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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Relationship Between Plant Microbiome and Immunity

edited by

Sergio Molinari

submission deadline 30 Sep 2025 | Viewed by 102 | Submission Open

Keywords: microbiome; plant immune system; rhizosphere of plant roots; microbe-associated molecular patterns (MAMPs)

(This special issue belongs to the Section Molecular Plant Sciences)

New Molecular Insights into Antibacterial Material

edited by Rahela Carpa

submission deadline 30 Sep 2025 | Viewed by 101 | Submission Open

Keywords: antimicrobial resistance; nanoparticles; biopolymers; antimicrobial peptides; antimicrobial materials

(This special issue belongs to the Section Materials Science)

Research on Plant Genomics and Breeding: 3rd Edition

edited by

Zhiyong Li

Jian Zhang

and

Dawei Xue

submission deadline 30 Sep 2025 | Viewed by 100 | Submission Open

Keywords: gene cloning and function; genetic engineering; molecular genetics; genome editing; regulatory mechanisms; germplasm enhancement; molecular breeding and marker-assisted selection

(This special issue belongs to the Section Molecular Plant Sciences)

The Influence of Genetics on Lymphatic System Diseases

edited by

Tomomi Watanabe-Asaka

submission deadline 30 Sep 2025 | Viewed by 99 | Submission Open

Keywords: lymphatic system; gene expression; disease model; medical application; lymphatic development; lymphatic function

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular-Scale Design, Synthesis, and Applications of (Photo)Electrochemical Materials for Sustainable Energy and Environmental Solutions

edited by

Shiwei Lin

and

Zhaohui Xiao

submission deadline 30 Sep 2025 | Viewed by 98 | Submission Open

Keywords: molecular-scale material engineering; photoelectrocatalysis/electrocatalysis; sustainable energy conversion; atomic-precision synthesis; environmental remediation technologies

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Bioactive Peptides: Function, Metabolism and Synthesis

edited by

Leandro Mantovani de Castro

submission deadline 30 Sep 2025 | Viewed by 97 | Submission Open

Keywords: bioactive peptides; antimicrobial peptides; antitumoral peptides; neurodegenerative diseases; metabolic diseases; chemical synthesis; cellular proteolysis; mass spectrometry; peptidomics; intracellular peptides; micropeptides

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nanomedicine: Application of Nanostructured Biomaterials in the Biomedical Field

edited by

Yaser Dahman

submission deadline 30 Sep 2025 | Viewed by 97 | Submission Open

Keywords: nanomedicine; nanostructured biomaterials; targeted drug delivery; tissue regeneration; biosensing

(This special issue belongs to the Section Molecular Nanoscience)

Study on the Microenvironment in Lymphoma

edited by

Jonathan P. Butchar

submission deadline 30 Sep 2025 | Viewed by 97 | Submission Open

Keywords: tumor microenvironment; lymphoma; hodgkin lymphoma; non-hodgkin lymphoma; burkitt lymphoma; follicular lymphoma; waldenströ m’ s macroglobulinemia; NK/T-cell lymphoma; diffuse large B-cell lymphoma; mantle cell lymphoma; marginal zone lymphoma; lymphoproliferative disorder; anaplastic large cell lymphoma; mediastinal B cell lymphoma; T-cell lymphomas

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathogenesis and Therapeutic Innovations in Oral Diseases

edited by Tatsuji Nishihara

submission deadline 30 Sep 2025 | Viewed by 97 | Submission Open

Keywords: molecular-based analysis; diagnosis of oral disease; oral disease treatment; regeneration therapy; drug therapy; periodontitis; implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Clinical Advances in Ophthalmic Inflammation, Infection, and Degeneration

edited by Hyun Jin Shin

submission deadline 30 Sep 2025 | Viewed by 96 | Submission Open

Keywords: ophthalmic inflammation; ocular infection; ocular degeneration; molecular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds in Bee Products: Chemistry, Mechanisms of Action and Nutritional Applications

edited by

Jarosław Widelski

and

Ioanna Chinou

submission deadline 30 Sep 2025 | Viewed by 96 | Submission Open

Keywords: honey; propolis; royal jelly; polyphenols; nutritional properties; bioactivity; analytical and isolation methods; bee pollen

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Bone Microenvironment and Bone Metastasis

edited by

Cristina Sanchez de Diego

submission deadline 30 Sep 2025 | Viewed by 96 | Submission Open

Keywords: bone metastasis; tumor– bone interaction; bone microenvironment; osteoclastogenesis; osteoblast signaling; bone remodeling; dormancy; immune evasion; extracellular matrix

(This special issue belongs to the Section Molecular Oncology)

Recent Progress in Nanomedicine for Cancer Therapy

edited by Peisheng Xu

submission deadline 30 Sep 2025 | Viewed by 96 | Submission Open

Keywords: nanomedicine; cancer-targeted therapy; theragnostic; nanodevice

(This special issue belongs to the Section Molecular Nanoscience)

New Insights into Adipose Tissue Metabolic Function and Dysfunction, 4th Edition

edited by

Federica Mannino

submission deadline 30 Sep 2025 | Viewed by 95 | Submission Open

Keywords: inflammation; browning; thermogenesis; adipogenesis; diabetes; adipokines; energy storage; insulin resistance; obesity; lipolysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioplastic-Related Toxicity in Humans: New Insights and Molecular Mechanisms

edited by

Antonietta Santoro

and

Marta Anna Szychlinska

submission deadline 30 Sep 2025 | Viewed by 94 | Submission Open

Keywords: bioplastics and biopolymers -related toxicity; microplastics and nanoplastics accumulation/degradation in mammals; cell cultures; human health; in vivo models; epigenetics effects; endocrine disruptor properties of bioplastics; bioplastics and inflammation; bioplastics in neurodegeneration and neuroinflammation; reproduction; cell metabolism; immunomodulation

(This special issue belongs to the Section Molecular Toxicology)

Advances in Plant Biotechnology: From Pathogen Diagnostics to Disease Management

edited by

Abdul Kader Jailani Amirudeen

submission deadline 30 Sep 2025 | Viewed by 93 | Submission Open

Keywords: plant pathogens; diagnostic; isothermal; biosensor; RNAi; CRISPRi; QTL mapping; GWAS; MAS or MABC

(This special issue belongs to the Section Molecular Plant Sciences)

Targeting MAPK in Human Diseases

edited by

Elisabetta Rovida

submission deadline 30 Sep 2025 | Viewed by 93 | Submission Open

Keywords: ERK; DUSP; cancer; inflammation; neurodegenerative diseases; autoimmune diseases; targeted therapy; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Immunosuppressive Therapy

edited by

Marta Grabowska

submission deadline 30 Sep 2025 | Viewed by 92 | Submission Open

Keywords: immunosuppressive drugs; calcineurin inhibitors; corticosteroids; inhibitors of purine synthesis; mammalian target of rapamycin inhibitors; biological treatment; cell-based therapies; biomarkers; genetic profiling

(This special issue belongs to the Section Molecular Immunology)

Molecular Research and Immune Landscape of Breast Cancer

edited by

Robson Monteiro

submission deadline 30 Sep 2025 | Viewed by 92 | Submission Open

Keywords: breast cancer; immune landscape; single-cell analysis; omics; therapy resistance; metastasis

(This special issue belongs to the Section Molecular Immunology)

Lifestyle Interventions in MASLD: Molecular and Clinical Perspectives

edited by Muhammad Y. Sheikh

submission deadline 30 Sep 2025 | Viewed by 92 | Submission Open

Keywords: NAFLD (nonalcoholic fatty liver disease); MASLD (metabolic syndrome-associated steatotic liver disease); metabolic syndrome; dyslipidemia; diabetes mellitus 2; hypertension; natural bioactive

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roles of Non-Coding RNAs in Cancer

edited by Amit K. Mitra

submission deadline 30 Sep 2025 | Viewed by 91 | Submission Open

Keywords: lncRNA; miRNA; cancer; genomics; targeted therapy; biomarkers; drug resistance

(This special issue belongs to the Section Molecular Genetics and Genomics)

Hormone Receptors and Signaling in Breast Cancer, 2nd Edition

edited by

Farzad Pakdel

submission deadline 30 Sep 2025 | Viewed by 91 | Submission Open

Keywords: breast cancer; hormone receptor; growth factor receptor; estrogen receptor; endocrine therapies; PI3K; AKT; mTOR; signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cytokines and Other Biomarkers of Health Status

edited by Anna Cywińska and

Ewelina Maculewicz

submission deadline 30 Sep 2025 | Viewed by 90 | Submission Open

Keywords: cytokine concentration; cytokine gene expression; cytokine receptors; biomarkers; pathogenesis; adaptation; homeostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Application of Biomaterial in Skin Diseases

edited by

Danuta Nowicka

submission deadline 30 Sep 2025 | Viewed by 89 | Submission Open

Keywords: chronic dermatoses; autologus material; PRP; stem cells; growth factors

(This special issue belongs to the Section Materials Science)

Mitochondrial Dysfunction and Oxidative Stress in Human Diseases: Molecular Targets and Therapeutic Strategies

edited by

Carlo Acierno

submission deadline 30 Sep 2025 | Viewed by 87 | Submission Open

Keywords: mitochondria; oxidative stress; redox signaling; mitophagy; immunometabolism; metabolic reprogramming; ROS; bioenergetics; molecular therapeutics; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Aging and Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics—2nd Edition

edited by Lilach Soreq

submission deadline 30 Sep 2025 | Viewed by 87 | Submission Open

Keywords: aging; Alzheimer’ s disease; bioinformatics; RNA-seq; Parkinson’ s disease

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insight into Polymer Dynamics

edited by

Sirui Ge

submission deadline 30 Sep 2025 | Viewed by 87 | Submission Open

Keywords: polymer dynamics; glass transition; segmental relaxation; bulk relaxation; structure– property relationship; functional polymers; spectroscopy; instrumental characterization; simulations and modeling; polymer diffusion

(This special issue belongs to the Section Materials Science)

Advances in Molecular Approaches to Asthma Management

edited by

Diego Bagnasco

and

Corrado Pelaia

submission deadline 30 Sep 2025 | Viewed by 87 | Submission Open

Keywords: severe asthma; type 2 and non-type 2 inflammation; antibodies; comorbidities; treatable traits

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MicroRNAs in Physiology and Pathophysiology

edited by Małgorzata Guz

submission deadline 30 Sep 2025 | Viewed by 86 | Submission Open

Keywords: miRNA; cell physiology; metabolism; cancer; biomarkers; disease; molecular mechanisms; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Endoplasmic Reticulum Stress and Apoptosis—Second Edition

edited by

Orsolya Kapuy

and

Beáta Lizák

submission deadline 30 Sep 2025 | Viewed by 86 | Submission Open

Keywords: ER stress; apoptosis initiated by ER stress; cellular survival; redox homeostasis of ER; autophagy initiated by ER stress; cell death pathways initiated by ER stress

(This special issue belongs to the Section Biochemistry)

Surfactants: Design, Synthesis and Properties

edited by

Joanna Krawczyk

submission deadline 30 Sep 2025 | Viewed by 85 | Submission Open

Keywords: design and synthesis of surfactants; adsorption and aggregation properties of surfactants; behavior of surfactants at different interfaces; application of biosurfactants and specialist surfactants (industry; agriculture; medicine; pharmacy)

(This special issue belongs to the Section Materials Science)

Statin Induced Neurotoxicity

edited by

Iain P. Hargreaves

and

Adam P. Lightfoot

submission deadline 30 Sep 2025 | Viewed by 85 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; coenzyme Q10; simvastatin; neurotoxicity; blood brain barrier

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights on Myogenic Progenitors: Regulation of Differentiation

edited by

James M. Holaska

submission deadline 30 Sep 2025 | Viewed by 84 | Submission Open

Keywords: myogenic progenitors; skeletal muscle; muscle regeneration; myogenesis

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis and Application of Cellulose Materials

edited by

Jian Zhao

and

Yehan Tao

submission deadline 30 Sep 2025 | Viewed by 84 | Submission Open

Keywords: cellulose; polymer materials; biomass

(This special issue belongs to the Section Materials Science)

Surfactant Sciences: Design, Synthesis, and Applications

edited by Zakaria Hafidi

submission deadline 30 Sep 2025 | Viewed by 84 | Submission Open

Keywords: surfactants; synthesis; biodegradation; catalysis; biological activity; nanoparticles; design; green chemistry; self-assembly; surface chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Molecular Research on Candida Resistance

edited by

Angela Maione

submission deadline 30 Sep 2025 | Viewed by 84 | Submission Open

Keywords: Candida resistance; antifungal resistance; biofilm; drug repurposing; novel therapies; molecular mechanisms; antifungal agents; Candida albicans; Candida auris; host– pathogen interactions

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Mechanisms of Apoptosis and Aging Complexes

edited by

Rumiana Tzoneva

submission deadline 30 Sep 2025 | Viewed by 83 | Submission Open

Keywords: cell biology; antioxidants; transmembrane signalisation; actin cytoskeleton; anti-tumor therapy; cytotoxicity; apoptosis; aging; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

RNA in Human Diseases: Challenges and Opportunities: 2nd Edition

edited by

Nicoletta Potenza

submission deadline 30 Sep 2025 | Viewed by 82 | Submission Open

Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification

(This special issue belongs to the Section Molecular Biology)

Research on System Biology Methods and Tools for Integrating Omics Data

edited by Yuanyan Xiong

submission deadline 30 Sep 2025 | Viewed by 80 | Submission Open

Keywords: systems biology; multi-omics integration; network analysis; computational biology; bioinformatics tools; machine learning; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies

edited by Noah R. Johnson and

Chih Hung Lo

submission deadline 30 Sep 2025 | Viewed by 80 | Submission Open

Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery

(This special issue belongs to the Section Molecular Neurobiology)

Cyclodextrins: Properties and Applications, 3rd Edition

edited by

Miguel A. Esteso

and

Carmen M. Romero

submission deadline 30 Sep 2025 | Viewed by 79 | Submission Open

Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties

(This special issue belongs to the Section Macromolecules)

New Perspectives in Protein Structure

edited by

Csaba Magyar

submission deadline 30 Sep 2025 | Viewed by 79 | Submission Open

Keywords: stability of protein complexes structural; background of protein function; allosteric regulation of proteins; fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins

(This special issue belongs to the Section Molecular Biophysics)

Advances in Plant-Derived Nanomaterials: From Molecular Mechanisms to Biofortification

edited by

Ágnes Szepesi

submission deadline 30 Sep 2025 | Viewed by 78 | Submission Open

Keywords: nanotechnology; green synthesis; sustainable nanomaterials; nano– bio interactions; crop production; plant-based solutions; bio-corona

(This special issue belongs to the Section Molecular Plant Sciences)

Computational Modeling of Protein Targets & Therapeutic Molecules

edited by

Whelton Miller

submission deadline 30 Sep 2025 | Viewed by 76 | Submission Open

Keywords: biophysics; chemistry; drug discovery; computer-aided drug design; protein target

(This special issue belongs to the Section Molecular Informatics)

3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics

edited by

Thomas J. Goodwin

submission deadline 30 Sep 2025 | Viewed by 76 | Submission Open

Keywords: 3D physiological relevance vs. 2D biology; 3D research; and diagnostic systems; evolving 3D “ omics” applications; research and clinical medicine; drug applications; toxicity evaluations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roles of Exosomes in Health and Disease

edited by

Paulo Pereira

submission deadline 30 Sep 2025 | Viewed by 76 | Submission Open

Keywords: exosomes; extracellular vesicles; intercellular communication; diagnostics; therapeutics; disease; biomarkers; cellular biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Stroke

edited by

Hee-Jung Song

submission deadline 30 Sep 2025 | Viewed by 76 | Submission Open

Keywords: stroke; microglia; neuroinflammation; molecular mechanisms; ischemic injury