Novel Insights into Neuroinflammation and Related Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 154
Special Issue Editor
Interests: neuroscience; neuroinflammation; neuropsychological disorders; pathway analysis
Special Issue Information
Dear Colleagues,
Neuroinflammation is a critical process in the pathogenesis of neuropsychological disorders, involving complex interactions between glial cells, neurons, and immune mediators. This Special Issue focuses on elucidating the cellular and molecular mechanisms underlying neuroinflammatory responses and their impact on affective and cognitive impairments. We welcome studies employing in vitro, in vivo, and in silico approaches to investigate neuroinflammation at the subcellular, cellular, and intercellular levels, with an emphasis on mechanistic insights.
Contributions should highlight novel experimental methodologies, molecular pathways, and cellular interactions that advance our understanding of neuroinflammation in disorders such as depression, anxiety, schizophrenia, and cognitive decline.
Topics of interest include, but are not limited to, the following:
- Glial–neuronal crosstalk in neuroinflammatory signaling;
- Molecular pathways (e.g., inflammasome activation, cytokine signaling) in affective and cognitive disorders;
- In vitro, in vivo, and in silico models dissecting cellular and molecular mechanisms of neuroinflammation;
- Microglia, astrocytes, and neuronal interactions in neuroinflammation;
- Novel therapeutic strategies targeting neuroimmune mediators (e.g., small molecules, biologics, gene therapy);
- Multi-omics approaches (transcriptomics, proteomics, metabolomics) to identify neuroinflammatory biomarkers;
- Advanced imaging techniques (e.g., super-resolution microscopy, live-cell imaging) for studying neuroinflammation;
- Cellular mechanisms of neuro–immune crosstalk in mood and cognitive dysfunction;
- Mitochondrial dysfunction, autophagy, and apoptosis in neuroinflammatory contexts.
We encourage submissions (original research articles and comprehensive reviews) of experimental in vitro assays and in vivo studies, as well as in silico and computational approaches, to unravel neuroinflammatory mechanisms and therapeutic advances.
Dr. Tahmineh Mokhtari
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neuroinflammation
- neuropsychological disorders
- neurodegeneration
- neuro-immune interactions
- glial-neuronal crosstalk
- autophagy and apoptosis
- cellular and molecular mechanisms
- neuroinflammatory biomarkers
- imaging techniques
- novel therapeutic strategies
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