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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in the Molecular Mechanisms of Neurodegenerative Diseases: Current Progress and Future Directions for Disease-Modifying Therapies

edited by

Rengasamy Balakrishnan

and

Balamuralikrishnan Balasubramanian

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1540 | Submission Open

Keywords: neuroprotection; new drug development; natural products; blood– brain barrier; molecular mechanisms; neuronal signaling; neuroinflammation; microglial cells; neurotoxicity; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

Mechanisms of Modulation of Sensory Plasticity in the Cerebral Cortex

edited by

Ángel A. Núñez

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1488 | Submission Open

Keywords: synaptic plasticity; synapses; LTP; LTD; ionotropic and metabotropic receptors

(This special issue belongs to the Section Cellular Neuroscience)

Cellular Mechanisms in Pregnancy and Foetal Development

edited by

Anya L. Arthurs

and

Giovanni Levi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1316 | Submission Open

Keywords: pregnancy; fetus; reproduction; placenta; maternal; fertility; preeclampsia; fetal growth restriction; gestational diabetes; stillbirth

From Energy Metabolism to Disease: The Multifaceted Roles of Mitochondria

edited by Amy H. Attaway and Saurabh Mishra

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1307 | Submission Open

Keywords: mitochondrial oxidation; ROS; aging; disease

The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine

edited by

Lucie Bacakova

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1236 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering

The Interplay Between Tumor Metabolism, Microenvironment and Cell Survival

edited by

Silvia Peppicelli

and Giulio Menegazzi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 765 | Submission Open

Keywords: tumor microenvironment; metabolic cross-talk; metabolic reprogramming; extracellular vesicles; cell survival; therapy resistance

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms of Alcohol-Induced Cellular/Organ Injury and Regeneration

edited by Mukund Srinivasan

submission deadline 31 Mar 2026 | 1 articles | Viewed by 439 | Submission Open

Keywords: alcohol use disorder; ethanol; liver; lung; pancreas; gut; brain; cellular toxicity; alcohol metabolism; alcohol metabolites; oxidative stress; mitochondrial stress; ER stress

Cellular and Molecular Insights into Allergies and Allergic Diseases

edited by

Toshiaki Kawakami

submission deadline 31 Mar 2026 | Viewed by 316 | Submission Open

Keywords: allergy; immune regulation; mast cells; Th2 responses; epithelial barrier; IgE; inflammation; cellular signaling; molecular mechanisms

(This special issue belongs to the Section Cellular Immunology)

Mechanisms and Dynamics in Cellular Adhesion in Development and Disease

edited by

Daniel Bouvard

submission deadline 31 Mar 2026 | Viewed by 304 | Submission Open

Keywords: actin; integrin; cell adhesion; signalling; mechanotransduction

Membrane Trafficking Components and Mechanisms in Bacterial, Viral or Fungal Infections

edited by

Bor Luen Tang

submission deadline 31 Mar 2026 | Viewed by 274 | Submission Open

Keywords: bacterial intracellular infections; bacterial intracellular sanctuaries; viral infection; viral hijacking of host trafficking machinery; membrane trafficking; Rab; secretory pathway; endocytic pathway; viral replication

Current Research on Immunotherapy for Glioblastoma

edited by Markella Zannikou

submission deadline 31 Mar 2026 | Viewed by 225 | Submission Open

Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy

(This special issue belongs to the Section Cellular Immunology)

Ubiquitin Ligases: Key Regulators in Cellular Homeostasis and Disease

edited by Praveen Koganti and

Michal Goldberg

submission deadline 31 Mar 2026 | Viewed by 225 | Submission Open

Keywords: ubiquitin ligases; protein ubiquitination; cellular homeostasis; proteasome pathway

Organelle Crosstalk: New Insights into Intracellular Communication and Dynamics

edited by

Jonathan Barra

submission deadline 31 Mar 2026 | Viewed by 212 | Submission Open

Keywords: organelle contact sites; membrane contact sites; intracellular communication; early endosomes; recycling endosomes; Golgi; mitochondrial dynamics; ER stress; mitophagy; autophagy; lysosome; calcium signaling; lipid transfer; proteostasis

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 31 Mar 2026 | Viewed by 199 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene– environment interactions; developing therapies

Neurodegenerative Diseases and Related Proteins

edited by Tian Liu

submission deadline 31 Mar 2026 | Viewed by 194 | Submission Open

Keywords: protein misfolding and aggregation; proteostasis and quality control; neuroinflammation; autophagy and mitophagy; molecular chaperones; Amyloid-β and tau; α -synuclein and TDP-43; multi-omics biomarkers; structural biology; therapeutic targets; mitochondrial– ER crosstalk; genetic and epigenetic regulation

Multi-Omics Technologies in Immunity Within Tumors

edited by

Muhammad A. Alsherbiny

and

Anas M. Abdel Rahman

submission deadline 31 Mar 2026 | Viewed by 191 | Submission Open

Keywords: multi-omics; proteomics; metabolomics; lipidomics; genomics and epigenomics; synergistic combinations for cancer; AI applications in multi-omics integrations; tumor microenvironment (TME); cancer immunotherapy; immuno-oncology; integrative analysis of multi-omics; biomarkers; precision medicine; tumor heterogeneity

Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities

edited by

Sherri R. Cervantes

and

Daruka Mahadevan

submission deadline 31 Mar 2026 | Viewed by 189 | Submission Open

Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer

(This special issue belongs to the Section Cell Microenvironment)

Therapeutic Targeting of MicroRNAs in Human Cancer

edited by

Behzad Mansoori

submission deadline 31 Mar 2026 | Viewed by 184 | Submission Open

Keywords: microRNAs; nanoparticle platforms; spatial miRNomics; combination therapeutic strategies

(This special issue belongs to the Section Cell and Gene Therapy)

Advances in CAR Cell Therapies and Manufacturing

edited by William J. Kelly and Madhuresh C. Sumit

submission deadline 31 Mar 2026 | Viewed by 180 | Submission Open

Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines

Molecular and Cellular Drivers of Parkinson's Disease

edited by

Fatema Currim

and

Jason Cannon

submission deadline 31 Mar 2026 | Viewed by 173 | Submission Open

Keywords: Parkinson’ s disease; neurodegeneration; mitochondrial dysfunction; α -synuclein aggregation; neurotoxicity; neuroinflammation; oxidative stress; environmental factors; gene– environment interactions; cell death

(This special issue belongs to the Section Cellular Neuroscience)

PI3K/AKT/mTOR Signaling Network in Human Health and Diseases, 3rd Edition

edited by

Jean Christopher Chamcheu

Claudia Bürger

and

Shile Huang

submission deadline 31 Mar 2026 | Viewed by 172 | Submission Open

Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics

Novel Biomarkers and Dose-Response Modifiers in Radiation Oncology and Nuclear Medicine: Molecular Insights for Personalized Therapy and Precision Medicine

edited by

Wolfgang Sauerwein

and Andrea Wittig

submission deadline 31 Mar 2026 | Viewed by 170 | Submission Open

Keywords: targeted therapies; predictive essays; radiosensitizers; radioprotectors; theranostics; BNCT; alpha-immunotherapy; biological response modifiers; biomarkers

GABA_A Receptor Dynamics: From Cellular Quality Control to Disease Mechanisms

edited by Tingwei Mu and Yajuan Wang

submission deadline 31 Mar 2026 | Viewed by 163 | Submission Open

Keywords: GABAA receptors; trafficking; biogenesis; proteostasis; structure and function; gating; neurotransmission; neurological diseases; disease mechanisms

Hepatoblastoma: Molecular Mechanisms and Therapeutic Strategies

edited by

Edward V. Prochownik

submission deadline 31 Mar 2026 | Viewed by 161 | Submission Open

Keywords: hepatoblastoma; APC; ARID1; β -catenin; hepatocellular carcinoma; hippo; YAP; pathogenesis; therapeutic strategies; molecular mechanisms

Cellular and Molecular Insights into Gynecologic Tumors

edited by

Mladen Anđić

and

Jianjun Wei

submission deadline 31 Mar 2026 | Viewed by 161 | Submission Open

Keywords: gynecologic cancers; cervical cancer; endometrial cancer; ovarian tumors; tumor microenvironment; molecular biomarkers; genetic mutations; targeted therapies

Stem Cells and Endometrium

edited by Shiying Jin

submission deadline 31 Mar 2026 | Viewed by 150 | Submission Open

Keywords: stem cell; homeostasis; regeneration; endometrium

(This special issue belongs to the Section Stem Cells)

Next-Generation CAR-T Cell Therapy: From Bench to Bedside

edited by

Ping Zhang

and

Yasushi Akahori

submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open

Keywords: chimeric antigen receptor T cells; cytokine release syndrome; immune effector cell-associated neurotoxicity syndrome (ICANS); immunotoxicity; T cell exhaustion; antigen discovery; CAR engineering; mouse models

(This special issue belongs to the Section Cellular Immunology)

Cell Death and Apoptosis

edited by

Marianna Pap

and

Judit Varga

submission deadline 31 Mar 2026 | Viewed by 125 | Submission Open

Keywords: apoptosis; necroptosis; pyroptosis; ferroptosis; regulated cell death; signaling pathways; tumor biology; resistance mechanisms

(This special issue belongs to the Section Cellular Pathology)

From Liver Transplantation to Gene Therapy: A Therapeutic Revolution in Argininosuccinic Aciduria

edited by Sonam Gurung

submission deadline 31 Mar 2026 | Viewed by 118 | Submission Open

Keywords: urea cycle disorder; argininosuccinic aciduria; gene therapies; mRNA therapies; liver transplantation; arginosuccinate lyase (ASL)

Lung Diseases: From Cellular and Molecular Mechanisms to Targeted Therapies

edited by

Christoph Beisswenger

and Daniela Yildiz

submission deadline 31 Mar 2026 | Viewed by 107 | Submission Open

Keywords: lung diseases; cellular and molecular mechanisms; targeted therapies; OMICS; single-cell sequencing

Regulation of Ca²⁺ Signals in Human Disease

edited by Yandong Zhou

submission deadline 31 Mar 2026 | Viewed by 107 | Submission Open

Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets

(This special issue belongs to the Section Cell Signaling)

Cellular and Molecular Mechanisms in Aging

edited by Michel Satya Naslavsky and Mateus Vidigal

submission deadline 1 Apr 2026 | 1 articles | Viewed by 1634 | Submission Open

Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly

(This special issue belongs to the Section Cellular Aging)

Glycolysis in Tumorigenesis: Mechanisms and Therapeutic Implications

edited by

Fabrizio Marcucci

, Shibo Wei and

Marco Cordani

submission deadline 1 Apr 2026 | Viewed by 150 | Submission Open

Keywords: glycolysis; tumorigenesis; moonlighting functions; Warburg effect; metabolic reprogramming; tumor microenvironment; therapeutic targets; cancer metabolism

Evolution, Structure, and Functions of Apolipoproteins L

edited by Etienne Pays

submission deadline 10 Apr 2026 | 4 articles | Viewed by 7809 | Submission Open

Keywords: APOL1 nephropathy; APOL1 risk variants; membrane traffic; membrane fission; membrane fusion; membrane dynamics; autophagy; mitophagy; viral replication; lipid droplets; pathogen resistance; inflammation

Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases

edited by

Morten Meyer

and Justyna Okarmus

submission deadline 10 Apr 2026 | 2 articles | Viewed by 6186 | Submission Open

Keywords: neurodegenerative diseases; experimental treatments; stem cell transplantation; immunotherapy; gene therapy; focused ultrasound; neuroprotective agents; Parkinson's disease; Alzheimer's disease; Huntington’ s disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cellular Neuroscience)

Galectins in Cancer, Fibrosis and Immune Modulation: Mechanisms, Therapeutic Strategies and Translational Advances

edited by Tsung-Chieh Shih

submission deadline 10 Apr 2026 | 3 articles | Viewed by 4763 | Submission Open

Keywords: Galectin; tumor microenvironment; immunosuppression; fibrosis; epithelial– mesenchymal transition (EMT); cancer metastasis; immune evasion; therapy resistance; myeloid-derived suppressor cells (MDSCs); tumor-associated macrophages (TAMs); extracellular matrix remodeling; Galectin-targeted therapy; combination immunotherapy; fibroblast activation; chronic inflammation; tumor– stroma interactions; novel inhibitors of Galectins

(This special issue belongs to the Section Cellular Immunology)

New Tools to Address Old Challenges in Tolerogenic Cellular Therapies

edited by Konstantinos Mengrelis and

Nina Pilat

submission deadline 10 Apr 2026 | Viewed by 80 | Submission Open

Keywords: tolerogenic strategies; immune tolerance; allogeneic cellular therapies; autoimmunity; allergy; systems immunology; artificial intelligence; biomarkers; immune regulation

Cellular Mechanisms of Testosterone in Metabolic Disorders

edited by Daniel M. Kelly

submission deadline 13 Apr 2026 | Viewed by 93 | Submission Open

Keywords: testosterone; metabolism; type 2 diabetes; obesity; metabolic syndrome; MASLD; skeletal muscle; adipose tissue; insulin resistance; endocrine signalling

Modeling Developmental Processes and Disorders in Zebrafish

edited by

Natascia Tiso

and

Francesco Argenton

submission deadline 15 Apr 2026 | 13 articles | Viewed by 55324 | Submission Open

(This special issue belongs to the Section Cellular Biophysics)

Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer

edited by Emiko Mizoguchi

submission deadline 15 Apr 2026 | 5 articles | Viewed by 23902 | Submission Open

Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer

(This special issue belongs to the Section Cellular Pathology)

Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration

edited by Aurora Almadori

submission deadline 15 Apr 2026 | 5 articles | Viewed by 11241 | Submission Open

Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; ageing; immune response; inflammation; scarring

(This special issue belongs to the Section Stem Cells)

Role of Thyroid Hormone in Neurodegenerative and Neurodevelopmental Disorders

edited by Janaína Sena de Souza

submission deadline 15 Apr 2026 | 5 articles | Viewed by 10722 | Submission Open

Keywords: thyroid hormones; neurodevelopmental and neurodegenerative disorders; central nervous system

(This special issue belongs to the Section Cellular Neuroscience)

Advances in Zebrafish Disease Models

edited by

Natalia Kasica

and

Jaroslaw Widelski

submission deadline 15 Apr 2026 | 3 articles | Viewed by 6114 | Submission Open

Keywords: zebrafish; human disease models; experimental disease models; novel drugs and therapies; organic diseases; functional disorders

Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies

edited by

Aida Paivandy

submission deadline 15 Apr 2026 | 2 articles | Viewed by 2404 | Submission Open

Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches

(This special issue belongs to the Section Cellular Immunology)

Epigenetic Regulatory Networks in Cancer: Understanding the Mechanisms of Disease Progression

edited by

Anand Singh

and Sudheer Kumar Gara

submission deadline 15 Apr 2026 | 1 articles | Viewed by 2149 | Submission Open

Keywords: cancer; epigenetics; miRNAs; BAP1; DNMTs; tumor suppressor; oncogenes; histone modification; chromatin remodeling

(This special issue belongs to the Section Cellular Pathology)

Increasing Incidence of Retinal Disorders: Addressing Preclinical Studies with Appropriate Animal Models and Advanced Methodologies

edited by

Paola Bagnoli

and

Maurizio Cammalleri

submission deadline 15 Apr 2026 | 3 articles | Viewed by 2040 | Submission Open

Keywords: hypoxia; oxidative stress; angiogenic markers; HIF-1/VEGF axis; retinal diseases; β -adrenoceptors; electroretinographic responses

(This special issue belongs to the Section Tissues and Organs)

Molecular Mechanisms and Pathophysiology of Diabetic Retinopathy

edited by

Siddharth Sunilkumar

, Stephanie L. Grillo and

Sandeep M. Subrahmanian

submission deadline 15 Apr 2026 | 1 articles | Viewed by 1728 | Submission Open

Keywords: diabetic retinopathy; retina; retinal neurodegeneration; diabetic macular edema; pathophysiology of diabetic retinopathy; proliferative and non-proliferative diabetic retinopathy; molecular mediators of diabetic retinopathy; cell-based therapies for diabetic retinopathy

(This special issue belongs to the Section Cellular Pathology)

Decoding Cancer Metabolism: Recent Insights and Future Directions

edited by Parash Prasad and Snehasis R. Mishra

submission deadline 15 Apr 2026 | Viewed by 540 | Submission Open

Keywords: glutamine metabolism; Warburg effect; anaplerosis; fatty acid metabolism; ferroptosis; oncometabolites; hypoxia; mitochondrial dynamics; reactive oxygen species; glutathione synthesis; nutrient sensing

Translational Aspects of Cell Signaling

edited by