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Cancers
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Clinical and Translational Research of Urological Cancer
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Clinical and Translational Research of Urological Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 645

Special Issue Editors

Dr. Mauro Ragonese

E-Mail Website
Guest Editor
Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy
Interests: urological cancer and surgery
Dr. Luca Di Gianfrancesco

E-Mail Website
Guest Editor
Department of Urology, Humanitas Gavazzeni, Bergamo, Italy
Interests: cystectomy; bladder cancer; prostate cancer; ureterocutaneostomy; urologic oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to collaborate on this Special Issue, ‘Clinical and Translational Research of Urological Cancer’.

The field of urological cancer is constantly evolving with new technologies, new therapeutic agents, and biomarkers with better perspectives for patients and urologists.

The aim of this Issue is to give a panoramic view of the novelties and most recent, relevant evidence in the field of clinical and translational research of urological cancers, from the application of artifical intelligence to predict oncological outcomes to the new biomarkers and promising immunotherapy that have completely changed how urological cancers are managed.

Original studies and reviews are more than welcome for this Issue to help increase our knowledge in the wide field of urological cancers.

We look forward to receiving your contributions.

Dr. Mauro Ragonese
Dr. Luca Di Gianfrancesco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • urological cancer
  • bladder cancer
  • surgery
  • conservative treatment
  • immunotherapy
  • radical cystectomy
  • artifical intelligence

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Published Papers (1 paper)

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Research

14 pages, 1540 KB  
Article
Preoperative MRI Predictors for Post-Prostatectomy Urinary Incontinence
by Franco Alchiede Simonato, Guglielmo Mantica, Martina Beverini, Francesca Ambrosini, Francesco Chierigo, Veronica Giasotto, Nicola Pavan, Alchiede Simonato and Carlo Terrone
Cancers 2025, 17(18), 3004; https://doi.org/10.3390/cancers17183004 - 15 Sep 2025
Viewed by 489
Abstract
Background: We investigated the predictive role of prostatic morphology on preoperative multiparametric magnetic resonance imaging for post-prostatectomy urinary incontinence. Methods: Patients who underwent robot-assisted radical prostatectomy between February 2018 and October 2021 and who were not previously incontinent, did not undergo [...] Read more.
Background: We investigated the predictive role of prostatic morphology on preoperative multiparametric magnetic resonance imaging for post-prostatectomy urinary incontinence. Methods: Patients who underwent robot-assisted radical prostatectomy between February 2018 and October 2021 and who were not previously incontinent, did not undergo radiotherapy, hormone therapy, or transurethral resection of the prostate, and who had a follow-up longer than 12 months were selected. For each patient, a radiology physician evaluated the preoperative magnetic resonance imaging, measuring prostatic and membranous urethral length, classifying prostatic apex according to the Lee Type, and estimating the presence of the median lobe and its intravesical protrusion. Multivariate logistic regression models evaluated the influence of anatomic features measured in magnetic resonance imaging on urinary continence recovery, defined as daily pad usage less than or equal to one, considering age, body mass index, prostate volume, International Prostatic Symptoms Score, the usage of a nerve sparing technique, and the International Society of Urological Pathology classification. Results: A total of 95 patients who underwent robot-assisted radical prostatectomy were enrolled. Median age, median body mass index, and median PSA density were respectively 66 years (62, 70), 26.12 kg/m2 (23.88, 28.09), and 0.16 ng/mL/cc (0.10, 0.26). Patients with urinary continence ranged from 32 (33.7%) at baseline to 93 (97.8%) after one year from surgery. At preoperative magnetic resonance, Lee Type was almost equally distributed, but Type C was less represented (18 patients, 18.9%) and Type D was more frequent (31 patients, 32.2%). Median prostatic urethral length, median membranous urethral length, and median intravesical prostatic protrusion were respectively 36 mm (31, 42), 15 mm (13, 16), and 0 mm (0, 0). Multivariate logistic regression models showed no statistical significance, except for Lee Type C and A comparison at vesical catheter removal after surgery (OR 0.17; 95% CI 0.04–0.71; p-value 0.01). Conclusions: The results of this study showed that patients who had Lee Type C might have higher probability of early urinary continence recovery, but no further statistically significant correlations were found. Full article
(This article belongs to the Special Issue Clinical and Translational Research of Urological Cancer)
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