Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functions of Cilia
edited by
submission deadline 15 Dec 2025 | Viewed by 245 | Submission Open
Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes
Recent Advances in the Understanding of Neuropsychiatric Illnesses
edited by and
submission deadline 15 Dec 2025 | Viewed by 195 | Submission Open
Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging
(This special issue belongs to the Section Cellular Neuroscience)
The Cross-Talk Between Obesity and Metabolism
edited by
submission deadline 15 Dec 2025 | Viewed by 176 | Submission Open
Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets
Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms—Second Edition
edited by
submission deadline 15 Dec 2025 | Viewed by 124 | Submission Open
Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition
(This special issue belongs to the Section Tissues and Organs)
Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts
edited by Simonetta Masieri and
submission deadline 15 Dec 2025 | Viewed by 123 | Submission Open
Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins
(This special issue belongs to the Section Tissues and Organs)
The Symphony of Nature—the Precision of Life’s Regulation
edited by Weiguang Wang and Baocheng Liu
submission deadline 15 Dec 2025 | Viewed by 111 | Submission Open
Keywords: protein structure and function; allosteric regulation; conformational switches; enzyme catalysis and modification; molecular machines; molecular regulation; protein folding and misfolding
(This special issue belongs to the Section Cell Methods)
Cancer and Immune System Interactions submission deadline 16 Dec 2025 | Viewed by 162 | Submission Open
Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor– immune interactions; immune checkpoint regulation; translational oncology
(This special issue belongs to the Section Cell Microenvironment)
Physiology of Telocytes
edited by and Mihail E. Hinescu
submission deadline 20 Dec 2025 | 1 articles | Viewed by 4914 | Submission Open
Keywords: telocytes; telopodes; physiology; pathology; tissue homeostasis; regenerative medicine
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms of Cognitive Function and Dysfunction submission deadline 20 Dec 2025 | 2 articles | Viewed by 4226 | Submission Open
Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy
(This special issue belongs to the Section Cellular Neuroscience)
Metabolic Hallmarks in Cancer
edited by , Ubaldo Martinez-Outshoorn and Marta Mauro-Lizcano
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3307 | Submission Open
Keywords: cancer; metabolic reprogramming; metabolic adaptation; cancer energy metabolism; glycolysis; the Warburg effect; the reverse Warburg effect; glutamine addiction; the pentose phosphate pathway; cellular and molecular mechanisms; tumor microenvironment; novel therapeutic interventions
(This special issue belongs to the Section Cellular Metabolism)
Advances in Human Pluripotent Stem Cells submission deadline 20 Dec 2025 | 1 articles | Viewed by 2619 | Submission Open
Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells  
(This special issue belongs to the Section Stem Cells)
Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets
edited by and María Martín Estebané
submission deadline 20 Dec 2025 | Viewed by 316 | Submission Open
Keywords: microglia; inflammation; neural damage; mitochondria; potential targets
(This special issue belongs to the Section Cellular Aging)
Advanced Research on Genomic Instability and Gene Expression in Developmental Disorders
edited by
submission deadline 20 Dec 2025 | Viewed by 244 | Submission Open
Keywords: development; neurological disease; cancer; genetic; epigenetic
Targeting Thermogenesis in Metabolic Disorders: Novel Pharmacological and Lifestyle Interventions
edited by
submission deadline 20 Dec 2025 | Viewed by 186 | Submission Open
Keywords: thermogenesis modulation; metabolic disorders; obesity; adipose tissue biology; thermogenic mechanisms; mitochondrial function
Evaluation of the Properties and Effectiveness of Nutritional Factors Using In Vitro Assays, Including Cell Cultures and Organoids
edited by and Sylwia Orczewska-Dudek
submission deadline 20 Dec 2025 | Viewed by 169 | Submission Open
Keywords: cell cultures; organoids; novel nutritional factors; extract; cells viability; cells proliferation; cells cytotoxicity; cell signaling; cells apoptosis; oxidative stress
Acute Myeloid Leukemia: Molecular Mechanisms and Novel Therapies
edited by Xiangguo Shi
submission deadline 20 Dec 2025 | Viewed by 149 | Submission Open
Keywords: acute myeloid leukemia (AML); genomics and epigenetics; therapeutic resistance; metabolic reprogramming; clonal evolution
(This special issue belongs to the Section Cellular Pathology)
Clockwork Cells: Decoding the Language of Cell Cycle Regulators
edited by , Kyung-sang Lee, and
submission deadline 20 Dec 2025 | Viewed by 131 | Submission Open
Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis
(This special issue belongs to the Section Cell Proliferation and Division)
Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae
edited by and Hisao Moriya
submission deadline 24 Dec 2025 | 1 articles | Viewed by 844 | Submission Open
Keywords: functional genomics; morphological profiling; Saccharomyces cerevisiae; overexpression
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Cellular Differentiation in Health and Disease
edited by Christine K. C. Loo and
submission deadline 25 Dec 2025 | 1 articles | Viewed by 2378 | Submission Open
Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation
(This special issue belongs to the Section Cell Microenvironment)
Advances in Molecular Genomics and Pathology of Cancers
edited by
submission deadline 25 Dec 2025 | Viewed by 242 | Submission Open
Keywords: cancer; somatic mutation; short tandem repeat; gene expression; methylation; cf-DNA; single-cell sequencing; NGS; liquid biopsy; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Dysregulated Synaptic Plasticity in Chronic Pain: Molecular Mechanisms, Circuit Dysfunction, and Translational Approaches
edited by
submission deadline 25 Dec 2025 | Viewed by 163 | Submission Open
Keywords: chronic pain; synaptic plasticity; circuit dysfunction
(This special issue belongs to the Section Cellular Pathology)
Role of T Cells in Immune Disease Treatment
edited by
submission deadline 25 Dec 2025 | Viewed by 122 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immunotherapy; immune diseases; T cells; B cells; natural killer T cells
(This special issue belongs to the Section Cellular Immunology)
Host Immunity to Bacterial Infections
edited by Karine Gloux
submission deadline 26 Dec 2025 | Viewed by 347 | Submission Open
Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections
(This special issue belongs to the Section Cellular Immunology)
Epigenetic Regulation in Neuronal Development, Neurodegeneration and Regeneration
edited by
submission deadline 28 Dec 2025 | 1 articles | Viewed by 1653 | Submission Open
Keywords: epigenetic regulation; neuronal development; neuronal regeneration; chromatin remodeling
(This special issue belongs to the Section Cellular Neuroscience)
Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights
edited by and
submission deadline 30 Dec 2025 | 2 articles | Viewed by 5765 | Submission Open
Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy
(This special issue belongs to the Section Tissues and Organs)
Fertility Disorders in Testes and Ovaries
edited by and Joanna Kochan
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1318 | Submission Open
Keywords: fertility; ovary; testis; aging; epigenetics; in vitro fertilization; IVF
(This special issue belongs to the Section Tissues and Organs)
Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease submission deadline 30 Dec 2025 | Viewed by 763 | Submission Open
Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein– protein interactions; post-translational modifications; pharmacological interventions
Emerging Roles of Glial Cells in Human Health and Disease submission deadline 31 Dec 2025 | 10 articles | Viewed by 43587 | Submission Open
Keywords: neurodegenerative diseases; glia cells; astrocyte; microglia; stroke; pain; epilepsy; trauma; demyelinating diseases’ inflammatory diseases; satellite glia; Schwann cells; enteric glia
(This special issue belongs to the Section Cellular Neuroscience)
Gene Therapy for Rare Diseases
edited by
submission deadline 31 Dec 2025 | 6 articles | Viewed by 37800 | Submission Open
Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses
edited by
submission deadline 31 Dec 2025 | 9 articles | Viewed by 25594 | Submission Open
(This special issue belongs to the Section Cellular Neuroscience)
New Insights into Vascular Biology in Health and Disease
edited by Bashir M. Rezk
submission deadline 31 Dec 2025 | 6 articles | Viewed by 18704 | Submission Open
Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization
(This special issue belongs to the Section Cells of the Cardiovascular System)
Biological Mechanisms in the Treatment of Neuropsychiatric Diseases
edited by Randall D Marshall and Frank S. Menniti
submission deadline 31 Dec 2025 | 6 articles | Viewed by 16214 | Submission Open
Keywords: neurodevelopmental conditions; rare neurological disease; molecular mechanisms of novel CNS treatments; precision medicine in neuropsychiatry; organoids; molecular mechanisms of effective treatments
(This special issue belongs to the Section Cellular Pathology)
Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction
edited by Zhengui Zheng, and Liang Ma
submission deadline 31 Dec 2025 | 7 articles | Viewed by 14462 | Submission Open
Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation
(This special issue belongs to the Section Reproductive Cells and Development)
Cellular Mechanisms of Anti-Cancer Therapies
edited by Ilgen Mender and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 12688 | Submission Open
Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 11946 | Submission Open
Keywords: bone morphogenic proteins (BMPs); bone union with cell therapy; advances in stem cell therapies for fracture non-union and cartilage regeneration; novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; regeneration and revascularization of bone osteonecrosis; evaluation of osteonecrosis regeneration with MRI and histology; and arteriography; identification and validation of new cartilage biomarkers; diaphyseal regeneration with callostasis; union with the membrane technique
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms Involved in Musculoskeletal and Other Tissue Injuries and Disruptions—Regenerative Potential of Exercise submission deadline 31 Dec 2025 | 2 articles | Viewed by 8867 | Submission Open
Keywords: tissue injury; tissue regeneration; growth factors; inflammation; oxidative stress; metabolic stress; myokines; adipokines; neurokines; hypertrophy; biochemical pathways; skeletal muscles; liver/hepatic regeneration; brain/neuroplasticity; adipose tissue; varia
(This special issue belongs to the Section Tissues and Organs)
Cell Stress and Intervention in Neurological Disease: In Honor of Dr. Jang-Yen Wu for His Long and Distinguished Career in Neuroscience
edited by Howard Prentice and
submission deadline 31 Dec 2025 | 6 articles | Viewed by 8011 | Submission Open
Keywords: neurodegenerative disease; gene therapy; excitotoxicity; calcium dysregulation; Alzheimer’ s disease; stroke; neuroprotection; neurogenesis
(This special issue belongs to the Section Cellular Neuroscience)
Cellular and Molecular Mechanisms in Oxidative Stress-Related Chronic Diseases
edited by Sara Spinelli, and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7868 | Submission Open
Keywords: aging; age-related diseases; redox system; cellular and molecular mechanisms; oxidative stress biomarkers; synthetic and natural antioxidant molecules
(This special issue belongs to the Section Cellular Pathology)
Signaling Pathways and Mechanisms in Cancer Therapy Resistance submission deadline 31 Dec 2025 | 3 articles | Viewed by 7854 | Submission Open
Keywords: cancer therapy; therapy resistance; molecular mechanisms; cell signaling pathways; genetic and epigenetic modifications; combination therapies
(This special issue belongs to the Section Cellular Pathology)
Redox and Metabolic Profile of Cancer
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 7835 | Submission Open
Keywords: cancer; metabolism; redox biology; redox-metabolic reprogramming; reactive species: oxygen; nitrogen; sulfur; etc; cancer microenvironment; cancer-tissue cooperation; mitochondria
(This special issue belongs to the Section Cellular Metabolism)
Ageing and Neurodegenerative Diseases, Second Edition
edited by Feng Wang and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7609 | Submission Open
Keywords: ageing; miRNAs; lncRNA; circRNAs; diabetes; neurodegenerative disease; insulin signaling
(This special issue belongs to the Section Cellular Pathology)
Cell Biology: State of the Art and Perspectives in Italy 2025
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 6903 | Submission Open
Keywords: cell biology; physiology; molecular biology
Mechanisms of Immune Responses and Therapy submission deadline 31 Dec 2025 | 2 articles | Viewed by 6686 | Submission Open
Keywords: immunity; immune signaling; immune regulation; cellular immunology; molecular immunology; autoimmunity; immune checkpoint; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders
edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6183 | Submission Open
Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism
(This special issue belongs to the Section Cell Signaling)
Cellular and Molecular Mechanisms of Liver Diseases
edited by Jieyun Jiang
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5425 | Submission Open
Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms
(This special issue belongs to the Section Cellular Pathology)
Computational Biophysics in Cellular Biological Systems
edited by and Wenhan Guo
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4533 | Submission Open
Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations
(This special issue belongs to the Section Cell Methods)
Organelle Contact and Its Physiological Implications submission deadline 31 Dec 2025 | 1 articles | Viewed by 4349 | Submission Open
Keywords: inter-organelle communication; membrane contact sites; organelle dynamics; mitochondria-associated membranes; cellular homeostasis
Understanding Aging Mechanisms to Prevent Age-Related Diseases: 2nd Edition
edited by , Pierre Jouanny, and Sonia Hammami
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3963 | Submission Open
Keywords: aging; age-related diseases; pathophysiology; cell mechanisms; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Cellular and Molecular Mechanisms of Vascular-Related Diseases
edited by and
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3826 | Submission Open
Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system
(This special issue belongs to the Section Cellular Pathology)
The Role of Mitochondria in Cell Development and Regeneration submission deadline 31 Dec 2025 | 1 articles | Viewed by 2745 | Submission Open
Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle
(This special issue belongs to the Section Mitochondria)
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