Development of Hepatitis C Virus-Related Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".
Deadline for manuscript submissions: 15 March 2026 | Viewed by 13
Special Issue Editor
Interests: viral hepatitis; hepatic and extrahepatic manifestations of hepatitis viruses; mixed cryoglobulinemia; lymphoproliferative disorders; mechanisms of viral oncogenesis
Special Issue Information
Dear Colleagues,
Chronic infection with hepatitis C virus (HCV) is a well-established risk factor for hepatocellular carcinoma. However, a growing body of evidence has demonstrated that HCV is also associated with a wide range of non-hepatic malignancies. Epidemiological and clinical studies have linked HCV infection with lymphoproliferative disorders, such as non-Hodgkin lymphoma, as well as certain solid tumors, including those of the pancreas, kidney, and oral cavity.
The mechanisms underlying these associations are multifactorial and may include chronic immune activation, sustained inflammation, and direct oncogenic effects of viral proteins. Understanding the broader oncogenic potential of HCV is essential for developing comprehensive screening, surveillance, and management strategies—especially in the era of direct-acting antivirals (DAAs), where long-term outcomes post SVR remain a key area of investigation.
This Special Issue aims to provide an updated overview of the oncogenic risks associated with HCV, taking into account both hepatic and extrahepatic sites, with a focus on the available pathogenetic data, the clinical relevance of these associations, and their implications for patient care.
Prof. Dr. Anna linda Zignego
Guest Editor
Manuscript Submission Information
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Keywords
- hepatitis C virus (HCV)
- hepatocellular carcinoma (HCC)
- extrahepatic malignancies
- lymphoproliferative disorders
- viral oncogenesis
- chronic inflammation and cancer
- direct-acting antivirals (DAAs)
- cancer surveillance in HCV patients
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