Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research on Islet Cell Biology
edited by Mazhar Kanak
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1303 | Submission Open
Keywords: islet inflammation; hypoxia in islets; functional assessment of islets ex vivo and in vivo; islet stress and EVs as markers of stress; encapsulation strategies for islet transplantation; hot topics in islet and SC-beta cell transplantation
Autophagy in Stress Responses: From Molecular Mechanisms to Disease Relevance
edited by and Kleiton Silva
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1190 | Submission Open
Keywords: autophagy; stress response; proteostasis; mitophagy; neurodegeneration; aging; stress granules; mTOR signaling; selective autophagy; disease models; exercise; muscle disorders
(This special issue belongs to the Section Autophagy)
Molecular Bases Underlying Early Embryonic Development in Mammals
edited by , Julio Ávila Marrero and Angela Palumbo
submission deadline 30 Nov 2026 | 1 articles | Viewed by 994 | Submission Open
Keywords: embryonic development; early embryogenesis; gene expression; miRNA profile; reproductive physiology; cell signalling; embryo quality; developmental competence; in vitro embryo culture
(This special issue belongs to the Section Reproductive Cells and Development)
Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
edited by Konrad Talbot
submission deadline 30 Nov 2026 | 1 articles | Viewed by 954 | Submission Open
Keywords: Alzheimer’s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’s disease
(This special issue belongs to the Section Cellular Neuroscience)
State-of-the-Art Insights into the Cell Microenvironment
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 927 | Submission Open
Keywords: cell microenvironment; stem cells; organoid and 3D culture models
(This special issue belongs to the Section Cell Microenvironment)
Emerging Roles of Glial Cells in the Nervous System
edited by Manuela Marcoli and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 742 | Submission Open
Keywords: glial cells; astrocytes; microglia; glia–neuron communication; neurotransmitters; gliotransmitters; transmitter receptors; synapse; physiology; neuron
(This special issue belongs to the Section Cellular Neuroscience)
Oxidative Stress in Neonatal Development and Diseases submission deadline 30 Nov 2026 | 1 articles | Viewed by 656 | Submission Open
Keywords: oxidative stress; neonatal development; hyperoxia; reactive oxygen species (ROS); neuroprotection; lung injury; inflammation; protection; biomarkers; translational research; antioxidant therapy; preterm infant; prematurity
(This special issue belongs to the Section Cellular Pathology)
Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets
edited by Shridhar Sanghvi, and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 635 | Submission Open
Keywords: ion channels; electrophysiology; cryo-electron microscopy; channelopathy; membrane protein; gating mechanism; structural biology
Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics
edited by
submission deadline 30 Nov 2026 | Viewed by 616 | Submission Open
Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis
Molecular Mechanisms of Fibrosis in Chronic Liver Diseases
edited by , Regina Golan-Gerstl and Ihab Ansari
submission deadline 30 Nov 2026 | Viewed by 489 | Submission Open
Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS
Advances in Cellular Mechanisms and Molecular Targets in Breast Cancer Research
edited by Rahul Sanawar, and Satheesh Kumar Sengodan
submission deadline 30 Nov 2026 | Viewed by 475 | Submission Open
Keywords: breast cancer; cancer stem cells; cell plasticity; immune evasion; drug resistance; tumor microenvironment; non-coding RNAs; circulating tumor cells (CTC); circulating tumor DNA (ctDNA); exosomes; signaling pathways (e.g., PI3K/AKT, MAPK); targeted therapy; immunotherapy
Epigenetic and Cellular Regulation in Hematologic Disorders
edited by
submission deadline 30 Nov 2026 | Viewed by 469 | Submission Open
Keywords: epigenetics; hematologic disorders; leukemia; myelodysplastic syndrome; thrombosis; thrombocytopenia; bleeding
Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration—Second Edition submission deadline 30 Nov 2026 | Viewed by 442 | Submission Open
Keywords: soft/hard tissue regeneration; therapeutic approaches; cell culture studies; inflammation-based diseases; degenerative diseases
(This special issue belongs to the Section Tissues and Organs)
Exclusive Review Papers in 'Cell Signaling'
edited by
submission deadline 30 Nov 2026 | Viewed by 408 | Submission Open
Keywords: signal transduction; receptor tyrosine kinases; G protein-coupled receptors (GPCRs); intracellular signaling networks; systems biology; pathway crosstalk; targeted therapies
(This special issue belongs to the Section Cell Signaling)
Mechanisms of Transcriptional Regulation in Disease: From Chromatin Dynamics to Therapeutic Innovation
edited by Valentina Caputo, Joana R. Costa, and
submission deadline 30 Nov 2026 | Viewed by 393 | Submission Open
Keywords: transcription regulation; epigenomics; multi-omics; non-coding genome; chromatin architecture/dynamics; enhancers
(This special issue belongs to the Section Cell and Gene Therapy)
Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes
edited by
submission deadline 30 Nov 2026 | Viewed by 366 | Submission Open
Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β-cells
(This special issue belongs to the Section Cell Signaling)
Nanoparticle-Mediated Immunotherapy: Reshaping the Tumor Microenvironment for Enhanced Cancer Treatment
edited by
submission deadline 30 Nov 2026 | Viewed by 358 | Submission Open
Keywords: tumor microenvironment; drug delivery; nanoparticle
(This special issue belongs to the Section Cell Methods)
Molecular Mechanisms of Asthmatic Airway Inflammation
edited by
submission deadline 30 Nov 2026 | Viewed by 354 | Submission Open
Keywords: asthma; airway inflammation; airway smooth muscle; airway remodeling; immune signaling; cytokines and chemokines; cell signaling; inflammatory mechanisms; airway epithelial cells
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Pathways in Immune Tolerance and Autoimmune Regulation submission deadline 30 Nov 2026 | Viewed by 345 | Submission Open
Keywords: immune tolerance; autoimmune regulation; immune homeostasis; regulatory T cells; regulatory B cells; cytokine networks; molecular mechanisms; therapeutic strategies
(This special issue belongs to the Section Cellular Immunology)
Regulatory Mechanisms of Vascular Smooth Muscle Cells and Immune Cells in Vascular Disease Progression
edited by and
submission deadline 30 Nov 2026 | Viewed by 339 | Submission Open
Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition
(This special issue belongs to the Section Cells of the Cardiovascular System)
Novel Insights into Myeloid Leukemias
edited by
submission deadline 30 Nov 2026 | Viewed by 324 | Submission Open
Keywords: leukemogenesis; bone marrow microenvironment; leukemia stem cells; immune evasion; hematopoiesis and myeloid differentiation; targeted therapy
(This special issue belongs to the Section Cellular Pathology)
Modeling Lung Regeneration and Injury Responses Using Organoids and Engineered Niches
edited by Tristan Frum
submission deadline 30 Nov 2026 | Viewed by 287 | Submission Open
Keywords: lung biology; regeneration; stem cells; intra- and extracellular signaling; cell techniques; organoids; bioengineering
(This special issue belongs to the Section Tissues and Organs)
Advances in Molecular Mechanisms and Modeling of Neuroendocrine Tumors
edited by Hermine Mohr, Natalia Simona Pellegata and Margo Dona
submission deadline 30 Nov 2026 | Viewed by 241 | Submission Open
Keywords: tumor microenvironment; molecular heterogeneity; preclinical models; PDX; PDO; treatment resistance
(This special issue belongs to the Section Cellular Neuroscience)
Cellular Responses to Metal-Based Therapeutics in Cancer Biology submission deadline 30 Nov 2026 | Viewed by 222 | Submission Open
Keywords: metal-based drugs; metalloptosis (including cuproptosis and ferroptosis); cancer cell metabolism targeting; mitochondrial targeting; tumor microenvironment; drug resistance; drug deliver strategy; therapeutic targeting; metalloimmunotherapy; redox homeostasis disruption
From Development to Degeneration: Advances in Stem Cell and Organoid Models of the Nervous System
edited by
submission deadline 30 Nov 2026 | Viewed by 217 | Submission Open
Keywords: neurodevelopment; neurodegeneration; stem cells; brain organoids; disease modeling; therapeutic strategies; personalized medicine
(This special issue belongs to the Section Stem Cells)
Neuronal Development and Disease: From Molecular Mechanisms to Neurological Disorders—Second Edition
edited by Ramiro Almeida
submission deadline 30 Nov 2026 | Viewed by 211 | Submission Open
Keywords: neuronal development; neurological disorders; neurogenesis; neuroinflammation; synaptic plasticity
(This special issue belongs to the Section Cellular Neuroscience)
Mitochondrial Dysfunction in Neurodegeneration and Aging
edited by Abhishek Jauhari
submission deadline 30 Nov 2026 | Viewed by 182 | Submission Open
Keywords: mitochondrial dysfunction; neurodegeneration; aging; mitophagy; oxidative stress
(This special issue belongs to the Section Mitochondria)
Cancer Stem Cells of Glioblastoma: Role of PI3K/Akt/mTOR Signaling Pathways
edited by Meena Jhanwar-Uniyal
submission deadline 30 Nov 2026 | Viewed by 155 | Submission Open
Keywords: glioblastoma; stem cells; mTOR; mTORC1; mTORC2; peritumor area; cancer resistance
(This special issue belongs to the Section Stem Cells)
Single-Cell Omics Decoding Cellular Heterogeneity in Kidney Diseases
edited by Jia Fu
submission deadline 30 Nov 2026 | Viewed by 148 | Submission Open
Keywords: single-cell omics; spatial omics; multi-omics integration; artificial intelligence; machine learning; kidney disease; cellular heterogeneity; cell–cell communication; organoids; immune microenvironment
(This special issue belongs to the Section Cellular Pathology)
Cellular Mechanisms and Therapeutic Potential of Natural Products and Their Derivatives Against Human Disease
edited by
submission deadline 30 Nov 2026 | Viewed by 143 | Submission Open
Keywords: bioactive compounds; secondary metabolites; molecular mechanisms; signal transduction; therapeutic targets; chronic diseases; phytochemicals; drug discovery
(This special issue belongs to the Section Cell Signaling)
Programming the Pancreas: Cell Fate, Plasticity, and the Future of Regenerative Medicine submission deadline 30 Nov 2026 | Viewed by 96 | Submission Open
Keywords: pancreatic progenitors; cell fate determination; cellular plasticity; single-cell transcriptomics; multi-omics; pancreatic organoids; islet organoids; islet differentiation; beta-cell regeneration; pancreatic regeneration; regenerative medicine
(This special issue belongs to the Section Cellular Pathology)
Coumarin-Based Compounds as Multifunctional Anticancer Agents
edited by
submission deadline 30 Nov 2026 | Viewed by 67 | Submission Open
Keywords: coumarin; anticancer agents; apoptosis; multitargeting; natural products; drug discovery; in vivo models; structure–activity relationship
(This special issue belongs to the Section Cellular Pathology)
Molecular Pathogenesis and Novel Therapeutic Strategies in Chordoma
edited by , Patricia L Sullivan and Jeremy J Reynolds
submission deadline 1 Dec 2026 | 2 articles | Viewed by 1990 | Submission Open
Keywords: chordoma; targeted therapy; brachyury; tumor microenvironment; epigenetics; immunotherapy; biomarkers; drug resistance; translational oncology; radiation resistance
Conditional Programming of Cells, Advanced Computational Methods, and Intelligent Systems in Prostate Cancer Research
edited by Ahmed Fadiel
submission deadline 1 Dec 2026 | 1 articles | Viewed by 1929 | Submission Open
Keywords: prostate cancer; conditional programming; cellular reprogramming; computational biology; cell-state transitions; lineage plasticity; tumor microenvironment; ex vivo models; machine learning
Cellular Mechanisms of Testosterone in Metabolic Disorders
edited by Daniel M. Kelly
submission deadline 1 Dec 2026 | 1 articles | Viewed by 865 | Submission Open
Keywords: testosterone; metabolism; type 2 diabetes; obesity; metabolic syndrome; MASLD; skeletal muscle; adipose tissue; insulin resistance; endocrine signalling
Cardiac Cell–Matrix Mechanotransduction: Linking Extracellular Matrix Properties to Signaling and Function
edited by Maja Theresa Dieterlen and Ricardo A. Spampinato
submission deadline 1 Dec 2026 | Viewed by 144 | Submission Open
Keywords: mechanotransduction; extracellular matrix; collagen; integrin; cardiac fibrosis; cell signaling; cardiac function
(This special issue belongs to the Section Cells of the Cardiovascular System)
Multifaceted Nature of Immune Responses to Viral Infection
edited by Homayon Ghiasi and Susmit Suvas
submission deadline 10 Dec 2026 | 5 articles | Viewed by 6402 | Submission Open
Keywords: viral infection; innate and adaptive immunity; protection; RNA and DNA viruses; autoimmunity; immune escape
Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease
edited by
submission deadline 10 Dec 2026 | 3 articles | Viewed by 4303 | Submission Open
Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood–brain barrier; neuropsychiatric disorders
(This special issue belongs to the Section Cellular Neuroscience)
Mesenchymal Stem/Stromal Cell Therapies: Innovations in Regenerative Medicine and Translational Applications
edited by Giandomenico Amico and Paolo Elia Cappella
submission deadline 10 Dec 2026 | 3 articles | Viewed by 4250 | Submission Open
Keywords: mesenchymal stem cells (MSCs); stromal cells; microvesicles; exosomes; extracellular vesicles (EVs); immunomodulatory properties; bone marrow; adipose tissue; Wharton’s jelly; cord blood; placenta; amnion
(This special issue belongs to the Section Stem Cells)
Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation submission deadline 10 Dec 2026 | 3 articles | Viewed by 4125 | Submission Open
Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics
(This special issue belongs to the Section Stem Cells)
The Multifaceted Role of Molecular Chaperones in Cancer: Pro-Tumoral or Therapeutic Function
edited by and Federica Scalia
submission deadline 10 Dec 2026 | 1 articles | Viewed by 3110 | Submission Open
Keywords: molecular chaperones; cancer biology; carcinogenesis; tumor progression; diagnostic/prognostic biomarkers; anti-tumor therapeutic strategies; in vitro/in vivo experimental approaches; in silico computational approaches
Mitochondria in Cancer Immune Evasion and Immunotherapy
edited by Loredana Moro and
submission deadline 10 Dec 2026 | 2 articles | Viewed by 2619 | Submission Open
Keywords: mitochondria; mtDNA; immunity; cancer immune evasion; tumor microenvironment; immune tolerance; lymphocytes; inflammation; immune response
(This special issue belongs to the Section Cellular Immunology)
Novel Insights into Developing Therapeutic Strategies for Neurological Disorders
edited by , Joanna A. Korecka and
submission deadline 10 Dec 2026 | 1 articles | Viewed by 2511 | Submission Open
Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders
Hematopoietic Cell Lines as Models for Leukemia and Lymphoma
edited by Stefan Nagel
submission deadline 10 Dec 2026 | 2 articles | Viewed by 2470 | Submission Open
Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes
Translating Extracellular Vesicle Science submission deadline 10 Dec 2026 | 2 articles | Viewed by 2292 | Submission Open
Keywords: extracellular vesicles (EVs); EV isolation; EV purification; EV characterization; EV images; EV tracking; EV-based diagnostics; EV-based monitoring; EV therapeutics; blood biomarkers; translational medicine; exosomes; cell signaling
Epithelial–Immune Cell Interactions in Gut Homeostasis and Inflammation
edited by Neeraj Kapur
submission deadline 10 Dec 2026 | 2 articles | Viewed by 1742 | Submission Open
Keywords: gut homeostasis; epithelial barrier; immune cell crosstalk; barrier dysfunction; intestinal inflammation; microbiota; dysbiosis
(This special issue belongs to the Section Cellular Immunology)
The Cross-Talk Between Obesity and Metabolism
edited by
submission deadline 10 Dec 2026 | 2 articles | Viewed by 1628 | Submission Open
Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets
The Function of Stem Cells in the Biomedical Applications
edited by Rakesh Kumar Srivastava
submission deadline 10 Dec 2026 | 1 articles | Viewed by 1571 | Submission Open
Keywords: stem cells; regenerative medicine; cell therapy; differentiation; disease modeling; tissue engineering; drug discovery
Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects submission deadline 10 Dec 2026 | 1 articles | Viewed by 1542 | Submission Open
Keywords: neurodevelopmental disorders; neuronal connectivity; precocious therapies; synaptic plasticity; neurogenesis; glial function
(This special issue belongs to the Section Cellular Neuroscience)
Cell Signaling in Neurodegenerative Disease
edited by , Yasuhiro Funahashi, Akira Sobue, and Md-nadim Hossain
submission deadline 10 Dec 2026 | 1 articles | Viewed by 1392 | Submission Open
Keywords: neurodegeneration; cell signaling; biomarkers; synaptic dysfunction; neuroinflammation; protein aggregation; IPSC and animal models; mitochondrial dysfunction; therapeutic targets; translational neuroscience
(This special issue belongs to the Section Cellular Neuroscience)
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