Molecular and Cellular Research on Spinal Cord Injury

Dear Colleagues,

Spinal cord injury (SCI) presents a formidable challenge for recovery due to intrinsic limitations that prevent the regeneration of descending and ascending axons and the re-establishment of functional neuronal connections within the central nervous system (CNS). The primary obstacle is the CNS's low capacity for cell replacement and axonal growth. Several inhibitory mechanisms come into play, significantly restricting the regeneration process. These inhibitory signals are predominantly the result of two critical factors: myelin degradation and the formation of glial and fibrotic scar areas surrounding the injury zone. These factors create a hostile environment for neural repair and functional recovery.

Understanding the cellular and molecular mechanisms underlying these inhibitory processes is crucial for developing therapeutic strategies aimed at promoting regeneration and functional recovery in SCI patients. This Special Issue delves into the latest research and advancements in overcoming these barriers, offering insights into potential therapeutic approaches to enhance CNS recovery post SCI.

Dr. Vinnitsa Buzoianu-Anguiano
Prof. Dr. Jörg Mey
Guest Editors

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