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Molecular Insights into RNA Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 536

Special Issue Editor

Special Issue Information

Dear Colleagues,

In higher eukaryotes, a variety of RNAs are transcribed from genomic DNAs. The transcribed RNAs are subjected to many editing processes such as RNA splicing, RNA editing and modification, followed by transport and eventual translation, often with degradation processes. These processes are rigorously regulated, and their defects and malfunctions often result in human diseases, which are called 'RNA diseases'. It is very important that the successfully uncovered molecular mechanism is a first critical step for the therapeutic approaches to serious diseases.

As the Guest Editor of this Special Issue titled ‘Molecular Insights into RNA Diseases’, I welcome submissions from many researchers working on various RNA diseases that are caused by any kinds of defects in RNA metabolic processes. The highlight of this topic is the crucial link between basic science elucidating the molecular mechanism for RNA regulation and the applications in the therapeutic approaches for RNA diseases. Articles from investigators studying the potential role of non-coding RNAs in diagnosis are also very welcome. The format of submission in this topic includes original research articles, reviews and methodology articles.

Dr. Naoyuki Kataoka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • RNA splicing
  • RNA modification
  • RNA processing
  • translation
  • RNA transport

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Published Papers (1 paper)

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Review

14 pages, 5703 KiB  
Review
The Regulatory Role of Long Non-Coding RNAs in the Development and Progression of Osteoporosis
by Rogelio F. Jiménez-Ortega, Diana I. Aparicio-Bautista, Adriana Becerra-Cervera, Alejandra I. Ortega-Meléndez, Nelly Patiño, Berenice Rivera-Paredez, Alberto Hidalgo-Bravo and Rafael Velázquez-Cruz
Int. J. Mol. Sci. 2025, 26(9), 4273; https://doi.org/10.3390/ijms26094273 - 30 Apr 2025
Abstract
Osteoporosis (OP) is a disease affecting bone metabolism, characterized by low bone mineral density and the deterioration of the bone microarchitecture, leading to increased bone fragility and risk of fracture. OP mainly results from alterations in the balance between osteoclast-mediated bone resorption and [...] Read more.
Osteoporosis (OP) is a disease affecting bone metabolism, characterized by low bone mineral density and the deterioration of the bone microarchitecture, leading to increased bone fragility and risk of fracture. OP mainly results from alterations in the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Currently, there are several molecular mechanisms underlying the development of OP that are not entirely clear. One such mechanism is the role of long non-coding RNAs, which are key regulators of gene expression through various mechanisms. In the last decade, it has been shown that these molecules participate in multiple biological processes and play essential roles in the pathogenesis of different diseases. In this review, we address recent advances on the relationship of long non-coding RNAs with OP, mainly over their regulatory functions during osteoclastogenesis and osteogenesis. Furthermore, we analyze their potential application as clinical or therapeutic resources focused on OP. Full article
(This article belongs to the Special Issue Molecular Insights into RNA Diseases)
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