnosis of Neuromuscular Diseases
edited by Silvia Consalvi
submission deadline 20 Jan 2026 | 2 articles | Viewed by 8941 | Submission Open
Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis
(This special issue belongs to the Section Molecular Neurobiology)
Respiratory Virus Infection
edited by Nikolaos Siafakas
submission deadline 20 Jan 2026 | 6 articles | Viewed by 8474 | Submission Open
Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus
(This special issue belongs to the Section Molecular Microbiology)
Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches submission deadline 20 Jan 2026 | 4 articles | Viewed by 8141 | Submission Open
Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition submission deadline 20 Jan 2026 | 5 articles | Viewed by 8137 | Submission Open
Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 8103 | Submission Open
Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils
(This special issue belongs to the Section Molecular Microbiology)
Protein and Protein Interactions
edited by Wu Xu
submission deadline 20 Jan 2026 | 3 articles | Viewed by 7901 | Submission Open
Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Electrochemical-Related Materials
edited by Celia García-Hernandez
submission deadline 20 Jan 2026 | 5 articles | Viewed by 7589 | Submission Open
Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications
(This special issue belongs to the Section Materials Science)
Abiotic Stresses in Plants: From Molecules to Environment—2nd Edition
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 7467 | Submission Open
Keywords: stress signaling; abiotic stress; oxidative stress; genotoxic stress
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research in Bone and Soft Tissue Tumors
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 7274 | Submission Open
Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
New Insights into the Immunopathology of Infectious Diseases
edited by Marta Camici
submission deadline 20 Jan 2026 | 4 articles | Viewed by 7095 | Submission Open
Keywords: infection immunology; immune dysregulation in infectious diseases; interactions between infective agents and immune responses; modeling of the immune system; new pathways of pathogenesis
(This special issue belongs to the Section Molecular Immunology)
Biomaterials for Drug Delivery and Advanced Therapies
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 6917 | Submission Open
Keywords: polymers; biomaterials; drug delivery; scaffold; ATMPs; tissue regeneration
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Therapies for Melanoma
edited by Anna Piotrowska
submission deadline 20 Jan 2026 | 3 articles | Viewed by 6812 | Submission Open
Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Electrode and Electrolyte Materials: Molecular Scale Design, Synthesis, Mechanisms and Applications
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 6810 | Submission Open
Keywords: cathode; anode; electrolyte; synthesis; electrochemistry; rechargeable batteries; lithium-ion batteries; all-solid-state lithium metal batteries
(This special issue belongs to the Section Materials Science)
Latest Research on Plant Genomics and Genome Editing, 2nd Edition
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 6782 | Submission Open
Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Mesenchymal Stem Cell-Based Therapy: Cell Therapy vs. EV Therapy
edited by Masahito Nakazaki
submission deadline 20 Jan 2026 | 1 articles | Viewed by 6649 | Submission Open
Keywords: mesenchymal stromal/stem cells; small extracellular vesicles; large extracellular vesicles; clinical trials; spinal cord injury; cerebrovascular disease
(This special issue belongs to the Section Biochemistry)
Oxidative Stress in Human Diseases
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 6626 | Submission Open
Keywords: inflammation; oxidative stress; free radicals; proteins; lipids; DNA damage; biomarkers
(This special issue belongs to the Section Biochemistry)
Investigating Host-Parasite Interactions for the Discovery of Novel Therapies and Vaccine Targets submission deadline 20 Jan 2026 | 3 articles | Viewed by 6570 | Submission Open
Keywords: parasites; host-pathogen interactions; helminths; worms; protozoans; leishmania; malaria; schistosomiasis; trypanosomiasis; ascariasis; anisakiasis; vectors; mosquitoes; ticks; neglected tropical diseases
(This special issue belongs to the Section Molecular Immunology)
Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition
edited by Jung-Hyun Lee
submission deadline 20 Jan 2026 | 5 articles | Viewed by 6393 | Submission Open
Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanism and Pathogenesis of Cardiac Disease
edited by Yu-Hsun Kao
submission deadline 20 Jan 2026 | 3 articles | Viewed by 6318 | Submission Open
Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Diabetes and Its Complications: From Molecular Mechanisms to Novel Therapeutic Approaches—2nd Edition submission deadline 20 Jan 2026 | 1 articles | Viewed by 6285 | Submission Open
Keywords: diabetes; diabetes complications; environmental factors; endocrine disruptors; nutrition; sleep; therapy; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Heart Failure: Insights and Therapeutic Strategies
edited by Emilio Vanoli and Eugenio Caradonna
submission deadline 20 Jan 2026 | 1 articles | Viewed by 6229 | Submission Open
Keywords: heart failure; autonomic nervous system; brain– gut interaction; gut microbiota; neurohumoral treatment; cardiac remodeling; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 6147 | Submission Open
Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models
(This special issue belongs to the Section Molecular Biology)
Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies submission deadline 20 Jan 2026 | 2 articles | Viewed by 6086 | Submission Open
Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions
(This special issue belongs to the Section Molecular Immunology)
The Structures, Syntheses of Natural Products, and Their Biological Effects
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 6068 | Submission Open
Keywords: structures of natural products; syntheses; biological effects; biomedical applications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research Landscape of Pulmonary Arterial Hypertension
edited by Cármen Brás-Silva
submission deadline 20 Jan 2026 | 3 articles | Viewed by 5846 | Submission Open
Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; molecular mechanisms; vascular disease; translational research; therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Parkinson's Disease
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 5710 | Submission Open
Keywords: Parkinson's disease; molecular regulation; genetic mutations; epigenetics; protein aggregation; mitochondrial dysfunction; neuroinflammation; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
Melanin and Other Pigments: Function, Synthesis and Characterization
edited by Koen P. Vercruysse
submission deadline 20 Jan 2026 | 3 articles | Viewed by 5675 | Submission Open
Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol
(This special issue belongs to the Section Biochemistry)
Advances in Drug Discovery and Synthesis: 2nd Edition submission deadline 20 Jan 2026 | 2 articles | Viewed by 5639 | Submission Open
Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure– activity relationships; structure-based drug design
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Diagnostics and Treatment Advances in Lung Diseases
edited by Eirini Vasarmidi
submission deadline 20 Jan 2026 | 2 articles | Viewed by 5636 | Submission Open
Keywords: lung diseases; pulmonary; alveolar; diagnosis; treatment; biomarkers; molecular; bronchoalveolar lavage; genetics; pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Research Insights in Cystic Fibrosis and CFTR-Related Diseases
edited by Judith A. Coppinger
submission deadline 20 Jan 2026 | 3 articles | Viewed by 5597 | Submission Open
Keywords: cystic fibrosis; CFTR related diseases; COPD; immune cells; extracellular vesicles; neutrophils; therapeutics; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Adult Stem Cell Research
edited by Dongsu Park
submission deadline 20 Jan 2026 | 4 articles | Viewed by 5596 | Submission Open
Keywords: tissue-resident stem cells; skeletal stem/progenitor cells; hematopoietic stem cells; tendon/ligament stem cells; musculoskeletal tissue regeneration; stem cell microenvironment; stem cell aging
(This special issue belongs to the Section Molecular Biology)
Endometriosis Pathophysiology, Diagnosis and Emerging Therapeutic Strategies submission deadline 20 Jan 2026 | 1 articles | Viewed by 5577 | Submission Open
Keywords: endometriosis; pathophysiology; infertility; biomarkers; pharmacological treatments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Developments in Obesity: Metabolism, Pathophysiology and Treatment
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 5456 | Submission Open
Keywords: obesity; adipokines; insulin sensitivity; lipid metabolism; pro-inflammatory cytokines; gut microbiota; GLP-1 receptor agonists; personalized nutrition; lifestyle interventions
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications
edited by Jordi Olloquequi and M. Emília Juan
submission deadline 20 Jan 2026 | 2 articles | Viewed by 5408 | Submission Open
Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling
(This special issue belongs to the Section Molecular Neurobiology)
Fat and Obesity: Molecular Mechanisms and Pathogenesis
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 5394 | Submission Open
Keywords: obesity; weight gain; adipogenesis; lipolysis; energy balance; hormones; fat oxidation; nutrition; phytomedicine; drug development; cohort studies; genetics and genomics studies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Neurodegeneration and Neuroinflammatory Processes in Age-Related Diseases
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 5372 | Submission Open
Keywords: age-related diseases; neurodegenerative diseases; neurodegeneration; neuroinflammation; aging
(This special issue belongs to the Section Molecular Neurobiology)
Biomarkers in Cardiovascular Diseases: Diagnosis, Pathology and Treatment submission deadline 20 Jan 2026 | 3 articles | Viewed by 5338 | Submission Open
Keywords: heart failure; myocardial remodeling; ischemic heart disease; myocarditis; cardiomyopathies; prevention; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Immunologic Perspectives on Mycobacterium tuberculosis Infection submission deadline 20 Jan 2026 | 1 articles | Viewed by 5093 | Submission Open
Keywords: M. tb infection; molecular immunology; HIV; AIDS; pathogenesis; host immune responses; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses
(This special issue belongs to the Section Molecular Immunology)
Neurological Diseases: From Molecular Basis to Therapy
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 5070 | Submission Open
Keywords: neurological diseases; pathogenesis; therapy; personalized medicine; early diagnosis; genetics; neurology; pharmacology
(This special issue belongs to the Section Molecular Neurobiology)
Plant Molecular Regulatory Networks and Stress Responses
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 4877 | Submission Open
Keywords: plant stress response; stress response gene; regulatory mechanism; gene regulatory network; transcriptional regulation; post-transcriptional regulation; multi-omics integration; single-cell RNA-seq; spatial genomics; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Tissue Regeneration and Repair in Airway Diseases
edited by Rolf Ziesche
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4813 | Submission Open
Keywords: chronic inflammation; structural integrity; regenerative repair; structural disintegration; impact of aging on inflammation and repair
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4759 | Submission Open
Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress
(This special issue belongs to the Section Molecular Biology)
New Insights into Satellite DNAs submission deadline 20 Jan 2026 | 2 articles | Viewed by 4744 | Submission Open
Keywords: satellite DNA; satellitome; satellite DNA organization; satellite DNA evolution; satellite DNA origin; satellite DNA transcription; satellite DNA function; satellite DNA regulation; satellite RNA; heterochromatin; centromere; telomere; gene regulation; cancer; biomarkers; epigenetics; next-generation sequencing (NGS); nanopore sequencing; PacBio sequencing
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Antimicrobial Activity submission deadline 20 Jan 2026 | 2 articles | Viewed by 4694 | Submission Open
Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and the Link Between Obesity, Diabetes and Inflammation submission deadline 20 Jan 2026 | 4 articles | Viewed by 4669 | Submission Open
Keywords: adipose tissue; biomarkers; diabetes; inflammation; obesity; cytokine; insulin resistance; signaling pathways; metabolic diseases
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
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