Breast Cancer Survivorship: Challenges and Innovations from Treatment to Long-Term Care

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 2153

Special Issue Editor


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Guest Editor
Laboratory of “Epidemiology of Radiations, Clinical Epidemiology and Cancer Survivorship”, Unit 1018 Centre for Research in Epidemiology and Population Health, National Institute for Medical Research (Inserm), B2M, 39 Rue Camille Desmoulins, 94800 Villejuif, France
Interests: radiation epidemiology; clinical epidemiology; cancer survivorship; breast cancer; radionuclide therapy; cancer treatments late effects; cardiovascular health; second primary cancer; aging

Special Issue Information

Dear Colleagues,

The advancement in screening, early diagnosis, and innovative treatments has significantly improved breast cancer survival rates. Subsequently, according to the World Health Organization, there are currently more than 7.8 million breast cancer survivors worldwide. Despite a good prognosis, breast cancer remains the most common cancer among women globally. Subsequently, the number of breast cancer survivors is expected to rise substantially in the coming decades. However, breast cancer and its treatments are not without late effects, which can impact both the health and well-being of breast cancer survivors.

Indeed, they are particularly vulnerable to life-threatening long-term complications such as cardiovascular complications and secondary primary cancers. Other late effects of breast cancer treatments, such as endocrine dysfunction, neurotoxicity, and societal impacts (such as reduced quality of life, persistent fatigue, and health inequalities), are also suggested but require further investigation. These challenges create a significant burden on both public health systems and economies.

In this Special Issue, we invite original research articles, reviews, and perspectives that deepen our understanding of the late effects of breast cancer treatments and their epidemiology, and potential beneficial interventions in breast cancer survivors. We are interested in a wide range of studies that can also explore the effects of supportive and monitoring care in breast cancer survivors, as well as those that address breast cancer survivors’ well-being, quality of life, and the societal and health inequalities they face.

Dr. Médéa Locquet
Guest Editor

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Keywords

  • breast cancer survivorship
  • cancer treatments
  • late effects: societal impact
  • supportive care
  • psychosocial well-being
  • cancer treatment optimization
  • interventions

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Published Papers (2 papers)

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Research

23 pages, 679 KiB  
Article
Pain Self-Management Behaviors in Breast Cancer Survivors Six Months Post-Primary Treatment: A Mixed-Methods, Descriptive Study
by Kaitlin M. McGarragle, Sunny Zheng, Lucia Gagliese, Doris Howell, Elizabeth Edwards, Cheryl Pritlove, David McCready, Christine Elser, Jennifer M. Jones and Lynn R. Gauthier
Cancers 2025, 17(7), 1087; https://doi.org/10.3390/cancers17071087 - 24 Mar 2025
Viewed by 391
Abstract
Background/Objectives: One-third of breast cancer (BC) survivors experience chronic treatment-related pain (CTP) that requires multimodal management strategies, which may include pain self-management behaviors (PSMBs). Most studies exploring PSMBs focus on patients with advanced cancer, who may differ from survivors in their pain management [...] Read more.
Background/Objectives: One-third of breast cancer (BC) survivors experience chronic treatment-related pain (CTP) that requires multimodal management strategies, which may include pain self-management behaviors (PSMBs). Most studies exploring PSMBs focus on patients with advanced cancer, who may differ from survivors in their pain management needs and access to resources. This mixed-methods study explored PSMBs of survivors of BC, referral sources, and goals for pain relief, and examined the relationship between PSMB engagement and pain intensity/interference. Methods: Survivors of BC who were six months post-treatment completed measures assessing their pain intensity/interference and PSMB engagement. Purposive sampling identified a subset of participants who completed interviews, which were analyzed using thematic analysis. Results: Participants (n = 60) were 60 ± 10 years old. Worst Pain Intensity and Pain Interference were 3.93 ± 2.36 and 2.09 ± 2.11, respectively. Participants engaged in 7 ± 3.5 PSMBs. The most common were walking (76%) and distraction (76%). PSMBs described in the interviews (n = 10) were arm stretching and strengthening exercises, seeking specialized pain management services, and avoidance. Most PSMBs were self-directed or suggested by friends. All pain relief goals were to minimize pain interference. PSMB engagement was not associated with Worst, Least, or Average Pain Intensity (all rs ≤ −0.2, p ≥ 0.05) but was associated with Pain Interference (rs = 0.3, p ≤ 0.01). Conclusions: The survivors of BC engaged in many PSMBs, with varying levels of effectiveness and a varying quality of supporting evidence. Most PSMBs were self-directed and some required intervention from healthcare providers or other people, while others required access to limited specialized pain management services. Full article
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13 pages, 243 KiB  
Article
Evaluating Outcomes for Women with Metastatic Breast Cancer: Palliative Care Consultations, Hospital Charges, and Length of Stay
by Leslie J. Hinyard, Divya S. Subramaniam, Alexandria M. Jenkins, Zachary Timmer and Noor Al-Hammadi
Cancers 2024, 16(22), 3724; https://doi.org/10.3390/cancers16223724 - 5 Nov 2024
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Abstract
Introduction: Women with late-stage metastatic breast cancer are at an increased risk of pain and distress from symptoms and often struggle with associated emotional and financial burden of their disease. Palliative care is known to alleviate symptom burden in patients with end-stage, [...] Read more.
Introduction: Women with late-stage metastatic breast cancer are at an increased risk of pain and distress from symptoms and often struggle with associated emotional and financial burden of their disease. Palliative care is known to alleviate symptom burden in patients with end-stage, terminal diseases but is often underutilized in both inpatient and outpatient settings. The current study aims to investigate the prevalence of palliative care consultation on inpatients with metastatic breast cancer and examine the association between palliative care consultation and length of hospital stay and total hospital charges. Methods: Patients diagnosed with metastatic breast cancer between 1998–2017 were abstracted from the Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Database (NIS). The primary outcome was the presence of a palliative care consultation (PCC) during the inpatient stay. Secondary outcomes were hospital length of stay and total hospital charges. Multivariable logistic regression was used to examine factors associated with the presence of a PCC. The relationship between PCC and hospital length of stay and total hospital charges were investigated using linear regression. Results: 513,509 cases of metastatic breast cancer were identified, 5.7% had a documented in-hospital palliative care encounter. Of those who received PCC, total hospital charges were about USD 5452 less than those who did not receive consultation. Women who received PCC had higher odds of a longer hospital stay. Predictors of PCC were older age, non-White race, and residing in a lower-income ZIP code. Conclusions: Palliative care remains to be an underutilized resource among patients with end-stage metastatic breast cancer. Full article
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