Robot-Assisted Surgery for Urologic Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 450

Special Issue Editors


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Guest Editor
1. Department of Urology, Onze-Lieve-Vrouwziekenhuis, Aalst, Belgium
2. ORSI Academy, Melle, Belgium
3. Department of Urology and Division of Experimental Oncology, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy
Interests: prostate cancer

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Guest Editor
Division of Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy
Interests: Erectile dysfunction; prostate cancer; prostate biopsy

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Guest Editor
Gaetano Barresi Department of Human and Paediatric Pathology, Urology Section, University of Messina, Messina, Italy
Interests: kidney cancer; prostate cancer; urothelial cancer

Special Issue Information

Dear Colleagues,

This Special Issue, "Robot-Assisted Surgery for Urologic Cancer", highlights the transformative role of robotic technology in urologic oncology. Robot-assisted surgery has become a cornerstone for treating cancers such as prostate, kidney, and bladder cancers, offering enhanced precision, reduced invasiveness, and superior patient outcomes compared to traditional techniques. This Issue will delve into topics such as technical innovations, an analysis of the outcomes, and the integration of artificial intelligence into robotic systems.

A key focus will be placed on the training and education required to develop surgical expertise, addressing challenges such as steep learning curves, simulator-based training, and accreditation standards for robotic surgeons. Leading experts will also explore cost effectiveness, patient selection criteria, and long-term oncological and functional outcomes. Emerging trends, including single-port robotic surgery and advanced imaging integration, will be examined for their potential to further refine surgical precision. By combining clinical insights with perspectives on training and technological advancements, this Special Issue aims to foster a comprehensive understanding of the clinical, educational, and ethical implications of robot-assisted surgery in urologic oncology, serving as a valuable resource for surgeons, researchers, and healthcare policymakers.

Dr. Gabriele Sorce
Dr. Francesco Pellegrino
Dr. Ettore Di Trapani
Guest Editors

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Keywords

  • robot-assisted surgery
  • urologic oncology
  • minimally invasive surgery
  • prostate cancer surgery
  • kidney cancer surgery
  • bladder cancer surgery
  • robotic platforms
  • robotic surgery training

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Published Papers (1 paper)

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Research

11 pages, 441 KiB  
Article
Adverse In-Hospital Outcomes Following Robot-Assisted vs. Open Radical Prostatectomy in Quadragenarians
by Fabian Falkenbach, Francesco Di Bello, Natali Rodriguez Peñaranda, Mattia Longoni, Andrea Marmiroli, Quynh Chi Le, Calogero Catanzaro, Michele Nicolazzini, Zhe Tian, Jordan A. Goyal, Nicola Longo, Stefano Puliatti, Riccardo Schiavina, Carlotta Palumbo, Gennaro Musi, Felix K. H. Chun, Alberto Briganti, Fred Saad, Shahrokh F. Shariat, Gisa Mehring, Lars Budäus, Markus Graefen and Pierre I. Karakiewiczadd Show full author list remove Hide full author list
Cancers 2025, 17(7), 1193; https://doi.org/10.3390/cancers17071193 - 31 Mar 2025
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Abstract
Background/Objectives: Adverse in-hospital outcomes at radical prostatectomy have not been specifically addressed in young patients aged 40–49 years (quadragenarians). Additionally, no comparison between robot-assisted (RARP) vs. open radical prostatectomy (ORP) has been reported in this population. Methods: Descriptive analyses, propensity score [...] Read more.
Background/Objectives: Adverse in-hospital outcomes at radical prostatectomy have not been specifically addressed in young patients aged 40–49 years (quadragenarians). Additionally, no comparison between robot-assisted (RARP) vs. open radical prostatectomy (ORP) has been reported in this population. Methods: Descriptive analyses, propensity score matching (PSM), and multivariable logistic/Poisson regression models addressed quadragenarians undergoing RARP or ORP within the National Inpatient Sample (2009–2019). Results: Of 5426 quadragenarians, 4083 (75.2%) and 1343 (24.8%) underwent RARP and ORP, respectively. The proportion of RARP increased from 68.1 to 84.5% (2009–2019, EAPC: +2.8%, p < 0.001). Adverse in-hospital outcomes after RARP were invariably lower than those after ORP. Specifically, the rates of overall complications (7.8 vs. 13.4%, Δ −5.6%, multivariable odds ratio (OR): 0.54), blood transfusions (1.2 vs. 6.3%, Δ −5.1%, OR: 0.21), and length of stay (LOS) > 2 days (10.6 vs. 28.7%, Δ −18.1%, OR: 0.32) were lower after RARP than after ORP (all p < 0.001). After additional one-to-one PSM between ORP and RARP patients, virtually the same results were reported (overall complications: 7.0 vs. 13.4%, Δ −6.4%, OR: 0.49; blood transfusion rates: 1.5 vs. 6.3%, Δ −4.8%, OR: 0.23; LOS > 2 days: 10.9 vs. 28.7%, Δ −17.8%, OR: 0.30). Conversely, RARP use resulted in higher total hospital charges (USD 43,690 vs. 36,840, Δ USD +6850, IRR: 1.18; p < 0.001). Conclusions: Quadragenarians exhibited a more favorable adverse in-hospital outcome profile after RARP vs. ORP. These advantages are offset by a small, albeit significant, increase in total hospital charges. Full article
(This article belongs to the Special Issue Robot-Assisted Surgery for Urologic Cancer)
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