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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Phytochemicals of Natural Products: Source, Analysis, and Bioactivities
edited by , Chi-I Chang and Chi-Chien Lin
submission deadline 20 Jun 2026 | 5 articles | Viewed by 14238 | Submission Open
Keywords: phytochemicals; bioactive compounds; natural products; bioactivities; purification; chemoprevention; chemotherapy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Coronavirus Disease (COVID-19): Pathophysiology (6th Edition) submission deadline 20 Jun 2026 | 5 articles | Viewed by 13666 | Submission Open
Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Functional Products for Health Prevention and Promotion
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 12987 | Submission Open
Keywords: functional foods; food fortification; biofortification; bioactive food ingredients; human nutrition; nutrition and immunity; health prevention; chronic non-communicable diseases; epigenetics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Antioxidant and Antibacterial Properties of Phytochemicals
edited by and Vytaute Starkute
submission deadline 20 Jun 2026 | 5 articles | Viewed by 11237 | Submission Open
Keywords: phytochemicals; natural preservatives; antioxidants; antibacterial properties; food; cosmetics; pharmaceuticals; animal feed
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Neurodegenerative Diseases and Inflammation: Pathogenesis, Biomarkers and Treatments
edited by and Anna Maria Ciaccio
submission deadline 20 Jun 2026 | 3 articles | Viewed by 10031 | Submission Open
Keywords: neurodegeneration; inflammation; biomarkers; Alzheimer’ s disease; molecular mechanism; pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Myocardial Disease: Molecular Pathology and Treatments
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 9303 | Submission Open
Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; amyloidosis; myocarditis; sarcoidosis; genetic abnormalities; immune mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanism of Acute Myeloid Leukemia
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 9165 | Submission Open
Keywords: leukemia; cytokine; signal transduction; apoptosis; immune therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Application of Machine Learning to Molecular Dynamics Simulations
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 8730 | Submission Open
Keywords: molecular dynamics simulations; machine learning; AI in drug discovery; pharmacokinetics prediction; protein folding simulations; toxicity prediction using ML; free energy calculations; virtual screening; protein– ligand interactions; protein– protein interactions
(This special issue belongs to the Section Molecular Informatics)
Role and Application of Stem Cells in Regenerative Medicine (Volume 5) submission deadline 20 Jun 2026 | 3 articles | Viewed by 8451 | Submission Open
Keywords: mesenchymal stem cells; tissue regeneration; regenerative medicine; immunomodulatory process
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Skin Diseases: 3rd Edition
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 8332 | Submission Open
Keywords: infection; inflammation; molecular; neoplasm; pathogenesis; skin diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Challenges and Opportunities: Extracellular Vesicles in Biological and Biochemical Processes, 2nd Edition submission deadline 20 Jun 2026 | 2 articles | Viewed by 7430 | Submission Open
Keywords: extracellular vesicles; exosomes intercellular; crosstalk liquid biopsy carcinogenesis; cell differentiation tissue; homeostasis; organ remodeling; biomedicine; advanced diagnostics
(This special issue belongs to the Section Molecular Immunology)
Oxidative Stress in Human Diseases
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 7347 | Submission Open
Keywords: inflammation; oxidative stress; free radicals; proteins; lipids; DNA damage; biomarkers
(This special issue belongs to the Section Biochemistry)
Deciphering Molecular Complexity of Pancreatic Cancer submission deadline 20 Jun 2026 | 4 articles | Viewed by 7055 | Submission Open
Keywords: pancreatic cancer; intratumor heterogeneity; bulk and single-cell multiomics; tumor microenvironment; cancer immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Advances in Cardiac Disease
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 6681 | Submission Open
Keywords: innovative cardiac research; multidisciplinary cardiovascular approaches; advances in cardio-vascular diagnosis; novel cardiac therapies; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products and Synthetic Compounds for Drug Development: 3rd Edition
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 6629 | Submission Open
Keywords: reactive oxygen; anti-inflammation; cancer; infectious diseases; liver diseases; lung disease; kidney disease; cardiac disease; neuro disease
(This special issue belongs to the Section Molecular Pharmacology)
Microglia in Neurological Disorders: Potential Therapeutic Targets and Underlying Mechanisms
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 6623 | Submission Open
Keywords: cerebral amyloid angiopathy; Alzheimer's disease; amyloid-β fibril formation
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research and Potential Effects of Medicinal Plants
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 6188 | Submission Open
Keywords: medicinal plants; natural products; disease treatment; drug screening; bioassays
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Biology of Soybean
edited by Zhengjun Xia
submission deadline 20 Jun 2026 | 6 articles | Viewed by 6151 | Submission Open
Keywords: soybean; growth and development; disease resistance; nodulation; nolecular mechanism; plant interaction
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research in Hematologic Malignancies
edited by and
submission deadline 20 Jun 2026 | 4 articles | Viewed by 6009 | Submission Open
Keywords: therapeutic targets; leukemogenesis; molecular regulation; cancer stem cells; epigenetics; novel biomarkers; non-coding RNA; DNA methylation; chemotherapy and genetic changes; cancer; hematologic malignancies
(This special issue belongs to the Section Molecular Oncology)
Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis
edited by and Jeffrey R. Koenitzer
submission deadline 20 Jun 2026 | 3 articles | Viewed by 5946 | Submission Open
Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins
(This special issue belongs to the Section Molecular Biology)
Therapeutic Potential of Antioxidants in the Prevention of Human Diseases, 2nd Edition
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 5896 | Submission Open
Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Biomarkers of Central Nervous System Diseases and Disorders
edited by and
submission deadline 20 Jun 2026 | 2 articles | Viewed by 5892 | Submission Open
Keywords: RNA biomarkers; CNS disorders; autism spectrum disorder; precision medicine
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Micro- and Nanomaterials for Biomedical Applications
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 5470 | Submission Open
Keywords: biomaterials; medical applications; natural and synthetic polymers; tissue engineering; hydrogels; bone cement; drug delivery systems; dendrimers; micro- and nanocomposites; nanotechnology; bioceramics; biopharmaceutics; biosensing
(This special issue belongs to the Section Molecular Nanoscience)
Tissue Engineering Related Biomaterials: Progress and Challenges
edited by , and Cristina Elena Dinu-Pirvu
submission deadline 20 Jun 2026 | 2 articles | Viewed by 5355 | Submission Open
Keywords: biomaterials; tissue engineering; scaffold materials; regenerative medicine; cell– material interactions; tissue regeneration; bioactive materials; nanotechnology in tissue engineering; electrospinning; 3D printing; biodegradable materials; growth factors
(This special issue belongs to the Section Materials Science)
Radiation-Induced DNA Damage and Toxicity submission deadline 20 Jun 2026 | 3 articles | Viewed by 5089 | Submission Open
Keywords: radiation; DNA damage; toxicity; immune response
(This special issue belongs to the Section Molecular Biology)
Advancements in Diagnostic and Preventive Pharmacogenomics
edited by Alireza Tafazoli
submission deadline 20 Jun 2026 | 2 articles | Viewed by 4969 | Submission Open
Keywords: genome profiling; pharmacogenetic analysis; diagnostic pharmacogenomics; pre-emptive pharmacogenomics; advanced genotyping technologies
(This special issue belongs to the Section Molecular Pharmacology)
Editorial Board Members’ Collection Series: “Protein Biophysics” submission deadline 20 Jun 2026 | 2 articles | Viewed by 4915 | Submission Open
Keywords: protein structure and prediction; protein biophysics; protein dynamics; peptide and protein aggregation; protein misfolding; protein folding; protein stability; protein function; posttranslational modifications; intrinsically disordered proteins; protein– ligand interactions; protein– protein interactions; protein– nucleic acid interactions; membrane proteins; liquid– liquid phase separation
(This special issue belongs to the Section Molecular Biophysics)
New Insights into Adipose Tissue Metabolic Function and Dysfunction, 4th Edition
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 4902 | Submission Open
Keywords: inflammation; browning; thermogenesis; adipogenesis; diabetes; adipokines; energy storage; insulin resistance; obesity; lipolysis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Glycoconjugates: From Structure to Therapeutic Application
edited by Rosana Ribić
submission deadline 20 Jun 2026 | 5 articles | Viewed by 4847 | Submission Open
Keywords: glycoconjugates (glycoproteins and glycopeptides; glycolipids; proteoglycans); glyconanoparticles; carbohydrate-based therapeutics; glycomics; glycosylation; glycoengineering; glycobiology; synthesis of glycoconjugates; vaccine development; drug delivery; biomarkers; diagnostics; immunotherapy; regenerative medicine; therapeutic applications
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Biomarkers for Targeted Therapies
edited by Vija Lavinia
submission deadline 20 Jun 2026 | 5 articles | Viewed by 4654 | Submission Open
Keywords: biomarkers; molecular targeted radiotherapies; prognostic biomarkers; predictive biomarkers; single or composite biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Focus on Metabolic Research Priorities in PCOS
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 4622 | Submission Open
Keywords: polycystic ovary syndrome; metabolism; insulin resistance; inflammation; hyperandrogenism
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Ovarian Cancer: Pathogenesis, Biomarkers and Treatment
edited by Alessandro Antonio Buda
submission deadline 20 Jun 2026 | 2 articles | Viewed by 4581 | Submission Open
Keywords: ovarian cancer; radiotherapy; diagnosis; prevention; treatment; fertility sparing
(This special issue belongs to the Section Molecular Oncology)
Regenerative Medicine: Molecular Mechanisms Driving Tissue Regeneration and Repair
edited by and Paul Jordan Christo
submission deadline 20 Jun 2026 | 2 articles | Viewed by 4552 | Submission Open
Keywords: stem cell; cell signaling; immune modulation; extracellular matrix; remodeling; gene regulation; gene editing; growth factors; extracellular vesicles; small molecules
(This special issue belongs to the Section Molecular Biology)
Plant Pathogen Interactions: 3rd Edition
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 4285 | Submission Open
Keywords: pathogenicity; plant immunity; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); effectors; avirulent; virulent; biotroph; necrotrophy; interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Mesenchymal Stem/Stromal Cells: Mechanisms and Applications in Tissue Regeneration
edited by
submission deadline 20 Jun 2026 | 5 articles | Viewed by 4198 | Submission Open
Keywords: MSC isolation; identification; and viability; MSC differentiation mechanisms; extracellular environment modifications; intracellular signalling systems; cytotoxicity investigations; tissue regeneration mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Plant–Environment Interactions submission deadline 20 Jun 2026 | 1 articles | Viewed by 4111 | Submission Open
Keywords: vascular biology; floral development; sex expression; fruit development; grafting; source– sink interactions; genetic resources; stress tolerance; molecular breeding; gene regulation; resistance to biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
MicroRNA (miRNA) Technology in Cancer
edited by
submission deadline 20 Jun 2026 | 3 articles | Viewed by 4001 | Submission Open
Keywords: miRNA; microRNA; cancer; oncology; drug delivery; technology; non-coding RNA
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances on Solubility and Diffusivity in Water-Based Systems and in Biological Media submission deadline 20 Jun 2026 | 1 articles | Viewed by 3804 | Submission Open
Keywords: water solubility  ; water-solute interactions  ; solvation; hydrophobic and hydrophilic effects  ; improving water solubility and prediction  ; solution of chemicals in biological media  ; diffusivity  ; drug transport and bioavailability; chemicals diffusivity across biological barriers
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Crop Biotic and Abiotic Stress Tolerance: 4th Edition
edited by
submission deadline 20 Jun 2026 | 4 articles | Viewed by 3792 | Submission Open
Keywords: biotic and abiotic stress tolerance; QTL/gene mapping and clones; gene editing; marker-assisted selection; genomic breeding
(This special issue belongs to the Section Molecular Plant Sciences)
25th Anniversary of IJMS: Updates and Advances in "Materials Science" Section submission deadline 20 Jun 2026 | 3 articles | Viewed by 3723 | Submission Open
Keywords: nanomaterials; functional polymers; bio-inspired systems; complex intelligent; responsive materials
(This special issue belongs to the Section Materials Science)
Plant Tolerance to Stress
edited by
submission deadline 20 Jun 2026 | 5 articles | Viewed by 3605 | Submission Open
Keywords: plant; genetic breeding; biotic stress; abiotic stress; gene regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Bioactive Compounds and Their Antioxidant Role: 2nd Edition
edited by Tamara Jurina
submission deadline 20 Jun 2026 | 3 articles | Viewed by 3392 | Submission Open
Keywords: bioactive compounds; antioxidants; polyphenolic compounds; nutraceuticals; phytochemicals; bioavailability; medicine
(This special issue belongs to the Section Bioactives and Nutraceuticals)
DNA Damage Response from Molecular Mechanisms to Cancer Therapy
edited by Luigi Alfano and
submission deadline 20 Jun 2026 | 2 articles | Viewed by 3374 | Submission Open
Keywords: DNA damage response; synthetic lethality; homologous recombination; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Signaling Pathways in Neuroinflammatory Disorders submission deadline 20 Jun 2026 | 2 articles | Viewed by 3352 | Submission Open
Keywords: blood– brain barrier; inducible pluripotent stem cells; organoids; scaffolds; neuroinflammation; microglia; mitochondria; endothelial cells; drug screening; virus infections; cryo-EM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroendocrine Tumors: From Molecular Pathology to Novel Therapeutic Approaches, Including Theranostics
edited by
submission deadline 20 Jun 2026 | 2 articles | Viewed by 3250 | Submission Open
Keywords: neuroendocrine tumors; NETs; molecular pathology; therapeutic strategies
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Precision Medicine During Surgery and Postoperative Care
edited by Lukas Andereggen and Markus M. Luedi
submission deadline 20 Jun 2026 | 3 articles | Viewed by 3219 | Submission Open
Keywords: genomics & pharmacogenomics; molecular mechanisms of anesthesia; perioperative biomarkers; perioperative care; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Reproductive Medicine
edited by Wei Chen
submission deadline 20 Jun 2026 | 1 articles | Viewed by 3157 | Submission Open
Keywords: spermatogenesis; oogenesis; microenvironment; organ interactions; molecular regulation; gametogenesis; signaling pathways; reproductive disorders
(This special issue belongs to the Section Molecular Biology)
ROS Signalling and Cell Turnover submission deadline 20 Jun 2026 | 2 articles | Viewed by 3156 | Submission Open
Keywords: metabolism; lipid droplets; nanoparticles; ROS; cancer therapy; redox homeostasis; mitochondria; cell death
(This special issue belongs to the Section Biochemistry)
Advances in the Pathogenesis of Allergic Diseases: From Mechanisms to Therapeutics
edited by Clinton B. Mathias and Michiko K. Oyoshi
submission deadline 20 Jun 2026 | 2 articles | Viewed by 2908 | Submission Open
Keywords: food allergy; allergic mechanisms; asthma; allergic disease; mast cells; ILC2s; Th2 cells; eosinophils; IL-4; IL-33; IL-13
(This special issue belongs to the Section Molecular Immunology)
Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications submission deadline 20 Jun 2026 | 2 articles | Viewed by 2875 | Submission Open
Keywords: oncogenes; tumor suppressors; cancer biology; molecular mechanisms; tumor microenvironment; biomarkers; targeted cancer therapy; cancer initiation and progression
(This special issue belongs to the Section Molecular Oncology)
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