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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gut–Brain Axis: Pathophysiological Mechanisms in Neurological Disorders and Metabolic Diseases

edited by

Giovanna Traina

submission deadline 20 May 2026 | Viewed by 236 | Submission Open

Keywords: gut– brain axis; intestinal microbiota; mood diseases; immune system; microbial molecules; behavior; metabolic diseases; signaling pathways; inflammation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Blood–Brain Barrier Dysfunction in Neurodegenerative Disorders

edited by

Amal Kaddoumi

submission deadline 20 May 2026 | Viewed by 229 | Submission Open

Keywords: blood– brain barrier; neurodegenerative diseases; Alzheimer’ s disease; amyotrophic lateral sclerosis; Parkinson's disease; BBB as a therapeutic target; neuroinflammation; molecular mechanisms; cerebral blood flow

(This special issue belongs to the Section Molecular Neurobiology)

mRNA/miRNAs Network in Diabetes and Its Complications

edited by

Daniela Lixandru

submission deadline 20 May 2026 | Viewed by 222 | Submission Open

Keywords: RNA/miRNAs; exosomes; regenerative medicine; translational medicine; adipose tissue biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Effects of Radiation on Human Cells and Tissues

edited by

Maria Paola Bertuccio

submission deadline 20 May 2026 | Viewed by 220 | Submission Open

Keywords: radiation exposure; molecular pathways; inflammation; immune response; biochemical markers; electromagnetic hypersensitivity

(This special issue belongs to the Section Molecular Biology)

AI and Machine Learning in Molecular Biomarker Discovery and Mechanisms of Neurodegenerative Disorders

edited by

Seyed Ehsan Saffari

submission deadline 20 May 2026 | Viewed by 211 | Submission Open

Keywords: artificial intelligence (AI); machine learning (ML); biomarker discovery; neurodegenerative disorders; Alzheimer’ s disease (AD); Parkinson’ s disease (PD); dementia; risk prediction models; multi-omics integration; translational bioinformatics

(This special issue belongs to the Section Molecular Neurobiology)

Stress-Activated Molecular Remodeling: Lipids, Chaperones, and the Cytoskeleton

edited by

Nikolas Nikolaidis

submission deadline 20 May 2026 | Viewed by 209 | Submission Open

Keywords: cellular stress response; molecular remodeling; lipid signaling; membrane dynamics; cytoskeletal reorganization; chaperones; heat shock proteins; proteostasis; membrane– protein interactions; stress-induced trafficking; mechano-transduction; cell survival signaling

(This special issue belongs to the Section Molecular Biology)

ErbB Family of Receptor Tyrosine Kinases in Cancer and Drug Therapy

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 20 May 2026 | Viewed by 208 | Submission Open

Keywords: ErbB; RTKs; EGFR; HER2; HER3; cancer; targeted therapies; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Environmental Stress-Induced Human Diseases

edited by

Silvia Cantara

submission deadline 20 May 2026 | Viewed by 208 | Submission Open

Keywords: environmental stress; oxidative stress; inflammation; epigenetic modifications; DNA damage and repair; cellular signaling pathways; mitochondrial dysfunction; autophagy; air pollution; heavy metal toxicity; endocrine disruptors; climate change and health; neurodegeneration; cancer biology; immune system dysregulation; gene– environment interactions; biomarkers of exposure and disease; systems biology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Perineuronal Nets and Fear Memories Erasure: State of the Art and Future Directions

edited by

Andrea Poli

submission deadline 20 May 2026 | Viewed by 202 | Submission Open

Keywords: perineuronal nets (PNNs); extracellular matrix (ECM); fear erasure; traumatic memories; PTSD; translation research; clinical treatment; therapeutical strategies

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Male Infertility and Fertility

edited by

Mariaimmacolata Preianò

submission deadline 20 May 2026 | Viewed by 199 | Submission Open

Keywords: male infertility; infertility treatment; omics approaches; proteomics; metabolomics; lipidomics; mass spectrometry; signaling pathways; biomarker discovery; reproductive medicine; precision medicine; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Omics Approaches to Unravel Plant Responses to Habitat Stresses

edited by

Claudia Uhde-Stone

submission deadline 20 May 2026 | Viewed by 195 | Submission Open

Keywords: omics; multi-omics; high-throughput technologies; biotic stress; abiotic stress; environmental stress; crosstalk; translational biology; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Autophagy and Apoptosis in Mammal Cells

edited by Kaja Urbańska and Anna Litwiniuk

submission deadline 20 May 2026 | Viewed by 189 | Submission Open

Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death

(This special issue belongs to the Section Molecular Biology)

Neuropeptides in Brain Health and Disease: From Molecular Mechanisms to Therapeutic Potential

edited by

Alessandro Castorina

submission deadline 20 May 2026 | Viewed by 189 | Submission Open

Keywords: neuropeptides; brain function; neuroinflammation; regeneration; neurodegeneration; biomarkers; therapy; CNS; brain disorders; demyelination

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Perspectives in Tissue Engineering and Regenerative Medicine

edited by

Sorina Dinescu

submission deadline 20 May 2026 | Viewed by 184 | Submission Open

Keywords: 3D scaffolds; personalized regenerative therapies; tissue engineering; stem cells; bone regeneration; regenerative biomarkers; cell– scaffold interactions; nanomaterials

(This special issue belongs to the Section Molecular Biology)

Natural Product as Therapeutic Agent: From Molecular Targets to Cellular and Functional Modulation

edited by Su-Yun Lyu

submission deadline 20 May 2026 | Viewed by 182 | Submission Open

Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Heart Failure: From Pathogenesis to Innovative Treatments

edited by Volker Adams and

Ephraim Bernhard Winzer

submission deadline 20 May 2026 | Viewed by 178 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress in Nanomedicine for Cancer Therapy

edited by Peisheng Xu

submission deadline 20 May 2026 | Viewed by 178 | Submission Open

Keywords: nanomedicine; cancer-targeted therapy; theragnostic; nanodevice

(This special issue belongs to the Section Molecular Nanoscience)

Genomic and Molecular Insights into Emerging and Reemerging Pathogens

edited by

Fabio Scarpa

submission deadline 20 May 2026 | Viewed by 177 | Submission Open

Keywords: pathogens genomic analysis; evolution transmission dynamics; pathogenic mechanisms; viruses; bacteria; fungi; parasites; next-generation sequencing; metagenomics; bioinformatics; genetic variations; adaptive mutations; host– pathogen interactions; emerging pathogens; molecular epidemiology; host immune responses; pathogen genetics

(This special issue belongs to the Section Molecular Immunology)

Drug and Non-Drug Treatment of Cerebral Diseases

edited by

Silvia Carloni

submission deadline 20 May 2026 | Viewed by 175 | Submission Open

Keywords: cerebral diseases; cerebral ischemia; neonatal hypoxic-ischemic encephalopathy (HIE); neuroprotection; therapeutic hypothermia; neurorehabilitation; oxidative stress; stem cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current and Emerging Therapeutic Approaches for MASLD

edited by

Chrysoula Boutari

submission deadline 20 May 2026 | Viewed by 174 | Submission Open

Keywords: MASLD; MASH; GLP-1 agonists; anti-inflammatory agents; anti-obesity drugs; FGF-21

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Plant-Derived Nanomaterials: From Molecular Mechanisms to Biofortification

edited by

Ágnes Szepesi

submission deadline 20 May 2026 | Viewed by 172 | Submission Open

Keywords: nanotechnology; green synthesis; sustainable nanomaterials; nano– bio interactions; crop production; plant-based solutions; bio-corona

(This special issue belongs to the Section Molecular Plant Sciences)

Bioactive Peptides: Function, Metabolism and Synthesis

edited by

Leandro Mantovani de Castro

submission deadline 20 May 2026 | Viewed by 169 | Submission Open

Keywords: bioactive peptides; antimicrobial peptides; antitumoral peptides; neurodegenerative diseases; metabolic diseases; chemical synthesis; cellular proteolysis; mass spectrometry; peptidomics; intracellular peptides; micropeptides

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of miRNAs in Healthy Lungs and Chronic Lung Diseases

edited by Victor Ruiz

submission deadline 20 May 2026 | Viewed by 169 | Submission Open

Keywords: miRNA; DROSHA; DICER; DGCR8; ADAR; pulmonary fibrosis; COPD; asthma; lung neoplasm

(This special issue belongs to the Section Molecular Biology)

Quantum Chemical Intelligence: New Horizons of Molecular Structure and Reactivity

edited by

Mihai V. Putz

submission deadline 20 May 2026 | Viewed by 166 | Submission Open

Keywords: chemical bond and bonding; quantum states and measurements; chemical reactivity; valence models; complex coordination; reaction coordinates and paths; bio-nano-materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Vector–Pathogen–Host Interaction, Vaccines and Immunobiologicals

edited by Carlo José Freire Oliveira and

Marcos Vinícius Da Silva

submission deadline 20 May 2026 | Viewed by 163 | Submission Open

Keywords: host– pathogen– vector interactions; active biomolecules; immunomodulation; vaccines; binding molecules; immunobiologicals

(This special issue belongs to the Section Molecular Immunology)

Latest Research in Neuroinflammation

edited by Reza Khorooshi

submission deadline 20 May 2026 | Viewed by 162 | Submission Open

Keywords: neuroinflammation; central nervous system disorders; neuroimmune interactions; inflammation and neurodegeneration; therapeutic strategies in neurology

(This special issue belongs to the Section Molecular Neurobiology)

Biometallic Nanoparticles: Synthesis, Functionalization and Multidisciplinary Applications

edited by

Elvira Rozhina

submission deadline 20 May 2026 | Viewed by 161 | Submission Open

Keywords: biogenic nanomaterials; antibacterial agents; plant extracts; biogenic silver nanoparticles; biofilms; cytotoxicity

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Nano-Based Drug Delivery and Theranostic Systems

edited by

Mukesh Meher

and

Yapei Zhang

submission deadline 20 May 2026 | Viewed by 160 | Submission Open

Keywords: nanoparticles; smart drug/gene delivery; multifunctional nanoparticles; theranostics; targeted therapy; molecular imaging; cancer

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Porous Polymers

edited by Bolin Ji

submission deadline 20 May 2026 | Viewed by 157 | Submission Open

Keywords: porous organic polymer; covalent organic framework; adsorption and separation of gases; energy storage materials; water treatment; antimicrobial; fluorescence imaging; tumor treatment

(This special issue belongs to the Section Materials Science)

Functional Genomics and Computational Biology of Horticultural Plants

edited by

Claudio Pugliesi

submission deadline 20 May 2026 | Viewed by 156 | Submission Open

Keywords: transcriptomics; computational model; genome editing; GWAS; multi-omics; NGS technologies; MAS; genomic selection; mutagenesis; RNA-silencing

(This special issue belongs to the Section Molecular Plant Sciences)

New Insight into Biomaterials for Tissue Engineering and Regenerative Medicine

edited by

Diana Torge

submission deadline 20 May 2026 | Viewed by 154 | Submission Open

Keywords: biomaterials; tissue regeneration; regenerative medicine; bone regeneration; periodontal disease; morphology; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Extracellular Vesicles in Microorganisms

edited by

Bao-Hong Lee

and

Tang-Long Shen

submission deadline 20 May 2026 | Viewed by 150 | Submission Open

Keywords: microbial extracellular vesicles; outer membrane vesicles; host– microbe interaction; interkingdom communication; EV cargo; microbial therapeutics; microbiota; nanovesicles; small RNAs; gut– brain axis

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research and Immune Landscape of Breast Cancer

edited by

Robson Monteiro

submission deadline 20 May 2026 | Viewed by 148 | Submission Open

Keywords: breast cancer; immune landscape; single-cell analysis; omics; therapy resistance; metastasis

(This special issue belongs to the Section Molecular Immunology)

Chlorophylls and Carotenoids: Metabolism and Regulation in Plants

edited by

Shan Lu

submission deadline 20 May 2026 | Viewed by 144 | Submission Open

Keywords: chlorophyll; carotenoid; metabolism; regulation; evolution; coordination

(This special issue belongs to the Section Molecular Plant Sciences)

The Involvement of the Ubiquitin Proteasome System in the Healthy and Diseased Heart

edited by

Ofer Binah

submission deadline 20 May 2026 | Viewed by 137 | Submission Open

Keywords: UPS; ubiquitin; proteasome; cardiac pathophysiology; coronary ischemia/reperfusion injury; heart failure; cardiomyopathies; E334K mutation; cMyBPC; electrophysiological dysfunction; hypertrophic cardiomyopathy; pharmacological targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Stem Cells: Molecular Characteristics and the Applications in Regenerative Medicine

edited by

Emi Shimizu

and

Motoki Okamoto

submission deadline 20 May 2026 | Viewed by 133 | Submission Open

Keywords: oral stem cells; regenerative medicine; molecular mechanisms; stem cell therapy; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Understanding and Combating Antimicrobial Resistance: Molecular Insights and Innovative Approaches

edited by

Giovanni Di Bonaventura

submission deadline 20 May 2026 | Viewed by 131 | Submission Open

Keywords: genetic mutations; horizontal gene transfer; efflux pump mechanisms; biofilm formation; novel antibiotic development; antimicrobial peptides; phage therapy; CRISPR-based tools; antimicrobial stewardship programs

(This special issue belongs to the Section Molecular Biology)

Regulatory Mechanisms in Kidney Development and Function

edited by Gary F. Gerlach

submission deadline 20 May 2026 | Viewed by 125 | Submission Open

Keywords: drosophila nephrocyte; zebrafish pronephros; mesonephros; murine nephrogenesis; slit diaphragm; podocytes; junctions; tubule; mesenchymal-to-epithelia transition (MET); epithelial-to-mesenchymal transition (EMT); tubule segmentation; transcription factors; signaling pathways; foot processes; cytoskeleton; brush boarder; intercalated cells; renin angiotensin; diabetic kidney disease; podocytopathies; FSGS; minimal change disease; IgAN

(This special issue belongs to the Section Molecular Biology)

Mitochondrial Dysfunction and Oxidative Stress in Human Diseases

edited by

Eiko Nakamaru-Ogiso

submission deadline 20 May 2026 | Viewed by 122 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Evolution and Genetic Diversity in Viruses

edited by

Jennifer H. Lun

submission deadline 20 May 2026 | Viewed by 109 | Submission Open

Keywords: viral mutation; recombination reassortment; viral genomics; quasispecies dynamics; antiviral resistance; viral phylogenetics; zoonotic transmission; genomic surveillance

(This special issue belongs to the Section Molecular Microbiology)

T Cell Malignancies: Translating Basic Research into Better Therapy

edited by

Grzegorz Przybylski

submission deadline 20 May 2026 | Viewed by 92 | Submission Open

Keywords: T-Cell malignancies; specific target antigens; gene-targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Innovative Nano- and Microcarrier Systems for Targeted Delivery

edited by

Matteo Perra

submission deadline 20 May 2026 | Viewed by 88 | Submission Open

Keywords: drug delivery systems; nanocarriers; microcarriers; targeted delivery; controlled release; bioactive compounds; nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights in Renal and Epithelial Physiology

edited by Pedro A. Jose

submission deadline 20 May 2026 | Viewed by 81 | Submission Open

Keywords: renal and epithelial physiology; ion transport; glomerulo-tubular balance

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence and Data Science-Driven Biomarker Discovery in Neurodegenerative Diseases

edited by

Andrzej Kloczkowski

and

Mubashir Hassan

submission deadline 20 May 2026 | Viewed by 53 | Submission Open

Keywords: large language models; big data analytics; Alzheimer’ s disease; Parkinson disease; neurodegeneration; neurogenerative disease; disease diagnosis; biomarker development; drug development

(This special issue belongs to the Section Molecular Informatics)

Latest Research in Alzheimer’s Disease

edited by

Prashant R Bharadwaj

submission deadline 20 May 2026 | Viewed by 48 | Submission Open

Keywords: Alzheimer’ s disease; neurodegenerative disease; disease diagnosis; biomarker development; drug development; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Smart and Sustainable Hydrogels for Environmental Applications

edited by Rolando Chamy

submission deadline 20 May 2026 | Viewed by 6 | Submission Open

Keywords: hydrogel; biomaterials; sustainable materials; regenerative medicine

(This special issue belongs to the Section Materials Science)

Nutrition of Crustaceans: A Molecular Perspective

edited by

Cheng Chi

submission deadline 25 May 2026 | Viewed by 84 | Submission Open

Keywords: crustacean nutrition; molecular mechanisms; aquaculture; nutrient metabolism; reproduction

(This special issue belongs to the Section Molecular Biology)

Cutting-Edge Research and Advancements in Neurodegenerative Diseases

edited by Meera Soundararajan

submission deadline 25 May 2026 | Viewed by 63 | Submission Open

Keywords: neurodegenerative disorders; neurons; Alzheimer’ s disease; Parkinsons disease; Amyotrophic Lateral Sclerosis (ALS); prion diseases; Huntington disease

(This special issue belongs to the Section Molecular Neurobiology)

DNA Damage and Repair Mechanisms in Cancer

edited by

Luigi Alfano

submission deadline 25 May 2026 | Viewed by 45 | Submission Open

Keywords: DNA damage response (DDR); genome instability ; synthethic lethality ; DNA repair

(This special issue belongs to the Section Molecular Oncology)

Cross-Kingdom Conversations: Deciphering Molecular Interactions in Microorganisms and Plants

edited by Eun-Hae Kwon

submission deadline 25 May 2026 | Viewed by 36 | Submission Open

Keywords: plant– microbe interactions; cross-kingdom signaling; plant growth-promoting microorganisms (PGPMs); molecular communication; synthetic microbial communities (SynComs)

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 3251-3300 on page 66 of 69.

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