Advances in the Role of Lipid Signaling in Diseases
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 5 February 2026 | Viewed by 33
Special Issue Editors
Interests: membrane homeostasis; lipid droplet biogenesis; lipid transport; sterol export; CAP proteins; fatty acid transport
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipids are fundamental components of biological membranes, and they also act as crucial signaling molecules in diverse biological systems. They exhibit a wide range of chemical properties, cellular distributions, abundances, and biological functions. Signaling lipids include sterols, phosphoinositides, fatty acids, and specific glycerophospholipids such as phosphatidic acid and phosphatidylserine.
Lipid signaling pathways regulate various cellular processes by modulating protein–protein interactions (e.g., the SREBP pathway), protein–lipid interactions (e.g., the PI3K–AKT pathway), and calcium signaling dynamics (e.g., the DAG–IP3 pathway). These pathways are essential for maintaining cellular homeostasis, and their dysregulation is implicated in numerous human diseases, including cancer and neurodegenerative disorders. For instance, mutations in phospholipase C gamma 1 (PLCγ1) are commonly found in several forms of leukemia, especially T-cell malignancies. Elucidating the roles and mechanisms of lipid signaling in disease progression is therefore of significant importance.
This Special Issue explores the following research areas:
- The mechanistic basis by which alterations in lipid signaling affect critical biological processes such as autophagy, transcriptional activation, protein trafficking, mitochondrial metabolism, and ubiquitin mediated degradation;
- The physiological relevance and importance of specific lipid signaling pathways in the context of human disease.
Prof. Dr. Roger Schneiter
Dr. Neng Wan
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lipid signaling
- membrane lipid dynamics
- autophagy
- disease pathology
- mitochondria
- transcription
- protein degradation
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