Elucidating Roles of Cell Adhesion Molecules in Health and Disease
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 20 February 2026 | Viewed by 12
Special Issue Editor
Interests: adhesion; synapse; neurons; axons; dendrites; signaling; synaptic vesicles; neuronal development; learning and memory; synaptic plasticity
Special Issue Information
Dear Colleagues,
Cell Adhesion Molecules (CAMs) are proteins involved in cell-to-cell adhesion and cell-to-extracellular matrix interactions. There are four major groups: immunoglobulin superfamily CAMs（IgSF-CAMs), integrins, cadherins, and selectins. In addition, CAMs that do not belong to the major groups, such as neuroligins, neurexins, or prion proteins, are also involved in mediating the adhesive interactions of cells.
In a healthy organism, CAMs of various families maintain tissue architecture and facilitate tissue remodeling by promoting cell migration and enabling cell-to-cell recognition, being involved in various processes such as embryogenesis, establishment of neuronal connectivity, and inflammatory response.
CAMs' dysregulation contributes to different pathologies including cancer, autoimmune disorders, and neurodegenerative diseases. Changes in CAM expression triggered by pathological processes contribute to the progression of disease in various pathological conditions, such as metastasis in cancer or lesion formation in atherosclerosis. Additionally, mutations in CAMs or copy number variations in CAM-coding genes are linked to genetic disorders, such as leukocyte adhesion deficiency and neurodevelopmental disorders. Understanding CAMs’ dual roles in health and disease offers insights into novel diagnostic and therapeutic strategies.
This Special Issue of Cells will collect the latest research on cell adhesion molecules. We encourage you to contribute by submitting a research article or a review dedicated to cell adhesion molecules and their role in human health and diseases.
Dr. Vladimir Sytnyk
Guest Editor
Manuscript Submission Information
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Keywords
- cell adhesion molecules (CAMs)
- immunoglobulin superfamily CAMs（IgSF-CAMs)
- integrins
- cadherins
- selectins
- proteoglycans
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