Current and Emerging Therapeutic Approaches for MASLD
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 39
Special Issue Editor
Interests: hypertension; blood pressure; heart failure; atherosclerosis; cardiovascular medicine; insulin resistance; metabolism; metabolic diseases; lipid metabolism; glucose metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, affecting over a billion individuals worldwide. A positive diagnosis of MASLD is based on the presence of hepatic steatosis coupled with at least one cardiometabolic risk factor and no other distinguishable cause. It can gradually develop into more severe liver pathologies, including metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and liver malignancy. Despite being a global health problem, there are very limited therapeutic options against MASLD and its related diseases. To date, in 2024, there is only one drug (resmetirom) that has been approved by the US Food and Drug Administration (FDA) for the treatment of MASH.
This Special Issue aims to present a collection of articles related to the current status of drug therapy for MASLD/MASH and the latest results of new and emerging medications either treating underlying metabolic co-morbidities or directly targeting the liver.
We invite scholars researching the synthesis of new MASLD drugs, as well as those focusing on the molecular mechanisms of their action, to contribute their work to this Special Issue. This includes those interested in the field of MASLD/MASH, who are welcome to submit articles presenting both research and review works and findings on molecular mechanisms related to MASLD/MASH therapy and prevention. We are pleased to invite all types of papers, including original, narrative, and systematic reviews, to this Special Issue to widen our knowledge of this topic.
Dr. Chrysoula Boutari
Guest Editor
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Keywords
- MASLD
- MASH
- GLP-1 agonists
- anti-inflammatory agents
- anti-obesity drugs
- FGF-21
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