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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research and Advances in Ocular Disease

edited by Da-Wen Lu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3003 | Submission Open

Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics

edited by

Mihai V. Putz

Hyotcherl Ihee

and

Carlos Miguel Costa

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2993 | Submission Open

Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Physicochemical Properties and Applications of Nanomaterials in Biology and Medicine

edited by

Gangho Lee

submission deadline 31 Dec 2025 | 4 articles | Viewed by 2669 | Submission Open

Keywords: nanoparticle; nanomaterial; biomedicine; synthesis; physicochemical properties; imaging; therapy; contrast agent; therapeutic agent

(This special issue belongs to the Section Molecular Nanoscience)

Nanobiomaterials and Beyond: Innovations in Drug Delivery, Diagnostics, and Therapeutics

edited by

Alexandru Mihai Grumezescu

and

Adelina-Gabriela Niculescu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2554 | Submission Open

Keywords: nanobiomaterials; drug delivery systems; targeted drug delivery; controlled drug release; stimulus-responsive nanomaterials; biocompatibility; biodegradability; functionalized nanocarriers; theranostics; nanocarriers for cancer therapy; tumor-targeted drug delivery; organ-specific delivery systems; pH-responsive materials; temperature-sensitive nanobiomaterials; light-activated drug delivery; enzyme-responsive systems; multimodal nanomaterials; translational nanomedicine; computational modeling in nanobiomaterials; preclinical studies of nanomaterials

(This special issue belongs to the Section Materials Science)

Advanced Technologies and Molecular Approaches in Brain Disease Diagnosis and Therapy

edited by

Furong Tian

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2338 | Submission Open

Keywords: neurodegenerative diseases; brain cancer; nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Research Progress in Cellular Senescence in Health and Disease

edited by

Gabriella Teti

and Mirella Falconi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2337 | Submission Open

Keywords: senotherapy; cellular senescence; physiological relations; pathological relations; cell biology in aging; age-related diseases; senescence in mesenchymal stroma cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

25th Anniversary of IJMS: Updates and Advances in Molecular Informatics

edited by

M. Natália D.S. Cordeiro

and

Giulio Vistoli

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2333 | Submission Open

Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering

(This special issue belongs to the Section Molecular Informatics)

Highlights in Pathophysiology and Treatment of Osteoarthritis

edited by

Antonella Fioravanti

and

Serena Guiducci

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2217 | Submission Open

Keywords: osteoarthritis; pathophysiology (cytokines; adipokines; chemokines; epigenetics; microbiome); cartilage; synovial membrane; subchondral bone; treatment; disease-modifying osteoarthritis drugs; non-pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomolecular Structure, Function and Interactions: 2nd Edition

edited by

Ivo Crnolatac

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2096 | Submission Open

Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability

(This special issue belongs to the Section Biochemistry)

25th Anniversary of IJMS: Updates and Advances in Molecular Pharmacology

edited by

Roberto Scatena

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1967 | Submission Open

Keywords: precision medicine; pharmacogenomics; targeted protein degradation (TPD); molecular pharmacology; RNA Therapeutics; novel drug modalities; proteomics; transcriptomics; personalized drug therapy

(This special issue belongs to the Section Molecular Pharmacology)

Plant Genome Evolution and Environmental Adaptation

edited by

Zhonghu Li

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1923 | Submission Open

Keywords: plant phylogeny; genome evolution; molecular evolution of cytoplasmic genomes; species divergence

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into RNA Diseases

edited by

Naoyuki Kataoka

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1824 | Submission Open

Keywords: RNA splicing; RNA modification; RNA processing; translation; RNA transport

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management

edited by

Jingli Yang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1805 | Submission Open

Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Ovarian Cancer Metastasis and Chemotherapy Resistance

edited by

Carmela Ricciardelli

and

Noor A. Lokman

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1731 | Submission Open

Keywords: ovarian cancer; metastasis; biomarkers; chemotherapy resistance; tumor microenvironment; peritoneal– cancer cell interactions; proteomics; novel therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Focus on Plant Biotechnology and Molecular Breeding

edited by

Magdalena Wróbel-Kwiatkowska

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1716 | Submission Open

Keywords: genetic engineering; plant transformation; applied biotechnology; functional genomics; crop plants; crop improvement; plant tissue cultures; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research of Plant-Pathogen Interaction

edited by

Hyong Woo Choi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1582 | Submission Open

Keywords: molecular plant-pathogen interactions; pathogen detection; secondary metabolism; multi-omics approaches; antibiotic resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Food Allergy: Molecular Mechanisms, Clinical Challenges, and Future Directions

edited by

Sylwia Smolińska

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1548 | Submission Open

Keywords: food allergy; allergen; environmental exposures; gut microbiome; non-IgE-mediated pathways

(This special issue belongs to the Section Molecular Immunology)

Molecular Biology of Human Reproduction

edited by

Houda Amor

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1374 | Submission Open

Keywords: human reproduction; genomics; transcriptomics; proteomics; imaging technologies

(This special issue belongs to the Section Molecular Biology)

Nature-Inspired and Synthetic Compounds: New Frontiers in Bioactivity and Drug Discovery

edited by

Alina Bora

and

Luminita Crisan

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1302 | Submission Open

Keywords: natural and synthetic products; drug discovery and development; drug repurposing; artificial intelligence and machine learning; biological evaluation; healthcare; green and sustainable chemistry; natural and synthetic drug applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Forensic Molecular Biology and Genetics

edited by

Anna Barbaro

submission deadline 31 Dec 2025 | Viewed by 1177 | Submission Open

Keywords: nuclear and mt-DNA; rapid DNA analysis; next-generation sequencing; mRNA analysis; microbiome analysis; barcode DNA; time since deposition; fluid identification; DNA phenotyping; DNA ancestry

(This special issue belongs to the Section Molecular Biology)

Upcycling Food Industry By-Products: Bioactive Ingredients for Nutrition and Health

edited by

Giusy Rita Caponio

and

Graziana Difonzo

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1145 | Submission Open

Keywords: bioactive compounds; food by-products; functional foods; molecular mechanisms; polyphenols; oxidative stress; inflammation; nutrigenomics; microbiome; prebiotics; postbiotics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets

edited by Leonid Livshits

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1114 | Submission Open

Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties

(This special issue belongs to the Section Molecular Biology)

The Role of Plant Extracts in the Treatment and Prevention of Human Diseases

edited by

Ferenc Budán

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1105 | Submission Open

Keywords: phytotherapy; herbal medicine; nutrition science; disease prevention; epigenetics; molecular mechanisms; biomarkers

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Inflammasomes

edited by

Roberto Negro

submission deadline 31 Dec 2025 | Viewed by 1065 | Submission Open

Keywords: inflammasome; pyroptosis; innate immunity; cancer; neurodegenerative diseases; microbiota; gasdermin; ninjurin; drug screening; personalized treatments; multi-omics analysis

(This special issue belongs to the Section Molecular Immunology)

Targeted Pharmacological Modulation of Cellular Pathology and Drug Discovery: A Translational Approach to Bridge Laboratory Discoveries with Clinical Practice

edited by Saurav Mallik

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1017 | Submission Open

Keywords: targeted pharmacotherapy; cellular pathology; translational medicine; drug mechanism of action; signal transduction modulation; precision medicine; apoptosis and autophagy; biomarker-guided therapy; pathophysiology-driven drug design; clinical applications of molecular targets; molecular docking

(This special issue belongs to the Section Molecular Pharmacology)

New Trends in Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics: 3rd Edition

edited by

Ramón Cacabelos

submission deadline 31 Dec 2025 | 1 articles | Viewed by 997 | Submission Open

Keywords: Alzheimer’ s disease; pathogenic mechanisms; genomics; epigenetics; biomarkers; prevention; treatment; pharmacogenetics

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Molecular Research and Therapeutic Strategies for Endometrial Cancer

edited by

Yung-Taek Ouh

submission deadline 31 Dec 2025 | 1 articles | Viewed by 925 | Submission Open

Keywords: endometrial cancer; molecular classification; biomarkers; precision medicine; targeted therapy; immunotherapy; early detection; non-invasive diagnostics; genomic profiling; translational research

(This special issue belongs to the Section Molecular Oncology)

Molecular Breeding for Important Economic Traits in Livestock

edited by

Dawei Wei

and

Syed Haidar Abbas Raza

submission deadline 31 Dec 2025 | Viewed by 908 | Submission Open

Keywords: molecular breeding; livestock genetics; economic traits; genomic selection; adipogenesis; feed efficiency; disease resistance; non-coding RNAs; multi-omics; genetic improvement

(This special issue belongs to the Section Molecular Biology)

Atherosclerosis and Comorbidities: From Molecular Pathogenesis to Diagnosis and Therapeutic Targets

edited by

Alexandr Ceasovschih

Victoriţa Şorodoc

and

Yusuf Ziya Şener

submission deadline 31 Dec 2025 | Viewed by 895 | Submission Open

Keywords: atherosclerosis; comorbidities; lipidology; inflammation; obesity; arterial stiffness; vascular remodeling; cardiovascular risk; cardiovascular diseases; targeted therapies; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis, 3rd Edition

edited by

Athina Geronikaki

submission deadline 31 Dec 2025 | 1 articles | Viewed by 887 | Submission Open

Keywords: enzyme; enzyme inhibitor; drug target; enzyme deficiency; enzyme overexpression; biomarker; drugs; diagnosis; therapy

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on the Pathology and Treatment of Sepsis and Non-Infectious Inflammatory Conditions

edited by

Andressa Freitas

submission deadline 31 Dec 2025 | 1 articles | Viewed by 853 | Submission Open

Keywords: sepsis; comorbidities; inflammation; molecular mechanisms; cytokine signaling; oxidative stress; leukocyte recruitment; therapeutic targets

(This special issue belongs to the Section Molecular Immunology)

Emerging Trends in Enzymology

edited by

Francesco Malatesta

submission deadline 31 Dec 2025 | Viewed by 826 | Submission Open

(This special issue belongs to the Section Biochemistry)

Microbial Fermentation: Advances in Synthetic Biology, Metabolic Engineering, and Biomanufacturing

edited by

Yaokang Wu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 826 | Submission Open

Keywords: microbial fermentation; synthetic biology; metabolic engineering; biomanufacturing; industrial biotechnology

(This special issue belongs to the Section Molecular Microbiology)

Molecular Tools in Environmental Microbiology

edited by

Živilė Strazdaitė-Žielienė

and

Juliana Lukša

submission deadline 31 Dec 2025 | 1 articles | Viewed by 799 | Submission Open

Keywords: environmental microbiology; molecular methods; microbial community analysis; low-abundance microorganisms; microbial identification; environmental DNA; next-generation sequencing (NGS); high-throughput sequencing

(This special issue belongs to the Section Molecular Microbiology)

Advances in the Synthesis and Study of Novel Bioactive Molecules

edited by

Adriana Georgieva Bakalova

and

Emiliya Demireva Cherneva

submission deadline 31 Dec 2025 | 1 articles | Viewed by 787 | Submission Open

Keywords: organic compounds; metal complexes; bioactive molecules

(This special issue belongs to the Section Biochemistry)

Bacterial Infections: Unraveling Pathogenesis, Resistance, and Therapeutic Frontiers

edited by

Jagoda Jablonska

submission deadline 31 Dec 2025 | 1 articles | Viewed by 773 | Submission Open

Keywords: antimicrobial resistance; host– pathogen interactions; bacterial molecular pathogenesis; therapeutic target discovery

(This special issue belongs to the Section Molecular Microbiology)

Advances in Plant RNA Biology: Non Coding RNAs in Plant Development, Defense, and Adaptation

edited by

Andrew Eamens

submission deadline 31 Dec 2025 | 1 articles | Viewed by 746 | Submission Open

Keywords: plant RNA biology; regulatory RNA; non-coding RNA; small RNA (including miRNAs and siRNAs); RNA interacting proteins; plant development; plant pathogen defense; plant environmental stress adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapeutic Strategies for Pregnancy Complications

edited by

Joško Osredkar

submission deadline 31 Dec 2025 | 1 articles | Viewed by 729 | Submission Open

Keywords: pregnancy complications; placenta diseases; molecular mechanisms; therapeutics; biomarkers; preeclampsia; gestational diabetes; intrauterine growth restriction; maternal-fetal exchange; inflammation mediators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Plasma in Seed and Plant Treatment

edited by

Ricardo Molina

and

Karina Balestrasse

submission deadline 31 Dec 2025 | Viewed by 682 | Submission Open

Keywords: seed; plant; plasma; germination; dormancy; sterilization; reactive oxygen species; reactive nitrogen species; molecular mechanism; growth promotion; essential oils; plant stem cells; seed coating and pelleting

(This special issue belongs to the Section Molecular Plant Sciences)

Chelating Ligands in Therapeutics: Recent Advances and Future Directions

edited by

Matteo Mori

and

Fiorella Meneghetti

submission deadline 31 Dec 2025 | Viewed by 655 | Submission Open

Keywords: metal complexes; chelation therapy; chelating agents; diagnostic imaging; metal detoxification; chelation pharmacokinetics

(This special issue belongs to the Section Biochemistry)

State-of-the-Art Electrochemical Reaction Technologies

edited by

Cornelia Bandas

and

Carmen Lǎzǎu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 633 | Submission Open

Keywords: energy storage; electrochemical sensors; electrocatalysis; supercapacitors; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advancing Research on Alexander Disease

edited by

Ming-Der Perng

submission deadline 31 Dec 2025 | Viewed by 631 | Submission Open

Keywords: Alexander disease; astrocyte dysfunction; intermediate filaments; GFAP; astrogliosis; neurodegeneration; leukodystrophy; rare disease; rosenthal fibers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Carbon Fiber, Carbon Nanofiber for Composites: Synthesis, Processing, Molecular Structure, Characterization, and Application

edited by Tridung Ngo

submission deadline 31 Dec 2025 | Viewed by 601 | Submission Open

Keywords: carbon fiber; carbon nanofiber; nanotube; carbon fiber composites; synthesis; advanced manufacturing; characterization; recent advancements; applications

(This special issue belongs to the Section Materials Science)

Functional Genomics and Molecular Mechanisms of Plant Stress Responses

edited by

Zupeng Wang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 595 | Submission Open

Keywords: plant stress responses; abiotic stress; biotic stress; molecular mechanisms; functional genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Trends of Quantum Mechanics, Computational Chemistry, and Spectroscopy in Physical Chemistry

edited by

Dongho Kim

submission deadline 31 Dec 2025 | Viewed by 582 | Submission Open

Keywords: quantum theory; computational chemistry; spectroscopy

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Supramolecular Liquid Crystal Compounds—from Molecular Design to Functional Materials

edited by

Katarzyna Merkel

submission deadline 31 Dec 2025 | Viewed by 579 | Submission Open

Keywords: supramolecular; self-assembled; liquid crystal; hydrogen bonding

(This special issue belongs to the Section Materials Science)

Molecular Entomology of Insects of Economic Importance: Advanced Molecular Approaches for Insect Pest Management

edited by

T. G. Emyr Davies

submission deadline 31 Dec 2025 | Viewed by 550 | Submission Open

Keywords: molecular entomology; insect pests; agricultural pests; disease vectors; beneficial insects; CRISPR; RNA interference; genome-wide approaches; computational biology; nanotechnology

(This special issue belongs to the Section Molecular Biology)

The Gut Microbiota—Its Role and Molecular Mechanisms in Nutritional Health

edited by

Xi Ma

and Peng Tan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 527 | Submission Open

Keywords: gut microbiota; microbiome; mucosal immunity; probiotics; omics; dysbiosis; microbiota– host interactions; microbiota manipulation

(This special issue belongs to the Section Molecular Microbiology)

Role of Mesenchymal Stem/Stromal Cells (MSCs) in Human Diseases and Their Treatment

edited by