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Prognostic and Predictive Markers in Gynecological Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Biomarkers".

Deadline for manuscript submissions: closed (1 March 2026) | Viewed by 562

Special Issue Editor


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Guest Editor
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada
Interests: breast and gynaecological pathology

Special Issue Information

Dear Colleagues,

Recent advances have led to improvements in the recognition and molecular characterization of tumours of the female genital tract, with the landscape of therapeutic options extending beyond the limited traditional management options. An expanded selection of treatments, including new medications, has been approved, often with companion diagnostic tests. Biomarkers are used for diagnosis, risk stratification, management options, and for the monitoring of progression and recurrence. When advanced treatment options are available, the assessment of biomarkers in gynecological malignancies becomes integral to pathologic assessment, contributing to the growing need for resources and expertise.

For this Special Issue of Cancers, we welcome original and review papers that discuss recent advances in biomarkers relating to gynecological cancer. We are especially keen on papers that provide insight into new and original research methodologies, improved early detection and monitoring strategies, and original treatment approaches. Cancers is a journal focusing on different aspects of oncological care in all tumour types, and this Special Issue is aimed at growing the literature around the topic of biomarkers, which are instrumental to the development of personalized medicine and of healthcare broadly, and to the creation of a cancer-free future.

I look forward to receiving your contributions.

Sincerely,

Dr. Anna Plotkin
Guest Editor

Manuscript Submission Information

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Keywords

  • biomarker
  • gynecological cancer
  • management
  • prognostic marker
  • predictive marker
  • personalized medicine

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Published Papers (1 paper)

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Review

20 pages, 1968 KB  
Review
Squamous Cancers and Precancers of the Vulva: Emerging Diagnostic, Prognostic and Predictive Biomarkers in Pathology
by Somayah Alsolami, Jennifer Ji and Lynn Hoang
Cancers 2026, 18(10), 1518; https://doi.org/10.3390/cancers18101518 - 8 May 2026
Viewed by 275
Abstract
Vulvar squamous cell carcinoma (VSCC) and its precursor lesions are relatively rare malignancies of the gynecologic tract. In recent years, international organizations and pathologic reporting guidelines endorse the subdivision of VSCC into human papillomavirus (HPV)-associated and HPV-independent types. There is also growing evidence [...] Read more.
Vulvar squamous cell carcinoma (VSCC) and its precursor lesions are relatively rare malignancies of the gynecologic tract. In recent years, international organizations and pathologic reporting guidelines endorse the subdivision of VSCC into human papillomavirus (HPV)-associated and HPV-independent types. There is also growing evidence for the further separation of HPV-independent into p53 abnormal and p53 wild-type cancers. Although the diagnosis and subclassification of VSCC is often straightforward, using immunohistochemical markers such as p16 and p53 as surrogate markers for high-risk HPV infection and TP53 mutation respectively, rare and unusual scenarios exist that can complicate VSCC classification. Herein we discuss these challenging scenarios in VSCC classification, as well as emerging VSCC prognostic biomarkers such as cyclin D1. In addition, the pathologic diagnosis of VSCC precursor lesions, particularly those of HPV-independent type, are frequently challenging to distinguish from benign conditions of the vulva. We discuss the recent literature describing the added diagnostic value of immunohistochemical biomarkers p53, CK17, CK13, SOX2, GATA3, GLUT1 and others, which may be particularly helpful when morphology is inconclusive. It is anticipated that with improved VSCC classification and precursor recognition, avenues for more tailored therapeutic strategies and earlier therapeutic intervention can be achieved. Full article
(This article belongs to the Special Issue Prognostic and Predictive Markers in Gynecological Cancers)
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