New Developments in Breast Cancer Surgery, Risk, and Related Quality of Life

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 1 June 2026 | Viewed by 1837

Special Issue Editors


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Guest Editor
Breast Unit, Helios University Hospital Wuppertal, University Witten/Herdecke, 58455 Witten, Germany
Interests: breast cancer; quality of life
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Guest Editor
Department of Gynecology and Obstetrics, University Hospital Schleswig, Holstein Campus Lübeck, 23562 Lübeck, Germany
Interests: breast cancer; breast surgery; oncology; oncoplastics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Breast-Center Zurich, Zurich, Switzerland
Interests: senology (breast care); gynaecology; obstetrics

Special Issue Information

Dear Colleagues,

The goal of surgical therapy for breast cancer is to achieve local disease control. In addition to this primary oncological objective, additional demands have been placed on surgical treatment over time. Not only oncological safety but also aesthetic outcomes and reduction of functional morbidity, thereby improving patients’ quality of life (QoL), have become central considerations.

The results of the studies and the realization that breast cancer is a systemic rather than a local disease led to the worldwide introduction of breast-conserving therapy (BCT), followed by radiation, as standard surgical therapy in BC patients. A significant advancement in reducing functional morbidity and improving quality of life was achieved through the introduction of sentinel node biopsy as the standard procedure, replacing axillary dissection.

In cases where axillary dissection is still standard, it will be more and more replaced by tailored axillary dissection or tailored lymphodonectomy. 

Next to BCT, the introduction and widespread use of oncoplastic techniques have led to improved aesthetic outcomes. These techniques combine safe oncological surgery with achieving an aesthetically pleasing breast shape. Over the past decade, refined and differentiated methods have been developed, allowing personalized treatment approaches for each patient.

The disease itself and the treatments administered result in significant physical changes, psychological stress, and disruptions in social and sexual life. All of these factors contribute to a diminished quality of life. Surgery, while essential, is just one piece of the overall puzzle in breast cancer management, impacting various aspects of affected women’s lives.

We invite you to submit your research (reviews or clinical studies) on current trends in the surgical treatment of breast cancer, as well as studies that assess quality of life in relation to the different types of surgical therapy.

Summary:

The aim of this Special Issue is to give an overview of the current trends in surgical therapy in breast cancer, as well as the influence of surgical therapy on the quality of life of breast cancer patients.

This Special Issue aims to publish research on the following topics:

Current trends in the axillary surgery;

Oncoplastic surgery: limitations and benefits; 

QoL questionnaire to assess surgical outcomes;

Immediate versus delay reconstruction: What is better?

Complication management of reconstructive breast surgery;

Trends in reconstructive breast surgery;

Influence of systemic therapy on surgery in BC patients;

Influence of surgical treatment of breast cancer on quality of life;

AI in breast surgery.

In this Special Issue, original research articles and reviews are welcome.

I look forward to receiving your contributions.

Prof. Dr. Vesna Bjelic-Radisic
Prof. Dr. Maggie Banys-Paluchowski
Dr. Constanze Elfgen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oncoplastic breast surgery
  • breast reconstruction
  • quality of life

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Published Papers (2 papers)

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15 pages, 974 KiB  
Article
Preoperative and Postoperative Change in Patient-Reported Health-Related Quality of Life Outcomes in Breast Cancer Surgery Patients Across Surgical Modalities: A Prospective Study
by Claire Liu, Aidan Beresford, Maria Saleeb, Guiping Liu, Trafford Crump, Rebecca Warburton, Jin-Si Pao, Carol K. Dingee, Amy Bazzarelli, Jason M. Sutherland and Elaine C. McKevitt
Cancers 2025, 17(9), 1409; https://doi.org/10.3390/cancers17091409 - 23 Apr 2025
Viewed by 562
Abstract
Background: This study compared the change in pre- and postoperative health-related quality of life (HRQoL) among breast cancer patients undergoing breast-conserving surgery (BCS), total mastectomy no reconstruction (TMNR), and total mastectomy immediate breast reconstruction (MIBR). Patient factors associated with postoperative anxiety and [...] Read more.
Background: This study compared the change in pre- and postoperative health-related quality of life (HRQoL) among breast cancer patients undergoing breast-conserving surgery (BCS), total mastectomy no reconstruction (TMNR), and total mastectomy immediate breast reconstruction (MIBR). Patient factors associated with postoperative anxiety and depression were also identified. Methods: This prospective cohort study enrolled breast cancer patients between September 2017 and August 2020. HRQoL changes from preoperative to six months postoperative were compared using patient-reported outcome tools assessing anxiety, depression, pain, perceived health, breast satisfaction, psychosocial, physical, and sexual well-being and analyzed with ANOVA and linear regression. Results: A total of 471 patients completed preoperative and postoperative surveys (BCS: 313, TMNR: 60, MIBR: 98). Postoperative anxiety decreased across all modalities, with MIBR showing the greatest reduction (p = 0.03), though still exhibiting the highest postoperative anxiety (p = 0.05). Depression and perceived health scores showed no significant difference in change across modalities (p = 0.15, p = 0.48). MIBR patients showed the greatest increase in pain (p = 0.05) and the highest postoperative pain scores (p = 0.04). All three modalities showed a clinically significant decline in physical and sexual well-being. TMNR and MIBR had additional reductions in breast satisfaction, with TMNR also showing a decline in psychosocial well-being. Absolute postoperative scores for breast satisfaction, psychosocial, physical, and sexual well-being remained highest in BCS compared to TMNR and MIBR (p < 0.01, for each domain). In multivariable regression analysis, postoperative depression and anxiety scores did not differ between surgical modalities, but younger age was significantly associated with higher postoperative depression, pain and anxiety (p < 0.01), and adjuvant chemotherapy with higher postoperative depression (p < 0.01). Conclusions: BCS may have better overall HRQoL outcomes, specifically in breast satisfaction, psychosocial, physical, and sexual well-being, compared to TMNR and MIBR. Additionally, younger age, rather than surgical modality, was found to be associated with higher postoperative depression, pain, and anxiety scores. Full article
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17 pages, 1723 KiB  
Systematic Review
Quality of Life After Locoregional Treatment in Women with De Novo Metastatic Breast Cancer: A Systematic Review and Meta-Analysis
by Camille Weiss, Philippe Trensz, Martin Schmitt and Massimo Lodi
Cancers 2025, 17(5), 751; https://doi.org/10.3390/cancers17050751 - 22 Feb 2025
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Abstract
Introduction: Primary site locoregional treatment (LRT) of metastatic breast cancer has been performed and evaluated with the aim to improve survival, prevent complications, and alleviate local symptoms. As some studies fail to show a survival benefit, the quality of life is important to [...] Read more.
Introduction: Primary site locoregional treatment (LRT) of metastatic breast cancer has been performed and evaluated with the aim to improve survival, prevent complications, and alleviate local symptoms. As some studies fail to show a survival benefit, the quality of life is important to consider when deciding on LRT. The aim of this study was to evaluate and quantify the impact of LRT on the quality of life of patients with de novo metastatic breast cancer (dnMBC) through a systematic review of the literature and a meta-analysis. Methods: Multiple databases were searched on May 2024 with the following keywords: (i) dnMBC; (ii) LRT, including surgery +/− radiotherapy; and (iii) QOL. Results: Six studies were included in the qualitative synthesis and four in meta-analysis (481 women, n = 251 in the LRT and n = 230 in the control groups). There was a significant QOL decrease in the LRT group at 18 months (standardized mean difference [SMD] = −0.63; 95% confidence interval [CI] −0.98–−0.26; p < 0.001, low heterogeneity I2 = 33%) and after 30 months (SMD −0.82; 95%CI −1.58–−0.06; p = 0.034, high heterogeneity I2 = 93%), while no statistically significant difference was observed at short term (6 months, p = 0.333). Conclusions: This study shows that there is lacking evidence regarding the QOL benefits after LRT in this population, and even a numerical deterioration in global QOL several months after the treatment. Future and ongoing research may provide additional insights into this question on dnMBC and specifics subgroups. Full article
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