Exploring the Interplay of Glioblastoma Angiogenesis, ROS, and Tumor Microenvironment: Advancements in Combination Therapy and Bioinformatics Approaches
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Metastasis".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 1972
Special Issue Editor
Interests: glioblastoma; autophagy; angiogenesis; bioactive natural products; cancer immunotherapy; in silico and network pharmacology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Glioblastoma (GBM) is an aggressive brain tumor with significant angiogenesis, triggered by hypoxia-inducible factors (HIFs) and aggravated by reactive oxygen species (ROS). The tumor microenvironment (TME), which comprises immune cells and stromal components, is critical in therapeutic resistance. Conventional treatments such as radiation (RT) frequently fail due to the adaptive processes of the TME. Autophagy and apoptosis are critical cellular mechanisms that contribute to this resistance. Recent advances in cancer immunotherapy and combination medicines have provided promising alternatives. In silico and network pharmacology techniques, along with bioinformatics, provide tools for identifying novel therapeutic targets and optimizing treatment options. This Special Issue will address these pathways in order to create novel treatment modalities that improve GBM patient outcomes by using a combination of therapeutic techniques and precision medicine. We welcome the submission of review and original research articles that explore the intricate relationship between glioblastoma angiogenesis, ROS, and the tumor microenvironment, focusing on recent advancements in combination therapies and bioinformatic approaches.
Dr. Md Ataur Rahman
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- glioblastoma
- angiogenesis
- reactive oxygen species (ROS)
- hypoxia-inducible factors (HIFs)
- radiotherapy (RT)
- bioactive natural compounds
- tumor microenvironment (TME)
- cancer immunotherapy
- combination therapy
- autophagy
- apoptosis
- in silico and network pharmacology
- bioinformatics
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
