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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Delivery Technologies for Nucleic Acid Therapeutics: From In Vitro to In Vivo Applications

edited by Karim Daliri

submission deadline 20 May 2026 | 1 articles | Viewed by 2507 | Submission Open

Keywords: nucleic acid therapeutics; nucleic acid delivery; mRNA; siRNA; ASOs; plasmid DNA; CRISPR/Cas9

(This special issue belongs to the Section Molecular Biology)

Cell Organelle Stress Responses and Implications in Human Diseases

edited by

Jaeseok Han

submission deadline 20 May 2026 | 2 articles | Viewed by 2448 | Submission Open

Keywords: organelle stresses; mitochondria; ER; lysosome; human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 20 May 2026 | 2 articles | Viewed by 2434 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Latest Insights into Glycobiology

edited by

Csaba Váradi

and

Cheorl-Ho Kim

submission deadline 20 May 2026 | 2 articles | Viewed by 2415 | Submission Open

Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis

(This special issue belongs to the Section Molecular Biology)

Advancing Interdisciplinary Science with Quantum/Molecular Mechanics (QM/MM) in Computational Chemistry

edited by

Yang Gao

submission deadline 20 May 2026 | 1 articles | Viewed by 2346 | Submission Open

Keywords: QM/MM; computational methods; electronic structure; f-electron systems; materials science; nanoclusters; nuclear medicine; computational catalysis; drug design; machine learning in computational chemistry

(This special issue belongs to the Section Materials Science)

Current Advance in Infectious and Inflammatory Diseases

edited by

Justyna Agier

and

Paulina Żelechowska

submission deadline 20 May 2026 | 1 articles | Viewed by 2242 | Submission Open

Keywords: inflammatory diseases; infectious diseases; host– pathogen interactions; antimicrobial resistance; immune modulation; cytokine signaling

(This special issue belongs to the Section Molecular Microbiology)

The Role of Lipoprotein in Cardiovascular Disease

edited by

Joan Carles Vallvé

submission deadline 20 May 2026 | 1 articles | Viewed by 2182 | Submission Open

Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Micro-RNA in Gastrointestinal Cancers—from Molecules to Novel Therapies

edited by

Jacek Baj

submission deadline 20 May 2026 | 1 articles | Viewed by 2133 | Submission Open

Keywords: micro-RNA; gastrointestinal cancer; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; neuroendocrine tumor; esophageal cancer; gallbladder cancer; rectal cancer

(This special issue belongs to the Section Molecular Oncology)

Advances in the Translational Preclinical Research

edited by

Mariano Gabri

submission deadline 20 May 2026 | 2 articles | Viewed by 2127 | Submission Open

Keywords: translational preclinical research; drug discovery; cancer therapies; in vitro and in vivo experiments; biological mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy

edited by

Mariusz Chabowski

submission deadline 20 May 2026 | 2 articles | Viewed by 2115 | Submission Open

Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biomaterials for Cartilage Regeneration

edited by

Valentina Vassallo

submission deadline 20 May 2026 | 1 articles | Viewed by 2112 | Submission Open

Keywords: osteoarthritis; glycosaminoglycans; biomaterials; cartilage regeneration; mesenchymal cells; chondrocytes

(This special issue belongs to the Section Biochemistry)

Antiviral Drug Targets: Structure, Function, and Drug Design—3rd Edition

edited by

Mattia Mori

and

Ilaria Vicenti

submission deadline 20 May 2026 | 2 articles | Viewed by 2110 | Submission Open

Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs

(This special issue belongs to the Section Molecular Pharmacology)

New Research on Bioactive Natural Products: 2nd Edition

edited by

Alexandros Tsoupras

submission deadline 20 May 2026 | 1 articles | Viewed by 2080 | Submission Open

Keywords: chronic disorders; bioactives; natural sources; sustainable sources; biomolecular; structure– activity relationship; synergism; health promoting; bio-functional; products; supplements; nutraceuticals; drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances and Mechanisms in Breast Cancer—2nd Edition

edited by

Ioannis Boutas

submission deadline 20 May 2026 | 2 articles | Viewed by 2039 | Submission Open

Keywords: breast cancer; genes and molecular pathways; targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Osteoblast Differentiation in Human Health and Disease

edited by

Younho Han

submission deadline 20 May 2026 | 2 articles | Viewed by 2021 | Submission Open

Keywords: osteoblast differentiation; bone remodeling; mesenchymal stem cells; skeletal diseases; osteogenesis; bone mineralization; osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Electrochemical Materials in Molecular Biology

edited by

Robert Ziółkowski

submission deadline 20 May 2026 | 1 articles | Viewed by 1999 | Submission Open

Keywords: electrochemistry; (bio)analytical chemistry; molecular biology; point-of-care; nanomaterials; (bio)molecules

(This special issue belongs to the Section Materials Science)

Molecular Pathophysiology and Treatment of Coronary Artery Disease

edited by

Kazufumi Nakamura

submission deadline 20 May 2026 | 2 articles | Viewed by 1890 | Submission Open

Keywords: coronary artery disease; ischemic cardiomyopathy; immune-related adverse events; CAD associated with autoimmune diseases; coronary artery disease-related cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Pathophysiology of Myocardial Disease, 2nd Edition

edited by

Ryan D. Sullivan

Inna P. Gladysheva

and Hongyu Qiu

submission deadline 20 May 2026 | 1 articles | Viewed by 1883 | Submission Open

Keywords: myocardial disease; cardiomyopathy; fibrosis and remodeling; inflammation; hypertension; heart failure; cardiometabolic; cardio-renal; heart-liver axis; comorbidity; molecular mechanisms; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Agents: Synthesis and Design

edited by

Silvana Alfei

submission deadline 20 May 2026 | 1 articles | Viewed by 1879 | Submission Open

Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Genomics Advances in Behaviours

edited by

Péter Pikó

submission deadline 20 May 2026 | 1 articles | Viewed by 1811 | Submission Open

Keywords: unhealthy and healthy behaviors; smoking; sleeping; eating; alcoholism; gambling; aggression; addictive behaviors; physical activity; mental disorders

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Treatment in Gastrointestinal Cancers

edited by

Dani Ran Castillo

submission deadline 20 May 2026 | 1 articles | Viewed by 1783 | Submission Open

Keywords: gastrointestinal cancers; tumor microenvironment; immune regulation; biomarkers; therapeutic resistance; liquid biopsy; targeted therapy; immune checkpoint inhibitors; epigenetic regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Novel Therapeutic Strategies for Cancers

edited by

Emanuela Grassilli

and

Maria Grazia Cerrito

submission deadline 20 May 2026 | 1 articles | Viewed by 1775 | Submission Open

Keywords: precision medicine; molecular targeted therapies; kinase inhibitors; PROTAC; CAR-T cell therapy; tumor microenvironment; host microbiota; resistance mechanisms; biomarkers; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Glycobiology: The New Discoveries, Approaches, and Technical Developments: 2nd Edition

edited by Sanja Dabelić

submission deadline 20 May 2026 | 2 articles | Viewed by 1746 | Submission Open

Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics

(This special issue belongs to the Section Macromolecules)

Molecular and Physiological Analysis of Stress in Plants

edited by

Yong Li

submission deadline 20 May 2026 | 1 articles | Viewed by 1727 | Submission Open

Keywords: plant stress; biotic stress; abiotic stress; stress response; gene expression; epigenetic stress memory; ABA; SA

(This special issue belongs to the Section Molecular Plant Sciences)

Applications of Phytochemicals in Drug Synthesis

edited by

Gregorio Peron

submission deadline 20 May 2026 | 1 articles | Viewed by 1722 | Submission Open

Keywords: natural products; phytochemistry; chemical synthesis; drugs; medicinal plants; natural sources; byproducts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances of Free-Radical Reactions in Organic Chemistry

edited by

José Justicia

submission deadline 20 May 2026 | 1 articles | Viewed by 1721 | Submission Open

Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Eukaryotic DNA Replication—from Bench to Bedside

edited by Heinz-Peter Nasheuer

submission deadline 20 May 2026 | 1 articles | Viewed by 1685 | Submission Open

Keywords: genome stability; cell cycle; DNA replication; chromatin replication; replication origins— selection; licensing and firing; replication forks— smoothly progressing and under stress; role of DNA replication in cancer and other human diseases; disease treatment opportunities

(This special issue belongs to the Section Molecular Genetics and Genomics)

Challenges of Acute Ischemic Stroke

edited by

Marta Iacobucci

submission deadline 20 May 2026 | 1 articles | Viewed by 1683 | Submission Open

Keywords: stroke; endovascular treatment; intravenous thrombolysis; futile recanalization; microvascular therapy

(This special issue belongs to the Section Molecular Neurobiology)

Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 20 May 2026 | 3 articles | Viewed by 1680 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

Toxicants and Their Effects on Innate Immune Function and Inflammatory Response

edited by

James M. Harper

submission deadline 20 May 2026 | 1 articles | Viewed by 1670 | Submission Open

Keywords: ecotoxicology; innate immunity; inflammation; pesticides; plasticizers; pattern-recognition receptors

(This special issue belongs to the Section Molecular Toxicology)

Molecular Pathology of the Placenta in Pregnancy Complications

edited by

Zoltan Kozinszky

and

Andrea Suranyi

submission deadline 20 May 2026 | 2 articles | Viewed by 1642 | Submission Open

Keywords: pregnancy complications; placental histology; biomarker; trophoblast invasion; molecular diagnostics and therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Kidney Diseases—2nd Edition

edited by

Kan Katayama

submission deadline 20 May 2026 | 1 articles | Viewed by 1634 | Submission Open

Keywords: kidney disease; focal segmental glomerulosclerosis; genetic kidney disease; minimal change disease; nephrotic syndrome; podocyte

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Progression of Movement Disorders

edited by

Michał Latalski

and

Pilar Gomez-Garre

submission deadline 20 May 2026 | 1 articles | Viewed by 1625 | Submission Open

Keywords: movement disorders; molecular mechanisms; neurodegenerative diseases; therapeutic targets; biomarkers; neuroinflammation; protein misfolding; mitochondrial dysfunction; environmental factors; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Regenerative Medicine Research

edited by

Rosa V. Ventrella

submission deadline 20 May 2026 | 1 articles | Viewed by 1604 | Submission Open

Keywords: regenerative medicine; tissue repair; wound healing; stem cells; cell differentiation; cell signalling; gene regulation; mechanotransduction; precision medicine

(This special issue belongs to the Section Molecular Biology)

Structural Characterization and Pharmacological Activity of Natural Compounds

edited by

Ana Amić

submission deadline 20 May 2026 | 1 articles | Viewed by 1578 | Submission Open

Keywords: natural compounds; bioactive molecules; molecular structure; characterisation; pharmacological activity; biochemical properties; pharmacokinetics; toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Exploring Rare Diseases: Genetic, Genomic and Metabolomic Advances: 2nd Edition

edited by

Judit Bene

and

Kinga Hadzsiev

submission deadline 20 May 2026 | 2 articles | Viewed by 1545 | Submission Open

Keywords: rare diseases; genotype– phenotype analyses; NGS; mass spectrometry; biomarker discovery; molecular targeted therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

DNA Replication, Damage and Repair in Repeat Instability: Their Role from Bacteria to Genetic Disorders in Humans

edited by

Enrique Viguera

submission deadline 20 May 2026 | 1 articles | Viewed by 1533 | Submission Open

Keywords: DNA repeat instability; DNA replication; DNA damage; DNA repair; tandem repeats; trinucleotide repeats; repeat expansion diseases; microsatellite instability; replication slippage; phenotypic variability; bacteria; genetic disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gastrointestinal Inflammation: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Nikolett Bódi

submission deadline 20 May 2026 | 2 articles | Viewed by 1514 | Submission Open

Keywords: gastrointestinal tract; inflammation; gastroenteritis; infection; microbiome; mucosal epithelium; immune cells; enteric nervous system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria as a Therapeutic Target for Anti-Cancer Drugs

edited by

Dalia Marija Kopustinskiene

submission deadline 20 May 2026 | Viewed by 1494 | Submission Open

Keywords: mitochondria; cancer; apoptosis; oxidative phosphorylation; Warburg effect; cardiolipin; inflammation

(This special issue belongs to the Section Molecular Oncology)

Neural Stem Cells: Latest Applications and Future Perspectives

edited by

Evangelos Delivopoulos

submission deadline 20 May 2026 | 1 articles | Viewed by 1444 | Submission Open

Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease

(This special issue belongs to the Section Molecular Biology)

Synthesis Manufacturing and Biomedical Applications of Nanofibers Scaffold

edited by

Marco Antonio Álvarez Pérez

and

Vincenzo Guarino

submission deadline 20 May 2026 | 1 articles | Viewed by 1436 | Submission Open

Keywords: scaffold manufacturing; nanofibers; 3D platforms; biohybrid scaffolds; biomolecules; functionalization; biomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Molecular Research on Pregnancy Complication Mechanisms

edited by

Aleksandra Stefanović

submission deadline 20 May 2026 | 1 articles | Viewed by 1422 | Submission Open

Keywords: hypertensive pregnancy disorders; gestational diabetes; intrauterine growth restriction; maternal metabolism in pregnancy complications; genetic and epigenetic mechanisms in pregnancy complications; immunology in pregnancy complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Recent Advances in the Structure, Biological Activity and Structure–Activity Relationship of Polysaccharides

edited by

Natalia Nowacka-Jechalke

and

Marta Kinga Lemieszek

submission deadline 20 May 2026 | 2 articles | Viewed by 1407 | Submission Open

Keywords: natural polysaccharides; phytochemicals; nutraceuticals; structure– activity relationship; anticancer potential; immunomodulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Endoplasmic Reticulum Stress and Apoptosis—Second Edition

edited by

Orsolya Kapuy

and

Beáta Lizák

submission deadline 20 May 2026 | 2 articles | Viewed by 1396 | Submission Open

Keywords: ER stress; apoptosis initiated by ER stress; cellular survival; redox homeostasis of ER; autophagy initiated by ER stress; cell death pathways initiated by ER stress

(This special issue belongs to the Section Biochemistry)

Pancreatic Diseases: Molecular Pathology and Therapeutics

edited by

Maria Ines Vaccaro

submission deadline 20 May 2026 | 1 articles | Viewed by 1356 | Submission Open

Keywords: pancreatic cancer; acute pancreatitis; chronic pancreatitis; diabetes; inflammation; molecular markers; therapeutic strategies; genetic predispositions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Breeding: High-Yield and Quality, Stress-Resistant Trait Genetic Improvement and Application

edited by Juwu Gong

submission deadline 20 May 2026 | 1 articles | Viewed by 1343 | Submission Open

Keywords: plant breeding; crop genetic improvement; gene editing; stress resistance; crop quality; crop yield; gene resource utilization

(This special issue belongs to the Section Molecular Plant Sciences)

Heart Failure: From Pathogenesis to Innovative Treatments

edited by Volker Adams and

Ephraim Bernhard Winzer

submission deadline 20 May 2026 | 1 articles | Viewed by 1313 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: From Molecular Mechanisms to Therapeutics

edited by Dorota Ciołczyk-Wierzbicka

submission deadline 20 May 2026 | 1 articles | Viewed by 1258 | Submission Open

Keywords: melanoma; molecular mechanism; signaling pathways; genetic mutations; cancer therapy/treatment; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Multifunctional Magnetic Nanoparticles: Synthesis, Properties, and Biomedical Applications

edited by

Krishtappa Manjunatha

submission deadline 20 May 2026 | Viewed by 1224 | Submission Open

Keywords: magnetic nanoparticles; molecular functionalization; magnetocaloric materials; drug delivery systems; molecular imaging; magnetic memory; nanocomposites; nanophosphors; environmental remediation; energy storage materials; magnetic biosensing; biofunctional interfaces

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Electrochemical Nanomaterials for Energy and Catalysis

edited by

Sankar Sekar

submission deadline 20 May 2026 | 1 articles | Viewed by 1222 | Submission Open

Keywords: advanced micro- and nanomaterials for electrochemical applications; electrochemical energy storage; electrocatalysis; photoelectrochemical water splitting; electrochemical sensors; supercapacitor; batteries; nanocomposites and functionalized materials; energy storage and conversion application; natural resources-based materials

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 2701-2750 on page 55 of 68.

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