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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Radiation Therapy for Head and Neck Cancer: 2nd Edition

edited by

Vassilis Kouloulias

submission deadline 31 Oct 2026 | Viewed by 188 | Submission Open

Keywords: adaptive radiotherapy; hyper- and hypo-fractionated radiotherapy; artificial intelligence in radiotherapy for head and neck cancer; quality assurance and set-up errors associated with IMRT, VMAT, IGRT, and SGRT techniques; protons and heavy ions for radiotherapy; re-irradiation; nanoparticles plus radiotherapy; hyperthermia plus radiotherapy; radiotherapy plus immunotherapy; the de-escalation of radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Pathological and Molecular Insights into Urothelial Carcinoma

edited by Gabriela M. Quiroga-Garza,

Maedeh Mohebnasab

and Dimitrios Korentzelos

submission deadline 31 Oct 2026 | Viewed by 179 | Submission Open

Keywords: bladder cancer; urothelial carcinoma; diagnosis; histopathology; molecular; genomics; biomarkers; prognosis; immunotherapy

Nutritional Strategies Across the Cancer Continuum: Prevention, Therapeutic Intervention, Support, and Survivorship

edited by

Ananya Gupta

submission deadline 31 Oct 2026 | Viewed by 170 | Submission Open

Keywords: cancer prevention; clinical nutrition; malnutrition and cachexia; sarcopenia and nutrition; dietary patterns as cancer therapy; treatment-related sensory changes; cancer survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Development and Application of Imaging Biomarkers in Cancer: 2nd Edition

edited by

Abhishek Mahajan

submission deadline 31 Oct 2026 | Viewed by 167 | Submission Open

Keywords: imaging biomarkers; oncology; cancer imaging; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Computational Multi-Omics in Liquid Biopsy: Integrating Tumor and Immune Signals for Precision Oncology

edited by

Giovanni Crisafulli

submission deadline 31 Oct 2026 | Viewed by 165 | Submission Open

Keywords: liquid biopsy; minimal residual disease (MRD); circulating tumor DNA (ctDNA); immunogenomics; tumor evolution; ultra-low frequency variant detection; computational oncology; error modeling and noise suppression; clonal hematopoiesis; longitudinal molecular monitoring; tumor/immune system coevolution

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Prevention, Diagnosis, and Therapy for Cervical and Vulvar Cancer

edited by

Dirk Michael Forner

submission deadline 31 Oct 2026 | Viewed by 163 | Submission Open

Keywords: vulvar carcinoma; cervical intraepithelial neoplasia; surgical management; colposcopy; lymph node management; molecular classification; sentinel lymph node procedure; HPV infection and prevention

Genetic, Epigenetic and Protein Biomarkers in Gynaecological and Breast Cancers

edited by

Apriliana Kartikasari

submission deadline 31 Oct 2026 | Viewed by 157 | Submission Open

Keywords: gynecological cancers; breast cancer; cancer biomarkers; genetic biomarkers; epigenetic biomarkers; protein biomarkers; microRNA (miRNA); cancer screening; early diagnosis; prognosis; disease monitoring; treatment stratification; therapeutic response; biomarker discovery; biomarker detection methods; translational research

(This special issue belongs to the Section Cancer Biomarkers)

Artificial Intelligence in Cancer Prevention and Control

edited by Syed Nabeel Zafar

submission deadline 31 Oct 2026 | Viewed by 155 | Submission Open

Keywords: artificial intelligence; machine learning; cancer continuum; low-resource settings; health equity; low- and middle-income countries; global health; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Research in Gynecological Cancers

edited by

Federica Perelli

submission deadline 31 Oct 2026 | Viewed by 155 | Submission Open

Keywords: gynecologic oncology; hereditary cancer syndrome; BRCA mutation; gynecologic surgery; gynecologic ultrasound; gynecologic oncology prevention; molecular biomarkers; minimally invasive surgery; STIC (serous tubal intraepithelial carcinoma); ovarian cancer; fertility-sparing surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Immune Therapies for Hematological Malignancies

edited by Mohammad S. Hossain

submission deadline 31 Oct 2026 | Viewed by 150 | Submission Open

Keywords: hematological malignancies; immunotherapy; bone marrow transplantation; graft-versus-host disease (GVHD); CAR T-cell therapy; immune checkpoint inhibitors; bispecific monoclonal antibodies; cytomegalovirus (CMV) infection; antigen–antibody interactions

(This special issue belongs to the Section Cancer Therapy)

Advances in MRI Applications for Neuro-Oncology

edited by

Siamak P. Nejad-Davarani

submission deadline 31 Oct 2026 | Viewed by 147 | Submission Open

Keywords: brain tumors; magnetic resonance imaging; MRI field strength; quantitative MRI; radiomics; imaging biomarkers

Molecular Biology for Germ Cell Tumors

edited by

Shi-Ming Tu

submission deadline 31 Oct 2026 | Viewed by 145 | Submission Open

Keywords: germ cell tumors; intratumoral heterogeneity; cancer stem cells; somatic transformation; extragonadal germ cells; subsequent malignant neoplasms

(This special issue belongs to the Section Molecular Cancer Biology)

Mechanisms of Resistance and Response to Immune Checkpoint Inhibitors in Squamous Cell Carcinomas

edited by

Dan Yaniv

and

Aviram Mizrachi

submission deadline 31 Oct 2026 | Viewed by 144 | Submission Open

Keywords: immune checkpoint inhibitors; immunotherapy resistance; squamous cell carcinoma; tumor microenvironment; tumor–immune interactions; immune evasion mechanisms; biomarkers of immunotherapy response; tumor–host interactions neuro-immune signaling; tumor metabolism and immunity

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Applications of High-Throughput Technologies in Cancer

edited by Timothy P. Spicer and

Rolf Renne

submission deadline 31 Oct 2026 | Viewed by 143 | Submission Open

Keywords: solid tumors; high throughput screening (HTS); artificial intelligence; drug discovery; antibody–drug conjugates (ADCs); CAR T cells; bispecific T cell engagers (BiTEs)

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Skull Base Tumor Surgery: From Diagnosis to Minimally Invasive Treatment

edited by James P Chandler and

Ahmad Pour Rashidi

submission deadline 31 Oct 2026 | Viewed by 137 | Submission Open

Keywords: skull base tumors; minimally invasive neurosurgery; advanced imaging; molecular diagnostics; cranial base reconstruction; targeted therapies; radiosurgery; precision medicine

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Diagnostic and Therapeutic Approaches in Hepato-Pancreato-Biliary Cancer

edited by

Timothy M. Pawlik

submission deadline 31 Oct 2026 | Viewed by 135 | Submission Open

Keywords: cholangiocarcinoma; intrahepatic; resection; targeted therapy; chemotherapy; outcomes

(This special issue belongs to the Section Cancer Therapy)

Progress in Skin Cancer: Diagnostics, Therapy, and Outcomes

edited by Marco Ardigo and Francesco Piscazzi

submission deadline 31 Oct 2026 | Viewed by 131 | Submission Open

Keywords: skin cancer; dermoscopy; reflectance confocal microscopy (RCM); line-field confocal optical coherence tomography (LC-OCT); non-invasive diagnostics; systemic therapy; locally advanced skin cancer; minimally invasive treatments; tumor prediction; clinical outcomes

Hepatocellular Carcinoma—from Molecular Insight to Surgical Strategy

edited by

Marcos Perini

submission deadline 31 Oct 2026 | Viewed by 120 | Submission Open

Keywords: hepatocellular carcinoma (HCC); clinical diagnosis; molecular biology; biomarkers; surgical strategy; liver transplantation; prognosis

From Metronomic Chemotherapy to Time-Optimized Cancer Treatments

edited by

Piotr J. Wysocki

submission deadline 31 Oct 2026 | Viewed by 116 | Submission Open

Keywords: metronomic chemotherapy; time-dependent treatment; chemotherapy; immunotherapy; pharmacokinetics; pharmacodynamics

Innovations in Pathological and Clinical Research in Colorectal Cancer

edited by

Seiichi Shinji

and

Toshiyuki Ishiwata

submission deadline 31 Oct 2026 | Viewed by 113 | Submission Open

Keywords: colorectal cancer; clinicopathological prognostic biomarkers; pathology-guided therapeutic strategies

Beyond Breast Cancer—Rehabilitation for Survivorship

edited by

Elisabeth Kenne Sarenmalm

and

Jenny Nyqvist-Streng

submission deadline 31 Oct 2026 | Viewed by 108 | Submission Open

Keywords: breast cancer; rehabilitation; person-centered: clinical follow-up; physiotherapy; psycho-social support; existential support; patient education and self-management

Biliary Tract Cancer: Challenges and Strategies in Centralizing Care for Rare Tumors

edited by Angela Lamarca

submission deadline 31 Oct 2026 | Viewed by 107 | Submission Open

Keywords: biliary tract cancer; centralization of care; recommendations

Optimizing Breast Cancer Treatment: Integration of Systemic Therapy, Surgical Innovation, and De-Escalation Strategies

edited by

Goro Kutomi

submission deadline 31 Oct 2026 | Viewed by 93 | Submission Open

Keywords: breast cancer; chemotherapy; neoadjuvant therapy; adjuvant therapy; axillary management; surgical innovation; energy devices; de-escalation; personalized medicine; multidisciplinary care

Advances in Virus-Associated Head and Neck Cancer

edited by

Joanna Katarzyna Strzelczyk

submission deadline 1 Nov 2026 | 3 articles | Viewed by 13101 | Submission Open

Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV

(This special issue belongs to the Section Infectious Agents and Cancer)

Urologic Cancer: Endoscopic, Laparoscopic, and Robot-Assisted Surgery Management (2nd Edition)

edited by Kouji Izumi

submission deadline 1 Nov 2026 | 1 articles | Viewed by 5758 | Submission Open

Keywords: prostate cancer; urothelial cancer; kidney cancer; adrenal cancer; transurethral technique; ureteroscopy; ureteral stent

(This special issue belongs to the Section Cancer Therapy)

Epigenetic Mechanisms Linking Aging and Cancer: Molecular Drivers, Hallmarks and Therapeutic Perspectives, with a Focus on Hepatocellular Carcinoma

edited by

Manlio Vinciguerra

submission deadline 1 Nov 2026 | 1 articles | Viewed by 995 | Submission Open

Keywords: aging; cancer; epigenetics; life span; health span

Cellular Immunotherapy for Hematological Malignancies

edited by

Diego Carbonell

submission deadline 1 Nov 2026 | Viewed by 189 | Submission Open

Keywords: cellular immunotherapy; CAR-T cell therapy; translational biomarkers; immune monitoring; cell manufacturing; hematological malignancies; clinical outcomes

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Perspectives on Claudins and Tight Junction Complexes: From Membrane Architecture to Targeted Cancer Therapy

edited by

Tracey A. Martin

and

Amber Xinyu Li

submission deadline 1 Nov 2026 | Viewed by 151 | Submission Open

Keywords: cancer; claudins; tight junction; metastasis; drug resistance; biomarkers; prognostic; tumour microenvironment; epithelial barrier function; epithelial–mesenchymal transition (EMT); targeted cancer therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Pediatric Cancer Surgery—New Techniques and Innovations

edited by Elisabeth T. Tracy

submission deadline 2 Nov 2026 | Viewed by 138 | Submission Open

Keywords: pediatric cancer; solid tumor; surgical oncology; operative techniques; complex tumor; 3D modeling; intraoperative localization

(This special issue belongs to the Section Pediatric Oncology)

Immune Cells Within the Tumor Microenvironment

edited by Diego Carlos dos Reis

submission deadline 3 Nov 2026 | Viewed by 170 | Submission Open

Keywords: tumor microenvironment; tumor-infiltrating lymphocytes; macrophage polarization; T cell exhaustion; immune evasion; cancer immunotherapy; single-cell transcriptomics; spatial pathology; immune checkpoint; innate and adaptive immunity

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Radiation Therapy for Brain Metastases

edited by Luis A. Pérez-Romasanta

submission deadline 5 Nov 2026 | 3 articles | Viewed by 3656 | Submission Open

Keywords: brain metastasis; metastatic brain tumor; imaging; radiotherapy; stereotactic radiosurgery; radiomics; machine learning; magnetic resonance imaging; positron emission tomography

(This special issue belongs to the Section Cancer Therapy)

Clinical and Molecular Biomarkers in Breast Cancer Management

edited by Zahi I. Mitri

submission deadline 5 Nov 2026 | 4 articles | Viewed by 3363 | Submission Open

Keywords: prognostic biomarkers; predictive biomarkers; molecular assays; therapeutics; special situations in breast cancer

(This special issue belongs to the Section Cancer Biomarkers)

Novel Insights into Glioma Immunotherapy

edited by

Tomasz Tykocki

submission deadline 5 Nov 2026 | Viewed by 202 | Submission Open

Keywords: glioma immunotherapy; tumor microenvironment; immune evasion; microglia; checkpoint inhibitors; CAR‑T; neoantigen vaccines

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Exosomes in Cancer Metastasis (2nd Edition)

edited by

Theresa L. Whiteside

submission deadline 10 Nov 2026 | 3 articles | Viewed by 4285 | Submission Open

Keywords: exosomes; biomarkers; cancer metastasis

(This special issue belongs to the Section Cancer Metastasis)

Systematic Reviews and Meta-Analyses in Cancer Research: The Therapeutic Potential of Phytochemicals and Bioactive Compounds with Defined Mechanisms and Safety Profiles

edited by

Lucas Fornari Laurindo

submission deadline 10 Nov 2026 | 1 articles | Viewed by 1729 | Submission Open

Keywords: phytochemicals in cancer therapy; bioactive natural compounds; systematic reviews and meta-analyses; molecular mechanisms of anticancer agents; translational oncology; pharmacokinetics and toxicity of natural products; evidence-based integrative oncology; natural product drug discovery; chemoprevention and cancer therapeutics; mechanistic and safety profiling of phytochemicals

(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)

Anticancer Drug Discovery and Development: Integrating Natural Compounds, Synthetic Chemistry, Nanotechnology and Computational Approaches

edited by Cheng-Hao Jin

submission deadline 12 Nov 2026 | Viewed by 133 | Submission Open

Keywords: anticancer drug development; natural compounds; synthetic chemistry; nanotechnology; cancer therapy

(This special issue belongs to the Section Cancer Drug Development)

Artificial Intelligence for Cancer Precision Medicine

edited by Chenyang Shen and

Yujie Chi

submission deadline 13 Nov 2026 | 1 articles | Viewed by 1092 | Submission Open

Keywords: artificial intelligence; cancer; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

New Advances in Flow Cytometry: From Diagnosis to Disease Monitoring in Acute Leukemia

edited by

Francesco Buccisano

Audi Francesca Setiadi

and Raffaele Palmieri

submission deadline 13 Nov 2026 | Viewed by 216 | Submission Open

Keywords: flow cytometry; multiparametric flow cytometry (MFC); acute leukemia; measurable residual disease (MRD); prognostic biomarker; MRD monitoring

Molecular and Genetic Diagnosis and Targeted Therapy of Myeloproliferative Neoplasms (2nd Edition)

edited by

Jinming Song

and

Ling Zhang

submission deadline 15 Nov 2026 | 2 articles | Viewed by 3408 | Submission Open

Keywords: myeloproliferative neoplasm; chronic myeloid leukemia; polycythemia vera; essential thrombocythemia; primary myelofibrosis; MPN; CML; PMF; PV; ET

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Advances in Endoscopic, Metabolomic, and Ultrasound Approaches to Gastrointestinal, Hepatic, and Pancreatic Tumors

edited by Ciprian Brisc and Nadim Al Hajjar

submission deadline 15 Nov 2026 | 1 articles | Viewed by 3159 | Submission Open

Keywords: gastrointestinal, hepatic and pancreatic tumors; metabolomics; endoscopy; ultrasound; elastography; molecular investigations and treatment; robotic surgery; laparoscopic surgery; early lesions; radiofrequency and microwave ablation; irreversible electroporation; cryoablation; targeted chemo- or radio-embolization

(This special issue belongs to the Section Cancer Therapy)

Advances in Locoregional Therapies for Gastrointestinal Cancer Metastases

edited by

Mazin Al-Kasspooles

submission deadline 15 Nov 2026 | 2 articles | Viewed by 2088 | Submission Open

Keywords: gastrointestinal cancer metastases; locoregional therapies; interventional radiology; endoscopy; radiation therapy; invasive operations; cytoreductive surgery (CRS); intraperitoneal chemotherapy (IP); heated intraperitoneal chemotherapy (HIPEC); tumor debulking; stereotactic body radiation therapy (SBRT); selective internal radiation therapy (SIRT)

(This special issue belongs to the Section Methods and Technologies Development)

Oncogenesis of Lymphoma (2nd Edition)

edited by

Annunziata Gloghini

and Giancarlo Pruneri

submission deadline 15 Nov 2026 | 1 articles | Viewed by 553 | Submission Open

Keywords: lymphomagenesis; molecular genetics; immunology; molecular virology; KSHV/HHV8; EBV; HIV; pathogenetic pathways; genotypic subgroups; tumor microenvironment; follicular lymphoma; mantle cell lymphoma; diffuse large B-cell lymphoma; targeted therapy; drug target

(This special issue belongs to the Section Molecular Cancer Biology)

Gene Editing and Delivery for Cancer Therapy (2nd Edition)

edited by

Yong Teng

and

Yamin Li

submission deadline 15 Nov 2026 | Viewed by 399 | Submission Open

Keywords: gene therapy; gene editing; gene delivery; oncolytic viruses; nanomaterial; peptides; nanostructures; exosomes; translational science

(This special issue belongs to the Section Cancer Therapy)

Targeting Head and Neck Cancer: From Tumor Microenvironment to Therapy Resistance

edited by

Ratna B. Ray

and

Subhayan Sur

submission deadline 15 Nov 2026 | Viewed by 364 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); tumor microenvironment (TME); therapy resistance; HPV-associated cancers; immunotherapy; cancer-associated fibroblasts (CAFs); tumor heterogeneity; precision oncology; biomarkers; metastasis

Evaluating the Clinical Impact of Robotic Surgery in the Management of Colorectal Cancer

edited by

Héctor Guadalajara

and Miguel Leon-Arellano

submission deadline 15 Nov 2026 | Viewed by 355 | Submission Open

Keywords: robotic surgery; colorectal cancer; oncological outcomes; surgical technique; laparoscopic comparison; margin status; postoperative recovery; quality of life; intraoperative imaging; surgical navigation; learning curve; complications; cost-effectiveness; surgical training; technological innovation

(This special issue belongs to the Section Clinical Research of Cancer)

Impact of Anesthetic/Analgetic Drugs on Cancer Recurrence

edited by

Alain Borgeat

and

Effrossyni Gina Votta-Velis

submission deadline 15 Nov 2026 | Viewed by 141 | Submission Open

Keywords: effect of amide-type local anesthetics; role of IV and analgesic drugs; opioids: pro or anti-cancer

Translational Research and Clinical Trials in Gastric Cancer: Advances and Future Directions

edited by Yanghee Woo

submission deadline 15 Nov 2026 | Viewed by 104 | Submission Open

Keywords: gastric cancer; multidisciplinary management; conversion gastrectomy; molecular biomarker testing; diagnostic laparoscopy; neoadjuvant therapy; upfront surgery; intraperitoneal treatment

(This special issue belongs to the Section Clinical Research of Cancer)

The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors: 2nd Edition

edited by

Salvatore Tafuto

Ottavia Clemente

and

Annabella Di Mauro

submission deadline 20 Nov 2026 | Viewed by 236 | Submission Open

Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy

Contemporary Surgical Management of Thyroid Cancer: Toward Precision and Multidisciplinary Care

edited by Marco Puccini and Benard Gjeloshi

submission deadline 20 Nov 2026 | Viewed by 196 | Submission Open

Keywords: thyroid cancer; surgery

(This special issue belongs to the Section Cancer Therapy)

Personalization of Non-Melanoma Skin Cancer Treatment

edited by

Nicco Krezdorn

and Frederik Penzien Wainer Mamsen

submission deadline 20 Nov 2026 | Viewed by 172 | Submission Open

Keywords: personalized medicine; non-melanoma skin cancer; local treatment

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 651-700 on page 14 of 23.

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