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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Diagnosis and Therapeutic Management of Gastrointestinal Cancers: 2nd Edition

edited by

Christian Sebesta

and

Harald Rosen

submission deadline 20 Dec 2025 | Viewed by 71 | Submission Open

Keywords: esophagus tumor; stomach tumor; liver tumor; colon tumor; rectum tumor; pancreato-biliary tumor; targeted immune and/or chemotherapy; surgical technology; multimodal approach; diagnosis; therapeutic management

(This special issue belongs to the Section Cancer Therapy)

Metastasis Associated Long Noncoding RNAs in Cancer Research

edited by

Kouhei Sakurai

submission deadline 21 Dec 2025 | Viewed by 243 | Submission Open

Keywords: lncRNA; metastasis; invasion; gene regulation; gene expression signature

(This special issue belongs to the Section Cancer Metastasis)

Tumor Immune Microenvironment in Gastric Cancers

edited by

Chandrani Sarkar

and

Debanjan Chakroborty

submission deadline 25 Dec 2025 | 4 articles | Viewed by 13798 | Submission Open

Keywords: tumor immune microenvironment; gastric cancer; therapeutic strategies; therapeutic response; tumor-associated macrophages

(This special issue belongs to the Section Tumor Microenvironment)

Study on Epidemiology of Childhood Cancer

edited by

Francesco Giusti

and

Carmen Martos

submission deadline 25 Dec 2025 | 3 articles | Viewed by 6483 | Submission Open

Keywords: childhood cancer; epidemiology; childhood cancer registries; incidence; prevalence; mortality; survival; time trends; special analysis; environmental factors; perinatal factors; inequalities

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Ovarian Cancer Research and Treatment: 2nd Edition

edited by

Maria Barbolina

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1882 | Submission Open

Keywords: ovarian carcinoma metastasis; mechanisms of dissemination; chemotherapy resistance; novel treatments and therapeutic approaches; novel molecular targets

(This special issue belongs to the Section Cancer Therapy)

Advancements in the Diagnosis and Surgical Treatment of Prostate Cancer

edited by

Christian Peter Gilfrich

and Christian Thomas

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1406 | Submission Open

Keywords: robotic-assisted radical prostatectomy; significance of pelvic lymph node dissection in the context of radical prostatectomy; complications of surgical therapy for prostate cancer; magnetic resonance imaging/ultrasound-guided target biopsy of the prostate; comparison of various robotic systems for radical prostatectomy; learning curves; hospital volume; prostate cancer centers

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Blood Cancers: How We Define Success

edited by

Stefano Molica

and

David Allsup

submission deadline 25 Dec 2025 | Viewed by 369 | Submission Open

Keywords: blood cancers; research-driven advancements; cure rates; novel agents

(This special issue belongs to the Section Cancer Therapy)

Epigenetics in Endocrine-Related Cancer

edited by Jennie N Jeyapalan

submission deadline 25 Dec 2025 | Viewed by 201 | Submission Open

Keywords: breast; ovarian; CRPC (castration-resistant prostate cancer); thyroid; histone modification; DNA methylation; epigenomics; chromatin; microRNAs; lncRNAs; epi-drugs

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Measurable Residual Disease in Cancer: 2nd Edition

edited by Krzysztof Jamroziak and

Bartosz Pula

submission deadline 25 Dec 2025 | Viewed by 109 | Submission Open

Keywords: MRD; measurable residual disease; minimal residual disease; cancer; tumor microenvironment; next generation sequencing; flow cytometry; imaging techniques

(This special issue belongs to the Section Cancer Drug Development)

Predictive Biomarkers for Lung Cancer

edited by Ole Hilberg

submission deadline 30 Dec 2025 | 8 articles | Viewed by 15791 | Submission Open

(This special issue belongs to the Section Cancer Biomarkers)

Recent Advances in Hematological Malignancies in Children

edited by

Radosław Chaber

submission deadline 30 Dec 2025 | 1 articles | Viewed by 1536 | Submission Open

Keywords: acute lymphoblastic leukemia; acute myeloid leukemia; hematological malignancies in children; diagnostic and therapeutic methods; supportive care strategies

(This special issue belongs to the Section Pediatric Oncology)

Cytokine and Growth Factor Signaling at the Interface between Immune Cells and Cancer

edited by

Subburaj Ilangumaran

and

Seung-Hwan Lee

submission deadline 30 Dec 2025 | Viewed by 411 | Submission Open

Keywords: cytokines; growth factors; chemokines; inflammation; oncogenic signaling; cancer initiation; cancer progression; tumor microenvironment; cancer immune suppression; antitumor immunity

(This special issue belongs to the Section Molecular Cancer Biology)

Palliative Radiotherapy for Cancer

edited by Rebecca Wong

submission deadline 30 Dec 2025 | Viewed by 200 | Submission Open

Keywords: symptom relief; symptom control; radiation medicine; radiotheranostics; theranostics; external beam radiotherapy; palliation; oligometastases; oligoprogression; systematic reviews and meta-analyses; patient reported outcomes; abscopal effect; combined modality; education; clinical practice

(This special issue belongs to the Section Cancer Therapy)

Combination Therapy in Geriatric Population with Cancer (2nd Edition)

edited by

Lore Decoster

submission deadline 30 Dec 2025 | Viewed by 148 | Submission Open

Keywords: older patients with cancer; surgery; radiotherapy; chemotherapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials for Thoracic Cancers

edited by

Monica Casiraghi

submission deadline 30 Dec 2025 | Viewed by 54 | Submission Open

Keywords: lung cancer; thoracic oncology; thymoma; mesothelioma

(This special issue belongs to the Section Clinical Research of Cancer)

Insights from the Editorial Board Member

edited by

Carlos S. Moreno

submission deadline 31 Dec 2025 | 39 articles | Viewed by 44802 | Submission Open

Keywords: cancer therapeutics; cancer biomarkers; precision medicine; cancer genomics; cancer immunology; cancer biology; clinical trials; cancer epidemiology and prevention; tumor microenvironment and metastasis; cancer informatics

Cervical Cancer: Screening and Treatment in 2024-2025

edited by

Fabrice Lécuru

and

Benedetta Guani

submission deadline 31 Dec 2025 | 6 articles | Viewed by 20233 | Submission Open

Keywords: cervical cancer; fertility sparing; screening; early stage cervical cancer; locally advanced cervical cancer; sentinel lymph node; staging lymphadenectomy; trachelectomy; immunotherapy in cervical cancer; target therapy in cervical cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management

edited by

Roberto Fabiani

and

Irene Giacchetta

submission deadline 31 Dec 2025 | 14 articles | Viewed by 19321 | Submission Open

Keywords: non-small-cell lung cancer (NSCLC); small-cell lung cancer (SCLC); prevention; risk management; mechanisms

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Oncology: State-of-the-Art Research and Initiatives in Japan

edited by

Satoshi Ikeda

and

Tateaki Naito

submission deadline 31 Dec 2025 | 8 articles | Viewed by 16582 | Submission Open

Keywords: Japan; cancer; oncology; research; clinical trial; survivorship; patient support

Disparities in Cancer Prevention, Screening, Diagnosis and Management

edited by

Eliza W. Beal

submission deadline 31 Dec 2025 | 15 articles | Viewed by 16537 | Submission Open

Keywords: social determinants of health (SDOH); financial toxicity; racial disparities; ethnic disparities; LGBTQIA+ disparities; cultural competency; cancer; health status disparities; healthcare disparities

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Integrating Palliative Care in Oncology

edited by

Albert Tuca-Rodríguez

submission deadline 31 Dec 2025 | 9 articles | Viewed by 14211 | Submission Open

Keywords: early palliative care; advanced cancer; complexity of care needs; integration of palliative care in oncology; cancer pain; symptom control; end-of-life; advance care planning

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Novel Therapeutic Strategies in Salivary Gland Tumor

edited by

Giovanni Salzano

Arianna Di Stadio

and

Luigi Angelo Vaira

submission deadline 31 Dec 2025 | 8 articles | Viewed by 14207 | Submission Open

Keywords: parotid gland; parotid tumors; facial nerve; novel therapeutic options; distant metastasis; liquid biopsy; prognostic factors; parotid robotic surgery; microRNA; imaging

(This special issue belongs to the Section Cancer Therapy)

Advanced Diagnostics and Optical Imaging Technologies in Cancer Research

edited by Vlad Mihai Voiculescu

submission deadline 31 Dec 2025 | 9 articles | Viewed by 14148 | Submission Open

Keywords: digital diagnostics; advanced diagnostics; optical imaging; medical images; artificial intelligence; image analysis; laser technologies

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Biology, Diagnosis and Management of Cervical Cancer

edited by

Georgios Androutsopoulos

Georgios Michail

, Thomas Vrekoussis and

George Valasoulis

submission deadline 31 Dec 2025 | 6 articles | Viewed by 13222 | Submission Open

Keywords: cervical cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Chronic Lymphocytic Leukaemia (CLL) Research

edited by

H. Denis Alexander

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11867 | Submission Open

Keywords: chronic lymphocytic leukaemia; CLL; aetiology; oncogenic transformation; survival; cure

(This special issue belongs to the Section Cancer Therapy)

Oral Potentially Malignant Disorders and Oral Cavity Cancer

edited by

I-Ta Lee

submission deadline 31 Dec 2025 | 7 articles | Viewed by 10541 | Submission Open

Keywords: OPMDs; oral cavity cancer; molecular biology; genomics; pathology; early detection; personalized therapy; immunotherapy; targeted treatment; translational medicine

(This special issue belongs to the Section Cancer Therapy)

New Perspectives in the Management of Breast Cancer

edited by

Sonia Santander Ballestín

and

María José Luesma

submission deadline 31 Dec 2025 | 9 articles | Viewed by 10298 | Submission Open

Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact

(This special issue belongs to the Section Cancer Therapy)

Surgery for Colorectal Cancer

edited by

Antonio V. Sterpetti

and

Raimondo Gabriele

submission deadline 31 Dec 2025 | 6 articles | Viewed by 7251 | Submission Open

Keywords: clinical and oncologic outcomes after new forms of therapy for colon– rectal cancer; colon cancer; rectal cancer; colorectal cancer

(This special issue belongs to the Section Cancer Therapy)

State-of-the-Art Treatment on Chemotherapy and Immunotherapy for Urological Cancer

edited by

Kouji Izumi

and Hiroshi Yaegashi

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7219 | Submission Open

Keywords: chemotherapy; immunotherapy; antibody– drug conjugate; radioligand therapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; urachal cancer; penile cancer; adrenal cancer; sarcoma; clinical trial; basic research

(This special issue belongs to the Section Tumor Microenvironment)

Medical Imaging and Artificial Intelligence in Cancer

edited by Debiao Li and

Stephen J. Pandol

submission deadline 31 Dec 2025 | 8 articles | Viewed by 7170 | Submission Open

Keywords: cancer; medical imaging; magnetic resonance imaging; computed tomography; artificial intelligence; image analysis; cancer detection; cancer prediction; cancer characterization

(This special issue belongs to the Section Methods and Technologies Development)

Updates in Neuroendocrine Neoplasms

edited by Jonathan Strosberg

submission deadline 31 Dec 2025 | 5 articles | Viewed by 6759 | Submission Open

Keywords: neuroendocrine tumors; neuroendocrine neoplasms; neuroendocrine carcinomas; therapy; germline mutations; somatic mutations

(This special issue belongs to the Section Cancer Therapy)

Technological Development for Advances in Cancer Research and Precision Oncology

edited by

Nelson Yee

Ilias Georgakopoulos-Soares

and Fenglong Ma

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5904 | Submission Open

Keywords: bioengineering; bioinformatics; biosensor; extracellular vesicles; genome editing; machine learning; molecular profiling; nanoparticles; organoids; robotics

(This special issue belongs to the Section Molecular Cancer Biology)

Ovarian Cancer Stem Cells and Tumor Microenvironment

edited by

Carrie House

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5601 | Submission Open

Keywords: cancer stem cells; stem-like cells; tumor initiation; chemotherapy resistance; tumor relapse; tumor microenvironment; tumor immunology; stromal cells; cancer-associated fibroblasts

(This special issue belongs to the Section Tumor Microenvironment)

Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition

edited by

Andrew Stephens

submission deadline 31 Dec 2025 | 5 articles | Viewed by 5382 | Submission Open

Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion

(This special issue belongs to the Section Cancer Biomarkers)

The Applications of Artificial Intelligence in Gastroenterology

edited by

Marcello F. Maida

Ciro Celsa

and Louis H. S. Lau

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5150 | Submission Open

Keywords: artificial intelligence; gastroenterology; endoscopy; inflammatory bowel diseases

(This special issue belongs to the Section Cancer Therapy)

Overcoming Chemoresistance in Cancer: Identifying Biomarkers and Novel Targets

edited by

Annapina Russo

Giulia Russo

and

Annalisa Pecoraro

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5093 | Submission Open

Keywords: cancer treatment; chemoresistance; tumor microenvironment; cancer signaling pathways; targeted therapy; personalized anti-cancer therapies; biomarker; anti-cancer drug response prediction

(This special issue belongs to the Section Cancer Therapy)

Advancements in Head and Neck Cancer Surgery

edited by

Carlos M. Chiesa-Estomba

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4879 | Submission Open

Keywords: minimal invasive; transoral; robotic; reconstructive; 3D printing; targeting therapies; imaging

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Surgical Treatment of Urinary Tumors

edited by Pierre I. Karakiewicz and

Simone Morra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4832 | Submission Open

Keywords: bladder cancer; prostate cancer; kidney cancer; quality of life; urologic oncology

(This special issue belongs to the Section Cancer Therapy)

Celebrating the 2024 Nobel Prize in Chemistry: Advancements in Artificial Intelligence and Machine Learning for Cancer Therapeutics

edited by

Athanasios G. Papavassiliou

and

Le Zhang

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4214 | Submission Open

Keywords: AI in cancer therapeutics; machine learning for drug discovery; protein structure prediction; personalized cancer treatment; clinical AI applications

(This special issue belongs to the Section Cancer Therapy)

Robotic Surgery in Colorectal Cancer

edited by James Chi Yong Ngu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3916 | Submission Open

Keywords: robotic surgery; colorectal cancer; minimally invasive surgery; therapeutic endoscopy; laparoscopy

(This special issue belongs to the Section Clinical Research of Cancer)

Clear Cell Renal Cell Carcinoma 2024–2025

edited by

José I. López

and

Claudia Manini

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3838 | Submission Open

Keywords: clear cell renal cell carcinoma; pathology; diagnosis; hypoxia; intratumor heterogeneity; immune checkpoint blockage antiangiogenic therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Radiation Therapy for Head and Neck Cancer

edited by

Vassilis Kouloulias

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3677 | Submission Open

Keywords: adaptive radiotherapy ; hyper- and hypo-fractionated radiotherapy ; artificial intelligence in radiotherapy for head and neck cancer ; quality assurance and set-up errors associated with IMRT; VMAT; IGRT; and SGRT techniques ; protons and heavy ions for radiotherapy ; re-irradiation ; nanoparticles plus radiotherapy ; hyperthermia plus radiotherapy ; radiotherapy plus immunotherapy ; the de-escalation of radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in Section "Tumor Microenvironment"

edited by

Sanjay Gupta

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3667 | Submission Open

Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response

(This special issue belongs to the Section Tumor Microenvironment)

Enhancing Cancer Treatments through Fluorescence-Guided Surgery

edited by Ibrahim Khot and Yazan Sulaiman Khaled

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3326 | Submission Open

Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Artificial Intelligence-Assisted Radiomics in Cancer

edited by

Seong K. Mun

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3310 | Submission Open

Keywords: radiomics; learning tools; data normalization; segmentation; artificial intelligence; quantitative imaging; multi-dimensional feature analysis; statistical models; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Physiotherapy in Advanced Cancer and Palliative Care

edited by Nele Adriaenssens

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3179 | Submission Open

Keywords: advanced cancer; palliative care; palliative needs; physiotherapy; physical therapy modalities; quality of life; physical autonomy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Spine Oncology: Research and Clinical Studies

edited by Oluwaseun O. Akinduro

submission deadline 31 Dec 2025 | 4 articles | Viewed by 2945 | Submission Open

Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2024–2025

edited by

Naoto T. Ueno

and David R. Gandara

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2928 | Submission Open

Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Artificial Intelligence-Based Approaches in Cancer Diagnosis, Treatment and Prognosis

edited by

Wei Wu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2855 | Submission Open

Keywords: cancer genomics; artificial intelligence; machine learning; deep learning; tumor microenvironment; graph-based convolutional neural network; computational cancer biology

(This special issue belongs to the Section Methods and Technologies Development)

Immunotherapy in Non-Small Cell Lung Cancers

edited by Marco Russano

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2567 | Submission Open

Keywords: non-small cell lung cancer; immune checkpoint inhibitors; PD-1/PD-L1 blockade; immunotherapy; biomarkers

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Displaying special issue 701-750 on page 15 of 23.

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