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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetics and Gene Regulation

edited by

Yujing Li

and

Han Yang

submission deadline 31 Jan 2026 | Viewed by 208 | Submission Open

Keywords: genetics; gene regulation; human diseases

New Trends and Advances in Molecular Targeted Therapy for Cancers

edited by Dhivya Sridaran and

Jeremy M. Crook

submission deadline 31 Jan 2026 | Viewed by 196 | Submission Open

Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody– drug conjugates; combination therapies

(This special issue belongs to the Section Cell and Gene Therapy)

Function of Stress Granules in Normal Cells and in Alzheimer’s Disease

edited by

Paul D. Coleman

and Benjamin Wolozin

submission deadline 31 Jan 2026 | Viewed by 173 | Submission Open

Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases

(This special issue belongs to the Section Cellular Aging)

New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response

edited by

Bernhard Ryffel

submission deadline 31 Jan 2026 | Viewed by 164 | Submission Open

Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors

Aquaporins at the Crossroads of Human Health and Disease

edited by

Anna Patrizia Gena

submission deadline 31 Jan 2026 | Viewed by 161 | Submission Open

Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics

Examining the Cellular Biology of Adenovirus

edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard

submission deadline 31 Jan 2026 | Viewed by 154 | Submission Open

Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome

Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation

edited by

Giuliana Mannino

and

Floriana D'Angeli

submission deadline 31 Jan 2026 | 1 articles | Viewed by 147 | Submission Open

Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics

(This special issue belongs to the Section Stem Cells)

The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders

edited by

Marilena Briglia

Alice Foti

and Adriana C. E. Graziano

submission deadline 31 Jan 2026 | Viewed by 129 | Submission Open

Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation

(This special issue belongs to the Section Cellular Neuroscience)

Role of Oxidative Stress in Cardiovascular Diseases

edited by

Nevena Jeremic

and

Vladimir Jakovljevic

submission deadline 31 Jan 2026 | Viewed by 98 | Submission Open

Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Advances in the Role of Lipid Signaling in Diseases

edited by

Roger Schneiter

and

Neng Wan

submission deadline 5 Feb 2026 | Viewed by 218 | Submission Open

Keywords: lipid signaling; membrane lipid dynamics; autophagy; disease pathology; mitochondria; transcription; protein degradation

Role of Alpha-Synuclein in Neurodegenerative Diseases

edited by

Carmela Conte

submission deadline 10 Feb 2026 | 1 articles | Viewed by 1657 | Submission Open

Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases

(This special issue belongs to the Section Cellular Aging)

Decoding Cellular Organization Through Spatial Omics

edited by Elizabeth Neumann

submission deadline 10 Feb 2026 | Viewed by 181 | Submission Open

Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology

Exclusive Review Papers in Autophagy—Second Edition

edited by

Harald W. Platta

submission deadline 15 Feb 2026 | 4 articles | Viewed by 20495 | Submission Open

Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades

(This special issue belongs to the Section Autophagy)

Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors

edited by

Yoshimasa Tanaka

submission deadline 15 Feb 2026 | 4 articles | Viewed by 15189 | Submission Open

Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells

(This special issue belongs to the Section Cellular Immunology)

State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)

edited by

Xiaohong Zhang

submission deadline 15 Feb 2026 | 4 articles | Viewed by 11336 | Submission Open

Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Molecular Therapeutic Advances for Neurodegenerative Diseases

edited by

Vanessa Castelli

submission deadline 15 Feb 2026 | 3 articles | Viewed by 6118 | Submission Open

Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders

(This special issue belongs to the Section Cellular Aging)

Spotlight on Natural Killer Cells in Immuno-Oncology

edited by

Anahid Jewett

and

Kawaljit Kaur

submission deadline 15 Feb 2026 | 1 articles | Viewed by 3922 | Submission Open

Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells

(This special issue belongs to the Section Cellular Immunology)

Epigenetic Mechanisms of Tumorigenesis

edited by

Hengbin Wang

submission deadline 15 Feb 2026 | 1 articles | Viewed by 2032 | Submission Open

Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine

Cancers and Metabolic Diseases—the Molecular Players in the Game

edited by

T.K.S. Kumar

submission deadline 15 Feb 2026 | Viewed by 153 | Submission Open

Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics

GPCR Signaling in PDA: Calcium, cAMP, and Ras Activation in Pancreatic Ductal Adenocarcinoma

edited by

Thomas Wilkie

submission deadline 15 Feb 2026 | Viewed by 131 | Submission Open

Keywords: G protein-coupled receptor (GPCR); receptor tyrosine kinases (RTK); oncogenic Kras; pancreatic ductal adenocarcinoma (PDA); epigenetic regulation; Wnt and Hedgehog (HH); second messengers (cAMP and intracellular calcium); acinar to ductal metaplasia (ADM); tumor microenvironment; therapeutic drugs list of solicited contributors

Cellular Mechanisms and Therapies of Hematologic Malignancies

edited by Sayantani Sinha and Stanley Chun-Wei Lee

submission deadline 15 Feb 2026 | Viewed by 110 | Submission Open

Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance

(This special issue belongs to the Section Cellular Pathology)

Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease

edited by

Paul M. Epstein

Stefan Brocke

, Michy P. Kelly and Leila Gobejishvili

submission deadline 20 Feb 2026 | 17 articles | Viewed by 54721 | Submission Open

Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction

(This special issue belongs to the Section Cell Microenvironment)

Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications

edited by

Ilaria Martinelli

and Elisabetta Zucchi

submission deadline 20 Feb 2026 | 5 articles | Viewed by 13374 | Submission Open

Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth

edited by Khondoker M. Akram

submission deadline 20 Feb 2026 | 3 articles | Viewed by 8589 | Submission Open

Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth

(This special issue belongs to the Section Cellular Pathology)

Ovarian Cancer and Endometriosis

edited by

Ji-Hye Ahn

and

Jung-Hye Choi

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4687 | Submission Open

Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product

(This special issue belongs to the Section Cellular Pathology)

T Cells in Inflammation and Cancer

edited by

Kihong Lim

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3916 | Submission Open

Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Molecular Mechanisms of Leukemias

edited by

María Hernández Valladares

and Frode Selheim

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2540 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML)

(This special issue belongs to the Section Cellular Pathology)

The Cell Biology of Heart Disease

edited by Rajeshwary Ghosh and

Samreen Sadaf

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2377 | Submission Open

Keywords: cardiomyopathy; endothelial dysfunction; cellular senescence; fibrosis; myocardial infarction; inflammation; mitochondrial dysfunction; CAD; arrhythmia; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

Role of Gene Regulation in Neurological Disorders

edited by

Yujing Li

and Yulin Jin

submission deadline 20 Feb 2026 | 2 articles | Viewed by 2194 | Submission Open

Keywords: gene regulation; neurological disorders; central nervous system (CNS); peripheral nervous system (PNS); Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); autism spectrum disorder (ASD); fragile X syndrome (FXS); fragile X-associated tremor/ataxia syndrome (FXTAS); amyotrophic lateral sclerosis (ALS); multiple sclerosis (MS)

(This special issue belongs to the Section Cell and Gene Therapy)

Current Advances in Plant Gene Regulatory Networks

edited by

Laszlo Kozma-Bognar

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1216 | Submission Open

Keywords: plants; light signaling; circadian clock; thermomorphogenesis; hormonal regulation; a/biotic stress-responsive gene expression; flowering time

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Transient Receptor Potential (TRP) Channels and Health and Disease

edited by Hiroki Kittaka and Makoto Tominaga

submission deadline 20 Feb 2026 | 1 articles | Viewed by 456 | Submission Open

Keywords: Transient Receptor Potential (TRP) channels; cell signaling; cell physiology

Advances in Molecular Research on Cancer Drug Targets and Drug Resistance

edited by

Yuhao Xie

Concettina La Motta

and Rakesh Kumar Srivastava

submission deadline 20 Feb 2026 | Viewed by 352 | Submission Open

Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers

Elucidating Roles of Cell Adhesion Molecules in Health and Disease

edited by Vladimir Sytnyk and

Grant Pfundstein

submission deadline 20 Feb 2026 | Viewed by 213 | Submission Open

Keywords: cell adhesion molecules (CAMs); immunoglobulin superfamily CAMs（IgSF-CAMs); integrins; cadherins; selectins; proteoglycans

Molecular Cell Biology of T Cells in Cancer and Infectious Diseases

edited by

Gustavo P. Amarante-Mendes

and João Viola

submission deadline 20 Feb 2026 | Viewed by 176 | Submission Open

Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism

(This special issue belongs to the Section Cellular Immunology)

Advances in T Cell Targeting for Cancer Immunotherapy

edited by Ryma Toumi

submission deadline 20 Feb 2026 | Viewed by 154 | Submission Open

Keywords: immunotherapy; immune checkpoint blockade; immunosuppressive microenvironment; exhaustion; armored T cells; adoptive cell therapy

Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications

edited by

Simone Patergnani

and

Alberto Danese

submission deadline 20 Feb 2026 | Viewed by 98 | Submission Open

Keywords: autophagy; pathology; physiology; therapy; methods

(This special issue belongs to the Section Autophagy)

Astrocytes: Roles and Functions in the Brain

edited by

Victor Huang

and

Rita Raisman-Vozari

submission deadline 21 Feb 2026 | Viewed by 150 | Submission Open

Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood– brain barrier; brain metabolism; reactive astrocytes; neuron– glia interaction; therapeutic targeting

Recent Advances in Regenerative Dentistry—Second Edition

edited by

Li Xiao

submission deadline 25 Feb 2026 | 6 articles | Viewed by 26379 | Submission Open

Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking

(This special issue belongs to the Section Tissues and Organs)

Natural Products and Their Derivatives Against Human Disease

edited by

Mamunur Rashid

submission deadline 25 Feb 2026 | 6 articles | Viewed by 13056 | Submission Open

Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 25 Feb 2026 | 1 articles | Viewed by 2685 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease

Research on Extracellular Vesicles in Health and Disease

edited by

Maria Concetta Cufaro

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1123 | Submission Open

Keywords: extracellular vesicles; molecular mechanism; biomarker discovery; therapeutics; translational medicine; proteins; DNA and RNA

Molecular, Cellular and Biochemical Approaches of Anti-Cancer Drugs

edited by

Gamaleldin Ibrahim Harisa

submission deadline 25 Feb 2026 | 1 articles | Viewed by 885 | Submission Open

Keywords: anti-cancer drugs; chemosensitizers; multidrug resistance; cellular techniques; nanoparticle delivery; in silico studies; in vivo studies; targeted therapies; cancer progression; bioactive compounds

Remyelination: From Molecular Mechanism to Therapy

edited by

Antonella Ragnini-Wilson

and

Gaetano Barbato

submission deadline 25 Feb 2026 | 1 articles | Viewed by 708 | Submission Open

Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration

Small Molecule Inhibitors: A New Era in Cancer Treatment

edited by

Natarajan Aravindan

Kousalya Lavudi

and Suman Asalla

submission deadline 25 Feb 2026 | 1 articles | Viewed by 481 | Submission Open

Keywords: small-molecule inhibitors; CAR-T cell therapy; immune responsiveness; cancer cell resistance

New Trends and Advances in Induced Neural Cells and iPSC Technologies

edited by

Guoqiang Sun

submission deadline 25 Feb 2026 | Viewed by 184 | Submission Open

Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling

(This special issue belongs to the Section Cellular Neuroscience)

Molecular and Cellular Mechanisms of Ischemic Stroke

edited by Milani Deb-Chatterji

submission deadline 25 Feb 2026 | Viewed by 164 | Submission Open

Keywords: ischemic stroke; neuroinflammation; blood– brain barrier; neurovascular unit; molecular targets for stroke therapy

Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives

edited by Peter Van Endert

submission deadline 25 Feb 2026 | Viewed by 157 | Submission Open

Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy

Molecular Mechanisms of Treatment Resistance in Prostate Cancer

edited by

Christopher J. Ong

submission deadline 25 Feb 2026 | Viewed by 154 | Submission Open

Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance

The Role of the Extracellular Matrix in Tissue Development, Repair, and Disease

edited by