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Cancers
Special Issues
Quality of Life in Patients with Brain Tumors
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Quality of Life in Patients with Brain Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 23 November 2025 | Viewed by 276

Special Issue Editors

Dr. Priya U. Kumthekar

E-Mail Website
Guest Editor
Department of Neurology, Northwestern Memorial Hospital, Chicago, IL 60611, USA
Interests: brain metastases; brain tumors; leptomeningeal disease; clinical trials; quality of life
Dr. Akanksha Sharma

E-Mail Website
Guest Editor
Pacific Neuroscience Institute/Saint John's Cancer Institute, Santa Monica, CA 90404, USA
Interests: palliative care; brain tumors; spinal cord tumors; brain metastases; quality of life
Dr. Margaret Johnson

E-Mail Website
Guest Editor
Department of Neurosurgery, Duke University School of Medicine, Durham, NC 27710, USA
Interests: palliative care; brain tumors; spinal cord tumors; brain metastases; quality of life

Special Issue Information

Dear Colleagues,

This Special Issue on “Quality of Life in Patients with Brain Tumors” delves into the multifaceted challenges faced by patients with brain tumors and their care partners. The quality of life in this patient population encompasses multiple domains—physical, cognitive, emotional, spiritual, social, financial. It affects more than the patient (heavily impacting the care partner(s)), evolves over time, and is impacted by existing inequities in healthcare. This Special Issue aims to present updates, original research, and expert perspectives on these critical aspects within this topic. We aspire to highlight advancements while emphasizing the ongoing need to improve the patient and caregiver experience in this field.

Dr. Priya U. Kumthekar
Dr. Akanksha Sharma
Dr. Margaret Johnson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • quality of life
  • palliative care
  • patient reported outcomes
  • survivorship
  • caregiver distress
  • symptom management

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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16 pages, 1321 KiB  
Systematic Review
Occurrence Rates of Delirium in Brain Tumor Patients: A Systematic Review and Meta-Analysis
by Zachary Tentor, Alexander Finnemore, Paul J. Miller, Joshua Davis, Erika Juarez Martinez, Charlotta Lindvall, Eyal Y. Kimchi and John Y. Rhee
Cancers 2025, 17(12), 1998; https://doi.org/10.3390/cancers17121998 - 15 Jun 2025
Viewed by 52
Abstract
Background: The occurrence (incidence or prevalence) of delirium in brain tumors is unknown, yet delirium is associated with increased morbidity and mortality and worse quality of life. We conducted a systematic review and meta-analysis to determine the occurrence of delirium in hospitalized [...] Read more.
Background: The occurrence (incidence or prevalence) of delirium in brain tumors is unknown, yet delirium is associated with increased morbidity and mortality and worse quality of life. We conducted a systematic review and meta-analysis to determine the occurrence of delirium in hospitalized patients with brain tumors. Methods: PubMed, Scopus, and Web of Science were systematically searched for papers from 1 January 1999 to 12 July 2024, including references from texts. Cross-sectional, prospective, and other cohort study designs were included, and individual case reports, case series, editorials, and reviews were excluded. The included papers were scored using a validated sensitivity analysis tool and tested for quality and bias using funnel plots and Egger’s test. We used random effects models for the summary estimates. We performed subgroup analyses by tumor type, tumor location, delirium subtype, and length of stay. Results: Of the 452 studies screened, 27 were included, representing 35,958 patients. The overall occurrence of delirium was 0.17 (95% CI [0.11–0.24]). Delirium occurrence in patients with low-grade gliomas, high-grade gliomas, and brain metastases was 0.10 [0.06–0.16], 0.21 [0.10–0.40], and 0.31 [0.16–0.50], respectively. Compared to the occipital lobe, there was a higher occurrence of delirium for tumors in the frontal (RR 3.08 [1.35–8.22]) and temporal lobes (RR 2.88 [1.22–7.93]). The patients were more likely to have hypoactive (RR 1.61 [1.30; 1.98]) than hyperactive delirium. Delirium was associated with 4.62 additional hospitalized days compared to those without delirium (CI [3.23–6.01]). Discussion: We confirmed high occurrence rates of delirium in patients hospitalized with brain tumors. Patients with brain metastases had a higher occurrence of delirium compared to patients with gliomas, and delirium occurrence rates were higher in patients with frontotemporal tumors. Delirium occurrence rates in the literature are very heterogeneous and point toward a need for tailored assessments in patients with brain tumors. Full article
(This article belongs to the Special Issue Quality of Life in Patients with Brain Tumors)
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