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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Patients’ Perspective in Gynecological Cancer
edited by
submission deadline 31 Dec 2025 | Viewed by 34 | Submission Open
Keywords: patient perspective; expectations; PROMs; quality of life; best supportive care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Tumor Microenvironment of Gynecological Tumors submission deadline 10 Jan 2026 | Viewed by 95 | Submission Open
Keywords: tumor microenvironment; gynecological cancers; immunomodulation; cancer-associated fibroblasts; angiogenesis; cancer-like stem cells; extracellular matrix; immune evasion; cell signaling; therapeutics
(This special issue belongs to the Section Tumor Microenvironment)
The Role of Flow Cytometry in Hematologic Malignancies
edited by and Lucy Fu
submission deadline 12 Jan 2026 | Viewed by 46 | Submission Open
Keywords: flow cytometry; hematology; oncology; malignancy; lymphoma; leukemia; pathology; innovation; methodology; diagnosis
(This special issue belongs to the Section Methods and Technologies Development)
Neoadjuvant Therapy of Breast Cancer
edited by and Takaaki Fujii
submission deadline 15 Jan 2026 | 8 articles | Viewed by 16800 | Submission Open
Keywords: neoadjuvant systemic therapy; chemotherapy; endocrine therapy; molecular targeted therapy; molecular subtypes; response-guided therapy; clinical trials
(This special issue belongs to the Section Cancer Therapy)
Cervical Cancer: Study on Molecular Landscape and Protein Biomarkers. Current Diagnostic and Therapeutic Capabilities submission deadline 15 Jan 2026 | 5 articles | Viewed by 9797 | Submission Open
Keywords: cervical cancer; cervical dysplasia; human papilloma virus (HPV); tumor markers; cancerogenesis; genotyping
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer
edited by Biniam Kidane
submission deadline 15 Jan 2026 | 5 articles | Viewed by 7563 | Submission Open
(This special issue belongs to the Section Clinical Research of Cancer)
Novel Advances in the Molecular Understanding of Myeloproliferative Neoplasms (MPNs)
edited by Wei Chen, Fei Li and
submission deadline 15 Jan 2026 | 2 articles | Viewed by 3574 | Submission Open
Keywords: MPNs; ET; PV; PMF; post-PV-MF; post-ET-MF; MDS/MPN; JAK2
(This special issue belongs to the Section Molecular Cancer Biology)
Circulating Tumour DNA and Liquid Biopsy in Oncology
edited by and Kevin Spring
submission deadline 15 Jan 2026 | 1 articles | Viewed by 808 | Submission Open
Keywords: cell-free DNA; circulating tumour DNA; liquid biopsy; mutation status; tumour mutational burden; methylation detection; fragmentomics; minimal residual disease; early detection
(This special issue belongs to the Section Cancer Biomarkers)
The Survival of Colon and Rectal Cancer (2nd Edition)
edited by
submission deadline 15 Jan 2026 | Viewed by 133 | Submission Open
Keywords: colorectal cancer; colorectal cancer surgery; multidisciplinary treatment; survival; prognostic factors; distant metastasis; locoregional recurrences; standardisation; individualisation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Recent Advances in Liquid Biopsy Biomarkers of Cancer
edited by
submission deadline 15 Jan 2026 | Viewed by 122 | Submission Open
Keywords: liquid biopsy; circulating tumor cells; circulating tumor DNA; extracellular vesicles; circulating RNA; cfDNA methylation; fragmentome; reference material; miRNA; multi-cancer detection
(This special issue belongs to the Section Cancer Biomarkers)
Updates on Urothelial Carcinoma
edited by and Yasmin Abu-Ghanem
submission deadline 15 Jan 2026 | Viewed by 100 | Submission Open
Keywords: urothelial carcinoma; systemic therapy; molecular biomarkers; personalized medicine
(This special issue belongs to the Section Cancer Therapy)
Cell Biology of Cancer Invasion: 2nd Edition
edited by
submission deadline 15 Jan 2026 | Viewed by 73 | Submission Open
Keywords: invasion; metastasis; intravasation; extravasation; invadopodia; tumor microenvironment; epithelial– mesenchymal transition; cell migration; cytoskeleton; cell adhesion; extracellular matrix; matrix metalloprotease; cancer-associated fibroblast; tumor-associated macrophage
(This special issue belongs to the Section Cancer Metastasis)
Pediatric Cancer Research from Basic Biology to Experimental Therapy
edited by
submission deadline 16 Jan 2026 | 3 articles | Viewed by 5398 | Submission Open
Keywords: pediatric tumors; solid cancers; leukemias; cancer predisposition syndromes; genetics; omics; immunotherapy; therapy resistance
(This special issue belongs to the Section Pediatric Oncology)
Survivorship Following Childhood, Adolescent and Young Adult Cancer
edited by Magdalena Balcerek and Judith Gebauer
submission deadline 20 Jan 2026 | 1 articles | Viewed by 911 | Submission Open
Keywords: cancer survivorship; late effects; long-term follow-up care; supportive care; health prevention and promotion
(This special issue belongs to the Section Pediatric Oncology)
Cancer Cell Vulnerabilities on Pathways Regulating the Cell Cycle
edited by
submission deadline 20 Jan 2026 | Viewed by 227 | Submission Open
Keywords: cell cycle; signaling pathway; precision medicine
(This special issue belongs to the Section Molecular Cancer Biology)
Recent Trends in the Development of Theranostics and Multifunctional Tracers in Oncology
edited by
submission deadline 20 Jan 2026 | Viewed by 101 | Submission Open
Keywords: multifunctional radiopharmaceuticls; PET/CT; multimodal imaging; cancer treatment  
(This special issue belongs to the Section Methods and Technologies Development)
The Prospect of Nanobiotechnology in Cancers
edited by
submission deadline 20 Jan 2026 | Viewed by 90 | Submission Open
Keywords: nanobiotechnology; cancer therapy; targeted drug delivery; tumor microenvironment
(This special issue belongs to the Section Methods and Technologies Development)
Recent Updates on Imaging and Staging of Gynecologic Cancers
edited by and Alexander B. Olawaiye
submission deadline 21 Jan 2026 | 1 articles | Viewed by 1109 | Submission Open
Keywords: imaging; surgical staging; molecular prognostic features; mortality; prognosis
(This special issue belongs to the Section Methods and Technologies Development)
Roles of the Tumor Microenvironment on Liquid Biopsy (2nd Edition)
edited by
submission deadline 22 Jan 2026 | Viewed by 179 | Submission Open
Keywords: liquid biopsy; CTCs; CTC characterization and CTC clustering; ctDNA and ctDNA profiling; exosomes/extracellular vesicles and biology; tumor microenvironment; bone marrow cellular/molecular heterogeneity; CTCs/blood/BM cells crosstalk; analytical validity; clinical validity; and clinical utility of liquid biopsy; liquid biopsy interplaying dormancy and metastasis
(This special issue belongs to the Section Tumor Microenvironment)
Advancements in Salivary Gland Tumors Management: From Diagnostic Imaging to Treatment Strategies
edited by Wioletta Pietruszewska, Małgorzata Wierzbicka and
submission deadline 22 Jan 2026 | Viewed by 106 | Submission Open
Keywords: salivary gland tumors; MRI; CT; and PET; minimally invasive approaches
(This special issue belongs to the Section Cancer Therapy)
Innovative Immunotherapies: CAR-T Cell Therapy for Cancers: 2nd Edition
edited by
submission deadline 23 Jan 2026 | Viewed by 88 | Submission Open
Keywords: CAR-T; NK-CAR; immunotherapy; cancer; resistance mechanisms
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Targeting Hallmarks of Cancer submission deadline 25 Jan 2026 | Viewed by 590 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
(This special issue belongs to the Section Cancer Biomarkers)
Towards a Personalized Medicine for the Diagnosis and Management of Gynecological Cancers
edited by and Gabriele Centini
submission deadline 30 Jan 2026 | 2 articles | Viewed by 9877 | Submission Open
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Advance of Pencil Beam Scanning Proton Beam Therapy in Cancers
edited by , Richard A. Amos and Heng Li
submission deadline 30 Jan 2026 | 5 articles | Viewed by 9104 | Submission Open
Keywords: proton therapy; pencil beam scanning; robustness; adaptive radiotherapy; imaging guidance; radiobiological model; FLASH radiotherapy; spatially fractionated radiotherapy (SFRT); proton arc
(This special issue belongs to the Section Cancer Therapy)
Advances in the Treatment of Upper Gastrointestinal Cancer
edited by Sang-ho Jeong and
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1210 | Submission Open
Keywords: upper gastrointestinal cancer; surgery therapy; chemotherapy therapy; radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Cancer Disparities: Biological, Social, and Environmental Determinants submission deadline 30 Jan 2026 | 1 articles | Viewed by 564 | Submission Open
Keywords: cancer epidemiology; cancer etiology; environmental factors; screening and diagnostics; SDGs
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Metastasis in Tumor Immunity: Current Perspectives
edited by , Sebastian Torke and
submission deadline 30 Jan 2026 | Viewed by 108 | Submission Open
Keywords: immune escape; immune evasion; immune microenvironment; intervention strategies; senescence on metastasis; anti-tumor immunity; cellular interactions; molecular interactions; immune suppression; immune checkpoints
(This special issue belongs to the Section Cancer Metastasis)
How COVID-19 Affects Cancer Patients
edited by
submission deadline 31 Jan 2026 | 15 articles | Viewed by 22374 | Submission Open
Keywords: COVID-19; pandemic; cancer; impact; incidence; mortality; lethality; disparities; gender
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Genetics and Epigenetics of Gynecological Cancer
edited by
submission deadline 31 Jan 2026 | 8 articles | Viewed by 19075 | Submission Open
Keywords: gynecologic cancers; epigenetics; genetics; immunogenetics; predisposing mutations; biomarkers; targeted therapies; chemoresistance
(This special issue belongs to the Section Cancer Pathophysiology)
Surgical Advances in Cancer Treatments: Exploring Innovative Approaches and Emerging Perspectives by the Italian College of Associate Professors of Surgery submission deadline 31 Jan 2026 | 13 articles | Viewed by 15081 | Submission Open
Keywords: surgical oncology; surgical innovation; image-guided surgery; robotic-assisted surgery; multidisciplinary oncology; surgical outcomes research; precision surgery; healthcare economics; surgical training and simulation
(This special issue belongs to the Section Cancer Therapy)
Advances in Drug Delivery for Cancer Therapy submission deadline 31 Jan 2026 | 8 articles | Viewed by 12703 | Submission Open
Keywords: cancer; oncology; therapeutic target; drug resistance; immunotherapy; chemotherapy; small molecule inhibitors; drug delivery; nanoparticle
(This special issue belongs to the Section Cancer Drug Development)
Screening, Early Detection and Prevention of Hepato-Pancreato-Biliary (HPB) Cancers
edited by Zaed Z.R. Hamady
submission deadline 31 Jan 2026 | 7 articles | Viewed by 9144 | Submission Open
Keywords: hepatobiliary cancer; pancreatic cancer; early detection; diagnosis; screening; prevention
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
CAR T Cells in Lymphoma and Multiple Myeloma submission deadline 31 Jan 2026 | 5 articles | Viewed by 8673 | Submission Open
Keywords: multiple myeloma; lymphoma; CAR T therapy; bi-specific antibodies; cellular therapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Pathology and Treatment of Triple-Negative Breast Cancer
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 8350 | Submission Open
(This special issue belongs to the Section Cancer Pathophysiology)
Implementation of Physical Activity Promotion in Cancer Care
edited by Sarah Hardcastle
submission deadline 31 Jan 2026 | 4 articles | Viewed by 6699 | Submission Open
Keywords: physical activity; cancer survivors; behaviour change; interventions; cancer care; implementation; health
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Recent Advances in Oncology Imaging: 2nd Edition
edited by and
submission deadline 31 Jan 2026 | 4 articles | Viewed by 5120 | Submission Open
Keywords: medical imaging; cancer; oncology; molecular imaging; theragnostics
(This special issue belongs to the Section Methods and Technologies Development)
Emerging Research on Primary Brain Tumors
edited by Jacob S Young and Mitchel S. Berger
submission deadline 31 Jan 2026 | 4 articles | Viewed by 4474 | Submission Open
Keywords: molecular biomarkers; drug delivery; immunotherapy; personalized medicine; targeted therapies; glioma
(This special issue belongs to the Section Cancer Therapy)
The Tumor Microenvironment: Interplay Between Immune Cells
edited by Jared Rowe and Kristen E. Pauken
submission deadline 31 Jan 2026 | 4 articles | Viewed by 4281 | Submission Open
Keywords: tumor immune microenvironment; metabolic microenvironment; immune cells
(This special issue belongs to the Section Tumor Microenvironment)
Prediction of Melanoma
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 2485 | Submission Open
Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Recent Advances and Challenges in Breast Cancer Surgery: 2nd Edition submission deadline 31 Jan 2026 | 4 articles | Viewed by 2295 | Submission Open
Keywords: breast cancer surgery; axillary management; sentinel node oncoplastic surgery; reconstructive surgery; surgical technology; cancer risk reduction surgery; radio-guided surgery
(This special issue belongs to the Section Cancer Therapy)
Computational Research in Cancer Neuroscience
edited by Shaolei Teng
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1972 | Submission Open
Keywords: machine learning; large language models; protein structure modeling; omics data analysis; neural– cancer communication; tumor microenvironments; personalized medicine; targeted therapies; cancer neuroscience
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Studies and Outcomes in Urologic Cancer
edited by Nikolaos Pyrgidis
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1553 | Submission Open
Keywords: urologic cancer; clinical outcomes; prostate cancer; urothelial cancer; kidney cancer; survival analysis; treatment response; quality of life; novel therapies; oncology
(This special issue belongs to the Section Clinical Research of Cancer)
Advances and Future Developments in Liver Transplantation for Cancers: 2nd Edition
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1519 | Submission Open
Keywords: machine perfusion; marginal graft; split liver; immunotherapy; auxiliary liver transplantation; digital twin; modeling; organoid
(This special issue belongs to the Section Transplant Oncology)
Oral Cancer: The Latest Advances in Clinical and Basic Research (Second Edition)
edited by and Fumihiko Uchida
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1082 | Submission Open
Keywords: oral cancer; clinical research; basic research; surgery; radiotherapy; chemotherapy; molecular biology; immune checkpoint inhibitor
(This special issue belongs to the Section Clinical Research of Cancer)
Advanced Glycation End-Products and Its Receptors in Cancer Progression
edited by Bhaumik B. Patel
submission deadline 31 Jan 2026 | 1 articles | Viewed by 896 | Submission Open
Keywords: advanced glycation end products; toxic advanced glycation end products; receptor for advanced glycation end products (RAGEs); glycosaminoglycans; cancer; cancer stem cells (CSCs); tumor immune microenvironment (TME)
(This special issue belongs to the Section Tumor Microenvironment)
Head and Neck Cancer: Survivorship Challenges and Therapeutic Approaches
edited by , Avraham Eisbruch and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 757 | Submission Open
Keywords: head and neck cancer; supportive care; survivorship care; physiotherapy; quality of life; lifestyle interventions
(This special issue belongs to the Section Cancer Therapy)
Exploring Skin Cancer: Insights into New Diagnostic, Prognostic, and Therapeutic Strategies
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 722 | Submission Open
Keywords: melanoma; non-melanoma skin cancer; NMSC; Merkel cell carcinoma; tumor microenvironment; prognosis; treatment
(This special issue belongs to the Section Tumor Microenvironment)
Empowering Cancer Survivors: A Comprehensive Approach to Supportive Care Through Pharmacological and Non-Pharmacological Approaches Including Exercise, Physical Activity and Nutrition
edited by Kellie Toohey
submission deadline 31 Jan 2026 | 1 articles | Viewed by 670 | Submission Open
Keywords: cancer; physical activity; exercise; supportive care; holistic care; rehabilitation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advanced Strategies in the Care of Hepatocellular Carcinoma Patients (2nd Edition) submission deadline 31 Jan 2026 | 1 articles | Viewed by 467 | Submission Open
Keywords: hepatocellular carcinoma; hepatic resection; hepatectomy; liver resection; liver surgery; parenchymal-sparing liver surgery; intraoperative ultrasound; liver-specific magnetic resonance imaging; trans-arterial therapy; liver function; FibroScan
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Minimally Invasive Approaches in Urological Oncology: Current Trends and Innovations submission deadline 31 Jan 2026 | 1 articles | Viewed by 427 | Submission Open
Keywords: minimally invasive; robotic; laparoscopic; uro-oncology; prostate cancer; bladder cancer; kidney cancer; testicular cancers; quality of life; penile cancer
(This special issue belongs to the Section Clinical Research of Cancer)
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