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Cancers
Special Issues
Prostate Cancer and Inflammation
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Prostate Cancer and Inflammation

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1179

Special Issue Editor

Dr. Takuji Hayashi

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Guest Editor
Department of Urology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Interests: prostate cancer; inflammation; immune cells; anti-inflammatory agents; diets

Special Issue Information

Dear Colleagues,

Prostate cancer is the most common type of cancer in men and the leading cause of cancer death among men in many countries.

Inflammation, which is induced by various factors such as infection, the microbiome, obesity, and a high-fat diet, is the major etiology in both the initiation and development of prostate cancer. Various immune cells including tumor-associated neutrophils, tumor-infiltrating macrophages, myeloid-derived suppressor cells, and mast cells promote prostate cancer via various intercellular signaling pathways.

Epidemiological investigations and basic research using human immune cells or mouse models have revealed that anti-inflammatory drugs and diets are potential interventions for preventing the progression of prostate cancer by suppressing inflammation. This Special Issue will highlight current evidence regarding the relationship between prostate cancer and inflammation.

Dr. Takuji Hayashi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer
  • inflammation
  • immune cells
  • cytokine
  • chemokine
  • anti-inflammatory agents
  • diet
  • microbiome

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Published Papers (1 paper)

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Research

14 pages, 3711 KiB  
Article
Analysis of Inflammatory Features in Suspicious Lesions for Significant Prostate Cancer on Magnetic Resonance Imaging—Are They Mimickers of Prostate Cancer?
by Juan Morote, Ana Celma, María E. Semidey, Andreu Antolín, Berta Miró, Olga Méndez and Enrique Trilla
Cancers 2025, 17(1), 53; https://doi.org/10.3390/cancers17010053 - 27 Dec 2024
Viewed by 931
Abstract
Background. Inflammatory features can mimic PCa in suspicious MRI-lesions. Objectives: To assess the incidence of inflammatory features in targeted biopsies to suspicious lesions. Methods. A prospective analysis was conducted of 531 MRI-suspicious lesions with Prostate Imaging-Reporting and Data System (PI-RADS) scores of 3 [...] Read more.
Background. Inflammatory features can mimic PCa in suspicious MRI-lesions. Objectives: To assess the incidence of inflammatory features in targeted biopsies to suspicious lesions. Methods. A prospective analysis was conducted of 531 MRI-suspicious lesions with Prostate Imaging-Reporting and Data System (PI-RADS) scores of 3 to 5 in 364 men suspected of having PCa. Results. The incidence of inflammatory features in the MRI-suspicious lesions without PCa was 69.6%, compared to 48.1% in those with PCa (p < 0.001). Among the suspicious lesions without PCa, the incidence of inflammatory features ranged from 68.6% to 71.2% across the PI-RADS categories (p = 0.870). Mild chronic prostatitis increased with higher PI-RADS scores, while acute prostatitis decreased, and granulomatous prostatitis was exclusively observed in patients with PI-RADS scores of 4 and 5. The incidence of inflammatory features in the lesions with insignificant PCa (grade group 1) was 66.7%, compared to 42.7% in those with significant PCa (grade group 2 to 5; p = 0.027). The detection of inflammatory features in MRI-suspicious lesions was identified as an independent predictor of a lower likelihood of significant PCa detection, with an odds ratio (OR) of 0.326 (95% CI 0.196–0.541). Mild chronic prostatitis was the only type of prostatitis which was an independent predictor of a lower likelihood of significant PCa, with an OR of 0.398 (95% CI 0.268–0.590). Conclusions. These data suggest that inflammatory features may be considered mimickers of significant PCa on MRI. Full article
(This article belongs to the Special Issue Prostate Cancer and Inflammation)
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