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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sarcoma: Clinical Trials and Management

edited by

Mohammed M. Milhem

and

John Rieth

submission deadline 30 Nov 2025 | 6 articles | Viewed by 6718 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; chemotherapy; immunotherapy; targeted therapy; radiotherapy; pediatric sarcoma; adult sarcoma

(This special issue belongs to the Section Clinical Research of Cancer)

Advancements in Surgical Approaches for Gynecological Cancers

edited by

Anna Myriam Perrone

and

Camelia Alexandra Coada

submission deadline 30 Nov 2025 | 6 articles | Viewed by 5715 | Submission Open

Keywords: gynecological cancers; minimally invasive surgery; advancements in oncological treatments; challenges; survival outcomes; complete surgical resection; management; cytoreduction; negative surgical margins

(This special issue belongs to the Section Cancer Therapy)

Immune Landscape of Renal Cell Carcinoma

edited by

Scott S. Tykodi

and Yuexin Xu

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4244 | Submission Open

Keywords: renal cell carcinoma; solid tumor; immunotherapy; immune checkpoint inhibitor; T cell; tumor microenvironment; biomarkers; tumor antigen; immune surveillance

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3941 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Cell Therapy in Solid Cancers: Current and Future Landscape

edited by Wenwee Ma, Jan Joseph Melenhorst and Li Yin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3688 | Submission Open

Keywords: cell therapy; solid tumors; immunotherapy; CAR-T; NK cell

(This special issue belongs to the Section Cancer Therapy)

Novel Computational Approaches for Molecular Target Discovery in Colorectal Cancer

edited by

Giovanni Crisafulli

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2920 | Submission Open

Keywords: colorectal cancer; genetics; bioinformatics; therapeutic targets; cancer evolution; personalized medicine; patient stratification; technological advancements; precision oncology; big data; computational approach

(This special issue belongs to the Section Methods and Technologies Development)

Novel Advances in Surgery for Prostate Cancer

edited by

Vincenzo De Marco

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2775 | Submission Open

Keywords: prostate cancer; radical prostatectomy; robot-assisted surgery; robotic platform; technology; single port; alternative approaches; focal therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Targeting Tumor Microenvironment in Cancer: An Impact on Therapeutic Efficacy

edited by

Inamul Haque

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2679 | Submission Open

Keywords: VEGF/VEGFR-targeted therapy; immune checkpoint blockade; recent advances and challenges in tumor microenvironment targeting; targeting cancer stem cells; tumor microenvironment and its therapeutic implications; microbiome

(This special issue belongs to the Section Cancer Therapy)

Growth Factors and Receptor Tyrosine Kinases in Development, Regeneration, and Tumorigenesis: 2nd Edition

edited by

Carl-Henrik Heldin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2132 | Submission Open

Keywords: receptor; tyrosine kinase; growth factor; signal transduction; development regeneration tumorigenesis

(This special issue belongs to the Section Molecular Cancer Biology)

Enhancing Precision in Cancer Treatment: AI-Driven Innovations in Imaging

edited by Andra Valentina Krauze

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1989 | Submission Open

Keywords: precision medicine; artificial intelligence; medical imaging; cancer treatment; AI-driven innovations

(This special issue belongs to the Section Methods and Technologies Development)

New and Future Focused Therapies for Thyroid Cancer

edited by

Alessandro Antonelli

, Poupak Fallahi, Silvia Martina Ferrari and Giusy Elia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1288 | Submission Open

Keywords: aggressive differentiated thyroid carcinoma; anaplastic thyroid cancer; tyrosine kinase inhibitors; immunotherapy; personalized medicine

(This special issue belongs to the Section Cancer Therapy)

Advances in Castration-Resistant Prostate Cancer Treatment

edited by

Eswar Shankar

and

Balaji Chandrasekaran

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1219 | Submission Open

Keywords: androgen receptor; CRPC; chemoresistance; combination therapy; small molecules; chemoprevention; ubiquitination

(This special issue belongs to the Section Cancer Therapy)

Molecular Pathways in Cancers (2nd Edition)

edited by

Ion Cristóbal

and

Marta Rodríguez Moreno

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1207 | Submission Open

Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

Tissue-Agnostic Drug Development in Cancer (2nd Edition)

edited by Shivaani Kummar and

Kyaw Thein

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1182 | Submission Open

Keywords: tissue-agnostic drug development; pembrolizumab; microsatellite instability-high (MSI-H); tumor mutational burden-high (TMB-H); dostarlimab-gxly; larotrectinib; entrectinib; neurotrophic tyrosine kinase (NTRK)-fusion-positive solid tumors; dabrafenib and trametinib; selpercatinib; rearranged during transfection (RET) gene fusion; precision medicine

(This special issue belongs to the Section Cancer Drug Development)

Evolution of B-Cell Malignancy Therapy and Treatment Resistance: Where Are We Headed? (2nd Edition)

edited by Jianguo Tao, Jeffrey W. Craig and Michael E. Williams

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1071 | Submission Open

Keywords: B-cell malignancy; drug resistance; novel therapy; TME; chemoimmunotherapy; targeted agents; immunotherapeutic approaches

(This special issue belongs to the Section Cancer Therapy)

Surgery in Metastatic Cancer (2nd Edition)

edited by

Ulrich Ronellenfitsch

submission deadline 30 Nov 2025 | 1 articles | Viewed by 662 | Submission Open

Keywords: metastatic cancer; surgery; metastasectomy; indication; timing

(This special issue belongs to the Section Cancer Therapy)

Calcium Signaling in Cancer Cell Progression

edited by

Amantini Consuelo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 612 | Submission Open

Keywords: interorganellar Ca2+ communication; membrane contact sites; tumor progression; intracellular Ca2+ flux; cation channels; calcium dysregulation; cell fate; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in the Surgical Treatment of Spinal Tumors

edited by Daniel Lubelski

submission deadline 30 Nov 2025 | 1 articles | Viewed by 541 | Submission Open

Keywords: spinal tumors; spinal metastases; minimally invasive spine surgery; radiosurgery; histology-specific treatment; prognostic modeling; machine learning; deep learning; spinal reconstruction; quality of life

(This special issue belongs to the Section Cancer Therapy)

The Advance of Clinical Therapy and Prognosis in Gastrointestinal Cancer

edited by Liliana Streba and Michael Schenker

submission deadline 30 Nov 2025 | 1 articles | Viewed by 432 | Submission Open

Keywords: gastrointestinal cancer; tumorigenesis; microbiome; early detection; molecular mechanisms; personalized medicine; novel therapeutics; translational research; clinical application; diagnostic innovations

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advances in the Molecular Genetics of Sarcomas

edited by Wei Jiang

submission deadline 30 Nov 2025 | Viewed by 401 | Submission Open

Keywords: sarcoma; bone and soft tissue; molecular genetics; molecular pathology; classification

(This special issue belongs to the Section Molecular Cancer Biology)

Surgical Treatment of Abdominal Tumors

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 30 Nov 2025 | Viewed by 363 | Submission Open

Keywords: abdominal; abdominal wall; tumors; surgery; cancer; malignancy; oncology; intraperitoneal; extraperitoneal

(This special issue belongs to the Section Clinical Research of Cancer)

Mesothelioma: Diagnosis and Therapy

edited by Avinash Aujayeb

submission deadline 30 Nov 2025 | Viewed by 246 | Submission Open

Keywords: malignant pleural mesothelioma; diagnostics; immunotherapy treatment; surgical treatments; intrapleural therapy

(This special issue belongs to the Section Cancer Therapy)

Targeted Therapies in Pancreatic Cancer—Current Landscape and Future Directions

edited by Yongwoo Dave Seo

submission deadline 30 Nov 2025 | Viewed by 233 | Submission Open

Keywords: pancreatic cancer; precision oncology; targeted therapies; immunotherapy; KRAS inhibitors; novel clinical trial design

(This special issue belongs to the Section Cancer Therapy)

Epigenetics in Cancer and Drug Therapeutics

edited by Bethsebie Sailo and Anup R. Sharma

submission deadline 30 Nov 2025 | Viewed by 210 | Submission Open

Keywords: cancer epigenetics; chromatin remodeling complexes; histone modifiers; DNA methylation; molecular target; cancer therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical Efficacy of Drug Therapy in Gastrointestinal Cancers

edited by

Francesco Tonelli

and

Enrico Mini

submission deadline 30 Nov 2025 | Viewed by 209 | Submission Open

Keywords: classical chemotherapy; targeted therapeutics; immunotherapy; adjuvant therapy; neoadjuvant therapy; induction therapy; multidisciplinary treatments; gastric cancer; colorectal cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Non-Coding RNAs and Extracellular Vesicles in Cancer Crosstalk: Diagnostic and Therapeutic Implications 2nd Edition

edited by

Simona Taverna

and

Giuseppe Cammarata

submission deadline 30 Nov 2025 | Viewed by 192 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer; inflammation; non-coding RNA; microRNAs; circular-RNAs; PIWI-RNAs; lnc-RNAs

(This special issue belongs to the Section Cancer Therapy)

Disparities in Thoracic Oncology Patients

edited by Jeffrey B. Velotta and

Nestor Villamizar

submission deadline 30 Nov 2025 | Viewed by 190 | Submission Open

Keywords: lung cancer; disparities; thoracic oncology

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Approaches in Modulating Transcription Factors for Cancer Therapy 2nd Edition

edited by

Sarah Walker

submission deadline 30 Nov 2025 | Viewed by 153 | Submission Open

Keywords: transcription factors; cancer treatment; degraders; inhibitors

(This special issue belongs to the Section Cancer Therapy)

Advances in Targeted Therapies in Cancer (2nd Edition)

edited by

Bulent Ozpolat

submission deadline 30 Nov 2025 | Viewed by 146 | Submission Open

Keywords: targeted therapy; cancer; antibody therapy; small molecule inhibitor; RNAi therapy; cell-based therapy

(This special issue belongs to the Section Cancer Therapy)

New Insights into Cancer Immunotherapy: From Immune Cell to Clinical Practice

edited by Xiaotong Song

submission deadline 30 Nov 2025 | Viewed by 141 | Submission Open

Keywords: T cell therapy; cancer immunotherapy; CAR T cells; immune checkpoint modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Radiotherapy for Head and Neck Squamous Cell Carcinoma (2nd Edition)

edited by Cesare Guida and Ida D'Onofrio

submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open

Keywords: head and neck squamous cell carcinoma; radiotherapy; biomarker; chemoradiotherapy; head and neck cancers

(This special issue belongs to the Section Cancer Therapy)

Gastric Cancers: Molecular Mechanisms, Novel Targets and Immunotherapies: From Bench to Clinical Therapeutics (2nd Edition)

edited by

Shumei Song

and

Jaffer A. Ajani

submission deadline 30 Nov 2025 | Viewed by 122 | Submission Open

Keywords: novel oncogene targets; interplay among cancer; stroma; and immune cells; tumor microenvironment (TME); immune biomarker; immunotherapy; new therapeutic modality; translational research; clinical trials

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical and Surgical Therapy for Colorectal Cancer

edited by Laura Koskenvuo

submission deadline 30 Nov 2025 | Viewed by 106 | Submission Open

Keywords: colorectal cancer; rectal cancer; anterior resection; minimally invasive surgery; robotic surgery; surgical oncology; neoadjuvant therapy; adjuvant therapy; quality of life; gut microbiome

(This special issue belongs to the Section Cancer Therapy)

Epstein-Barr Virus-Associated Cancers: From Pathogenesis to Treatment (2nd Edition)

edited by

Kwok-Wai Lo

submission deadline 30 Nov 2025 | Viewed by 106 | Submission Open

Keywords: EBV; lymphomas; Burkitt lymphoma; Hodgkin lymphoma; NK/T cell lymphoma; nasopharyngeal carcinoma; gastric cancer; biomarkers; immunotherapy; targeted therapy

(This special issue belongs to the Section Infectious Agents and Cancer)

PET/CT in Radiation Oncology

edited by Gurdip Azad and

Gary Cook

submission deadline 30 Nov 2025 | Viewed by 94 | Submission Open

Keywords: PET-CT; radiation oncology; theranostics; artificial intelligence; personalised care; tumour volume delineation; adaptive radiotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Image Analysis and Machine Learning in Cancers: 2nd Edition

edited by

Helder C. R. De Oliveira

and

Arianna Mencattini

submission deadline 30 Nov 2025 | Viewed by 91 | Submission Open

Keywords: cancer detection and diagnosis system; machine learning; deep learning; medical imaging analysis; few-shot deep learning; attention segmentation; feature extraction; probabilistic models; explainability; image fusion; generative adversarial network

(This special issue belongs to the Section Methods and Technologies Development)

Integrin Beta-1 Signaling in Cancers

edited by Adama Sidibé and Bernhard Wehrle-Haller

submission deadline 30 Nov 2025 | Viewed by 87 | Submission Open

Keywords: integrin beta-1; cancer cell; tissue stroma; fibrosis; talin-1; paxillin; kinases; acetyltransferases; FAK; SRC kinase; SFK; cell proliferation; adhesion; migration; drug resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Nanoparticle and Exosome Technology for Delivery of Payloads in CNS Tumors

edited by

Ali S. Arbab

submission deadline 30 Nov 2025 | Viewed by 55 | Submission Open

Keywords: glioblastoma; brain metastasis; nanoparticles; exosomes; viral therapy; delivery of payload; imaging probes

(This special issue belongs to the Section Cancer Drug Development)

In Vitro and In Vivo Pharmacology for Glioma Drug Discovery

edited by

Anna Bielecka-Wajdman

submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open

Keywords: pre-clinical modern in vitro /in vivo glioma models; complementary glioma therapy; immunotherapy in glioma; inhibition of glioma recurrence

(This special issue belongs to the Section Cancer Drug Development)

Tumor Microenvironment in Primary Liver Cancer 2nd edition

edited by

Stefania Mantovani

and

Barbara Oliviero

submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open

Keywords: liver cancer; hepatocellular carcinoma; cholangiocarcinoma; tumor immunology; immune system; tumor microenvironment; NK cells; cancer-associated fibroblast; extracellular vesicles; secretome

(This special issue belongs to the Section Tumor Microenvironment)

Gastrointestinal and Its Associated Malignancies: Diagnosis, Targets and Therapies

edited by Ganji P. Nagaraju and

Seema Kumari

submission deadline 1 Dec 2025 | 3 articles | Viewed by 3569 | Submission Open

Keywords: GI cancers; oncogenesis; diagnosis; target identification; biomarkers; therapy

(This special issue belongs to the Section Cancer Therapy)

Post-transcriptional Regulation of Cancer-Related Processes

edited by

Cyril Sobolewski

submission deadline 1 Dec 2025 | 1 articles | Viewed by 2559 | Submission Open

Keywords: microRNAs; long-non-coding RNA; RNA-binding proteins; stress granules; P-bodies

(This special issue belongs to the Section Tumor Microenvironment)

Clinical Studies in Gastrointestinal Malignancies

edited by

Ulrich Ronellenfitsch

submission deadline 1 Dec 2025 | 3 articles | Viewed by 1753 | Submission Open

Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Latest Breakthroughs in Tumor Immune Microenvironment: From Cellular Discovery to Cutting-Edge Technology

edited by

Ira-Ida Skvortsova

Johjong Huang

and

Hsin-Hua Lee

submission deadline 5 Dec 2025 | 4 articles | Viewed by 9059 | Submission Open

Keywords: tumor microenvironment; natural food extracts; molecular markers; abscopal effect; RT technology; prognosis; side effects and abscopal effects

(This special issue belongs to the Section Tumor Microenvironment)

Mesothelioma—from Diagnosis to Treatment

edited by

Nobukazu Fujimoto

submission deadline 5 Dec 2025 | 3 articles | Viewed by 6815 | Submission Open

Keywords: asbestos; BAP-1; CAR-T; CTLA-4; immunotherapy; mesothelioma; PD-1; PD-L1

(This special issue belongs to the Section Cancer Therapy)

NK Cells in the Tumor Microenvironment: Immunosuppressive Mechanisms and Therapy

edited by

Alexander Barrow

and Julian Vivian

submission deadline 5 Dec 2025 | 2 articles | Viewed by 1667 | Submission Open

Keywords: immunosuppression; activation; inhibition; receptor; NK-CAR; checkpoint; adoptive cell therapy; immunotherapy; tumor microenvironment; nanoparticles

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical Research on Thoracic Cancer

edited by

Yuichi Saito

and Hiroyuki Adachi

submission deadline 6 Dec 2025 | 1 articles | Viewed by 574 | Submission Open

Keywords: thoracic cancer; lung cancer; thymic cancer; malignant mesothelioma; radiotherapy; surgery; chemotherapy; immunotherapy; driver mutation

(This special issue belongs to the Section Clinical Research of Cancer)

Preclinical and Clinical Research on the Efficacy of Anticancer Drugs

edited by Andrzej Hellmann, Joanna Jakobkiewicz-Banecka and Jan Lica

submission deadline 10 Dec 2025 | 2 articles | Viewed by 3146 | Submission Open

Keywords: clinical trials; preclinical research; anticancer drugs; drug efficacy; drug development; cancer therapy; therapeutic strategies; safety assessment; pharmacodynamics; pharmacokinetics

(This special issue belongs to the Section Clinical Research of Cancer)

New Advances in Oncology Research and Practice

edited by

Dumitru A. Iacobas

submission deadline 10 Dec 2025 | Viewed by 792 | Submission Open

Keywords: cancer bioinformatics; cancer biology; cancer diagnosis; cancer genomics; cancer immunotherapy; corona virus and cancer; cancer molecular mechanisms; organ-specific cancers; palliative cancer care

(This special issue belongs to the Section Cancer Therapy)

The Impact of Treatment Resistance in Prostate Cancer

edited by

Noel Andrew Warfel

submission deadline 10 Dec 2025 | Viewed by 101 | Submission Open

Keywords: prostate cancer; treatment resistance; progression; drug target; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 651-700 on page 14 of 22.

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