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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Harnessing the Gut Microbiome to Improve Colorectal Cancer Outcomes
edited by Carole S. Richard
submission deadline 25 Feb 2026 | Viewed by 46 | Submission Open
Keywords: colorectal cancer (CRC); gut microbiome; screening; CRC cells; the gut microenvironment; oncological outcomes
(This special issue belongs to the Section Infectious Agents and Cancer)
Understanding HTLV-1 Induced Cancer: From Molecular Pathways to Treatment Strategies
edited by and Suchitra Mohanty
submission deadline 25 Feb 2026 | Submission Open
Keywords: HTLV-1; adult T-cell leukemia/lymphoma (ATLL); tax protein; HBZ protein; epigenetic regulation; immune evasion; chronic inflammation; host– pathogen interactions; viral oncogenesis; translational research
(This special issue belongs to the Section Infectious Agents and Cancer)
Advances in the Treatment of Gastrointestinal (GI) Cancers
edited by
submission deadline 27 Feb 2026 | Viewed by 63 | Submission Open
Keywords: gastrointestinal cancers; targeted therapy; immunotherapy; precision oncology; biomarkers; molecular mechanisms; tumor microenvironment; resistance to therapy; translational research; clinical trials
(This special issue belongs to the Section Cancer Therapy)
Clinical and Translational Updates in Renal Cell Carcinoma (2nd Edition)
edited by
submission deadline 27 Feb 2026 | Viewed by 50 | Submission Open
Keywords: renal cell carcinoma; RCC; machine cearning; clinical; translational developments
(This special issue belongs to the Section Clinical Research of Cancer)
Application of Imaging in Breast Cancer
edited by , and Chung Wai-Shan
submission deadline 28 Feb 2026 | 6 articles | Viewed by 12921 | Submission Open
Keywords: breast cancer; mammography/tomosynthesis/contrast-enhanced mammography; sonography/contrast-enhanced sonography; magnetic resonance imaging; PET/CT; quantitative imaging; elastography; optical imaging; artificial intelligence; image-guided biopsy
(This special issue belongs to the Section Methods and Technologies Development)
Challenges and Opportunities for Novel Therapeutic Strategies in Pediatric Oncology
edited by and
submission deadline 28 Feb 2026 | 6 articles | Viewed by 10570 | Submission Open
Keywords: antibody-drug conjugate; bispecific antibody; cancer predisposition; CAR T cell; immunotherapy; leukemia; monoclonal antibody; neuroblastoma; pediatric cancer; photoimmunotherapy; precision medicine; sarcoma; translational research; tyrosine kinase inhibitor
(This special issue belongs to the Section Cancer Therapy)
Advances in Bladder Preservation Approaches for Bladder Cancer (2nd Edition)
edited by and Todd A. Yezefski
submission deadline 28 Feb 2026 | 3 articles | Viewed by 6330 | Submission Open
Keywords: bladder cancer; bladder preservation; trimodality therapy; chemoradiation; immunotherapy; intravesical therapy; BCG refractory or unresponsive
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Improving Surgical Care for Patients with Hepatobiliary and Pancreatic Cancers
edited by Christopher B. Nahm and Kai M. Brown
submission deadline 28 Feb 2026 | 2 articles | Viewed by 6152 | Submission Open
Keywords: hepatobiliary; pancreatic; surgery; biomarkers; prognosis; treatment strategy
(This special issue belongs to the Section Cancer Therapy)
Advances in Oncological Imaging (2nd Edition) submission deadline 28 Feb 2026 | 2 articles | Viewed by 4225 | Submission Open
Keywords: oncological imaging; radiomics; deep learning; machine learning; image reconstruction; artificial intelligence; outcome prediction; oncological treatment planning; advanced imaging; personalized medicine
(This special issue belongs to the Section Methods and Technologies Development)
Cervical Cancer: Clinical Feature, Trial and Management
edited by , and Carlo Saccardi
submission deadline 28 Feb 2026 | 2 articles | Viewed by 3873 | Submission Open
Keywords: cervical cancer; diagnosis; minimally invasive surgery; laparoscopy; locally advanced disease; management; treatment; adjuvant chemotherapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
State of the Art and Novelties in Multidisciplinary Approach to Soft Tissue and Bone Sarcomas
edited by Ron Batash, Alberto Crimì, Moshe Schaffer and
submission deadline 28 Feb 2026 | 3 articles | Viewed by 3220 | Submission Open
Keywords: soft tissue sarcoma; bone sarcoma; treatment; diagnosis; radiation therapy; chemotherapy
(This special issue belongs to the Section Cancer Therapy)
Navigating the Landscape of Female Cancers: Recent Discoveries and Treatment Trends
edited by and Giacomo Barchiesi
submission deadline 28 Feb 2026 | 2 articles | Viewed by 2447 | Submission Open
Keywords: female malignancies; breast cancer; gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer
(This special issue belongs to the Section Cancer Therapy)
New Insights into General, Functional and Oncologic Urology
edited by Kajetan Juszczak and
submission deadline 28 Feb 2026 | 2 articles | Viewed by 1609 | Submission Open
Keywords: basic science; experimental models; urological cancer; management innovations; multidisciplinary approaches; treatment outcomes
(This special issue belongs to the Section Clinical Research of Cancer)
Heterogeneity in Intra-Cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications
edited by , Shawn L. Hervey-Jumper and Thiebaud Picart
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1516 | Submission Open
Keywords: glioma; histo-molecular classification; intra-tumoral heterogeneity; inter-tumoral heterogeneity; meningioma; neuro-oncology; neurosurgery
(This special issue belongs to the Section Cancer Metastasis)
Innovative and Personalized Approaches to Improve Patient Outcomes in Gynecological Oncology
edited by Anke Smits and James Dilley
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1480 | Submission Open
Keywords: gynecological cancer; lifestyle; prehabilitation; rehabilitation; survival; quality of life
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Cell Therapy in Hematological Malignancies submission deadline 28 Feb 2026 | 1 articles | Viewed by 1473 | Submission Open
Keywords: cell therapy; immunotherapy; target therapy; hematological malignancies; tumor immunology
(This special issue belongs to the Section Cancer Therapy)
Diagnosis, Staging, and Management for Gynecologic Oncology
edited by
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1246 | Submission Open
Keywords: gynecologic oncology; cancer biology; HPV infection; molecular risk factors; translational medicine; cancer staging systems; radiation therapy; brachytherapy; radioresistance
(This special issue belongs to the Section Cancer Therapy)
Advancements in Technologies for Radiation Biology, Oncology, and Protection
edited by and
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1136 | Submission Open
Keywords: radiation biology; oncology; radiation protection; carcinogenesis; multi-omics; radiomics; radiotherapy; biodosimetry; adverse outcome pathway (AOP); personalized medicine
(This special issue belongs to the Section Cancer Informatics and Big Data)
Immunoediting in Cancer Therapies
edited by Vijay Kumar
submission deadline 28 Feb 2026 | 1 articles | Viewed by 1088 | Submission Open
Keywords: cancer; cancer immunology; immunosurveillance; immunoediting; immunotherapy; immunomodulation; immunometabolism
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Personalized Radiotherapy in Cancer Care (2nd Edition)
edited by and
submission deadline 28 Feb 2026 | 2 articles | Viewed by 1044 | Submission Open
Keywords: predictive biomarkers; treatment-related toxicity; radiation treatments; radiation dose and volume; personalized radiation therapy
(This special issue belongs to the Section Methods and Technologies Development)
MRI and Artificial Intelligence in Oncology: Current Research and Future Directions submission deadline 28 Feb 2026 | 1 articles | Viewed by 630 | Submission Open
Keywords: MRI; AI; radiology; oncology; clinical trials
(This special issue belongs to the Section Methods and Technologies Development)
Advances in the Diagnosis and Treatment of Genitourinary Cancers (2nd Edition)
edited by Piotr Radziszewski and
submission deadline 28 Feb 2026 | 1 articles | Viewed by 619 | Submission Open
Keywords: genitourinary cancer; point-of-care diagnostics; personalized treatment; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Predictive and Prognostic Biomarkers for Response to Neoadjuvant Chemotherapy for Breast Cancer
edited by Tarek M. A. Abdel-Fatah
submission deadline 28 Feb 2026 | 1 articles | Viewed by 609 | Submission Open
Keywords: breast cancer; predictive and prognostic biomarkers; neoadjuvant chemotherapy; HER2-targeting agents; complete pathological response
(This special issue belongs to the Section Cancer Therapy)
Perioperative Care in Gynecologic Oncology: 2nd Edition
edited by Nikolaos Thomakos and
submission deadline 28 Feb 2026 | 1 articles | Viewed by 578 | Submission Open
Keywords: enhanced recovery; ERAS; immunonutrition; prehabilitation; gynecologic oncology; minimally invasive surgery
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Precision Health Care and Interventions in Hereditary Breast and Ovarian Cancer and Lynch Syndrome (2nd Edition)
edited by
submission deadline 28 Feb 2026 | Viewed by 494 | Submission Open
Keywords: breast cancer; ovarian Cancer; lynch Syndrome; precision healthcare
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Clinical Research and Prognosis of HER2-Positive Breast Cancer
edited by
submission deadline 28 Feb 2026 | 1 articles | Viewed by 475 | Submission Open
Keywords: HER2-positive breast cancer; targeted therapy; anti-HER2 therapy; long-term impacts; prognostic
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in PET/CT Application in Urological Cancer
edited by
submission deadline 28 Feb 2026 | Viewed by 262 | Submission Open
Keywords: prostate cancer; urothelial cancer; kidney cancer; diagnosis; staging; treatment; PSMA PET CT; FDG PET CT; CAIX imaging
(This special issue belongs to the Section Cancer Therapy)
MYC Oncogene in Cancer: Cancer Cell Intrinsic and Immune Inhibitory Functions
edited by Wadie Mahauad Fernandez and Konstantinos V. Floros
submission deadline 28 Feb 2026 | Viewed by 164 | Submission Open
Keywords: MYC oncogene; molecular oncology; immuno-oncology; tumor microenvironment
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Choroidal Melanoma: From Treatment to Prognosis
edited by
submission deadline 28 Feb 2026 | Viewed by 153 | Submission Open
Keywords: melanoma; uveal; choroid; treatments; target; immunotherapy; genetics
(This special issue belongs to the Section Molecular Cancer Biology)
Image-Assisted High-Precision Radiation Oncology
edited by He C. Wang
submission deadline 28 Feb 2026 | Viewed by 131 | Submission Open
Keywords: medical imaging; radiation oncology; artificial intelligence; radiomics; adaptation; tumor response
(This special issue belongs to the Section Cancer Therapy)
Advances in Radiotherapy for Gynecological Cancers
edited by Roxolyana Abdah-Bortnyak
submission deadline 28 Feb 2026 | Viewed by 131 | Submission Open
Keywords: gynecological cancer; radiotherapy; brachytherapy; IMRT; SBRT; adaptive radiotherapy; treatment planning; radiomics; toxicity management; quality of life; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Novel Approaches to Machine Learning and Artificial Intelligence in Cancer Research and Care (2nd Edition)
edited by and Chris J. Gibbons
submission deadline 28 Feb 2026 | Viewed by 129 | Submission Open
Keywords: machine learning; deep learning; artificial intelligence; interpretable AI; data quality; metadata; data quality; cancer; MLOps; data science; real-world data
(This special issue belongs to the Section Cancer Informatics and Big Data)
Childhood Acute Lymphoblastic Leukemia
edited by Noriko Satake
submission deadline 28 Feb 2026 | Viewed by 125 | Submission Open
Keywords: childhood acute lymphoblastic leukemia; diagnosis; novel agents; targeted therapy; personalized medicine
(This special issue belongs to the Section Pediatric Oncology)
Risk of Skin Cancer: Non-Melanoma/Melanoma
edited by
submission deadline 28 Feb 2026 | Viewed by 123 | Submission Open
Keywords: melanoma; non-melanoma skin cancer; keratinocyte cancer; Merkel cell carcinoma; UV exposure; immunosuppression; skin cancer prevention
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Mitochondria and Cancer: From Hidden Culprits to Healing Targets submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open
Keywords: mitochondria; mitochondrial dynamics; cancer-associated mitochondrial defects; mitochondrial metabolism
(This special issue belongs to the Section Cancer Pathophysiology)
State-of-the-Art Research on Multiple Myeloma Progression: 2nd Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 84 | Submission Open
Keywords: multiple myeloma; novel targets; novel therapies; molecular therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Drug Resistance Mechanisms and Tumor Microenvironment in Upper Gastrointestinal Cancers
edited by and Heng Lu
submission deadline 28 Feb 2026 | Viewed by 64 | Submission Open
Keywords: drug resistance; tumor microenvironment; gastric cancer; esophageal cancer; immunotherapy; targeted therapy; biomarkers; precision medicine
(This special issue belongs to the Section Tumor Microenvironment)
The Genetics of Head and Neck Squamous Cell Carcinoma submission deadline 28 Feb 2026 | Viewed by 63 | Submission Open
Keywords: head and neck squamous cell carcinoma; tumor genetics; genomic profiling; precision oncology; biomarkers; tumor microenvironment; epigenetics; somatic mutations; molecular pathways; targeted therapies
(This special issue belongs to the Section Molecular Cancer Biology)
Chronic Lymphocytic Leukemia: From Genetics to Therapy submission deadline 28 Feb 2026 | Viewed by 63 | Submission Open
Keywords: chronic lymphocytic; leukemia treatment; biology
(This special issue belongs to the Section Cancer Therapy)
Epigenetic and Chromatin Alterations in Hematologic Malignancies
edited by Mineko Terao and
submission deadline 28 Feb 2026 | Viewed by 61 | Submission Open
Keywords: myelodysplastic syndrome; acute myeloid leukemia; epigenetics; chromatin alterations; leukemogenesis
(This special issue belongs to the Section Cancer Pathophysiology)
Clinical Application of Proton Pencil Beam Scanning Radiotherapy in Cancer
edited by Pavel Vítek
submission deadline 28 Feb 2026 | Viewed by 60 | Submission Open
Keywords: proton radiotherapy; pencil beam scanning; randomized trial; dosimetry; plan robustness; LET— linear energy transfer; RBE— radiobiologic equivalence; lymphocyte; immunologic reaction
(This special issue belongs to the Section Clinical Research of Cancer)
Novel Drugs for Treating Gynecologic Cancers: 2nd Edition submission deadline 28 Feb 2026 | Viewed by 56 | Submission Open
Keywords: gynecological cancers; novel treatment strategies; cytotoxic chemotherapeutic agents; molecularly targeted agents; immune-checkpoint inhibitors
(This special issue belongs to the Section Cancer Drug Development)
Evolution of Cancer Therapies: Access of Developing Countries to Modern Oncology
edited by
submission deadline 28 Feb 2026 | Viewed by 53 | Submission Open
Keywords: conventional cancer therapies; modern oncology; recission medicine; cancer immunotherapy; artificial intelligence; targeted agents; equity and globally equal access
(This special issue belongs to the Section Cancer Therapy)
Neoadjuvant Immunotherapy in Genitourinary Tumors (2nd Edition)
edited by , Nadia Cordua and
submission deadline 28 Feb 2026 | Viewed by 50 | Submission Open
Keywords: immunotherapy; immune checkpoint inhibitor; bladder cancer; urothelial cancer; kidney cancer; renal cell carcinoma; prostate cancer; testicular cancer; penile cancer; adrenocortical carcinoma
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Lung Cancer—Advances in Therapy and Prognostic Prediction
edited by Chinmay T. Jani and Estela Rodriguez
submission deadline 28 Feb 2026 | Viewed by 26 | Submission Open
Keywords: lung cancer; biomarkers; targeted therapies; immunotherapy; precision medicine
(This special issue belongs to the Section Cancer Biomarkers)
AI-Enhanced Radiotherapy in Oncology: Optimization from Planning to Clinical Impact
edited by Christian Fiandra and Linda Rossi
submission deadline 28 Feb 2026 | Viewed by 7 | Submission Open
Keywords: radiotherapy; oncology; artificial intelligence (AI); image segmentation; dose prediction and monitoring; deep learning; treatment planning optimization; adaptive radiotherapy; clinical decision support; personalized cancer treatment
(This special issue belongs to the Section Methods and Technologies Development)
Mechanistic Insights and Therapeutic Advances in the Prostate Tumor Microenvironment
edited by Omar E. Franco
submission deadline 28 Feb 2026 | Viewed by 5 | Submission Open
Keywords: prostate stromal cells; tumor microenvironment; stromal– epithelial interactions; extracellular matrix; tumor immune evasion; metabolic reprogramming; hypoxia; single-cell data analysis; in vitro/in vivo model systems; carcinoma-associated fibroblasts (CAFs)
(This special issue belongs to the Section Tumor Microenvironment)
The Role of Regucalcin in Cancer submission deadline 1 Mar 2026 | 2 articles | Viewed by 2596 | Submission Open
Keywords: cancer suppressor protein; cell signaling; metabolic regulation; transcription factor; cell proliferation; cell death; drug development; cancer therapy
(This special issue belongs to the Section Tumor Microenvironment)
Lynch Syndrome (HNPCC): Symptoms, Causes, and Outlooks
edited by
submission deadline 1 Mar 2026 | Viewed by 513 | Submission Open
Keywords: Lynch syndrome; genotype– phenotype correlation; highly immunogenic frame-shift neo-peptides; immunotherapy; mismatch repair genes; unclassified genetic variants; new role of MMR proteins; miRNAs; functional assay MMR deficiency
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Brain and Spinal Cord Tumors: Symptoms, Diagnosis and Treatment—2nd Edition submission deadline 1 Mar 2026 | Viewed by 75 | Submission Open
Keywords: brain; spinal cord; primary tumors; metastases; imaging; neuro-oncology
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
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