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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Trends in Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics: 3rd Edition

edited by

Ramón Cacabelos

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1762 | Submission Open

Keywords: Alzheimer’s disease; pathogenic mechanisms; genomics; epigenetics; biomarkers; prevention; treatment; pharmacogenetics

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Prostate Cancer, 2nd Edition

edited by

Yaser Gamallat

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1736 | Submission Open

Keywords: prostate cancer; molecular biology; genomics; biomarkers; signaling pathways; precision medicine; treatment resistance; epigenetics; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Virus Infection, Resistance and Control

edited by

Carl Spetz

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1733 | Submission Open

Keywords: plant virus; host–pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanisms in Biofilm Formation, Tolerance and Control: 3rd Edition

edited by

Manuel Simões

and Lúcia Chaves Simões

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1699 | Submission Open

Keywords: adhesion; antimicrobial action; antimicrobial resistance; biofilm development; biofilm matrix; biofilm structure; quorum sensing; motility; surfaces

(This special issue belongs to the Section Molecular Microbiology)

Unraveling the Molecular Landscape of Systemic Lupus Erythematosus

edited by Yoshinori Matsumoto

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1686 | Submission Open

Keywords: systemic lupus erythematosus; autoimmunity; molecular mechanisms; immune regulation; type I interferon; biomarkers; multi-omics; signal transduction; precision medicine; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Molecular Research on the Malaria Parasite

edited by Hajime Hisaeda and

Takashi Imai

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1667 | Submission Open

Keywords: plasmodium; malaria parasite; molecular biology; genomics; gene expression; host–parasite interaction; drug resistance; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Heterogeneous Catalysis Towards a Sustainable Future: Energy Conversion and Green Synthesis

edited by Chen Wu and

Shaodong Zhou

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1659 | Submission Open

Keywords: heterogeneous catalysis; CO2 hydrogenation; CO2 electroreduction; water splitting; Fischer-Tropsch synthesis; oxidative coupling of methane; methane dry reforming; green synthesis; fine chemicals; sustainable energy; catalyst design; active site engineering; single-atom catalysts; metal–organic frameworks; zeolites; nanostructured catalysts; in situ and operando characterizations; photocatalysis; electrocatalysis; biomass valorization; reaction engineering; renewable feedstocks

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Using Model Organisms to Study Complex Human Diseases—2nd Edition

edited by

Roberto Piergentili

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1649 | Submission Open

Keywords: model organism; Escherichia coli; yeast; Caenorhabditis elegans; Drosophila melanogaster; zebrafish; Arabidopsis thaliana; Xenopus laevis; rat and mouse model; human disease; inherited disease; cancer; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Herpesviruses (2nd Edition)

edited by

Marisa Granato

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1613 | Submission Open

Keywords: α-herpesviridae; β-herpesviridae; γ-herpesviridae; herpesviruses associated diseases

(This special issue belongs to the Section Molecular Microbiology)

Beyond the Resolution Revolution: The Next Era of Cryo-EM and Structural Biology

edited by

Gaya P. Yadav

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1609 | Submission Open

Keywords: cryo-electron microscopy (cryo-EM); membrane protein structure; cryo-tomography and 3D reconstruction; advances in sample vitrification; structure-guided drug discovery; lipid–protein dynamics; innovations in cryo-EM methodology

(This special issue belongs to the Section Molecular Biology)

Epigenetics and RNA Processing Involved in Disease

edited by

Naoyuki Kataoka

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1572 | Submission Open

Keywords: RNA processing; RNA splicing; epigenetics; DNA modification; histone modification; RNA modification; RNA diseases; genetic diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Mitochondrial Dysfunction in Disease: Mechanisms, Biomarkers and Emerging Therapies

edited by

Alexandre Umpierrez Amaral

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1528 | Submission Open

Keywords: mitochondria; bioenergetic homeostasis; calcium homeostasis; redox homeostasis; oxidative stress; biogenesis; mitophagy; dynamics

(This special issue belongs to the Section Biochemistry)

Health Impacts of Environmental Pollution on the Urogenital and Reproductive Systems

edited by

Anna Perri

and

Silvestro Antonio Ruffolo

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1491 | Submission Open

Keywords: pollution; endocrine toxicity; endocrine disruptors; human biomonitoring; infertility; cancer; inflammation; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis and Molecular Applications of Nanomaterials

edited by

Fernando J. Pereira

A. Javier Aller

and

Roberto Lopez

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1467 | Submission Open

Keywords: nanomaterials; synthesis; molecular applications

(This special issue belongs to the Section Molecular Nanoscience)

Marine Fungi: From Molecular Biology to Biotechnology Application

edited by

Guang-Lei Liu

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1441 | Submission Open

Keywords: marine fungi; marine yeasts; marine filamentous fungi; biosynthesis; metabolic engineering; regulatory mechanism; functional biomolecules; exopolysaccharides; glycolipids; organic acids; biofuel; enzymes; cell factories; gene editing tools; fermentation optimization

(This special issue belongs to the Section Molecular Microbiology)

Sex Differences in Preclinical and Clinical Studies

edited by

Flavia Franconi

Valeria Raparelli

and

Ilaria Campesi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1436 | Submission Open

Keywords: cellular and in vitro studies; genetic and epigenetic studies; intersectional studies; observational studies; pharmacological studies; pragmatic studies; randomized control trials; disease management

(This special issue belongs to the Section Molecular Biology)

Recent Research of Nanomaterials in Molecular Science: 3rd Edition

edited by

Giovanna Iezzi

and

Tania Vanessa Pierfelice

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1385 | Submission Open

Keywords: nanomaterials; medical research; synthesis and characterization; molecular formula; molecular dynamics; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy

(This special issue belongs to the Section Molecular Nanoscience)

Oral Diseases: Molecular Research and Novel Therapy

edited by

I-Ta Lee

submission deadline 20 Sep 2026 | Viewed by 1385 | Submission Open

Keywords: oral diseases; molecular mechanisms; inflammation and immunity; redox signalling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antioxidant and Antidiabetic Potential of Natural Products in the Management of Diabetes and Its Complications

edited by

Ochuko Lucky Erukainure

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1382 | Submission Open

Keywords: diabetes; natural products; obesity; medicinal plants; oxidative stress; antioxidants

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research for Ovarian Cancer Biology and Therapeutics (Second Edition)

edited by

Carmela Ricciardelli

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1381 | Submission Open

Keywords: ovarian cancer; chemotherapy resistance; metastasis; novel therapeutic agents; immunotherapy; CAR-T cells; cancer chemotherapy; pre-clinical models

(This special issue belongs to the Section Molecular Oncology)

Advances in Molecular Biology of Ovarian Cancer

edited by

Stefania Scicchitano

and Cinzia Garofalo

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1360 | Submission Open

Keywords: ovarian cancer; signaling pathways; transcription factors; cancer metabolism; chemoresistance; tumor microenvironment; ovarian cancer stem cells; cancer therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Strategies for the Discovery, Optimization, and Efficient Use of Green Pesticides

edited by

Hongjian Song

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1356 | Submission Open

Keywords: natural-product-based pesticides; total synthesis; structural optimization; bioactivity evaluation; structure–activity relationship

(This special issue belongs to the Section Molecular Pharmacology)

Sigma-1 Receptor: Signaling, Functions and Therapeutic Potential

edited by Gabriela Cristina Brailoiu and Eugen Brailoiu

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1339 | Submission Open

Keywords: Sigma-1R; intracellular receptor; molecular mechanisms; calcium signaling; neurological diseases; neurodegenerative diseases; pain; cancer; addiction

(This special issue belongs to the Section Molecular Biology)

Drug Discovery and Development for Renal Disease Treatment

edited by

Keiko Hosohata

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1338 | Submission Open

Keywords: kidney disease; medicinal chemistry; drug discovery; computer-assisted drug design; drug targets; in vitro assays; epigenetic targets; multi-targeting compounds; biophysical methods; target engagement studies

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Alzheimer’s Disease: From Metabolic Dysregulation to Molecular Pathophysiology and Therapeutics

edited by Pedro Cisternas

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1330 | Submission Open

Keywords: Alzheimer’s disease; metabolic dysregulation; brain insulin resistance; neuroenergetics; mitochondrial dysfunction; adipokines; neuroinflammation; gut–brain axis; multi-omics biomarkers; therapeutics and precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Understanding the Molecular Basis of Antimicrobial Properties in Natural Products, Functional Additives, and Food-Derived Compounds

edited by

Aleksandra Maria Kocot

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1324 | Submission Open

Keywords: natural antibacterial substances; antibacterial activity; bacterial metabolites; functional additives; antibacterial peptides

(This special issue belongs to the Section Biochemistry)

New Advances in Cardio-Oncology: Mechanisms, Biomarkers, and Therapeutic Strategies

edited by Valentina Citi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1308 | Submission Open

Keywords: cardio-oncology; cardiotoxicity; cancer therapies; cardiovascular complications; risk stratification; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Vitamin K in Disease Mechanisms and Therapy

edited by Maria Kokozidou

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1290 | Submission Open

Keywords: vitamins K; vitamins K-soluble proteins; vitamin K-dependent clotting factors; matrix Gla protein; calcification of blood vessels; vascular stiffness; cardiac output; stroke volume

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Natural Compounds: Biosynthesis and Application

edited by

Abdellah Zinedine

, Marya Raji and El Habib Ait Addi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1289 | Submission Open

Keywords: natural compounds; chemical composition; biological activities; biosynthesis; bioconversion; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Roles and Mechanisms of Non-Coding RNAs in Cancer

edited by Stefano Sechi and Daniela Scarabino

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1274 | Submission Open

Keywords: cancer; non-coding RNA (ncRNA); translational medicine; oncological therapy; biomarker; piRNA; lncRNA; circRNA

(This special issue belongs to the Section Molecular Genetics and Genomics)

Metabolic Signaling and Inflammation in Cardiac Pathophysiology

edited by

Maria Luisa Barcena

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1273 | Submission Open

Keywords: cardiac metabolism; inflammation; metabolic signaling; heart disease; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Environmental and Human Adverse Effects of Micro and Nanoplastics: 2nd Edition

edited by

Elena Niccolai

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1252 | Submission Open

Keywords: micro and nanoplastics; environmental pollution; micro and nanoplastic toxicity; human health

(This special issue belongs to the Section Molecular Toxicology)

Oxygen Variations, 3rd Edition

edited by

Gerardo Bosco

Costantino Balestra

and

Simona Mrakic-Sposta

submission deadline 20 Sep 2026 | Viewed by 1240 | Submission Open

Keywords: hypoxia; hyperoxia; normoxia; biochemichal response; integrative approach; normo-hypo-hyperbaric; molecular research; gene expression; adaptive reactions; extreme environments

(This special issue belongs to the Section Molecular Biology)

Application of Spectroscopic Methods in Molecular Biology Research

edited by

Łukasz Laskowski

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1165 | Submission Open

Keywords: spectroscopy; molecular characterization; biomaterials; computational chemistry; structure–property relationships; biomolecular interactions; biomedical applications

(This special issue belongs to the Section Molecular Biology)

The Role of Selenium in Human Health and Disease

edited by

Youcef M. Rustum

submission deadline 20 Sep 2026 | Viewed by 1140 | Submission Open

Keywords: selenium; oxidative stress; immune modulation; cancer prevention and therapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Future of Biomaterials in Dentistry: Innovations in Drug Delivery and Regenerative Medicine

edited by

Victor Martin

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1134 | Submission Open

Keywords: dentistry; regenerative medicine; drug delivery; tissue engineering; biomaterials; tooth; periodontal

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Targeted Therapy of Lymphedema and Lipedema

edited by

Raghu P. Kataru

and Geoffrey E. Hespe

submission deadline 20 Sep 2026 | Viewed by 1127 | Submission Open

Keywords: secondary lymphedema; breast cancer related lymphedema; chronic CD4+ T cell inflammtion Th2 driven fribrosis; lymphatic pathophysiology; tissue fibrosis; lymphovenous bypass; lymph node transplanatation; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Pulsed Electric Fields in Cancer Therapy

edited by Siqi Guo

submission deadline 20 Sep 2026 | 2 articles | Viewed by 1115 | Submission Open

Keywords: pulsed electric fields; cancer therapy; ablation; minimally invasive; tumor microenvironment; combination therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms in Postharvest Biology

edited by

Kangdi Hu

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1108 | Submission Open

Keywords: postharvest biology; fruit ripening; senescence; stress tolerance; disease resistance; molecular biology; gene regulatory networks; genomics; synthetic biology; nanotechnology; controlled atmosphere; biostimulants

(This special issue belongs to the Section Molecular Plant Sciences)

Gastrointestinal Diseases and Pharmacology

edited by

Giuseppe Esposito

and Irene Palenca

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1101 | Submission Open

Keywords: gastrointestinal diseases; gastrointestinal pharmacology; inflammatory bowel diseases; gastrointestinal cancer; irritable bowel syndrome; visceral hypersensitivity; enteric nervous system; gut–brain axis; intestinal motility; neurogastroenterology; drug discovery; gastrointestinal inflammation; translational pharmacology; therapeutic targets; microbiota–drug interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Training Immunity and Reprogramming Monocytes and Macrophages in Health and Disease

edited by Eugenio A. Carrera Silva

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1094 | Submission Open

Keywords: monocytes; macrophage plasticity; regulatory reprogramming; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Advances in Diagnostics and Therapeutics of Neurodegenerative Disease

edited by

Romina Combi

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1063 | Submission Open

Keywords: neurodegenerative disorders; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular, Cellular Mechanism of Oxidative Stress in Physiological and Pathophysiological Conditions, 2nd Edition

edited by Dominika Marta Stygar

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1061 | Submission Open

Keywords: oxidative stress; inflammation; obesity; civilization; diseases; molecular mechanism; cellular mechanism; biomarkers; bacterial and viral diseases; environmental stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Product-Based Therapeutics: Molecular Mechanisms and Cellular Modulation

edited by Mario Garcia-Dominguez

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1030 | Submission Open

Keywords: natural products; molecular mechanisms; cellular modulation; molecular targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Handshakes: Engineering Protein–Ligand Interfaces for Precision Drug Design

edited by Tarun Jairaj Narwani

submission deadline 20 Sep 2026 | 1 articles | Viewed by 1016 | Submission Open

Keywords: structure-based drug design (SBDD); AI-driven drug discovery; protein–ligand dynamics; molecular interface engineering; structural biology; chemical biology; allosteric modulation; undruggable targets and drug resistance

(This special issue belongs to the Section Biochemistry)

Ion Transporter-Based Biomarkers for Sperm Quality

edited by

Elisabeth Pinart

submission deadline 20 Sep 2026 | Viewed by 971 | Submission Open

Keywords: ion transporters; sperm quality; cryotolerance

(This special issue belongs to the Section Molecular Biology)

Molecular Toxicology of Nano- and Microplastics: Mechanisms of Cellular Disruption and Biochemical Pathways

edited by Ioannis Alexandros Charitos

submission deadline 20 Sep 2026 | 1 articles | Viewed by 890 | Submission Open

Keywords: nanoplastics; microplastics (NMP); toxicology; toxicological impact; human health; human microbiota; metabolome

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanism and Pathogenesis of Neuroinflammation in Neurological Disorders

edited by

Masashi Tanaka

submission deadline 20 Sep 2026 | Viewed by 884 | Submission Open

Keywords: age-related disorders; Alzheimer’s disease; amyloid-β; bioactive molecules; cognitive impairment; dementia; glial activation; microglia; neuroinflammation; neurological disorders; neurotherapeutics; tau hyperphosphorylation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Retinal Degeneration

edited by

Sayan Ghosh

submission deadline 20 Sep 2026 | 1 articles | Viewed by 875 | Submission Open

Keywords: retinal degeneration; photoreceptors; retinal pigmented epithellium (RPE) cells; retinal ganglion cells; glial cells; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Drug Synthesis Reactions: From Bench to Breakthroughs

edited by

Hadia Almahli

submission deadline 20 Sep 2026 | Viewed by 857 | Submission Open

Keywords: organic synthesis; sustainability; scale-up synthesis; bio-orthogonal reactions; flow chemistry; green chemistry; natural product scaffolds; electrochemical synthesis; chemoenzymatic synthesis; automated and high-throughput synthesis

(This special issue belongs to the Section Molecular Pharmacology)

Displaying special issue 1001-1050 on page 21 of 65.

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