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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oral Cancer: From Molecular Mechanisms to Therapeutics

edited by Diana Russo

submission deadline 30 May 2026 | Viewed by 30 | Submission Open

Keywords: oral cancer; molecular mechanisms; carcinogenesis; therapeutic strategies; biomarkers; immunotherapy; tumor microenvironment; drug resistance; precision medicine; head and neck oncology

(This special issue belongs to the Section Molecular Oncology)

Design and Application of Biocatalysts: Emerging Advances in Enzyme Technology

edited by

Salvadora Ortega-Requena

submission deadline 30 May 2026 | Viewed by 29 | Submission Open

Keywords: biocatalysis; enzyme engineering; green chemistry; directed evolution; computational design; industrial enzymes; nano-biocatalysts

(This special issue belongs to the Section Biochemistry)

Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy (Second Edition)

edited by

Karolina Orywal

submission deadline 30 May 2026 | Viewed by 28 | Submission Open

Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers

(This special issue belongs to the Section Molecular Oncology)

Decoding Parkinson’s: Molecular Symphonies and Dysregulated Pathways

edited by Hortensia Alonso-Navarro

submission deadline 30 May 2026 | Viewed by 26 | Submission Open

Keywords: Parkinson’ s disease; neuropharmacology; movement disorders

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Interplay Between Food Components and the Gut: From Mechanisms to Microbiome Interaction

edited by

Mattia Di Nunzio

and Lorenzo Nissen

submission deadline 30 May 2026 | Viewed by 18 | Submission Open

Keywords: intestinal cells; nutrients; in vitro digestion; nutrigenomics; nutrigenetics; gut microbiota

(This special issue belongs to the Section Molecular Microbiology)

Novel Therapeutic Strategies for Hepatocellular Carcinoma

edited by

Soon Kyu Lee

submission deadline 30 May 2026 | Viewed by 17 | Submission Open

Keywords: hepatocellular carcinoma; immune checkpoint inhibitors; tyrosine kinase inhibitors; radiotherapy; embolization; surgery; transplantation

(This special issue belongs to the Section Molecular Oncology)

Mitochondrial Metabolism in Human Diseases

edited by Neelanjan Vishnu

submission deadline 30 May 2026 | Viewed by 2 | Submission Open

Keywords: mitochondrial function; pathophysiology; cellular processes; disease development

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Natural and Synthetic Compounds for Management, Prevention and Treatment of Obesity, 3rd Edition

edited by

Marianna Lauricella

and

Antonella D'Anneo

submission deadline 31 May 2026 | 4 articles | Viewed by 24519 | Submission Open

Keywords: obesity; adipokines; obesogens; genetic predisposition; natural/synthetic compounds; cardiovascular disorders; type II diabetes; non-alcoholic fatty liver disease; cancer

(This special issue belongs to the Section Molecular Pharmacology)

State-of-the-Art Molecular Oncology in Brazil, 3rd Edition

edited by

Tiago Rodrigues

and

Roger Chammas

submission deadline 31 May 2026 | 7 articles | Viewed by 15283 | Submission Open

Keywords: apoptosis; autophagy; calcium; cancer; cell death; chemotherapy; metabolism; mitochondria; drug resistance; oxidative stress

(This special issue belongs to the Section Molecular Oncology)

Molecular and Translational Research on Bone Tumors, 2nd Edition

edited by

Michela Rossi

and

Andrea Del Fattore

submission deadline 31 May 2026 | 2 articles | Viewed by 13022 | Submission Open

Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapeutic Targets for Neuroinflammation and Neurodegeneration

edited by Muhammad Sohail Khan and

Cassie S. Mitchell

submission deadline 31 May 2026 | 4 articles | Viewed by 6522 | Submission Open

Keywords: neurodegenerative diseases; inflammatory response; nervous system; neuroinflammations

(This special issue belongs to the Section Molecular Neurobiology)

Functional Food Ingredients in Immunity Improvement

edited by

Prodromos Skenderidis

submission deadline 31 May 2026 | 1 articles | Viewed by 5149 | Submission Open

Keywords: functional food ingredients; bioactive compounds; health potentials; food processing and immunomodulation; green extraction techniques; molecular mechanisms; nutritional immunology; dietary intervention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Selected Papers from the 5th International Symposium on Frontiers in Molecular Science (ISFMS)

edited by

Yoshinori Marunaka

Masayuki Takahashi

Yusaku Iwasaki

, Atsushi Shiozaki and Akiyuki Taruno

submission deadline 31 May 2026 | 2 articles | Viewed by 3030 | Submission Open

Keywords: protein structure and function; multidomain proteins; drug design and drug resistance; enzymes; molecular biology of galectins; glycobiophysics; NMR spectroscopy; specific sensory systems; brain and systemic function

(This special issue belongs to the Section Biochemistry)

Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology

edited by

Giuseppe Murdaca

and

Sebastiano Gangemi

submission deadline 31 May 2026 | 1 articles | Viewed by 2709 | Submission Open

Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies

(This special issue belongs to the Section Molecular Immunology)

Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments

edited by

Katarzyna B. Lewandowska

and

Monika Szturmowicz

submission deadline 31 May 2026 | 2 articles | Viewed by 1702 | Submission Open

Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Molecules in Infection and Toxicity: Antimicrobial Peptides and Drug-Induced Damage in Disease Models

edited by

Oleksii Skorokhod

submission deadline 31 May 2026 | 1 articles | Viewed by 666 | Submission Open

Keywords: antimicrobial peptides (AMPs); infectious diseases; drug-induced toxicity; disease models; therapeutic strategies; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Diversity in Structure, Function, and Regulation of Calcium-Permeable Channels

edited by

Lucie Parent

submission deadline 31 May 2026 | Viewed by 661 | Submission Open

Keywords: calcium-permeable channels in health and disease; calcium-permeable channels in calcium cycling; TRP channels; voltage-gated calcium channels; STIM / Orai complexes; intracellular IP3 calcium channels; intracellular RyR calcium channels; posttranslational calcium channel modifications; calcium-permeable channel inhibitors; calcium-permeable channel biophysics; calcium-permeable channel evolution

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Infections and Viral Pathogenesis

edited by

Shymaa E. Bilasy

submission deadline 31 May 2026 | 1 articles | Viewed by 450 | Submission Open

Keywords: viral pathogenesis; viral– host interactions; viral persistence; long COVID; molecular virology; immune dysregulation; diagnosis; vaccines; oncoviruses; antiviral and gene therapy

(This special issue belongs to the Section Molecular Microbiology)

The Future of Drug Discovery and Development, 2nd Edition

edited by

William C. (Trey) Putnam

submission deadline 31 May 2026 | Viewed by 435 | Submission Open

Keywords: drug discovery; drug development; biotechnology; target identification; target validation; regulatory affairs; regulatory sciences; drug commercialization; pharmaceutical market access; drug screening; novel nonclinical models/approaches; advanced manufacturing; continuous manufacturing; process analytical technology; adaptive clinical trials; in silico laboratory and clinical development; rolling submissions; accelerated approvals; real-world evidence

(This special issue belongs to the Section Molecular Pharmacology)

Microbiota-Mediated Regulation of Stem Cells in Cancer Initiation, Progression, and Treatment Response

edited by

Ciro Gargiulo Isacco

submission deadline 31 May 2026 | Viewed by 379 | Submission Open

Keywords: microbiota stem cell cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeted Molecular Radio-Immuno-Theranostics: From Cancer to Other Human Diseases—in Honor of Prof. Dr. Otmar Dieter Wiestler

edited by Michael Philipp Bachmann and Holger Stephan

submission deadline 31 May 2026 | Viewed by 150 | Submission Open

Keywords: molecular diagnostics; radiotherapy; immunotherapy; endoradionuclide therapy; radiodiagnostics; radio-immuno-theranostics; radionuclides; PET/SPECT imaging; nanomaterials; chelators; chimeric antigen receptors (CARs); adapter CAR T cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Natural Products in the Treatment and Prevention of Human Diseases

edited by

Jae-Hyun Kim

submission deadline 31 May 2026 | Viewed by 143 | Submission Open

Keywords: natural products; bone metabolism; sarcopenia; osteoporosis; herbal medicine; osteo-sarcopenic obesity; bone– muscle crosstalk; low-molecular-weight compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Gene Delivery in Cancer Therapy: Next-Generation Platforms and Translational Advances

edited by

Ksenija Božinović

submission deadline 31 May 2026 | Viewed by 128 | Submission Open

Keywords: gene delivery; gene therapy; viral vectors; non-viral vectors; lipid nanoparticles; extracellular vesicles; mRNA therapeutics; CRISPR/Cas genome editing; tumor microenvironment; translational oncology

(This special issue belongs to the Section Molecular Oncology)

Advances in Cancer Epigenetics for Precision Medicine

edited by

Alessandro Lavoro

and

Saverio Candido

submission deadline 31 May 2026 | Viewed by 106 | Submission Open

Keywords: cancer epigenetics; DNA methylation; precision medicine; cancer biomarker; therapeutic target; epidrugs

(This special issue belongs to the Section Molecular Oncology)

Cellular and Molecular Mechanisms of Neuroinflammation

edited by

Maria Anttonietta Panaro

submission deadline 31 May 2026 | Viewed by 105 | Submission Open

Keywords: neuroinflammation; astrocytes; microglia; CNS; cytokines; brain; diseases; immune response

(This special issue belongs to the Section Molecular Neurobiology)

Innovations in Analytical Chemistry for Environmental and Food Safety: Methodologies and Molecular Insights

edited by

Cosima Damiana Calvano

and

Francesco Longobardi

submission deadline 31 May 2026 | Viewed by 99 | Submission Open

Keywords: innovative sample preparation; food quality and safety; advanced analytical techniques; risk assessment

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular and Systems Mechanisms of Neural Circuit Function and Plasticity

edited by

Hyunjung Oh

submission deadline 31 May 2026 | Viewed by 97 | Submission Open

Keywords: neural circuits; neuroplasticity; synaptic organization; brain aging; mood disorders; neurodegenerative disorders; cognitive function

(This special issue belongs to the Section Molecular Neurobiology)

Characterization and Engineering of Functional Nanomaterials

edited by

P. Sivaprakash

and Shanmugam Vignesh

submission deadline 31 May 2026 | Viewed by 94 | Submission Open

Keywords: functional nanomaterials; molecular-level engineering; engineered materials; materials characterization; energy and environmental applications; materials design and performance

(This special issue belongs to the Section Molecular Nanoscience)

Physiological and Molecular Responses of Plants to Drought Stress

edited by

Muhammad Waseem

submission deadline 31 May 2026 | Viewed by 94 | Submission Open

Keywords: drought stress; photosynthesis; stomatal regulation; signal transduction; phytohormones; anti-oxidants

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Natural Products: Redox Balance, Inflammation Control, and Apoptosis Modulation

edited by Rosanna Avola

submission deadline 31 May 2026 | Viewed by 93 | Submission Open

Keywords: natural antioxidants; inflammation; apoptosis; bioactive natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in the Pharmacology of Depression and Mood Disorders

edited by

Guillaume Lucas

submission deadline 31 May 2026 | Viewed by 85 | Submission Open

Keywords: new antidepressants; rapid antidepressant action; ketamine in depression; glutamatergic antidepressants; psychedelics in depression; 5-HT receptors as targets for antidepressant research; neu-roplasticity and antidepressant action

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Crosstalk in Allergy, Barrier Dysfunction, and Asthma

edited by

Elisa Boni

submission deadline 31 May 2026 | Viewed by 82 | Submission Open

Keywords: barrier dysfunction; asthma; allergy; molecular pathways; molecular crosstalks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Materials for Biomedical Applications and Uses

edited by

Magdalena Laskowska

submission deadline 31 May 2026 | Viewed by 79 | Submission Open

Keywords: functional materials; nanomaterials; biomedical applications; molecular engineering

(This special issue belongs to the Section Materials Science)

Microorganisms and Invertebrates in Molecular Dialogue: Mechanisms, Dynamics, and Applications

edited by

Monika Mioduchowska

submission deadline 31 May 2026 | Viewed by 73 | Submission Open

Keywords: microorganism– invertebrate interactions; symbiosis; stress tolerance; co-evolution; omics approaches; biotechnological applications

(This special issue belongs to the Section Molecular Microbiology)

Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights

edited by

Luigi Rosa

and

Pietro Giorgio Spezia

submission deadline 31 May 2026 | Viewed by 69 | Submission Open

Keywords: human virome; molecular virology; functional virology; metagenomics; virus– host interactions; immune modulation; pseudovirus assays; antiviral screening; omics integration; molecular immunology

(This special issue belongs to the Section Molecular Microbiology)

Emerging Biomarkers in Cardiovascular Risk Assessment and Myocardial Injury

edited by Beatriz Martín-Carro

submission deadline 31 May 2026 | Viewed by 66 | Submission Open

Keywords: cardiovascular disease; myocardial injury; heart failure; biomarkers; risk stratification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Molecular Insights into Aging in Vertebrate Models

edited by

Antonio Palladino

submission deadline 31 May 2026 | Viewed by 62 | Submission Open

Keywords: aging; vertebrate models; molecular mechanisms; cellular senescence; translational medicine

(This special issue belongs to the Section Molecular Biology)

Cryo-EM and Cryo-Tomography in Macromolecular Structure Analysis

edited by

R. Holland Cheng

submission deadline 31 May 2026 | Viewed by 58 | Submission Open

Keywords: macromolecular structure; precision nanomedicine; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET); viral capsids; AI/ML in structural analysis; time-resolved imaging; nanoparticle delivery; in-cell tomography; structural dynamics; molecular mechanisms; protein complexes; membrane proteins; macromolecular assemblies; conformational changes; integrative structural biology; cellular structural biology; drug delivery systems; therapeutic design

(This special issue belongs to the Section Macromolecules)

Eosinophils: Function and Related Disorders

edited by Giulia Costanzo

submission deadline 31 May 2026 | Viewed by 53 | Submission Open

Keywords: eosinophils; polymorphonuclear cells; interleukin; cytotoxic proteins; host defense; tissue remodeling; dysregulation; eosinophilic disorders; therapeutics

(This special issue belongs to the Section Biochemistry)

Platelet-Mediated Immune Regulation in Cancer

edited by

Bennett D. Elzey

submission deadline 31 May 2026 | Viewed by 53 | Submission Open

Keywords: platelets; tumor immunity; megakaryocyte; immunotherapy; lymphocytes; microvesicles; immune suppression; metastasis

(This special issue belongs to the Section Molecular Immunology)

Biocatalysis: Mechanisms of Proteolytic Enzymes, 3rd Edition

edited by

Peter Goettig

submission deadline 31 May 2026 | Viewed by 52 | Submission Open

Keywords: aspartic proteases; catalytic mechanisms; cysteine proteases; enzyme kinetics; metalloproteases; non-natural amino acids; protease engineering; real time activity monitoring; serine proteases; viral proteases

(This special issue belongs to the Section Molecular Biophysics)

The Role of Ferroptosis in Cancer Biology and Therapy

edited by Alessandra Di Paola and Elvira Pota

submission deadline 31 May 2026 | Viewed by 52 | Submission Open

Keywords: ferroptosis; cancer biology; tumor microenvironment; therapeutic targeting; anticancer immunity; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Metabolic Alterations in Health and Disease: From Molecular Mechanisms to Biomarkers in Clinical Applications

edited by

Ramona D'Amico

and

Rosalba Siracusa

submission deadline 31 May 2026 | Viewed by 51 | Submission Open

Keywords: metabolic syndrome; diabetes; oxidative stress; cellular metabolism; biomarkers; molecular pathways; metabolic disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Biology, Genetics, Diagnosis, Management and Therapy of Dermatological Diseases

edited by

Elisa Molinelli

and Corrado Tagliati

submission deadline 31 May 2026 | Viewed by 51 | Submission Open

Keywords: genodermatoses; hydradenitis suppurativa; inflammatory dermatoses; metabolic disorders; infections; esthetic medicine; neoplastic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research of Gastrointestinal Disease, 3rd Edition

edited by

Ainsley Robinson

and

Kulmira Nurgali

submission deadline 31 May 2026 | Viewed by 48 | Submission Open

Keywords: gastrointestinal health; gastrointestinal disorders; gastrointestinal disease; gastrointestinal homeostasis; molecular targets; mechanisms; pathways; molecular markers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Computational Innovations in Forensic Genetics: From Degraded DNA to Predictive Models

edited by Eugenio Alladio and

Elena Pilli

submission deadline 31 May 2026 | Viewed by 47 | Submission Open

Keywords: degraded DNA; low-template DNA; molecular forensics; NGS; machine learning; deep learning; chemometrics; data integration; predictive models; forensic applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Adaptive Strategies of Plants to Water Stress

edited by Weitao Jia

submission deadline 31 May 2026 | Viewed by 45 | Submission Open

Keywords: adaptive strategies; submergence; post-submergence; waterlogging; drought; plant physiology; phenotypic plasticity; omics; epigenetic regulation; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Lung Research: From Mechanisms to Therapeutic Innovation

edited by

Johnatas D Silva

and Fernanda Ferreira Cruz

submission deadline 31 May 2026 | Viewed by 45 | Submission Open

Keywords: lung disease; molecular mechanisms; lung injury and repair; regeneration; biomarkers; therapeutic innovation; translational research; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Next Chapter in HIV: Molecular Pathways and Novel Therapeutic Strategies

edited by

Isabella Abbate

submission deadline 31 May 2026 | Viewed by 45 | Submission Open

Keywords: HIV; transcription; provirus; microRNA; epigenetic silencing; reservoir; integration site; latency; immune activation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Treatment for Bacterial Infections: 2nd Edition

edited by Janusz Madaj

submission deadline 31 May 2026 | Viewed by 44 | Submission Open

Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms

(This special issue belongs to the Section Molecular Pharmacology)

Displaying special issue 2901-2950 on page 59 of 68.

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