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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Investigating Host-Parasite Interactions for the Discovery of Novel Therapies and Vaccine Targets

edited by

Natalie Nieuwenhuizen

submission deadline 20 Jan 2026 | 6 articles | Viewed by 7956 | Submission Open

Keywords: parasites; host-pathogen interactions; helminths; worms; protozoans; leishmania; malaria; schistosomiasis; trypanosomiasis; ascariasis; anisakiasis; vectors; mosquitoes; ticks; neglected tropical diseases

(This special issue belongs to the Section Molecular Immunology)

Latest Research on Plant Genomics and Genome Editing, 2nd Edition

edited by

Fabrizio Carbone

submission deadline 20 Jan 2026 | 5 articles | Viewed by 7941 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into the Immunopathology of Infectious Diseases

edited by Marta Camici

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7922 | Submission Open

Keywords: infection immunology; immune dysregulation in infectious diseases; interactions between infective agents and immune responses; modeling of the immune system; new pathways of pathogenesis

(This special issue belongs to the Section Molecular Immunology)

Mesenchymal Stem Cell-Based Therapy: Cell Therapy vs. EV Therapy

edited by Masahito Nakazaki

submission deadline 20 Jan 2026 | 1 articles | Viewed by 7909 | Submission Open

Keywords: mesenchymal stromal/stem cells; small extracellular vesicles; large extracellular vesicles; clinical trials; spinal cord injury; cerebrovascular disease

(This special issue belongs to the Section Biochemistry)

Advanced Electrode and Electrolyte Materials: Molecular Scale Design, Synthesis, Mechanisms and Applications

edited by

Christian Julien

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7587 | Submission Open

Keywords: cathode; anode; electrolyte; synthesis; electrochemistry; rechargeable batteries; lithium-ion batteries; all-solid-state lithium metal batteries

(This special issue belongs to the Section Materials Science)

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

edited by Jung-Hyun Lee

submission deadline 20 Jan 2026 | 5 articles | Viewed by 7560 | Submission Open

Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution

(This special issue belongs to the Section Molecular Immunology)

Endometriosis Pathophysiology, Diagnosis and Emerging Therapeutic Strategies

edited by

Mariarosaria Boccellino

submission deadline 20 Jan 2026 | 1 articles | Viewed by 7544 | Submission Open

Keywords: endometriosis; pathophysiology; infertility; biomarkers; pharmacological treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials for Drug Delivery and Advanced Therapies

edited by

Annalisa Bianchera

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7479 | Submission Open

Keywords: polymers; biomaterials; drug delivery; scaffold; ATMPs; tissue regeneration

(This special issue belongs to the Section Materials Science)

Molecular Mechanism and Pathogenesis of Cardiac Disease

edited by Yu-Hsun Kao

submission deadline 20 Jan 2026 | 3 articles | Viewed by 7446 | Submission Open

Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)

edited by

Elisabetta Palazzo

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7363 | Submission Open

Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Adult Stem Cell Research

edited by Dongsu Park

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7349 | Submission Open

Keywords: tissue-resident stem cells; skeletal stem/progenitor cells; hematopoietic stem cells; tendon/ligament stem cells; musculoskeletal tissue regeneration; stem cell microenvironment; stem cell aging

(This special issue belongs to the Section Molecular Biology)

The Structures, Syntheses of Natural Products, and Their Biological Effects

edited by

Ran Jia

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6929 | Submission Open

Keywords: structures of natural products; syntheses; biological effects; biomedical applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Developments in Obesity: Metabolism, Pathophysiology and Treatment

edited by

Peteris Tretjakovs

submission deadline 20 Jan 2026 | 1 articles | Viewed by 6896 | Submission Open

Keywords: obesity; adipokines; insulin sensitivity; lipid metabolism; pro-inflammatory cytokines; gut microbiota; GLP-1 receptor agonists; personalized nutrition; lifestyle interventions

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Biomarkers in Cardiovascular Diseases: Diagnosis, Pathology and Treatment

edited by

Marco Valerio Mariani

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6794 | Submission Open

Keywords: heart failure; myocardial remodeling; ischemic heart disease; myocarditis; cardiomyopathies; prevention; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Heart Failure: Insights and Therapeutic Strategies

edited by Emilio Vanoli and Eugenio Caradonna

submission deadline 20 Jan 2026 | 1 articles | Viewed by 6649 | Submission Open

Keywords: heart failure; autonomic nervous system; brain– gut interaction; gut microbiota; neurohumoral treatment; cardiac remodeling; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Research Insights in Cystic Fibrosis and CFTR-Related Diseases

edited by Judith A. Coppinger

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6565 | Submission Open

Keywords: cystic fibrosis; CFTR related diseases; COPD; immune cells; extracellular vesicles; neutrophils; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Parkinson's Disease

edited by

Yi-Chuan Cheng

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6442 | Submission Open

Keywords: Parkinson's disease; molecular regulation; genetic mutations; epigenetics; protein aggregation; mitochondrial dysfunction; neuroinflammation; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Fat and Obesity: Molecular Mechanisms and Pathogenesis

edited by

Seon-Yong Jeong

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6428 | Submission Open

Keywords: obesity; weight gain; adipogenesis; lipolysis; energy balance; hormones; fat oxidation; nutrition; phytomedicine; drug development; cohort studies; genetics and genomics studies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Diagnostics and Treatment Advances in Lung Diseases

edited by Eirini Vasarmidi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6361 | Submission Open

Keywords: lung diseases; pulmonary; alveolar; diagnosis; treatment; biomarkers; molecular; bronchoalveolar lavage; genetics; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Molecular Regulatory Networks and Stress Responses

edited by

Xiujun Zhang

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6253 | Submission Open

Keywords: plant stress response; stress response gene; regulatory mechanism; gene regulatory network; transcriptional regulation; post-transcriptional regulation; multi-omics integration; single-cell RNA-seq; spatial genomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Neurodegeneration and Neuroinflammatory Processes in Age-Related Diseases

edited by

Barbara Mroczko

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6225 | Submission Open

Keywords: age-related diseases; neurodegenerative diseases; neurodegeneration; neuroinflammation; aging

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Drug Discovery and Synthesis: 2nd Edition

edited by

Lidia Ciccone

and

Susanna Nencetti

submission deadline 20 Jan 2026 | 2 articles | Viewed by 6210 | Submission Open

Keywords: medicinal chemistry; drug discovery; design and synthesis of bioactive compounds; molecular modeling; X-ray crystallography; structure– activity relationships; structure-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research Landscape of Pulmonary Arterial Hypertension

edited by Cármen Brás-Silva

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6193 | Submission Open

Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; molecular mechanisms; vascular disease; translational research; therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and the Link Between Obesity, Diabetes and Inflammation

edited by

Maria Chiara Pelle

and

Arturi Franco

submission deadline 20 Jan 2026 | 4 articles | Viewed by 6168 | Submission Open

Keywords: adipose tissue; biomarkers; diabetes; inflammation; obesity; cytokine; insulin resistance; signaling pathways; metabolic diseases

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Melanin and Other Pigments: Function, Synthesis and Characterization

edited by Koen P. Vercruysse

submission deadline 20 Jan 2026 | 3 articles | Viewed by 6012 | Submission Open

Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol

(This special issue belongs to the Section Biochemistry)

New Insights into Male Infertility and Sperm Biology

edited by

Monica Muratori

submission deadline 20 Jan 2026 | 4 articles | Viewed by 5992 | Submission Open

Keywords: male infertility; sperm DNA fragmentation; sperm oxidative stress; sperm nuclear condensation; assisted reproductive technologies; genomics; epigenomics; transcriptomics; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications

edited by Jordi Olloquequi and M. Emília Juan

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5972 | Submission Open

Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Antimicrobial Activity

edited by

Liliana Mititelu Tartau

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5780 | Submission Open

Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic

(This special issue belongs to the Section Molecular Microbiology)

Molecular Immunologic Perspectives on Mycobacterium tuberculosis Infection

edited by

Vishwanath Venketaraman

submission deadline 20 Jan 2026 | 1 articles | Viewed by 5744 | Submission Open

Keywords: M. tb infection; molecular immunology; HIV; AIDS; pathogenesis; host immune responses; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses

(This special issue belongs to the Section Molecular Immunology)

Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Ligia Petrica

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5658 | Submission Open

Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress

(This special issue belongs to the Section Molecular Biology)

Tissue Regeneration and Repair in Airway Diseases

edited by Rolf Ziesche

submission deadline 20 Jan 2026 | 2 articles | Viewed by 5348 | Submission Open

Keywords: chronic inﬂammation; structural integrity; regenerative repair; structural disintegration; impact of aging on inﬂammation and repair

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Perspectives in Steroidomics

edited by

Martin Hill

submission deadline 20 Jan 2026 | 3 articles | Viewed by 5263 | Submission Open

Keywords: steroidomics; steroids; pathophysiology; physiology; diagnostics; treatment; prediction; prognosis; LC-MS/MS; GC-MS/MS

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into Lipodystrophy

edited by

Sofía Sánchez-Iglesias

and

David Araújo-Vilar

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4971 | Submission Open

Keywords: lipodystrophy; adipogenesis; animal models; lipid metabolism; therapeutic targets; insulin signaling pathways; adipose tissue

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Compounds: Structural Diversity, Modifications, and Biological Activities

edited by Tomasz Pospieszny

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4969 | Submission Open

Keywords: bile acids; molecular research; biological activity; natural products; steroids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into Satellite DNAs

edited by

Isidoro Feliciello

and

Đurđica Ugarković

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4943 | Submission Open

Keywords: satellite DNA; satellitome; satellite DNA organization; satellite DNA evolution; satellite DNA origin; satellite DNA transcription; satellite DNA function; satellite DNA regulation; satellite RNA; heterochromatin; centromere; telomere; gene regulation; cancer; biomarkers; epigenetics; next-generation sequencing (NGS); nanopore sequencing; PacBio sequencing

(This special issue belongs to the Section Molecular Biology)

Hormone Metabolism and Signaling in Human Health and Disease

edited by

Kuo-Hu Chen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 4905 | Submission Open

Keywords: hormone metabolism; signaling pathways; pathophysiology; molecular and cellular biology; diseases originating from hormone disorders; hormonal therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances and Emerging Trends in Marine Natural Products

edited by Rafael Alexandre Faria da Costa Félix and

Carina Félix

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4825 | Submission Open

Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies

(This special issue belongs to the Section Molecular Pharmacology)

Research and Innovations in Green Monomers and Macromolecular Materials

edited by

Joanna Rydz

Marta Musioł

and

Wanda Sikorska

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4817 | Submission Open

Keywords: green monomers and macromolecular material for a sustainable future; current barriers and future needs of green macromolecular materials; latest breakthroughs and approaches in molecular sciences; bio-based and/or biodegradable polymers based on natural; renewable; and synthetic polymers; synthesis; design; characterization; and development of innovative; technologically advanced; adaptable; and multifunctional green polymers in chemistry; biology; and medicine; relationships between structure; properties; functions; and performance of green polymers; sustainability; recycling; and environmental issues of green macromolecular materials; commercial applications: concepts; methodologies; and tools; 3D printing for personalized consumer products

(This special issue belongs to the Section Materials Science)

Diabetic Bone Disease: New Insights into Molecular Mechanisms and Therapeutic Approaches

edited by

Ioannis Kanakis

submission deadline 20 Jan 2026 | 1 articles | Viewed by 4801 | Submission Open

Keywords: diabetic bone disease; molecular mechanisms; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Machine Learning in Bioinformatics and Biomedicine

edited by

Fuyi Li

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4801 | Submission Open

Keywords: bioinformatics; computational biology; machine learning; deep learning; AI for biology

(This special issue belongs to the Section Molecular Informatics)

Oral Squamous Cell Carcinoma: Insights into Molecular Pathways and Emerging Therapeutic Approaches

edited by

Silvia Pomella

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4627 | Submission Open

Keywords: oral squamous cell carcinoma; epigenetics; molecular genetics; gene expression targeted therapy; molecular biomarkers

(This special issue belongs to the Section Molecular Oncology)

Novel Insights into Molecular Mechanisms of Pulmonary Pathology

edited by Qiaozhen Liu

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4617 | Submission Open

Keywords: fibrosis; infection; COPD; asthma; IPF; pneumonia; lung cancer; molecular mechanism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress Responses in Cardiovascular Diseases

edited by Vladimir Jakovljevic

submission deadline 20 Jan 2026 | 1 articles | Viewed by 4527 | Submission Open

Keywords: antioxidant capacity; cardiovascular disease; cell death; endothelial dysfunction; ischemia/reperfusion injury; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Plant Stress

edited by

Pandiyan Muthuramalingam

Subramani Pandian

and

Hyunsuk Shin

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4464 | Submission Open

Keywords: abiotic stress; biotic stress; bioinformatics; artificial intelligence; biotechnology; breeding; crop plants; horticultural plants; GWAS; CRISPR-Cas; multi-omics; genomics; epigenomics; transcriptomics; proteomics; genetic diversity; gene expression

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer

edited by

Daniela Gabbia

and

Sara De Martin

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4463 | Submission Open

Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell and Molecular Perspectives in Breast Cancer

edited by Seungbaek Lee

submission deadline 20 Jan 2026 | 1 articles | Viewed by 4411 | Submission Open

Keywords: breast cancer; molecular biology; cell biology; biomarker; novel therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biofunctionalization of Metals for Medical Application: Molecular Aspects

edited by

Luca Scotti

and Xiaoming Zhang

submission deadline 20 Jan 2026 | 1 articles | Viewed by 4382 | Submission Open

Keywords: biofunctionalization; medical applications; nanomaterials; nanofunctionalized materials; molecular mechanisms; bacterial membranes; membrane polarity; bacterial resistance

(This special issue belongs to the Section Molecular Nanoscience)

The Role of Artificial Intelligence in Cancer Treatment: Molecular Perspective

edited by Andra Valentina Krauze

submission deadline 20 Jan 2026 | 2 articles | Viewed by 4269 | Submission Open

Keywords: cancer treatment; artificial intelligence; machine learning; precision medicine; molecular insights

(This special issue belongs to the Section Molecular Informatics)

Genomics of Human Disease

edited by

Sungkyoung Choi

submission deadline 20 Jan 2026 | 3 articles | Viewed by 4255 | Submission Open

Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Current Research for Heart Disease Biology and Therapeutics (Third Edition)

edited by Claudia Kusmic

submission deadline 20 Jan 2026 | 5 articles | Viewed by 4107 | Submission Open

Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 551-600 on page 12 of 68.

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