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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders

edited by Mohamed Eldeeb

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1844 | Submission Open

Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration

(This special issue belongs to the Section Mitochondria)

Novel Insights into Mechanism and Treatment of Degenerative Disc Disease

edited by Yejia Zhang

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1695 | Submission Open

Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury

(This special issue belongs to the Section Cellular Pathology)

Targeting of Cancer Cells with Small Molecule Drugs

edited by

Jannet Kocerha

submission deadline 27 Feb 2026 | Viewed by 135 | Submission Open

Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology

(This special issue belongs to the Section Cellular Pathology)

Ion Channels in Cancer: From Molecular Mechanisms to Therapeutic Targets

edited by Saverio Gentile

submission deadline 27 Feb 2026 | Viewed by 132 | Submission Open

Keywords: ion channels; cancer therapeutic targeting; tumor microenvironment

Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by Kyle Lauren Poulsen

submission deadline 27 Feb 2026 | Viewed by 129 | Submission Open

Keywords: alcohol-associated hepatitis; drug screening; drug delivery; pathophysiology; therapeutics

Role of Extracellular Matrix in Cancer and Disease

edited by

Maurizio Onisto

Marco Franchi

and

Valentina Masola

submission deadline 28 Feb 2026 | 6 articles | Viewed by 16711 | Submission Open

Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling

(This special issue belongs to the Section Cell Microenvironment)

Signaling in Cancer Stem Cells

edited by Upasana Ray

submission deadline 28 Feb 2026 | 3 articles | Viewed by 15732 | Submission Open

Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs

(This special issue belongs to the Section Stem Cells)

The Role of IgE and IgG Antibodies in Allergic Reactions: Cellular Mechanisms and Biological Implications

edited by

Monique Vogel

and

Paul Engeroff

submission deadline 28 Feb 2026 | 3 articles | Viewed by 14028 | Submission Open

Keywords: IgE; IgG; allergy; inflammation; glycosylation; immunotherapy; autoantibodies; Fc receptors; soluble receptors

(This special issue belongs to the Section Cellular Immunology)

The Potential of Induced Pluripotent Stem Cells

edited by Yun Chang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 6651 | Submission Open

Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials

(This special issue belongs to the Section Stem Cells)

Cell Migration and Invasion

edited by Veronika Miskolci

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5994 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 28 Feb 2026 | 3 articles | Viewed by 5053 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application

edited by

Andrea Cruz

and

Carla Carvalho

submission deadline 28 Feb 2026 | 3 articles | Viewed by 4188 | Submission Open

Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics

Membrane Dynamics and the Role of Aquaporins in Plant Cells

edited by

Farzana Sabir

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3865 | Submission Open

Keywords: aquaporins; membrane dynamics; plant cell; water transport; osmoregulation; cell membrane permeability; aquaglyceroporins; stress response; membrane trafficking

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Skeletal Muscle: Structure, Physiology and Diseases

edited by

Vincenzo Sorrentino

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3850 | Submission Open

Keywords: excitation– contraction coupling; store-operated calcium entry; sarcomeric proteins; skeletal muscle metabolism; skeletal muscle diseases; muscle plasticity; development; sarcopenia; aging

(This special issue belongs to the Section Tissues and Organs)

Cell Therapeutics for Corneal Diseases

edited by

Dimitrios Karamichos

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3338 | Submission Open

Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair

(This special issue belongs to the Section Tissues and Organs)

Unconventional T Cells in Health and Disease

edited by Lauren Howson

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3128 | Submission Open

Keywords: MR1-restricted T cells; γ δ T cells; CD1-restricted T cells; unconventional T cells

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition

edited by

Qiwei Yang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2501 | Submission Open

Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome

(This special issue belongs to the Section Cellular Pathology)

Cellular Mechanisms in Oral Cavity Homeostasis and Disease

edited by

Mohamed Mekhemar

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2101 | Submission Open

Keywords: oral cavity; cell signaling; periodontal disease; stem cells; regeneration; inflammation; oral epithelium; tissue homeostasis; immunomodulation; cellular microenvironment

Signal Transduction and Targeted Therapy for Tumors

edited by

Rodolfo Daniel Cervantes-Villagrana

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1839 | Submission Open

Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy

(This special issue belongs to the Section Cell Signaling)

Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis

edited by

Mona Batish

submission deadline 28 Feb 2026 | 3 articles | Viewed by 1511 | Submission Open

Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition

edited by

Paola Palumbo

and Silvano J. Santini

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1323 | Submission Open

Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment

Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology

edited by

Jinu Kim

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1193 | Submission Open

Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms

(This special issue belongs to the Section Tissues and Organs)

Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics

edited by

Aijaz Ahmad John Bhat

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1137 | Submission Open

Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling

(This special issue belongs to the Section Tissues and Organs)

Recent Advances in Microfluidics and Organoids for Biomedical Applications

edited by Lionel Fernel Gamarra

submission deadline 28 Feb 2026 | 2 articles | Viewed by 911 | Submission Open

Keywords: microfluidics; organoids; biomimetic models; organ-on-a-chip; tissue engineering; pharmacology; biosensors; computational modeling; artificial intelligence; nanomedicine; personalized medicine; bioprinting; in silico; induced pluripotent stem cells (iPSCs); mesenchymal and pluripotent stem cells

(This special issue belongs to the Section Tissues and Organs)

Novel Insights into Neuroinflammation and Related Diseases

edited by Tahmineh Mokhtari

submission deadline 28 Feb 2026 | Viewed by 354 | Submission Open

Keywords: neuroinflammation; neuropsychological disorders; neurodegeneration; neuro-immune interactions; glial-neuronal crosstalk; autophagy and apoptosis; cellular and molecular mechanisms; neuroinflammatory biomarkers; imaging techniques; novel therapeutic strategies

(This special issue belongs to the Section Cellular Neuroscience)

Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies

edited by

Asad Jan

and Sara Elfarrash

submission deadline 28 Feb 2026 | Viewed by 284 | Submission Open

Keywords: Parkinson’ s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics

(This special issue belongs to the Section Cellular Aging)

Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms

edited by Tirthadipa Pradhan-Sundd

submission deadline 28 Feb 2026 | Viewed by 264 | Submission Open

Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells

Ocular Surface and Adnexal Diseases: Molecular Mechanisms and Treatment Progresses

edited by

Edit Tóth-Molnár

submission deadline 28 Feb 2026 | Viewed by 224 | Submission Open

Keywords: ocular surface and adnexal diseases; dry eye disease; eyelid diseases; lacrimal gland diseases; molecular mechanisms; therapeutic strategies

The Lipid Metabolism and Signaling in Dry Eye Disease

edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak

submission deadline 28 Feb 2026 | Viewed by 207 | Submission Open

Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms

Microautophagy: The Least Known of the Autophagy Strategies

edited by

Patrice X. Petit

submission deadline 28 Feb 2026 | Viewed by 187 | Submission Open

Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs

(This special issue belongs to the Section Autophagy)

The Role of Pancreatic Beta-Cells in Obesity and Type 2 Diabetes

edited by Mayur Doke, Juan Domínguez-Bendala and Oscar Alcazar

submission deadline 28 Feb 2026 | Viewed by 182 | Submission Open

Keywords: pancreatic beta-cells; GLP-1; obesity; type 2 diabetes; islet biology; beta-cell regeneration; insulin resistance; incretin therapies; single-cell transcriptomics; metabolic stress

Exploring New Treatments: Innovative Strategies Based on the Mechanism and Pathogenesis of Neurodevelopmental Disorders

edited by

Muhammad Nauman Arshad

and

Bruce Carter

submission deadline 28 Feb 2026 | Viewed by 152 | Submission Open

Keywords: rett syndrome; fragile X; GABA; seizures; cognition; Cdkl5 deficiency disorder; motor deficits; developmental delay

Lung Development: Challenges and Opportunities

edited by David Warburton

submission deadline 28 Feb 2026 | Viewed by 151 | Submission Open

Keywords: alveolar gas diffusion surface; alveolar development; injury; repair; and replacement; alveolar stresses and strains; lung microenvironment; tissue engineering in pulmonary regeneration

(This special issue belongs to the Section Tissues and Organs)

Cellular and Molecular Mechanisms in Sepsis: Pathogenesis, Immune Response, and Therapeutic Strategies

edited by

Bogdan Pavel

and

Mingui Fu

submission deadline 28 Feb 2026 | Viewed by 122 | Submission Open

Keywords: sepsis; cytokine signaling; immune cell dynamics; epigenetic regulation; metabolic reprogramming; non-coding RNAs; redox signaling; receptor polymorphisms; systems immunology; single-cell omics

(This special issue belongs to the Section Cellular Pathology)

Molecular Insights into Inherited Metabolic Disorders

edited by Paul Gissen

submission deadline 28 Feb 2026 | Viewed by 118 | Submission Open

Keywords: metabolic disorders; enzyme defects; protein misfolding; metabolic pathways; cellular metabolism; molecular pathology; disease mechanisms; therapeutic targets; organelle dysfunction; metabolic networks

(This special issue belongs to the Section Cellular Metabolism)

The Role of Cell Signaling Pathway Starvation Therapy for Cancer

edited by

Niramol Savaraj

and Min You

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: signaling pathways; nutrient deprivation; starvation therapy; metabolic reprogramming; metabolic pathways

(This special issue belongs to the Section Cell Signaling)

Advanced Cell-Analyzing Technologies and Their Biosensing Applications

edited by

Tiean Zhou

and

Linhong Deng

submission deadline 28 Feb 2026 | Viewed by 84 | Submission Open

Keywords: cell analysis; biosensors; single-cell technologies; microfluidics; organ-on-a-chip; AI-driven biosensing diagnostics; nanotechnology; cell mechanics; cellular function analysis; cell phenotype assays

Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer

edited by

Madalina Anca Moldovan

and

Ciprian Tomuleasa

submission deadline 1 Mar 2026 | 1 articles | Viewed by 605 | Submission Open

Keywords: tumor microenvironment; epithelial– mesenchymal transition (EMT); tumor– stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology

Synaptic Senescence in Health and Neurodegeneration: Cellular and Molecular Mechanisms

edited by

Isabel Martinez-Pena y Valenzuela

submission deadline 9 Mar 2026 | Viewed by 286 | Submission Open

Keywords: synapses; synaptic transmission; aging; senescent synapse; neurodegeneration; synaptic plasticity; glial cells

Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects

edited by

Markus Mandl

submission deadline 10 Mar 2026 | 1 articles | Viewed by 2497 | Submission Open

Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics

α-Synuclein in Parkinson’s Disease

edited by

Maria Ilenia De Bartolo

and

Matteo Costanzo

submission deadline 10 Mar 2026 | 1 articles | Viewed by 804 | Submission Open

Keywords: α -synuclein; protein aggregation; neurodegeneration; Parkinson’ s disease; clinical subtypes; biomarkers; detection techniques; disease heterogeneity; prognostic stratification; translational neuroscience

Targeting Tumor Suppressor Genes for Cancer Therapy

edited by Jogendra Pawar, Smita Kumari and Naseem Akhter

submission deadline 10 Mar 2026 | Viewed by 430 | Submission Open

Keywords: tumor suppressor genes; cancer therapy; gene editing; CRISPR-Cas9; DNA damage repair; oncogenic signaling; immunotherapy; tumor microenvironment; artificial intelligence; personalized medicine

Omics Technologies for Understanding Cell Pathophysiology

edited by

Ciro Isidoro

Annalisa Chiocchetti

and

Alessandra Ferraresi

submission deadline 10 Mar 2026 | Viewed by 422 | Submission Open

Keywords: epigenomics; cytomics; immunomics; exosomics; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Endothelial Dysfunction in Vascular Diseases

edited by Antonio Nesci

submission deadline 10 Mar 2026 | Viewed by 208 | Submission Open

Keywords: endothelial dysfunction; vascular diseases; atherosclerosis; oxidative stress; nitric oxide; hypertension; vascular inflammation; endothelial repair

Neural Governance of Gastrointestinal Motility

edited by Jiande Chen

submission deadline 10 Mar 2026 | Viewed by 189 | Submission Open

Keywords: enteric nervous system; gastrointestinal motility; neural circuitry; neurotransmitter signaling; smooth muscle regulation; neuron– epithelial; organoid models; gut-brain axis; neuro-immune interaction; neuromodulation

Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis III

edited by

Ralf Weiskirchen

submission deadline 15 Mar 2026 | 7 articles | Viewed by 24873 | Submission Open

(This special issue belongs to the Section Tissues and Organs)

Oral Tissue Stem Cells in Regenerative Dentistry

edited by

Jelena Milasin

and

Miloš M. Lazarević

submission deadline 15 Mar 2026 | 6 articles | Viewed by 20645 | Submission Open

Keywords: oral tissue stem cells; oral tissue regeneration; dental materials; stem cell-derived exosomes; stem cell engineering

(This special issue belongs to the Section Stem Cells)

Nanofluidics, Nanopores, and Nanomaterials for Understanding Biology

edited by

Malgorzata A. Witek

submission deadline 15 Mar 2026 | 2 articles | Viewed by 4316 | Submission Open

Keywords: nanofluidics; nanopores; nanomaterials; biology; biochemistry; bioengineering; biotechnology; drug delivery; sequencing; reaction kinetics; single-molecule detection

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Research on Spinal Cord Injury

edited by

Vinnitsa Buzoianu-Anguiano

and

Jörg Mey

submission deadline 15 Mar 2026 | 1 articles | Viewed by 2630 | Submission Open

Keywords: spinal cord injury; growth inhibitory factors; axonal regeneration; neuroprotection; combined therapies; cell trasnplants; regenerative medicine; inhibition scar formation; extracellular matrix molecules

(This special issue belongs to the Section Cellular Pathology)

Host–Pathogen Interactions and Immune Responses

edited by Harish Chandra

submission deadline 15 Mar 2026 | 1 articles | Viewed by 778 | Submission Open

Keywords: multidrug-resistant bacteria; environmental mycobacteria; exosomes; oxidative stress; catalases; antimicrobial resistance; polycyclic aromatic hydrocarbons (PAHs); cellular signaling

(This special issue belongs to the Section Cellular Immunology)

Displaying special issue 151-200 on page 4 of 14.

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