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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Technologies in Thoracic Surgery

edited by Filippo Lococo and

Carolina Sassorossi

submission deadline 31 Jan 2026 | Viewed by 141 | Submission Open

Keywords: lung cancer; molecular biology; liquid biopsy; immunotherapy; precision surgery; minimally invasive surgery; new technologies; artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

Recent Advances in the Molecular Biology of Urologic Cancers: Integrative Insights from Pathogenesis to Clinical Applications

edited by

Whi-An Kwon

submission deadline 31 Jan 2026 | Viewed by 100 | Submission Open

Keywords: urologic cancers; molecular biology; pathogenesis; precision medicine; biomarkers; multi-omics; targeted therapies; immunotherapy; translational research; clinical applications

(This special issue belongs to the Section Molecular Cancer Biology)

Surgery for Lung Cancer: Robot-Assisted Versus Video-Assisted Thoracoscopic Surgery and Open Thoracotomy

edited by

Mariusz Chabowski

submission deadline 31 Jan 2026 | Viewed by 99 | Submission Open

Keywords: laparoscopic thoracic surgery; open thoracotomy; robotic thoracic surgery (RTS); lung cancer; surgical treatment; minimally invasive intervention

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Pancreatic Surgery for Pancreatic Ductal Adenocarcinoma (2nd Edition)

edited by Shuji Isaji

submission deadline 31 Jan 2026 | Viewed by 97 | Submission Open

Keywords: neoadjuvant therapy; adjuvant therapy; resectability; conversion surgery; surgical technique; laparoscopic surgery; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Radiosensitivity and Radiotoxicity in Cancer

edited by

Alexandros Georgakilas

submission deadline 31 Jan 2026 | Viewed by 95 | Submission Open

Keywords: radiation therapy; clinical outcome; radiosensitivity; radiotoxicity; biomarkers; bioinformatics; systems biology

(This special issue belongs to the Section Methods and Technologies Development)

The Biology of Hepatocellular Carcinoma: Implications for Genomic and Immune Therapies (2nd Edition)

edited by

Naoshi Nishida

submission deadline 31 Jan 2026 | Viewed by 92 | Submission Open

Keywords: hepatocellular carcinoma; diagnosis; treatment; molecular targeted agent; immune checkpoint inhibitor; artificial intelligence

(This special issue belongs to the Section Molecular Cancer Biology)

Post-Neoadjuvant Strategies in Breast Cancer (2nd Edition)

edited by

Edwin Bölke

, Tanja Fehm and

Stefanie Corradini

submission deadline 31 Jan 2026 | Viewed by 86 | Submission Open

Keywords: chemotherapy; prospective trials; clinical investigation; breast tumor; local recurrence; overall survival

(This special issue belongs to the Section Cancer Therapy)

Prostate-Specific Membrane Antigen (PSMA)-Targeted Radionuclide Therapy in Cancer

edited by

Ning Zhou

and

Sashi Debnath

submission deadline 31 Jan 2026 | Viewed by 83 | Submission Open

Keywords: PSMA-TRNT; radioligand therapy; radionuclide therapy; theranostics; prostate-specific membrane antigen (PSMA); PSMA targeted; PSMA ligands; prostate cancer (PCa); metastatic castration-resistant prostate cancer (mCRPC)

(This special issue belongs to the Section Methods and Technologies Development)

Novel Perspectives in Hepato-Biliary and Pancreatic Cancer

edited by Tudor Mocan and Emil-Ioan Moiș

submission deadline 31 Jan 2026 | Viewed by 75 | Submission Open

Keywords: HCC; cholangiocarcinoma; surgery; biliary drainage; pancreatic cancer; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Nutrition in Survivors with Advanced Cancer: The Role of Appetite, Muscle Wasting, Obesity, and Altered Body Composition

edited by Egidio Del Fabbro

submission deadline 31 Jan 2026 | Viewed by 63 | Submission Open

Keywords: advanced cancer; nutrition; wasting; body composition; multimodal

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Breast Cancer and Stem Cells

edited by Leandro Marcelo Martinez

submission deadline 31 Jan 2026 | Viewed by 63 | Submission Open

Keywords: breast cancer; cancer stem cells; tumor microenvironment; metastasis; therapeutic strategies; in vitro models

(This special issue belongs to the Section Molecular Cancer Biology)

Transformative Drug Innovations Reshaping Myeloma Treatment

edited by Despina Fotiou

submission deadline 31 Jan 2026 | Viewed by 60 | Submission Open

Keywords: multiple myeloma; cellular therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Neoadjuvant Therapy for Urologic Cancer

edited by Marlon Perera and David Chen

submission deadline 31 Jan 2026 | Viewed by 55 | Submission Open

Keywords: urologic oncology; neoadjuvant therapy; treatment; improved survival

(This special issue belongs to the Section Cancer Therapy)

Diagnosis and Biomarkers for Hematologic Malignancies

edited by

Luis Colomo

and

Francesco Lanza

submission deadline 31 Jan 2026 | Viewed by 55 | Submission Open

Keywords: hematologic malignancies; diagnosis; biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Curative Therapies for Non-Small and Small Cell Lung Cancers

edited by John Michael Varlotto

submission deadline 31 Jan 2026 | Viewed by 55 | Submission Open

Keywords: radiotherapy; surgery; early stage NSCLC; oligometastases; immunotherapy; small-cell lung cancer

(This special issue belongs to the Section Cancer Therapy)

Immune Profiling in Gastrointestinal Cancers: Implications for Precision Immunotherapy

edited by

Paulina Mertowska

submission deadline 31 Jan 2026 | Viewed by 47 | Submission Open

Keywords: gastrointestinal cancer; immune profiling; immunocompetent cells; personalized immunotherapy; biomarkers; precision medicine; tumor microenvironment; tumor-infiltrating lymphocytes; immune checkpoint inhibitors; microbiota– immunity interactions; single-cell analysis; spatial transcriptomics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications

edited by Francesco Mattioli

submission deadline 31 Jan 2026 | Viewed by 45 | Submission Open

Keywords: laryngeal cancers; diagnosis; laryngeal surgery; transoral laser microsurgery; transoral robotic surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Conversion Surgery for Initially Unresectable, Locally Advanced, Metastatic or Recurrent Gastrointestinal Cancers

edited by

Takashi Murakami

submission deadline 31 Jan 2026 | Viewed by 42 | Submission Open

Keywords: conversion surgery; locally advanced disease; metastatic disease; chemotherapy; radiotherapy; immunotherapy; heptobiliary-pancreatic cancers; gastrointestinal tract cancers

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Approaches in the Management of Gynecological Cancers

edited by

Mikel Gorostidi

Martina Aida Angeles

and

Ignacio Zapardiel

submission deadline 31 Jan 2026 | Viewed by 41 | Submission Open

Keywords: gynecological cancer; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; surgical management; clinical management

(This special issue belongs to the Section Cancer Therapy)

Updates on Imaging of Common Urogenital Neoplasms 2nd Edition

edited by Athina C Tsili

submission deadline 31 Jan 2026 | Viewed by 34 | Submission Open

Keywords: urogenital neoplasms; renal cell carcinoma; prostatic neoplasms; urinary bladder neoplasms; testicular neoplasms; uterine neoplasms; ovarian neoplasms; ultrasonography; computed tomography; magnetic resonance imaging

(This special issue belongs to the Section Methods and Technologies Development)

Therapy for HER2 Breast Cancer

edited by

Junji Tsurutani

and Sandra M. Swain

submission deadline 1 Feb 2026 | Viewed by 29 | Submission Open

Keywords: antibody– drug conjugate; trastuzumab; pertuzumab; tyrosine kinase inhibitor; trastuzumab deruxtecan

(This special issue belongs to the Section Cancer Therapy)

New Insights into Prostate Cancer Radiotherapy

edited by

Grace Lu-Yao

submission deadline 10 Feb 2026 | 5 articles | Viewed by 8715 | Submission Open

Keywords: prostate cancer; radiotherapy; radiation therapy

(This special issue belongs to the Section Cancer Therapy)

New Insights into Cancer Radiotherapy

edited by

Michael L. F. Lerch

submission deadline 10 Feb 2026 | 2 articles | Viewed by 772 | Submission Open

Keywords: radiotherapy; X-rays; gamma rays; external beam radiation therapy; brachytherapy; palliative care; intensity-modulated radiotherapy (IMRT); stereotactic body radiotherapy (SBRT); proton therapy

(This special issue belongs to the Section Cancer Therapy)

Recent Developments in the Field of Radiotherapy Treatment for Lung Cancer

edited by Ioannis C. Maroulis

submission deadline 10 Feb 2026 | 1 articles | Viewed by 561 | Submission Open

Keywords: lung cancer; radiotherapy; non-small-cell lung cancer (NSCLC)

(This special issue belongs to the Section Cancer Therapy)

Transforming Liver Cancer Care: From Molecular Understanding to Novel Therapeutic Strategies

edited by

Chencheng Xie

submission deadline 10 Feb 2026 | Viewed by 163 | Submission Open

Keywords: liver cancer; molecular research; biomarkers; targeted therapy; translational research

(This special issue belongs to the Section Tumor Microenvironment)

Exercise and Cancer Treatment: The Clinical Application of Exercise Oncology

edited by

Helena Batatinha

submission deadline 10 Feb 2026 | Viewed by 95 | Submission Open

Keywords: exercise oncology; cancer therapy; immunotherapy; patient outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Metronomic Chemotherapy in Female Cancers

edited by

Luca Roncati

submission deadline 14 Feb 2026 | 1 articles | Viewed by 984 | Submission Open

Keywords: metronomic chemotherapy; female cancers; anti-tumor mechanisms; clinical trials and outcomes; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Advances in Surgical Treatment of Gynecological Cancers

edited by

Denis Querleu

, Joanna P. Kacperczyk-Bartnik and

Aleksandra Strojna

submission deadline 14 Feb 2026 | Viewed by 196 | Submission Open

Keywords: gynecological oncology; image-guided surgery; lymphadenectomy; minimally invasive surgery; ovarian cancer surgery; patient outcomes; perioperative care; precision surgery; radical hysterectomy; robotic-assisted surgery; surgical oncology

(This special issue belongs to the Section Cancer Therapy)

New Strategies in Diagnosis and Treatments for Brain Tumors: 2nd Edition

edited by Sven Rainer Kantelhardt

submission deadline 15 Feb 2026 | 4 articles | Viewed by 11029 | Submission Open

Keywords: glioma; brain tumor; molecular guided therapy; personal medicine; radiomics; digital analysis; artificial intelligence; intraoperative imaging; surgical resection

(This special issue belongs to the Section Cancer Therapy)

New and Emerging Strategies for Targeting Genomic Instability and Overcoming Drug Resistance in Lung Cancer

edited by Kelsie L. Thu

submission deadline 15 Feb 2026 | 5 articles | Viewed by 10301 | Submission Open

Keywords: lung cancer; genomic instability; drug resistance; treatment strategy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Neoadjuvant Therapy in Hepatopancreatobiliary Malignancies: Current Trends and Future Directions

edited by

Daniela Cornelia Lazăr

submission deadline 15 Feb 2026 | 1 articles | Viewed by 1133 | Submission Open

Keywords: neoadjuvant therapy; hepatopancreatobiliary malignancies; hepatocellular carcinoma; pancreatic cancer; cholangiocarcinoma; chemotherapy; radiotherapy; immunotherapy; targeted therapies; personalized treatment

(This special issue belongs to the Section Cancer Therapy)

The Elderly Multiple Myeloma Patient in the Era of Quad Therapy and CAR-T Cells

edited by James J. Ignatz-Hoover and Koen Van Besien

submission deadline 15 Feb 2026 | Viewed by 163 | Submission Open

Keywords: multiple myeloma; quad therapy; CAR-T; elderly

(This special issue belongs to the Section Cancer Therapy)

Advances in Precision Medicine: Targeting Known and Emerging Oncogenic Targets in Lung Cancer (2nd Edition)

edited by

Tianhong Li

submission deadline 15 Feb 2026 | Viewed by 81 | Submission Open

Keywords: precision oncology; lung cancer; oncogenic target; targeted therapy; biomarker; diagnosis

(This special issue belongs to the Section Molecular Cancer Biology)

Genetic Changes in CNS Neoplasms

edited by Kimberly Bojanowski Hoang

submission deadline 15 Feb 2026 | Viewed by 52 | Submission Open

Keywords: primary brain tumor; secondary brain tumor; metastasis; glioma; genetics; genomics; CNS; neoplasms

(This special issue belongs to the Section Cancer Biomarkers)

Epigenetics and Non-Coding RNAs in Multiple Myeloma

edited by

Rui Bergantim

submission deadline 15 Feb 2026 | Viewed by 31 | Submission Open

Keywords: multiple myeloma; epigenetics; non-coding RNAs; microRNAs (miRNAs); long non-coding RNAs (lncRNAs); circular RNAs (circRNAs); DNA methylation; histone modifications; drug resistance; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Diagnosis, Treatment and Prevention of Gastrointestinal Cancer (2nd Edition)

edited by

Anna Kakehashi

and Min Gi

submission deadline 18 Feb 2026 | 2 articles | Viewed by 2606 | Submission Open

Keywords: cancer; screening; diagnosis; anti-cancer; drugs; mechanisms of carcinogenesis; chemopreventive agents

(This special issue belongs to the Section Cancer Therapy)

Gaps in Cancer Cachexia Research

edited by Jose M. Garcia and

Lindsey J. Anderson

submission deadline 20 Feb 2026 | 3 articles | Viewed by 8097 | Submission Open

Keywords: cancer cachexia; physical function; innovative models; rehabilitation; patient-reported outcomes; gender; aging; skeletal muscle; brain; adipose tissue

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Chronic Intestinal Inflammation and Cancers (2nd Edition)

edited by Livia Biancone and David Laharie

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1933 | Submission Open

Keywords: colorectal cancer; chronic inflammation; inflammatory bowel disease; inflammation-associated dysplasia; outcomes; cancer molecular pathways

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Quality of Life and Side Effects Management in Cancer Treatment (3rd Edition)

edited by

António Araújo

submission deadline 20 Feb 2026 | 2 articles | Viewed by 773 | Submission Open

Keywords: cancer treatment adverse events; quality of life in cancer patients; chemotherapy adverse events; target therapy adverse events; immunotherapy adverse events; hormonotherapy adverse events; chemotherapy-induced nausea and vomiting; cancer pain

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Multiple Myeloma: Recent Advances in Diagnosis, Analysis and Therapeutic Management: 2nd Edition

edited by

Juan Manuel Rosa-Rosa

submission deadline 20 Feb 2026 | 1 articles | Viewed by 600 | Submission Open

Keywords: multiple myeloma (MM); hematologic malignancies; next-generation sequencing; heterogeneous disease; tumor heterogeneity; genomic landscape; outcomes; novel treatments; clinical trial

(This special issue belongs to the Section Cancer Therapy)

Fibroblasts as Playmakers of Cancer Progression: Current Knowledge and Future Perspectives (2nd Edition)

edited by

Kenichiro Ishii

submission deadline 20 Feb 2026 | Viewed by 166 | Submission Open

Keywords: tumor microenvironment; reactive stroma; fibroblasts; cancer progression; heterotypic interactions between cancer cells and fibroblasts; reactive stroma-targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular Tumor Boards: Promise and Limitations for Personalized Cancer Therapy: 2nd Edition

edited by

Claudia Paret

submission deadline 20 Feb 2026 | Viewed by 109 | Submission Open

Keywords: targeted therapy; drug repositioning; biomarkers; basket trials; precision oncology; personalized medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Advanced Surgical Modalities in Breast Cancer Treatment

edited by Jan Žatecký

submission deadline 20 Feb 2026 | Viewed by 64 | Submission Open

Keywords: breast cancer surgery; breast cancer localization; breast conserving surgery; mastectomy; oncoplastic surgery; axillary lymph node staging; sentinel lymph node biopsy; targeted axillary dissection

(This special issue belongs to the Section Clinical Research of Cancer)

Radiation Therapy for Modern Management of Bone Metastases (2nd Edition)

edited by

Francesco Cellini

submission deadline 25 Feb 2026 | Viewed by 87 | Submission Open

Keywords: radiotherapy; palliative care; steretactic radiotherapy; SBRT; immunotherapy; chemotherapy; oligometastases

(This special issue belongs to the Section Cancer Therapy)

Minimal Residual Disease in Solid Tumors: Emerging Technologies and Clinical Applications

edited by

Sofia Agelaki

Kleita Michaelidou

and Aristeidis Boukouris

submission deadline 25 Feb 2026 | Viewed by 77 | Submission Open

Keywords: minimal residual disease (MRD); solid tumors; circulating tumor DNA (ctDNA); liquid biopsy; tumor-informed assays; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

Harnessing the Gut Microbiome to Improve Colorectal Cancer Outcomes

edited by Carole S. Richard

submission deadline 25 Feb 2026 | Viewed by 46 | Submission Open

Keywords: colorectal cancer (CRC); gut microbiome; screening; CRC cells; the gut microenvironment; oncological outcomes

(This special issue belongs to the Section Infectious Agents and Cancer)

Understanding HTLV-1 Induced Cancer: From Molecular Pathways to Treatment Strategies

edited by

George Eric Blair

and Suchitra Mohanty

submission deadline 25 Feb 2026 | Submission Open

Keywords: HTLV-1; adult T-cell leukemia/lymphoma (ATLL); tax protein; HBZ protein; epigenetic regulation; immune evasion; chronic inflammation; host– pathogen interactions; viral oncogenesis; translational research

(This special issue belongs to the Section Infectious Agents and Cancer)

Advances in the Treatment of Gastrointestinal (GI) Cancers

edited by

Yoshiyasu Kono

submission deadline 27 Feb 2026 | Viewed by 63 | Submission Open

Keywords: gastrointestinal cancers; targeted therapy; immunotherapy; precision oncology; biomarkers; molecular mechanisms; tumor microenvironment; resistance to therapy; translational research; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Clinical and Translational Updates in Renal Cell Carcinoma (2nd Edition)

edited by

Irbaz B Riaz

submission deadline 27 Feb 2026 | Viewed by 50 | Submission Open

Keywords: renal cell carcinoma; RCC; machine cearning; clinical; translational developments

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Imaging in Breast Cancer

edited by

Yun-Chung Cheung

Yao Melissa Min-Szu

and Chung Wai-Shan

submission deadline 28 Feb 2026 | 6 articles | Viewed by 12943 | Submission Open

Keywords: breast cancer; mammography/tomosynthesis/contrast-enhanced mammography; sonography/contrast-enhanced sonography; magnetic resonance imaging; PET/CT; quantitative imaging; elastography; optical imaging; artificial intelligence; image-guided biopsy

(This special issue belongs to the Section Methods and Technologies Development)

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