The Impact of Minimally Invasive Surgery on Gynecologic Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 516

Special Issue Editor


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Guest Editor
The Department of Gynecologic Oncology, Jewish General Hospital, McGill University, Montreal, QC, Canada
Interests: minimally invasive surgery; robotic assisted surgery; gynecologic malignancy; laparoscopy

Special Issue Information

Dear Colleagues,

Minimally invasive surgery (MIS) has transformed the landscape of gynecologic cancer treatment, offering significant benefits such as reduced postoperative pain, shorter hospital stays, and faster recovery compared to traditional open surgery. Advances in laparoscopic and robotic-assisted techniques have improved surgical precision, leading to better patient outcomes. However, ongoing debates persist regarding the oncologic safety of MIS, particularly in cervical and endometrial cancers, as well as challenges related to surgeon training, cost, and accessibility. As the field continues to evolve, it is crucial to assess the latest evidence, address existing controversies, and explore innovations that may further refine surgical approaches.

The aim of this Special Issue is to explore the impact of minimally invasive surgery (MIS) in the management of gynecologic cancers, providing a comprehensive overview of its benefits, limitations, and future directions. By bringing together original research, systematic reviews, and expert opinions, this issue seeks to evaluate surgical outcomes, oncologic safety, technological advancements, and challenges in implementing MIS. Additionally, it aims to address ongoing debates surrounding patient selection, training requirements, and disparities in access to MIS. Through this collection of studies, we hope to advance the understanding of MIS in gynecologic oncology and guide future surgical innovations and clinical practices.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  1. Outcomes and Safety
    • Long-term survival and recurrence rates following MIS in cervical, endometrial, and ovarian cancers.
    • Comparative studies between MIS and open surgery in gynecologic oncology.
    • Patient selection criteria for MIS in gynecologic cancer treatment.
  1. Surgical Innovations and Technological Advances
    • The role of robotic-assisted surgery in gynecologic oncology.
    • Novel techniques and emerging technologies in minimally invasive gynecologic cancer surgery.
    • Artificial intelligence and machine learning applications in MIS.
  1. Training, Learning Curve, and Surgical Expertise
    • The impact of surgeon experience on MIS outcomes in gynecologic cancers.
    • The standardization of training and credentialing for laparoscopic and robotic surgery.
    • Challenges in implementing MIS training programs worldwide.
  1. Patient-Centered Outcomes and Quality of Life
    • Postoperative recovery, pain management, and hospital stay comparisons.
    • Fertility preservation and reproductive outcomes following MIS.
    • Patient-reported outcomes and quality of life assessments after MIS.
  1. Economic and Global Perspectives
    • The cost-effectiveness of MIS compared to traditional open surgery.
    • Disparities in access to MIS across different healthcare settings.
    • The implementation of MIS in low-resource settings and developing countries.

I look forward to receiving your contributions.

Dr. Gabriel Levin
Guest Editor

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Keywords

  • minimally invasive surgery
  • robotic-assisted surgery
  • gynecologic malignancy
  • laparoscopy

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Published Papers (1 paper)

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Research

10 pages, 1073 KiB  
Article
Examining the Association of Body Mass Index and Complications When Including Sentinel Lymph Node Biopsy in Minimally Invasive Surgery for Endometrial Intraepithelial Neoplasia
by Gabriel Levin, Pedro T. Ramirez, Jason D. Wright, Brian M. Slomovitz, Walter H. Gotlieb, Matthew T. Siedhoff, Kelly N. Wright and Raanan Meyer
Cancers 2025, 17(8), 1257; https://doi.org/10.3390/cancers17081257 - 8 Apr 2025
Viewed by 380
Abstract
Objective: We aimed to study the association of patient’s body mass index (BMI) with postoperative complications in patients surgically treated for endometrial intraepithelial neoplasia, with and without sentinel lymph node biopsy. Methods: A cohort study using the prospective National Surgical Quality [...] Read more.
Objective: We aimed to study the association of patient’s body mass index (BMI) with postoperative complications in patients surgically treated for endometrial intraepithelial neoplasia, with and without sentinel lymph node biopsy. Methods: A cohort study using the prospective National Surgical Quality Improvement Program database. Women with endometrial intraepithelial neoplasia on postoperative pathology who underwent minimally invasive hysterectomy from January 2012 to December 2020 were included. The cohort was dichotomized based on the performance of sentinel lymph node biopsy. We analyzed postoperative complications based on the World Health Organization (WHO) categories of BMI. Results: A total of 4428 patients met the inclusion criteria. Of those, 584 (13.2%) had sentinel lymph node biopsy. Overall, 76.5% of patients (n = 3389) were obese (BMI > 30.0), with 1840 (41.6%) patients of BMI ≥ 40.0. The rate of any complications was 6.0% (n = 264), major complications 2.3% (n = 101), and minor complications 4.2% (n = 187). When comparing the rate of any complications between patients who had sentinel lymph node biopsy vs. those without a sentinel lymph node biopsy procedure, stratified by BMI category, there was no association between sentinel lymph node biopsy performance and any complications in any of the BMI categories. In a multivariable binary regression analysis, BMI and the performance of sentinel lymph node biopsy were not independently associated with any complication [adjusted odds ratio (aORs) 1.001, 95% confidence interval (CI) (0.98–1.01), and aORs 1.1, 95% CI (0.82–1.65), respectively]. In an analysis of the cohort of patients who underwent sentinel lymph node biopsy, there was no association between the rates of any major or minor complications with BMI categories or obesity. ROC analyses for the association between BMI and occurrence of any major or minor complications had a low performance. Conclusions: In minimally invasive surgery for endometrial intraepithelial neoplasia, there is no association between body mass index and increased risk for postoperative complications when performing hysterectomy with sentinel lymph node biopsy versus hysterectomy alone. Full article
(This article belongs to the Special Issue The Impact of Minimally Invasive Surgery on Gynecologic Cancers)
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