The Pathogenesis and Treatment of Diffuse Midline Glioma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 30
Special Issue Editor
Special Issue Information
Dear Colleagues,
Pediatric brain tumors are the most common solid tumor in children, and diffuse midline gliomas (DMGs) persist as the most morbid despite decades of research and clinical trials aiming to improve clinical outcomes. However, increasingly safe access to tumor tissue for study has led to the elucidation of the genomic landscape contributing to tumorigenesis, including the prevalence of the H3K27M mutation, and has provided an opportunity to better understand DMG biology and identify novel, targeted, and more effective therapies. Coupled with advances in surgical tissue acquisition, advancing sequencing techniques and data sharing platforms have led to a significant increase in scientific studies and clinical trials for DMGs in the last decade, meeting a critical unmet need for better treatment for these patients.
Given these recent developments in studies investigating DMG biology, diagnosis, clinical monitoring and molecularly targeted treatment, we aim to gather contemporary reports from experts in the field to curate a Special Issue of Cancers focused on this topic to advance the understanding of tumor biology and treatment for this disease. This Special Issue is intended to highlight recent studies on the biology and clinical features of diffuse midline glioma, as well as novel findings related to mechanisms of tumorigenesis, the effects of and resistance to targeted therapy, as well as the development of biomarker detection and liquid biopsy techniques for diagnosis and disease monitoring. We also highlight the role of patient advocacy and philanthropic organizations, who have significantly advanced attention to and research into this diagnosis with their support. Here, we present original research and review articles addressing our current understanding of the clinical course and biology of diffuse midline glioma, and together aim to identify future directions for improved clinical outcomes for these patients.
Dr. Amanda Muhs Saratsis
Guest Editor
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Keywords
- pediatric brain tumors
- diffuse midline glioma
- high-grade glioma
- H3K27M mutant glioma
- liquid biopsy
- diffuse intrinsic pontine glioma
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