Breast Cancer and Hormone-Related Therapy: 2nd Edition
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: closed (31 May 2026) | Viewed by 1752
Editor
Interests: molecular biology; breast cancer; estrogen receptor; hormone-based therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Breast cancer remains the most common malignancy in women. Over 70% of all breast tumors are initially characterized as being “hormonally sensitive” based on the expression of estrogen receptor alpha (ERα). ERα-positive tumors are known to be driven by estrogens and, as such, numerous therapies have been developed to either directly target ERα (such as tamoxifen and fulvestrant) or to suppress the production of estrogen throughout the body using ovarian function suppression and/or aromatase inhibitors. More recently, a newer class of drugs known as CDK4/6 inhibitors have demonstrated profound activity in the metastatic setting and are now commonly used in combination with aromatase inhibitors as a first line therapy for patients with recurrent ERα-positive tumors.
In addition to ERα, a number of other hormone-activated transcription factors, including ERβ, progesterone receptor, androgen receptor, and glucocorticoid receptor, have been shown to be expressed in breast cancer, and substantial efforts have been made to determine the contribution of these factors in breast cancer development, progression, and treatment. As a result of these efforts, and the world-wide uptake of many different forms of hormonal therapy, breast cancer has become a more manageable disease. However, with the significant extension of lifespan comes the increased probability of treatment failure, disease recurrence, and diminished efficacy of additional hormone-based treatment strategies.
This Special Issue relates to emerging hormonal therapies, both for newly diagnosed and resistant forms of breast cancer, the molecular mechanisms by which such therapies elicit their anti-cancer effects, and the cellular processes that are ultimately responsible for treatment failure.
This is the 2nd edition of the Special Issue. You are welcome to read the publications under the 1st edition “Breast Cancer and Hormone-Related Therapy”.
Dr. John R. Hawse
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer
- estrogen receptor
- hormone activated transcription factors
- hormonal therapy
- molecular mechanisms
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Related Special Issue
- Breast Cancer and Hormone-Related Therapy in Cancers (12 articles)
