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Cells
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Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental...
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Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2726

Editors

Dr. Simonetta Masieri

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Guest Editor
Department of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy
Interests: rhinology; ENT; allergology; immunology
Special Issues, Collections and Topics in MDPI journals
Dr. Carlo Cavaliere

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Guest Editor
Department of Sense Organs, Sapienza University, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: rhinology; ENT; allergology; immunology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The nasal mucosa, a critical interface between the external environment and the internal milieu, is a frequent site of inflammatory disorders. This Special Issue of Cells aims to explore the latest advancements and emerging concepts in the understanding of nasal inflammation. We invite submissions that delve into the intricate interplay between diagnostic innovations, the evolving definition of inflammatory endotypes, the coexistence of distinct inflammatory patterns, and the significant role of environmental factors and their changes in shaping the nasal landscape.

This Special Issue will highlight cutting-edge research focusing on, but not limited to, the following: novel diagnostic approaches: innovative techniques and biomarkers for the accurate and early diagnosis of nasal inflammatory conditions; refining inflammatory endotypes: advances in characterizing and classifying the underlying inflammatory mechanisms in the nose; the spectrum of inflammation: investigations into the co-occurrence and interaction of different inflammatory profiles within the nasal mucosa; and environmental influences: studies exploring the impact of environmental factors, including pollutants, allergens, climate change, and the microbiome, on nasal inflammation and disease progression.

You may choose our Joint Special Issue in Medical Sciences.

Dr. Simonetta Masieri
Dr. Carlo Cavaliere
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • rhinology
  • allergy
  • immunology
  • environment
  • pollution
  • microbiome
  • inflammation
  • united airway disease
  • lymphocyte cells
  • interleukins

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Published Papers (1 paper)

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Review

25 pages, 680 KB  
Review
The Oral Microbiota: Implications in Mucosal Health and Systemic Disease—Crosstalk with Gut and Brain
by Vincenzo Miranda, Kamilia Laarej and Carlo Cavaliere
Cells 2026, 15(1), 82; https://doi.org/10.3390/cells15010082 - 4 Jan 2026
Cited by 4 | Viewed by 2331
Abstract
During the last ten years, the scientific community has increasingly acquired greater knowledge of the importance of oral microbiota, in general, for the physical condition of humans. Not only oral diseases, related to oral dysbiosis, are examined, but also several systemic inflammatory degenerative [...] Read more.
During the last ten years, the scientific community has increasingly acquired greater knowledge of the importance of oral microbiota, in general, for the physical condition of humans. Not only oral diseases, related to oral dysbiosis, are examined, but also several systemic inflammatory degenerative diseases induced by this condition. This narrative review aims to shed light on the communication mechanisms between the oral cavity and different mucosal compartments, and to explain how the changes in microorganisms may alter their balance, leading to disease. Many potential pathogenic bacteria can induce oral dysbiosis, among them Porphyromonas gingivalis and Fusobacterium nucleatum are the most explored; however, other bacterial species such as Tannerella forsythia, Treponema denticola, Aggregatibacter actinomycetemcomitans and Filifactor alocis are able to give rise to local and systemic diseases through the release of toxins. The two-way communication system between the gastrointestinal tract and the central nervous system, known as the gut–brain axis, is strongly influenced by the gut microbiota and can ultimately be studied even more broadly and in depth if we consider the influence of the oral microbiota on this axis. Taste receptors’ activity also has a significant role, being able to affect a subject’s food choice by interacting with the microbiota. Qualitative and quantitative alterations in microorganisms existing in the main mucosal compartments may easily lead the host to develop systemic degenerative inflammatory diseases. Full article
(This article belongs to the Special Issue Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts)
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