Special Issues

Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pheochromocytoma, Paraganglioma and Neuroblastoma: Focus on Genetics—the Never-Ending Story
edited by María Currás-Freixes
submission deadline 30 Sep 2025 | Viewed by 132 | Submission Open
Keywords: hypoxia; treatment; surveillance; metastasis; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Treatment of Hepatopancreatobiliary Cancers: Open Question, Challenge, and Future Directions (2nd Edition) submission deadline 30 Sep 2025 | Viewed by 130 | Submission Open
Keywords: carcinoma; hepatocellular; liver neoplasms; transplant oncology; neoadjuvant and adjuvant therapy; artificial intelligence; cholangiocarcinoma; colorectal and non-colorectal liver metastasis; pancreatic neoplasms
(This special issue belongs to the Section Cancer Therapy)
The Role of Actin Binding Proteins in Cancer Progression
edited by Partha Roy
submission deadline 30 Sep 2025 | Viewed by 122 | Submission Open
Keywords: actin binding proteins; cancer biology; cell migration; angiogenesis; signaling pathways
(This special issue belongs to the Section Cancer Pathophysiology)
Soft Tissue Sarcomas—New Diagnostic and Therapeutic Perspectives Through Clinical Genomic Profiling
edited by and
submission deadline 30 Sep 2025 | Viewed by 103 | Submission Open
Keywords: soft tissue sarcoma; molecular profiling; cancer genomics; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Innovative Strategies and Techniques in Diagnosing, Treating and Surveying Soft Tissue Sarcomas
edited by H. Thomas Temple
submission deadline 30 Sep 2025 | Viewed by 94 | Submission Open
Keywords: sarcoma; soft tissue; pediatric; adult; biopsy; radiography; pathology; radiotherapy; surgery; molecular
(This special issue belongs to the Section Cancer Therapy)
Developments, Challenges and Uncertainties in Delivering Stereotactic Ablative Body Radiotherapy to Solid Tumours
edited by Crispin T. Hiley and Iain Phillips
submission deadline 30 Sep 2025 | Viewed by 22 | Submission Open
Keywords: radiotherapy; oligometastatic cancer; oligoprogressive cancer; SABR
(This special issue belongs to the Section Cancer Therapy)
Radiobiological Modelling in the New Era of Precision Radiation Oncology
edited by
submission deadline 1 Oct 2025 | 4 articles | Viewed by 7371 | Submission Open
Keywords: radiobiological modelling; precision radiation oncology; radiation therapy; cancers
(This special issue belongs to the Section Cancer Therapy)
Skin Cancer: Epidemiology, Management and New Therapies
edited by and Francesco Fortarezza
submission deadline 1 Oct 2025 | 1 articles | Viewed by 1495 | Submission Open
Keywords: skin cancer; melanoma; basal cell carcinoma; squamous cell carcinoma; Merkel cell carcinoma; adnexal tumor; metastatic cutaneous neoplasms; epidemiology; management; therapy
(This special issue belongs to the Section Cancer Therapy)
Updates on Liver Cancer Management
edited by
submission deadline 1 Oct 2025 | 1 articles | Viewed by 1170 | Submission Open
Keywords: laparoscopic liver resection; minimally invasive liver resection; deteriorated liver function; anatomical resection; preoperative simulation; intraoperative navigation; liver metastasis; hepatocellular carcinoma biliary tract cancers; robot-assisted liver resection
(This special issue belongs to the Section Cancer Therapy)
The Role of Chromosomal Instability in Cancer: 2nd Edition
edited by
submission deadline 1 Oct 2025 | 1 articles | Viewed by 763 | Submission Open
Keywords: aneuploidy; cancer evolution; chromothripsis; chromosomal translocation; genome chaos; genome instability; heterogeneity; karyotype coding; polyploid giant cancer cells
(This special issue belongs to the Section Molecular Cancer Biology)
Exploring Immunotherapy in Colorectal Cancer
edited by , Luca Esposito and Chiara Gallio
submission deadline 1 Oct 2025 | Viewed by 178 | Submission Open
Keywords: colorectal cancer; immunotherapy; immune checkpoint inhibitors; mismatch repair; microsatellite instability; biomarkers
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
3D Cultures and Organoids in Cancer Research submission deadline 1 Oct 2025 | Viewed by 166 | Submission Open
Keywords: 3D cell cultures; organotypic 3D cultures; 3D spheroids models; induced pluripotent stem (iPS); organoids; tumoroids
(This special issue belongs to the Section Molecular Cancer Biology)
The Genomic Landscape of Gynecological Cancers
edited by
submission deadline 1 Oct 2025 | Viewed by 88 | Submission Open
Keywords: gynecological cancers; tumor genomics; molecular profiling; precision oncology; targeted therapy; genetic alterations; multi-omics; tumor heterogeneity; biomarker discovery; translational research
(This special issue belongs to the Section Molecular Cancer Biology)
Cellular and Molecular Mechanisms of Medulloblastoma
edited by
submission deadline 1 Oct 2025 | Viewed by 50 | Submission Open
Keywords: medulloblastoma diagnosis and prognostic markers; WNT signaling; SHH signaling; MYC; DNA methylation; medulloblastoma treatment approaches and strategies (chemotherapy; radiation therapy; immunotherapy; and targeted therapy); high-risk medulloblastoma; resistance mechanisms; tumor microenvironment; molecular characteristics of tumor heterogeneity
(This special issue belongs to the Section Molecular Cancer Biology)
Immunometabolic Disorders and Early-Onset Gastrointestinal Cancer: Etiology, Incidence, Survival and Disparities
edited by Yunxia Lu
submission deadline 3 Oct 2025 | Viewed by 110 | Submission Open
Keywords: immunometabolic disorders; early-onset gastrointestinal cancer; cancer etiology; cancer incidence; cancer screening; cancer disparities; cancer survival; type 2 diabetes; diet and nutrition; obesity; autoimmune diseases; metabolic syndrome
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Recent Research on Soft Tissue Sarcomas
edited by
submission deadline 6 Oct 2025 | Viewed by 165 | Submission Open
Keywords: soft tissue sarcoma; chondrosarcoma; Ewing sarcoma; osteosarcoma; precision medicine; emphasizing detection; treatment; surgery; radiologic imaging
(This special issue belongs to the Section Cancer Therapy)
Digital Health Technologies in Oncology submission deadline 10 Oct 2025 | 6 articles | Viewed by 8782 | Submission Open
Keywords: digital healthcare; digital health technologies; diagnosis; wearable devices; rehabilitation technologies; assistive technologies; robotic surgery; (remote) monitoring; precision medicine; data analytics; healthcare teleassistance; AI-driven diagnostics and monitoring; AI-driven analytics
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Ovarian Cancer: Pathogenesis, Molecular Mechanism and Opportunities for Interventions submission deadline 10 Oct 2025 | 1 articles | Viewed by 520 | Submission Open
Keywords: ovarian cancer; pathogenesis; therapy; biomarkers; molecular
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Near-Infrared Photoimmunotherapy for Cancer Treatment: 2nd Edition
edited by
submission deadline 10 Oct 2025 | Viewed by 134 | Submission Open
Keywords: NIR-PIT; phototherapy; monoclonal antibody; imaging biomarker; immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Onco-Nephrology: From Molecular to Clinical Studies submission deadline 12 Oct 2025 | Viewed by 340 | Submission Open
Keywords: acute kidney injury in oncology; chronic kidney disease and cancer; paraneoplastic glomerulonephritis; immunotherapy-related nephrotoxicity; tumor lysis syndrome; nephrotoxicity of chemotherapeutic agents; DNA damage; epigenetic modifications; molecular pathways in cancer-associated kidney injury; biomarkers for early detection of kidney injury
(This special issue belongs to the Section Clinical Research of Cancer)
Cancer and Chronic Illness submission deadline 15 Oct 2025 | 7 articles | Viewed by 14709 | Submission Open
Keywords: cancer; chronic disease; inflammatory disease; cytokines; immune disease; radiotherapy-induced diseases; immunotherapy-induced disease; gastrointestinal chronic disorders; end-stage renal disease; lung cancer chronic disease
(This special issue belongs to the Section Cancer Pathophysiology)
New Precision Medicine Approaches in Haematological Malignancies: Novel Targets and Advanced Therapies (2nd Edition) submission deadline 15 Oct 2025 | 3 articles | Viewed by 9571 | Submission Open
Keywords: blood cancer; cancer relapse; resistance; targeted therapies; immune therapies; metabolism; cancer mutations
(This special issue belongs to the Section Methods and Technologies Development)
Imaging in Breast Cancer Diagnosis and Treatment
edited by and Jacopo Nori Cucchiari
submission deadline 15 Oct 2025 | 5 articles | Viewed by 8325 | Submission Open
Keywords: mammography; breast ultrasound; axillary ultrasound; breast MRI; contrast-enhanced mammography; digital breast thomosynthesis; thermoablation; crioablation
(This special issue belongs to the Section Cancer Therapy)
Treatment of Peripheral T-cell Lymphomas
edited by
submission deadline 15 Oct 2025 | 4 articles | Viewed by 6132 | Submission Open
Keywords: T-cell lymphoma; PTCL; molecular targets; targeted therapy; immunotherapy; combination therapy; biomarker
(This special issue belongs to the Section Tumor Microenvironment)
De-escalation of Axillary and Breast Cancer Surgery in the Setting of Neo-Adjuvant Chemotherapy
edited by Corrado Tinterri and
submission deadline 15 Oct 2025 | 2 articles | Viewed by 3203 | Submission Open
Keywords: breast neoplasm; breast cancer; surgery; breast cancer surgery; systemic therapy; neo-adjuvant chemotherapy; axilla; axillary surgery; sentinel lymph node biopsy; de-escalation surgery
(This special issue belongs to the Section Cancer Therapy)
Targeting Pathogenic Variants in Hereditary Cancer Diagnosis and Screening
edited by Yanhong Liu
submission deadline 15 Oct 2025 | 1 articles | Viewed by 2644 | Submission Open
Keywords: disease susceptibility; prognosis and outcomes; genetic association; genetic epidemiology; germline variants; pathogenic variants; rare variants; exome sequencing; whole genome sequencing; target sequencing
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Recent Advance in Colorectal Cancer Liver Metastases
edited by and Jennifer Kalil
submission deadline 15 Oct 2025 | 2 articles | Viewed by 2477 | Submission Open
Keywords: colorectal cancer liver metastases; histological growth patterns; chemotherapy optimization; liver regeneration; future liver remnant; liquid biopsy; treatment resistance
(This special issue belongs to the Section Cancer Metastasis)
Current Progress in the Clinical Management and Basic Science of Head and Neck Cancer
edited by
submission deadline 15 Oct 2025 | 2 articles | Viewed by 2405 | Submission Open
Keywords: head and neck cancer; immunotherapy; chemoradiotherapy; surgery; molecular biology; oncogenesis; cancer immunology
(This special issue belongs to the Section Clinical Research of Cancer)
First-Line Therapy in Thoracic Oncology
edited by Antonio D'Andrilli and
submission deadline 15 Oct 2025 | 1 articles | Viewed by 1285 | Submission Open
Keywords: thoracic oncology; lung cancer; thymoma; mediastinal tumors
(This special issue belongs to the Section Cancer Therapy)
Endoscopic Management of Pancreatic Neoplasms (2nd Edition)
edited by
submission deadline 15 Oct 2025 | 1 articles | Viewed by 969 | Submission Open
Keywords: pancreatic cancer; pancreatic neoplasm; endoscopic retrograde cholangiopancreatography; endoscopic ultrasound; fine needle aspiration/biopsy; local treatment; biliary stent; biliary drainage; contrast enhancement
(This special issue belongs to the Section Methods and Technologies Development)
Inflammatory Bowel Disease and Cancers
edited by
submission deadline 15 Oct 2025 | 1 articles | Viewed by 833 | Submission Open
Keywords: inflammatory bowel disease; ulcerative colitis; Crohn’ s disease; cancer; malignancy
(This special issue belongs to the Section Cancer Therapy)
Cutaneous Metastases: State-of-the-Art Research and Management
edited by Marios Papadakis and
submission deadline 15 Oct 2025 | Viewed by 246 | Submission Open
Keywords: cutaneous metastases; cancer skin metastasis; metastatic skin lesions; diagnosis of cutaneous metastases; oncology; skin oncology; patient outcomes
(This special issue belongs to the Section Cancer Metastasis)
Head and Neck Cancer Recurrence: Diagnosis, Treatment and Prognosis (2nd Edition)
edited by
submission deadline 15 Oct 2025 | Viewed by 196 | Submission Open
Keywords: head and neck cancer; recurrence; squamous cell carcinoma; HPV; larynx; oral cavity; oropharynx
(This special issue belongs to the Section Cancer Therapy)
Radiomics and Molecular Biology in Glioma: A Synergistic Approach
edited by Anna Luisa Di Stefano and Gianluca Grimod
submission deadline 15 Oct 2025 | Viewed by 113 | Submission Open
Keywords: glioma; radiomics; molecular biology; MRI; PET; genomics; proteomics; liquid biopsy; personalized medicine; prognostic biomarkers
(This special issue belongs to the Section Methods and Technologies Development)
Liquid Biopsy in Cancer 2.0 submission deadline 20 Oct 2025 | 9 articles | Viewed by 21011 | Submission Open
Keywords: circulating biomarkers; clinical utility; circulating tumor DNA; circulating tumor cells; exosomes; circulating RNA; precision medicine
(This special issue belongs to the Section Cancer Therapy)
What’s behind the Scenes? New Insights in Endometrial Cancer Management and Risk Stratification
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 11419 | Submission Open
Keywords: endometrial cancer; molecular classification; surgical staging; surgery; target therapy; gynecologic oncology; precision medicine; immunohistochemistry
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Clinical Treatment of Osteosarcoma
edited by
submission deadline 20 Oct 2025 | 3 articles | Viewed by 7087 | Submission Open
(This special issue belongs to the Section Clinical Research of Cancer)
State-of-the-Art Strategies for Non-Coding RNA Function Detection and Regulation in Cancer submission deadline 20 Oct 2025 | 3 articles | Viewed by 6757 | Submission Open
Keywords: long non-coding RNAs; miRNAs; regulatory non-coding variants; ribodiagnostics; RNA therapeutics; targeted therapy; cancer
(This special issue belongs to the Section Tumor Microenvironment)
Obesity and Cancers
edited by Edward Sauter and Tanya Agurs-Collins
submission deadline 20 Oct 2025 | 4 articles | Viewed by 6628 | Submission Open
Keywords: obesity; cancer; mitigating factors; weight loss; weight gain; obesity interventions
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advanced Research in Oncology in 2025
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 2314 | Submission Open
Keywords: cancer; tumour; oncology
Clinical Applications of Ultrasound in Cancer Imaging and Treatment
edited by Gregory Jan Czarnota
submission deadline 20 Oct 2025 | 1 articles | Viewed by 2196 | Submission Open
Keywords: ultrasound; imaging; CT; MRI; treatment
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Salivary Gland Carcinoma: 2nd Edition
edited by
submission deadline 20 Oct 2025 | 2 articles | Viewed by 2116 | Submission Open
Keywords: salivary gland tumors; head and neck cancer; facial nerve preservation; facial nerve reconstruction; facial nerve sacrifice; parotid cancer; parotidectomy; prognostic factors
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Potential Biomarkers in Immune Checkpoint Inhibitors
edited by Goulnar Kasymjanova
submission deadline 20 Oct 2025 | Viewed by 102 | Submission Open
Keywords: advanced metastatic cancer; personalized immunotherapy; predictive biomarkers; circulating tumor DNA; resistance mechanisms; tumor microenvironment (TME); adverse events; real-world evidence
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Protein Structure and Cancer—2nd Edition submission deadline 20 Oct 2025 | Viewed by 79 | Submission Open
Keywords: protein structure dynamics; structural cancer biology; protein pathways in cancer; structure– function alterations; in silico protein structure prediction; protein interactions; cancer mutations and protein structure alterations
(This special issue belongs to the Section Molecular Cancer Biology)
Cancer Epigenetic Biomarkers: 2nd Edition
edited by
submission deadline 22 Oct 2025 | 1 articles | Viewed by 994 | Submission Open
Keywords: cancer; biomarker; epigenetics; DNA methylation; miRNA; diagnostic biomarkers; pharmacoepigenetics; epigenetic drugs
(This special issue belongs to the Section Cancer Biomarkers)
Prostate Cancer: Contemporary Standards and Challenges submission deadline 23 Oct 2025 | Viewed by 248 | Submission Open
Keywords: prostate cancer; molecular pathogenesis; precision oncology; biomarkers; treatment de-escalation
(This special issue belongs to the Section Cancer Therapy)
New Developments in Adolescent and Young Adult Oncology submission deadline 24 Oct 2025 | 1 articles | Viewed by 1651 | Submission Open
Keywords: adolescent and young adult oncology; epidemiology; health-related quality of life; late effects; survivorship; clinical care
(This special issue belongs to the Section Clinical Research of Cancer)
Radiation Therapy for Brain Tumors
edited by
submission deadline 25 Oct 2025 | 3 articles | Viewed by 8368 | Submission Open
Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife
(This special issue belongs to the Section Cancer Therapy)
Research on Surgical Treatment for Ovarian Cancer
edited by Antonios Apostolos K. Tentes and Theo Panoskaltsis
submission deadline 25 Oct 2025 | 4 articles | Viewed by 4550 | Submission Open
Keywords: ovarian cancer; surgical; cancer treatment
(This special issue belongs to the Section Cancer Therapy)
Prevention, Screening and Early Detection of Cancer
edited by and
submission deadline 25 Oct 2025 | 3 articles | Viewed by 2334 | Submission Open
Keywords: cancer prevention; screening; early detection; risk factors; lifestyle modification; biomarkers; genetic testing; lifestyle interventions; cancer risk factors; liquid biopsy; pan-cancer screening tests
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
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