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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Mitochondria in Cell Development and Regeneration

edited by

Kenny Rodriguez-Wallberg

and

Xia Hao

submission deadline 31 Dec 2025 | Viewed by 721 | Submission Open

Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders

edited by Irina Balan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 628 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors

(This special issue belongs to the Section Cellular Pathology)

The Blueprint of Female Reproductive Longevity: From Ovarian Biology to Modifiable Risks and Protective Strategies

edited by

Chiara Di Berardino

and

Yves St.-Pierre

submission deadline 31 Dec 2025 | 1 articles | Viewed by 448 | Submission Open

Keywords: ovarian aging; folliculogenesis; oocyte quality; hormonal regulation; epigenetics of reproduction; reproductive lifespan; stem cells in ovarian function; oxidative stress and fertility; metabolic influences on reproduction; cellular signaling in ovarian decline

(This special issue belongs to the Section Reproductive Cells and Development)

Epigenetic Mechanisms and Aging

edited by

Nicholas Tolwinski

submission deadline 31 Dec 2025 | Viewed by 350 | Submission Open

Keywords: drosophila melanogaster; model organism; cell biology; developmental biology; genetics; molecular biology; cell signaling; cellular differentiation; cell proliferation; cell cycle; cellular morphogenesis; cell-cell communication; stem cells; cell migration; apoptosis; cytoskeleton; cell adhesion; cellular metabolism; functional genomics; CRISPR/Cas9 in drosophila; omics technologies; disease models; drug discovery; regeneration; genetic screens; cellular stress responses

(This special issue belongs to the Section Cellular Aging)

Cellular and Molecular Mechanisms of Heart Diseases

edited by

Sumita Mishra

submission deadline 31 Dec 2025 | Viewed by 215 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies

(This special issue belongs to the Section Cellular Pathology)

Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases

edited by

Timothy Martin Palmer

and Katie S. Wraith

submission deadline 31 Dec 2025 | Viewed by 187 | Submission Open

Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer

edited by

Jessica Petiti

and Marika Fava

submission deadline 31 Dec 2025 | Viewed by 185 | Submission Open

Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards

Integrated Approaches Between Metabolomics and Cellular Aging

edited by Maria Nikolaou and

Nikolaos Theodorakis

submission deadline 31 Dec 2025 | Viewed by 131 | Submission Open

Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism

(This special issue belongs to the Section Cellular Aging)

Rho Family Small GTPases in Health and Diseases

edited by

Katalin Szászi

submission deadline 31 Dec 2025 | Viewed by 126 | Submission Open

Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors

(This special issue belongs to the Section Cell Signaling)

How Does Gene Regulation Affect Cancer Development?

edited by

Ru Chih C. Huang

and

Kotohiko Kimura

submission deadline 31 Dec 2025 | Viewed by 124 | Submission Open

Keywords: cancer; mutation; transcription factor; non-coding RNA; micro-RNA; gene regulation; histones; gene promoters; anticancer drugs

(This special issue belongs to the Section Cell Microenvironment)

Genetic Mechanisms in Cellular Genomics and Therapeutics

edited by Elaine T. Lim and Yingleong Chan

submission deadline 31 Dec 2025 | Viewed by 94 | Submission Open

Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases

The Role of T Cells and Cellular Signalling in Immune Diseases

edited by Daniela Gallo

submission deadline 31 Dec 2025 | Viewed by 64 | Submission Open

Keywords: T cells; autoimmune disorders; autoimmune endocrine disorders; targeted therapies

(This special issue belongs to the Section Cellular Immunology)

Mechanisms of Immune Responses and Therapy

edited by

Zhuang Wang

and

Bernhard Ryffel

submission deadline 31 Dec 2025 | Viewed by 60 | Submission Open

Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Interplay Between Intestinal Bacteria and Epigenetic Markers in Pathogenesis of Metabolic and Neuropsychiatric Disorders

edited by

Shabnam Nohesara

submission deadline 31 Dec 2025 | Viewed by 60 | Submission Open

Keywords: gut microbiome; epigenetic marks; metabolic diseases; neuropsychiatric disorders; probiotics; prebiotics; postbiotics; indole derivatives; epigeneic metabolites

Immunology and Immune Therapies for Cancer

edited by

Mei Yu

submission deadline 31 Dec 2025 | Viewed by 53 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; CAR-T cells; immune checkpoint inhibitors; immune surveillance; cancer vaccines; immuno-oncology

(This special issue belongs to the Section Cell Microenvironment)

Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities

edited by

Vesna Ceriman Krstic

and Dragana Jovanovic

submission deadline 31 Dec 2025 | Viewed by 53 | Submission Open

Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy

(This special issue belongs to the Section Cell Microenvironment)

Kinin System in Health and Disease: Cellular and Molecular Perspectives

edited by Marcos Gregnani and Leonardo Martins

submission deadline 31 Dec 2025 | Viewed by 51 | Submission Open

Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways

(This special issue belongs to the Section Cellular Pathology)

Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures

edited by

Ivo Bozovic

and

Bogdan Bjelica

submission deadline 31 Dec 2025 | Viewed by 42 | Submission Open

Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Mechanisms of Traumatic Injury and Resolution

edited by

Upendra K. Kar

and Hamed Moheimani

submission deadline 31 Dec 2025 | Viewed by 34 | Submission Open

Keywords: traumatic injury-associated immunometabolism; trauma-induced coagulopathy; endothelial dysfunction; cell death pathways; extracellular vesicles; single-cell and spatial omics; multi-omics; damage-associated molecular patterns; biomarker discovery; precision therapeutics

(This special issue belongs to the Section Cellular Pathology)

Inflammation and Aging in Acute and Chronic Kidney Injury

edited by

Massimiliano Migliori

Vincenzo Cantaluppi

and

Marita Marengo

submission deadline 31 Dec 2025 | Viewed by 28 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; inflammation; aging

(This special issue belongs to the Section Cellular Aging)

The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis

edited by

Sanjit Mukherjee

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: oral submucous fibrosis (OSMF); collagen deposition; epigenetic modifications; next-generation sequencing; oral cancer; progressive fibrosis

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles in Obesity and Metabolic Disease: Emerging Mechanisms, Inter-Organ Crosstalk, and Translational Opportunities

edited by

Mangesh Hade

submission deadline 31 Dec 2025 | Viewed by 2 | Submission Open

Keywords: extracellular vesicles; exosomes; metabolic syndrome; obesity; insulin resistance; type 2 diabetes; cardiovascular disease; MAFLD; fatty liver; adipose tissue; microRNA; metabolic inflammation; inter-organ communication; biomarker; therapeutic EVs

(This special issue belongs to the Section Cellular Immunology)

Colorectal Cancer: Molecular Mechanisms and Treatment Progress

edited by

Maurizio Capuozzo

submission deadline 31 Dec 2025 | Viewed by 1 | Submission Open

Keywords: colorectal cancer (CRC); tumor microenvironment; genetic and epigenetic alterations; immune evasion; targeted therapy and personalized medicine

(This special issue belongs to the Section Tissues and Organs)

Molecular and Genetic Pathogenesis of Hematological Disorders

edited by

Hong Chang

submission deadline 10 Jan 2026 | 1 articles | Viewed by 1591 | Submission Open

Keywords: hematological disorders; molecular and genetic mechanisms; signal transduction pathways; microenvironment; gene editing technologies; targeted therapies; novel biomarkers; mechanisms of treatment resistance; innovative therapeutic strategies

(This special issue belongs to the Section Cellular Pathology)

New Insights into Therapeutic Targets for Cardiovascular Diseases

edited by

Tamer Elbayoumi

and

Molly (Mingyi) Yao

submission deadline 15 Jan 2026 | 2 articles | Viewed by 5418 | Submission Open

Keywords: cardiovascular disease prevention and treatment; ischemic cardiomyopathies; endothelium injury/damage; cardiac remuscularization and repair; cardiovascular/angiogenic targets and biomarkers; targeted delivery platforms/systems/formulations; precision nanomedicine; targeted nano-theranostic applications; localized and systemic administration; safety and efficacy

(This special issue belongs to the Section Cells of the Cardiovascular System)

Recent Progress on Fibrosis and Cardiac Dysfunction

edited by

Tabito Kino

and

Tomoaki Ishigami

submission deadline 15 Jan 2026 | Viewed by 318 | Submission Open

Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Targeting Breast Cancer: Mechanisms of Resistance and Innovative Therapeutic Strategies

edited by Stefania Belli,

Daniela Esposito

and

Roberto Bianco

submission deadline 15 Jan 2026 | Viewed by 50 | Submission Open

Keywords: breast cancer; targeted therapies; novel therapeutic targets; mechanisms of drug resistance; innovative therapeutic strategies; targeting tumor microenvironment; immunotherapy in breast cancer

(This special issue belongs to the Section Cell Microenvironment)

Organ Regeneration: Cells, Organoids and Organs

edited by Jia Huang

submission deadline 15 Jan 2026 | Viewed by 24 | Submission Open

Keywords: organ regeneration; stem cells; organoids; tissue engineering; 3D bioprinting; regenerative medicine; interspecies chimera; blastocyst complementation; vascularization; immune compatibility

(This special issue belongs to the Section Tissues and Organs)

Role of Cell Organelles in Normal Aging, Senescence, and Cancer

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 20 Jan 2026 | Viewed by 394 | Submission Open

Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8

(This special issue belongs to the Section Cellular Aging)

Study on Human Mesenchymal Stem Cells—2nd Edition

edited by

Michela Noseda

submission deadline 20 Jan 2026 | Viewed by 230 | Submission Open

Keywords: mesenchymal stem cells; disease; cardiac; therapy

(This special issue belongs to the Section Stem Cells)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | 1 articles | Viewed by 3248 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

Mechanisms Underlying Cardiovascular Aging

edited by Soheil Saeedi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 625 | Submission Open

Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Advanced Technology for Cellular Imaging

edited by Alessandro Grinzato,

Vittoria Raimondi

and

J. Bernard Heymann

submission deadline 31 Jan 2026 | 7 articles | Viewed by 15237 | Submission Open

Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases

edited by

Prathapan Ayyappan

submission deadline 31 Jan 2026 | 5 articles | Viewed by 11733 | Submission Open

Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods

(This special issue belongs to the Section Cells of the Cardiovascular System)

Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance

edited by

Xinyu Wang

Lei Zhu

and Yuancheng Li

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3994 | Submission Open

Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product

(This special issue belongs to the Section Cell Microenvironment)

Single-Molecule Tracking for Live Cells

edited by

Zeno Földes-Papp

submission deadline 31 Jan 2026 | Viewed by 42 | Submission Open

Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory

New Advances in Tissue Engineering and Regeneration

edited by

Giorgia Borciani

and

Giorgia Montalbano

submission deadline 31 Jan 2026 | Viewed by 36 | Submission Open

Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research

(This special issue belongs to the Section Tissues and Organs)

Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities

edited by Fabio Guolo

submission deadline 31 Jan 2026 | Viewed by 33 | Submission Open

Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers

(This special issue belongs to the Section Cellular Immunology)

Examining the Cellular Biology of Adenovirus

edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard

submission deadline 31 Jan 2026 | Viewed by 11 | Submission Open

Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome

Role of Alpha-Synuclein in Neurodegenerative Diseases

edited by

Carmela Conte

submission deadline 10 Feb 2026 | Viewed by 53 | Submission Open

Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases

(This special issue belongs to the Section Cellular Aging)

Spotlight on Natural Killer Cells in Immuno-Oncology

edited by

Anahid Jewett

and

Kawaljit Kaur

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1776 | Submission Open

Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells

(This special issue belongs to the Section Cellular Immunology)

Cellular Mechanisms and Therapies of Hematologic Malignancies

edited by Sayantani Sinha and Stanley Chun-Wei Lee

submission deadline 15 Feb 2026 | Submission Open

Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance

Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease

edited by

Paul M. Epstein

Stefan Brocke

, Michy P. Kelly and Leila Gobejishvili

submission deadline 20 Feb 2026 | 13 articles | Viewed by 20142 | Submission Open

Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction

(This special issue belongs to the Section Cell Microenvironment)

Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications

edited by

Ilaria Martinelli

and Elisabetta Zucchi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2881 | Submission Open

Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy

(This special issue belongs to the Section Cells of the Nervous System)

Natural Products and Their Derivatives Against Human Disease

edited by

Mamunur Rashid

submission deadline 25 Feb 2026 | 4 articles | Viewed by 5498 | Submission Open

Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Mitophagy and Mitochondrial Quality Control

edited by Mohamed Eldeeb

submission deadline 27 Feb 2026 | Viewed by 293 | Submission Open

Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration

(This special issue belongs to the Section Mitochondria)

Targeting of Cancer Cells with Small Molecule Drugs

edited by

Jannet Kocerha

submission deadline 27 Feb 2026 | Viewed by 15 | Submission Open

Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology

Cellular Pathology: Emerging Discoveries and Perspectives in the USA

edited by

Mohammed S. Razzaque

submission deadline 28 Feb 2026 | Viewed by 274 | Submission Open

Keywords: cellular pathology; diseases; mechanisms

(This special issue belongs to the Section Cellular Pathology)

Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics

edited by

Aijaz Ahmad John Bhat

submission deadline 28 Feb 2026 | Viewed by 188 | Submission Open

Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling

(This special issue belongs to the Section Tissues and Organs)

Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology

edited by

Jinu Kim

submission deadline 28 Feb 2026 | Viewed by 83 | Submission Open

Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms

(This special issue belongs to the Section Tissues and Organs)

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