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Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease
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Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 3542

Special Issue Editors

Dr. Miguel Hueso

E-Mail Website
Guest Editor
Department of Nephrology, Hospital Universitari de Bellvitge, 08907 L’Hospitalet de Llobregat, Spain
Interests: kidney pathology; dialysis; vascular pathology; molecular medicine; predictive medicine; personalized medicine; inflammation; ncRNAs; organs-on-chip; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Dr. Alfredo Vellido

E-Mail Website
Guest Editor
IDEAI_UPC Research Center, Universitat Politècnica de Catalunya (UPC BarcelonaTech), 08034 Barcelona, Spain
Interests: machine learning; data science; medical applications of artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to explore the role of precision medicine in kidney disease from a molecular perspective, which is critical in research on the molecular mechanisms and precision therapy underlying kidney disease.

Through research, we can identify biomarkers for early molecular diagnosis, uncover new therapeutic targets, and develop innovative therapies, such as gene editing technologies, regenerative medicine, and immunotherapy. The Special Issue highlights the latest breakthroughs in ingenomics, proteomics, and metabolomics, all of which enable personalized approaches to kidney disease.

For this Special Issue, we will gather a diverse collection of research papers, reviews, and expert insights that delve into various aspects of personalized medicine for kidney diseases. We welcome you to share your expertise in exploring innovative diagnostic techniques and novel therapeutic methods that enable molecular research and treatments based on an individual's genetic makeup and disease progression.

Dr. Miguel Hueso
Dr. Alfredo Vellido
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized medicine
  • kidney diseases
  • genomics
  • biomarkers
  • therapeutics
  • proteomics
  • metabolomics
  • machine learning

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Published Papers (1 paper)

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Review

19 pages, 660 KiB  
Review
Detailed Pathophysiology of Minimal Change Disease: Insights into Podocyte Dysfunction, Immune Dysregulation, and Genetic Susceptibility
by Maja Roman and Michał Nowicki
Int. J. Mol. Sci. 2024, 25(22), 12174; https://doi.org/10.3390/ijms252212174 - 13 Nov 2024
Viewed by 3017
Abstract
Minimal Change Disease (MCD) is a predominant cause of idiopathic nephrotic syndrome in the pediatric population, yet presents significant clinical challenges due to its frequent relapses and steroid resistance. Despite its relatively benign histological appearance, MCD is characterized by severe proteinuria, hypoalbuminemia, and [...] Read more.
Minimal Change Disease (MCD) is a predominant cause of idiopathic nephrotic syndrome in the pediatric population, yet presents significant clinical challenges due to its frequent relapses and steroid resistance. Despite its relatively benign histological appearance, MCD is characterized by severe proteinuria, hypoalbuminemia, and edema, which may affect patient outcomes. Current treatment strategies primarily rely on corticosteroids, which are effective in inducing remission but are associated with high relapse rates, steroid resistance, and numerous long-term side effects, underscoring the need for more targeted and effective therapeutic approaches. This narrative review synthesizes current knowledge on the pathophysiological mechanisms underlying MCD, focusing on the following three critical areas: podocyte dysfunction, immune dysregulation, and genetic susceptibility. Podocyte dysfunction, particularly involving alterations in nephrin, plays a central role in the breakdown of the glomerular filtration barrier, leading to the characteristic proteinuria observed in MCD. Immune dysregulation, including the presence of autoantibodies against nephrin and other podocyte components, exacerbates podocyte injury and contributes to disease progression, suggesting an autoimmune component to the disease. Genetic factors, particularly mutations in the NPHS1 and NPHS2 genes, have been identified as significant contributors to disease susceptibility, influencing the variability in treatment response and overall disease severity. Understanding these mechanisms is crucial for developing targeted therapies that address the underlying causes of MCD rather than merely managing its symptoms. This review highlights the need for further research into these pathophysiological processes to pave the way for more personalized and effective treatment strategies, ultimately improving patient outcomes and reducing reliance on corticosteroids. Full article
(This article belongs to the Special Issue Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease)
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