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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Health Services Research in Cancer Care

edited by

Francesco Giusti

and

Carmen Martos

submission deadline 31 May 2026 | 7 articles | Viewed by 20782

Keywords: cancer care; cancer care outcomes; cancer care services; cancer costs; treatment; health systems; quality; survival; indicators; health technology assessments

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Developments in the Management of Gastrointestinal Malignancies (2nd Edition)

edited by Zachary J. Brown

submission deadline 31 May 2026 | 9 articles | Viewed by 20104

Keywords: gastrointestinal malignancies; multimodal therapy; chemotherapy; radiotherapy; immunotherapy; localized and metastatic

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Survivorship: Challenges and Innovations from Treatment to Long-Term Care

edited by Médéa Locquet

submission deadline 31 May 2026 | 12 articles | Viewed by 18739

Keywords: breast cancer survivorship; cancer treatments; late effects: societal impact; supportive care; psychosocial well-being; cancer treatment optimization; interventions

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Gut Microbiome, Diet and Cancer Risk

edited by

Byeongsang Oh

submission deadline 31 May 2026 | 5 articles | Viewed by 14201

Keywords: gut microbiome; cancer; diet; dysbiosis; immunity; dietary fiber; probiotic; short-chain fatty acids (SCFAs)

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Cancer Biomarkers—Detection and Evaluation of Response to Therapy

edited by

Giulio Francia

and

Jianying Zhang

submission deadline 31 May 2026 | 6 articles | Viewed by 11826

Keywords: biomarkers; cancer detection; biomarkers of response to antineoplastic drugs; biomarkers of resistance to chemotherapy; biomarkers for targeted therapies

(This special issue belongs to the Section Cancer Biomarkers)

Advances in Treatment of Uveal Melanoma

edited by

Bożena Romanowska-Dixon

and

Michał S. Nowak

submission deadline 31 May 2026 | 6 articles | Viewed by 11526

Keywords: uveal melanoma; distant metastases; treatment modalities

(This special issue belongs to the Section Cancer Therapy)

Exploring the Interplay of Glioblastoma Angiogenesis, ROS, and Tumor Microenvironment: Advancements in Combination Therapy and Bioinformatics Approaches

edited by

Md. Ataur Rahman

submission deadline 31 May 2026 | 1 articles | Viewed by 10568

Keywords: glioblastoma; angiogenesis; reactive oxygen species (ROS); hypoxia-inducible factors (HIFs); radiotherapy (RT); bioactive natural compounds; tumor microenvironment (TME); cancer immunotherapy; combination therapy; autophagy; apoptosis; in silico and network pharmacology; bioinformatics

(This special issue belongs to the Section Cancer Metastasis)

Local Management of Breast Cancer: The Evolving Relationship Between Radiotherapy and Surgery

edited by Shengyang Peter Wu

submission deadline 31 May 2026 | 3 articles | Viewed by 9966

Keywords: biomarker-guided personalized breast treatment; targeted axillary dissection; neoadjuvant therapy; local therapy; radiotherapy reduction; ultrahypofractionated partial breast irradiation

(This special issue belongs to the Section Cancer Therapy)

Advances in Proton Therapy for Head and Neck Cancer: Techniques, Outcomes and Planning Variations

edited by Jun Zhou

submission deadline 31 May 2026 | 3 articles | Viewed by 9773

Keywords: proton head and neck cancer therapy; protons vs. photons for head and neck cancer treatment; adaptive proton therapy; robustness in proton head and neck cancer therapy; online vs. offline adaptation in proton head and neck cancer therapy

(This special issue belongs to the Section Cancer Therapy)

Updates on Thyroid Cancer

edited by

Kwangsoon Kim

and

Ja Seong Bae

submission deadline 31 May 2026 | 4 articles | Viewed by 8684

Keywords: thyroid cancer; surgery; updates; diagnosis; molecular biology; personalized medicine; artificial intelligence; novel therapeutic strategies; patient outcomes

(This special issue belongs to the Section Cancer Therapy)

MicroRNA in Cancer: From Molecular Mechanisms to Therapeutic Applications

edited by Girish Shukla and

Sivakumar Vijayaraghavalu

submission deadline 31 May 2026 | 6 articles | Viewed by 7276

Keywords: microRNA (miRNA) therapeutics; cancer biomarkers; oncogenic and tumor-suppressive miRNAs; miRNA delivery systems; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

Prostate Cancer and Inflammation

edited by Takuji Hayashi

submission deadline 31 May 2026 | 2 articles | Viewed by 6310

Keywords: prostate cancer; inflammation; immune cells; cytokine; chemokine; anti-inflammatory agents; diet; microbiome

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Quality of Life in Patients with Brain Tumors

edited by Priya U. Kumthekar, Akanksha Sharma and Margaret Johnson

submission deadline 31 May 2026 | 5 articles | Viewed by 6176

Keywords: quality of life; palliative care; patient reported outcomes; survivorship; caregiver distress; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Molecular Pathways in Cancers (2nd Edition)

edited by

Ion Cristóbal

and

Marta Rodríguez Moreno

submission deadline 31 May 2026 | 2 articles | Viewed by 5272

Keywords: highly prevalent cancers; tumor microenvironment; oncogenesis; progression; novel targeted therapy; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

The Role of Circulating Tumor Cells in Colorectal Cancer

edited by

Chiara Nicolazzo

submission deadline 31 May 2026 | 1 articles | Viewed by 4591

Keywords: circulating tumor cells (CTC); colorectal cancer (CRC); liquid biopsy; biomarkers; tumor progression; personalized medicine; molecular profiling; metastasis; diagnostic techniques; prognostic evaluation

(This special issue belongs to the Section Cancer Biomarkers)

Focus on Focal Therapy for Prostate Cancer

edited by Abhinav Sidana and Samuel Tremblay

submission deadline 31 May 2026 | 2 articles | Viewed by 4557

Keywords: focal therapy; prostate cancer treatment; image-guided therapy; oncological outcomes; functional outcome; patient selection; surveillance

(This special issue belongs to the Section Cancer Therapy)

Evolution of Cancer Therapies: Access of Developing Countries to Modern Oncology

edited by

Salem Chouaib

submission deadline 31 May 2026 | 3 articles | Viewed by 4155

Keywords: conventional cancer therapies; modern oncology; recission medicine; cancer immunotherapy; artificial intelligence; targeted agents; equity and globally equal access

(This special issue belongs to the Section Cancer Therapy)

Therapeutic Optimization of Anti-Tumor Drugs Based on Pharmacokinetics

edited by Paula Fresco and Joaquim António Faria Monteiro

submission deadline 31 May 2026 | 1 articles | Viewed by 3901

Keywords: anti-cancer drugs; pharmacokinetics; therapeutic drug monitoring; cancer; populational pharmacokinetics models

(This special issue belongs to the Section Cancer Drug Development)

Survivorship and Quality of Life in Endometrial Cancer

edited by George Koukourakis,

Antonios Anagnostopoulos

, Georgios Angelopoulos and Anthi Miliadou

submission deadline 31 May 2026 | 4 articles | Viewed by 3787

Keywords: endometrial cancer; quality of life; survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Cell and Gene Therapy in Tumors: From Bench to Bedside

edited by Shuhang Wang

submission deadline 31 May 2026 | 1 articles | Viewed by 3335

Keywords: cell therapy; gene therapy; genetically engineered cells; cancer treatment; clinical trials; pre-clinical study

(This special issue belongs to the Section Cancer Therapy)

Lymphoid and Myeloid Leukemias—Current Progress in Biology and Treatment

edited by Ewa Robak and

Tadeusz Robak

submission deadline 31 May 2026 | 2 articles | Viewed by 3114

Keywords: acute myeloid leukemia; promyelocytic leukemia; myelomonocytic leukemia; chronic lymphocytic leukemia; hairy cell leukemia; prolymphocytic leukemia; large granular lymphocyte leukemia; acute lymphoblastic leukemia

(This special issue belongs to the Section Molecular Cancer Biology)

Clinical and Translational Research of Urological Cancer

edited by

Mauro Ragonese

and

Luca Di Gianfrancesco

submission deadline 31 May 2026 | 2 articles | Viewed by 2946

Keywords: urological cancer; bladder cancer; surgery; conservative treatment; immunotherapy; radical cystectomy; artifical intelligence

(This special issue belongs to the Section Clinical Research of Cancer)

Current Status and Prospects of Multimodal Treatment for Upper Gastrointestinal Cancer

edited by Koichi Okamoto

submission deadline 31 May 2026 | 3 articles | Viewed by 2625

Keywords: upper gastrointestinal cancer; esophageal cancer; gastric cancer; esophagogastric junction cancer; chemotherapy; oncology; endoscopic resection; minimally invasive surgery; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

What’s Behind the Scenes? New Insights in Endometrial Cancer Management and Risk Stratification (2nd Edition)

edited by

Emanuele Perrone

submission deadline 31 May 2026 | 2 articles | Viewed by 2178

Keywords: endometrial cancer; molecular classification; surgical staging; surgery; target therapy; gynecologic oncology; precision medicine; immunohistochemistry

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

The Impact of Minimally Invasive Surgery on Gynecologic Cancers

edited by

Gabriel Levin

submission deadline 31 May 2026 | 1 articles | Viewed by 1821

Keywords: minimally invasive surgery; robotic-assisted surgery; gynecologic malignancy; laparoscopy

(This special issue belongs to the Section Cancer Therapy)

Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms

edited by

Kumar Ganesan

and

Kunka Mohanram Ramkumar

submission deadline 31 May 2026 | 2 articles | Viewed by 1804

Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways

(This special issue belongs to the Section Cancer Pathophysiology)

Breast Cancer and Hormone-Related Therapy: 2nd Edition

edited by

John R. Hawse

submission deadline 31 May 2026 | 1 articles | Viewed by 1619

Keywords: breast cancer; estrogen receptor; hormone activated transcription factors; hormonal therapy; molecular mechanisms

(This special issue belongs to the Section Cancer Therapy)

Head and Neck Cancer: MRI and PET/CT Diagnosis and Surgical Treatment

edited by

Lavinia Manuela Lenghel

submission deadline 31 May 2026 | 2 articles | Viewed by 1587

Keywords: head and neck cancer; MRI; PET/CT; diagnostic imaging; surgical treatment; tumor staging; image-guided surgery; multidisciplinary approach; oncologic outcomes

(This special issue belongs to the Section Cancer Therapy)

Advances in Primary and Secondary Bone and Soft Tissue Tumors

edited by

Frank Traub

submission deadline 31 May 2026 | 3 articles | Viewed by 1556

Keywords: primary bone tumors; soft tissue sarcomas; metastatic bone disease; molecular diagnostics including liquid biopsy; surgical management including reconstruction; immunotherapy; tumor microenvironment; biomarkers and prognostic factors; cancer surveillance; translational oncology

Nano-Targeting of Cancer

edited by Thomas Ming Swi Chang OC MD CM PhD DSc FRCPC FRSC FCAHS

submission deadline 31 May 2026 | 1 articles | Viewed by 1472

Keywords: drug delivery; artificial intelligence; targeted delivery; nanorobotics; prodrug activation; intracellular action; liposome; PEGylation; nanoparticles; nanocapsules; nanoartificial cells

(This special issue belongs to the Section Cancer Therapy)

Gastric Cancers: Molecular Mechanisms, Novel Targets and Immunotherapies: From Bench to Clinical Therapeutics (2nd Edition)

edited by

Shumei Song

and

Jaffer A. Ajani

submission deadline 31 May 2026 | 1 articles | Viewed by 1382

Keywords: novel oncogene targets; interplay among cancer; stroma; and immune cells; tumor microenvironment (TME); immune biomarker; immunotherapy; new therapeutic modality; translational research; clinical trials

(This special issue belongs to the Section Molecular Cancer Biology)

PET/CT in Radiation Oncology

edited by Gurdip Azad and

Gary Cook

submission deadline 31 May 2026 | 1 articles | Viewed by 1267

Keywords: PET-CT; radiation oncology; theranostics; artificial intelligence; personalised care; tumour volume delineation; adaptive radiotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Targeted Therapy in Gastrointestinal Cancer (2nd Edition)

edited by

Wei Kang

and

Ka Fai To

submission deadline 31 May 2026 | 1 articles | Viewed by 953

Keywords: gastrointestinal cancer; tumor microenvironment; gut microbiome; molecular mechanism; cancer treatment; prognostic and predictive biomarker; therapeutic target; cancer prognosis; targeted therapy; targeted drug development

(This special issue belongs to the Section Cancer Therapy)

The Intelligent Scalpel: AI and the Future of Cancer Surgery

edited by Abdallah S. Attia and Kristen E. Limbach

submission deadline 31 May 2026 | 1 articles | Viewed by 605

Keywords: artificial intelligence; surgical oncology; radiomics; pathomics; robotic surgery; large language models; multimodal learning; explainable AI; precision surgery; ethical AI

(This special issue belongs to the Section Methods and Technologies Development)

Single-Cell and Spatial Data Analytics in Cancers

edited by

Yu Shyr

and Qi Liu

submission deadline 31 May 2026 | 1 articles | Viewed by 529

Keywords: single-cell and spatial omics; tumor heterogeneity; tumor progression; tumor microenvironment; cancer immunotherapy

(This special issue belongs to the Section Cancer Informatics and Big Data)

Emerging Nanotechnology and Advanced Materials for Cancer Therapy

edited by

Iraj Alipourfard

submission deadline 31 May 2026 | Viewed by 473

Keywords: biomaterials; theranostics; cancer therapy; targeted drug delivery; precision oncology

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Imaging and Immunotherapy in Cancer Research

edited by

Fabio Sandomenico

submission deadline 31 May 2026 | Viewed by 300

Keywords: immunotherapy; immune checkpoint inhibitors; molecular imaging; tumor microenvironment; artificial intelligence (AI); radiomics

(This special issue belongs to the Section Clinical Research of Cancer)

Noncoding RNA and Molecular Mechanisms of Metastasis in Gastrointestinal Cancers

edited by

Kaihong Huang

submission deadline 31 May 2026 | Viewed by 300

Keywords: noncoding RNA; gastrointestinal cancers; metastasis; molecular mechanisms; microRNA; long noncoding RNA; circular RNA; cancer biology; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Cancer Biology)

Image-Guided Radiotherapy in Head and Neck Cancer

edited by Petar Suton

submission deadline 31 May 2026 | Viewed by 289

Keywords: image-guided radiotherapy (IGRT); head and neck cancer; radiation therapy; cone-beam CT (CBCT); adaptive radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Infectious Agents and Oesophageal Cancer (2nd Edition)

edited by

Shan Rajendra

and Mohammed Rabiei

submission deadline 31 May 2026 | Viewed by 283

Keywords: oesophageal cancer; human papillomavirus; infection; Barrett’ s oesophagus; cancer; oesophageal adenocarcinoma; oesophageal squamous cell carcinoma

(This special issue belongs to the Section Infectious Agents and Cancer)

Multimodality Imaging for More Precise Radiotherapy (2nd Edition)

edited by Stefano Arcangeli,

Denis Panizza

and

Valeria Faccenda

submission deadline 31 May 2026 | Viewed by 237

Keywords: multimodality imaging; radiotherapy; stereotactic radiotherapy

(This special issue belongs to the Section Cancer Therapy)

The Pathogenesis and Treatment of Diffuse Midline Glioma

edited by

Amanda Muhs Saratsis

submission deadline 31 May 2026 | Viewed by 234

Keywords: pediatric brain tumors; diffuse midline glioma; high-grade glioma; H3K27M mutant glioma; liquid biopsy; diffuse intrinsic pontine glioma

(This special issue belongs to the Section Cancer Therapy)

Role of Protein and Metabolite in Cancers

edited by

Md. Wasim Khan

submission deadline 31 May 2026 | Viewed by 218

Keywords: cancer progression; cancer cells; proteins; metabolites; signaling pathway; metabolic dysregulations

(This special issue belongs to the Section Tumor Microenvironment)

Multiple Myeloma: From Molecular Insights to Clinical Treatment

edited by Mikala Gabor

submission deadline 31 May 2026 | Viewed by 214

Keywords: multiple myeloma; novel therapy; bispecific; CelMod; CAR-T; CAR-NK; ADC; CD38; BCMA; GPRC5D; FcRH5; transplantation

Updates on Progress in Stem-Cell Transplantation in Cancer Patients

edited by Nidhi Jyotsana

submission deadline 31 May 2026 | Viewed by 193

Keywords: hematopoietic stem cell transplantation (HSCT); acute myeloid leukemia (AML); leukemic stem cells; optimize transplant protocols

(This special issue belongs to the Section Transplant Oncology)

Chemoradiotherapy for Non-Small Cell Lung Cancer

edited by Carlo Greco

submission deadline 31 May 2026 | Viewed by 187

Keywords: NSCLC; concurrent chemoradiotherapy; immunotherapy consolidation; adaptive radiotherapy; functional imaging; radiomics; biomarkers; re-irradiation; toxicity mitigation; AI decision support

(This special issue belongs to the Section Cancer Therapy)

Neuroimaging Biomarkers of Cancer Therapy-Related CNS Complications

edited by Jasmina Boban

submission deadline 31 May 2026 | Viewed by 169

Keywords: neuroimaging; multimodal imaging; chemotherapy; immunotherapy; chemotherapy-related cognitive dysfunction; drug- related side effects and adverse reactions

Drug Repurposing and Reformulation for Cancer Treatment: 2nd Edition

edited by

Arati Sharma

Dhimant Desai

and

Abhijit Date

submission deadline 1 Jun 2026 | 2 articles | Viewed by 20588 | Submission Open

Keywords: drug repurposing; cancer; drug resistance; metastasis; drug delivery; liposomes; nanoparticles; bioavailability; drug targeting; reformulation

(This special issue belongs to the Section Cancer Drug Development)

The Role of Medical Imaging in Gynecological Cancer

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 1 Jun 2026 | 6 articles | Viewed by 18703 | Submission Open

Keywords: cervical cancer; endometrial cancer; ovarian cancer; staging; ultrasound; MRI; PET-CT; radiotherapy; image-guided brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

New Developments in Breast Cancer Surgery, Risk, and Related Quality of Life

edited by Vesna Bjelic-Radisic,

Maggie Banys-Paluchowski

and Constanze Elfgen

submission deadline 1 Jun 2026 | 3 articles | Viewed by 8067 | Submission Open

Keywords: oncoplastic breast surgery; breast reconstruction; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

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